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Found 5 Enz. Inhib. hit(s) with all data for entry = 774
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM290032(N-(3-bromopyridin-4-yl)-7-methoxy-2-oxo-8-propyl-2...)
Affinity DataEC50:  19nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM290121(N-(2-bromophenyl)-7-methoxy-2-oxo-8-propyl-2H-chro...)
Affinity DataEC50:  26.4nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM290124(N-{4-[(ethylsulfonyl)amino]-2-methylphenyl}-7-meth...)
Affinity DataEC50:  14.3nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM290123(N-[4-(aminosulfonyl)-2-bromophenyl]-7-methoxy-2-ox...)
Affinity DataEC50:  3.5nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM290122((4R)-4-amino-5-[(4-{[(7-methoxy-2-oxo-8-propyl-2H-...)
Affinity DataEC50:  3.10nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent