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Patent code WO2021205290

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510018
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)[C@@H]1CCCN1C
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WIPO WO2021205290
n/an/a 0.0300n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510022
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1ccncc1
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WIPO WO2021205290
n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510043
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)ncnc1C
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WIPO WO2021205290
n/an/a 0.930n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510024
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)[C@H]1CCCCN1C
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WIPO WO2021205290
n/an/a 1.42n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510019
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)[C@H]1CCCN1C
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WIPO WO2021205290
n/an/a 2.47n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM509969
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)CN(C)C
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WIPO WO2021205290
n/an/a 2.98n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510036
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)ccnc1C
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WIPO WO2021205290
n/an/a 4.29n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510023
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1ccccn1
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WIPO WO2021205290
n/an/a 4.43n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510027
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1ccnn1C
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WIPO WO2021205290
n/an/a 5.25n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510047
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)nc(nc1C)C1CCOCC1
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WIPO WO2021205290
n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510042
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)nc(C)nc1C
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WIPO WO2021205290
n/an/a 5.89n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510021
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1CCN(C)CC1
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WIPO WO2021205290
n/an/a 6.13n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510041
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)cncc1C
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WIPO WO2021205290
n/an/a 7.56n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510038
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cc(cc1C)C#N
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WIPO WO2021205290
n/an/a 7.67n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510040
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cccc1Cl
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WIPO WO2021205290
n/an/a 8.82n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510044
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cccc1F
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WIPO WO2021205290
n/an/a 8.91n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510020
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cccnc1
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WIPO WO2021205290
n/an/a 9.57n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510011
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1ccccc1Cl
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WIPO WO2021205290
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510034
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1ccccc1CN(C)C
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WIPO WO2021205290
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510017
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cccnc1C
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WIPO WO2021205290
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510035
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)ccnc1CN(C)C
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WIPO WO2021205290
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510012
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1(C)CCN(C)CC1
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WIPO WO2021205290
n/an/a 18n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510016
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cnccc1C
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WIPO WO2021205290
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM509970
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES CCC(=O)OCC(=O)[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc2c(OC)cccc2[nH]1
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WIPO WO2021205290
n/an/a 34n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510037
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES CCOc1nccc(C)c1C(=O)OCC(=O)[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc2c(OC)cccc2[nH]1
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WIPO WO2021205290
n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510039
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cccc1C
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WIPO WO2021205290
n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510030
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cncn1C
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WIPO WO2021205290
n/an/a 41n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510046
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cc(F)cc1C
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WIPO WO2021205290
n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM509971
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C(C)C
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WIPO WO2021205290
n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510014
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES CC[C@@H](C)C(=O)OCC(=O)[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc2c(OC)cccc2[nH]1
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WIPO WO2021205290
n/an/a 65n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510013
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES CC[C@H](C)C(=O)OCC(=O)[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc2c(OC)cccc2[nH]1
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WIPO WO2021205290
n/an/a 66n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM509974
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1ccccc1
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WIPO WO2021205290
n/an/a 71n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510007
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1CCCCC1
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WIPO WO2021205290
n/an/a 74n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510029
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cnn(C)c1
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WIPO WO2021205290
n/an/a 91n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510025
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cn(C)nc1C
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WIPO WO2021205290
n/an/a 92n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510015
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1(C)CC1
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WIPO WO2021205290
n/an/a 104n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510045
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cc(C)c(CC(=O)OCC(=O)[C@H](C[C@@H]2CCNC2=O)NC(=O)[C@H](CC(C)C)NC(=O)c2cc3c(OC)cccc3[nH]2)c(C)c1
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WIPO WO2021205290
n/an/a 117n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510028
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1ccn(C)n1
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WIPO WO2021205290
n/an/a 118n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510008
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1(C)CCCCC1
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WIPO WO2021205290
n/an/a 139n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510010
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1ccccc1CC(=O)OCC(=O)[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc2c(OC)cccc2[nH]1
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WIPO WO2021205290
n/an/a 147n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510032
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cn(C)cn1
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WIPO WO2021205290
n/an/a 152n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510031
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)nn(C)c1C
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WIPO WO2021205290
n/an/a 255n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510026
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1cnn(C)c1C
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WIPO WO2021205290
n/an/a 306n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510009
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1(C)CCC1
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WIPO WO2021205290
n/an/a 348n/an/an/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510007
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1CCCCC1
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WIPO WO2021205290
n/an/an/an/a 109n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510042
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(C)nc(C)nc1C
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WIPO WO2021205290
n/an/an/an/a 4.80E+3n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510038
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cc(cc1C)C#N
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WIPO WO2021205290
n/an/an/an/a 51n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510043
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)ncnc1C
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WIPO WO2021205290
n/an/an/an/a 315n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510034
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1ccccc1CN(C)C
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WIPO WO2021205290
n/an/an/an/a 538n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM509971
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C(C)C
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WIPO WO2021205290
n/an/an/an/a 205n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510040
PNG
((3S)-3-({N-[(4-methoxy-1 H-indol-2-yl)carbonyl]-L-...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)Cc1c(C)cccc1Cl
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
WIPO WO2021205290
n/an/an/an/a 163n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM510009
PNG
((3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-l...)
Show SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)C1(C)CCC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
WIPO WO2021205290
n/an/an/an/a 505n/an/an/an/a



Pfizer Inc.

WIPO


Assay Description
The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...


WIPO WO2021205290 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%