Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 1508
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327829(2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Affinity DataIC50:  0.934nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327832(2-((R)-2-methyl-4-((R)-phenyl(3-(trifluoromethyl)p...)
Affinity DataIC50:  0.980nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327844(2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)me...)
Affinity DataIC50:  1.5nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327827((R)-2-(4-benzhydryl-2-methylpiperazin-1-yl)acetic ...)
Affinity DataIC50:  1.51nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327833((S)-2-((R)-4-(bis(4-chlorophenyl)methyl)-3-methylp...)
Affinity DataIC50:  2.14nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327842(2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)p...)
Affinity DataIC50:  2.70nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327828(2-((R)-4-((R)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Affinity DataIC50:  3.94nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327835(2-((R)-2-methyl-4-((R)-phenyl(m-tolyl)methyl)piper...)
Affinity DataIC50:  4.32nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327836(2-((R)-2-methyl-4-((R)-phenyl(3-(thiophen-2-yl)phe...)
Affinity DataIC50:  4.80nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327834(US9663476, Compound 30 | [(R)-4-((R)-biphenyl-3-yl...)
Affinity DataIC50:  7.20nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327841(US9663476, Compound 49 | [(R)-2-methyl-4-[(R)-(4&#...)
Affinity DataIC50:  17.8nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327838(2-((R)-2-methyl-4-((R)-(3-(methylthio)phenyl)(phen...)
Affinity DataIC50:  37.6nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327845((R)-2-(4-(bis(4-chlorophenyl)methyl)-2-methylpiper...)
Affinity DataIC50:  41.1nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327826((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Affinity DataIC50:  79.1nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327826((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Affinity DataIC50:  134nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327839(US9663476, Compound 48 | [(R)-2-methyl-4-[(R)-(3&#...)
Affinity DataIC50:  217nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327840((R)-2-((R)-4-(bis(4-chlorophenyl)methyl)-2-methylp...)
Affinity DataIC50:  1.19E+3nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM327843(2-((R)-2-methyl-4-((R)-thiophen-2-yl(3-(trifluorom...)
Affinity DataIC50:  2.20E+3nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent