Compile Data Set for Download or QSAR
maximum 50k data
Found 62 Enz. Inhib. hit(s) with all data for entry = 1559
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330363(2-(3-Fluoro-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-t...)
Affinity DataIC50:  6nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330356((1S)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...)
Affinity DataIC50:  13nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330355((1R)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...)
Affinity DataIC50:  14nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330354(2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  14nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330378(2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  18nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330368((1R)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...)
Affinity DataIC50:  19nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330371((1S)-1-methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...)
Affinity DataIC50:  20nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330346(2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  20nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330374(1-Methyl-6- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,3- t...)
Affinity DataIC50:  23nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330361(2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  24nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330367((1S)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...)
Affinity DataIC50:  25nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330351(2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  32nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330373((1S)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...)
Affinity DataIC50:  34nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330357(1-Cyclopropyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...)
Affinity DataIC50:  36nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330352(1-(2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  41nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330379(2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  45nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330365(6-{[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- triazol-2-...)
Affinity DataIC50:  80nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330360(1-Cyclobutyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2...)
Affinity DataIC50:  82nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330358(1-Cyclopentyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...)
Affinity DataIC50:  86nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330347(1,1,1-Trifluoro-2-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-...)
Affinity DataIC50:  89nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330342(1-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  98nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330376((1R)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...)
Affinity DataIC50:  112nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330345(1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...)
Affinity DataIC50:  119nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330370((1R)-1-Methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...)
Affinity DataIC50:  123nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330377((1S)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...)
Affinity DataIC50:  164nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330364(5-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50:  183nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330366((1R)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...)
Affinity DataIC50:  238nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330356((1S)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...)
Affinity DataIC50:  241nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330363(2-(3-Fluoro-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-t...)
Affinity DataIC50:  259nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  271nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330371((1S)-1-methyl-5-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...)
Affinity DataIC50:  289nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330355((1R)-1-cyclopropyl- 1-(2-{[(3R,6R)-6- methyl-1-{[2...)
Affinity DataIC50:  297nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330362(2-(4-Fluoro-3-{[(3R,6R)- 6-methyl-1-{[2-(2H- 1,2,3...)
Affinity DataIC50:  354nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330372((1R)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...)
Affinity DataIC50:  390nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330369((1S)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...)
Affinity DataIC50:  394nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330354(2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  436nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330373((1S)-1-Methyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2...)
Affinity DataIC50:  648nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330374(1-Methyl-6- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,3- t...)
Affinity DataIC50:  742nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330361(2-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  827nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330346(2-(2-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  996nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330376((1R)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...)
Affinity DataIC50:  1.17E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330368((1R)-6-{[(3R,6R)- 6-Methyl-1-{[2- (2H-1,2,3-triazo...)
Affinity DataIC50:  1.34E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330352(1-(2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  1.52E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330367((1S)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- tria...)
Affinity DataIC50:  1.53E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330365(6-{[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- triazol-2-...)
Affinity DataIC50:  2.07E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330357(1-Cyclopropyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...)
Affinity DataIC50:  2.10E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330377((1S)-1-Methyl-6- {[(3R,6R)-6- methyl-1-{[2- (2H-1,...)
Affinity DataIC50:  3.35E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330358(1-Cyclopentyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,...)
Affinity DataIC50:  3.42E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330345(1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...)
Affinity DataIC50:  4.24E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330342(1-(3-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-...)
Affinity DataIC50:  4.51E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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