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Found 10 Enz. Inhib. hit(s) with all data for entry = 7114
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175209(US9115126, Example 1)
Affinity DataIC50:  0.800nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175205(US9115126, Example 2a)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175204(US9115126, Example 35)
Affinity DataIC50:  3.30nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50:  8.30nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175206(US9115126, Example 4b)
Affinity DataIC50:  9nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175208(US9115126, Example 44)
Affinity DataIC50:  13nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175207(US9115126, Reference imidazopyridine derivative EP...)
Affinity DataIC50:  26nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)
Affinity DataIC50:  32nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323258(6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  234nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent