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Found 15 Enz. Inhib. hit(s) with all data for entry = 6558
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329914(1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluor...)
Affinity DataIC50:  1nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329929(8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylam...)
Affinity DataIC50:  1nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50:  2nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50:  3nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM41577(US8614220, A98B1C3Z)
Affinity DataIC50:  5nMpH: 3.0Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329913(1-(2-fluoroethyl)-8-(5-(piperazin-1-yl)-2-(trifluo...)
Affinity DataIC50:  5nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM41579(US8614220, A47B1C1Z)
Affinity DataIC50:  7nMpH: 3.0Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50343568(1-methyl-8-(5-(1-methyl-1,2,3,6-tetrahydropyridin-...)
Affinity DataIC50:  8nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM139106(US8614220, A51B1C3Z)
Affinity DataIC50:  10nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM41575(CHEMBL1094408 | US8614220, A85B1C1Z)
Affinity DataIC50:  10nMpH: 3.0Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329916(1-(2-chloroethyl)-8-(5-(piperazin-1-yl)-2-(trifluo...)
Affinity DataIC50:  13nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50318085(1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-...)
Affinity DataIC50:  14nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM41576(US8614220, A45B2C1Z)
Affinity DataIC50:  26nMpH: 3.0Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM139107(US8614220, A85B1C4Z)
Affinity DataIC50:  26nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM41578(US8614220, A101B1C1Z)
Affinity DataIC50:  46nMpH: 3.0Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In DepthDetails US Patent