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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530430 (6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530432 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530442 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530441 ((S*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530439 ((R*)-7-Fluoro-6-(2-(1-hydroxyethyl)-1-methyl-1H-im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530444 (2-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-6-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530432 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530435 (7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530435 (7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530445 (2-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-6-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530438 ((S*)-7-Fluoro-6-(2-(1-hydroxyethyl)-1-methyl-1H-im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530441 ((S*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530433 (Racemic 7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530454 (7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530453 (7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530436 (7-Fluoro-6-(2-(hydroxymethyl)-1-methyl-1H-imidazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530455 (2-(3-Chloro-6-methylpyridin-2-yl)-7-fluoro-6-(2-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530440 ((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530434 (6-(5-Acetyl-1-methyl-1H-1,2,4-triazol-3-yl)-7-fluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530440 ((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530446 (2-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-6-(2-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530447 (2-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-6-(5-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530443 ((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530437 (7-Fluoro-6-(5-(hydroxymethyl)-1-methyl-1H-1,2,4-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530429 (6-(5-Cyclopropylpyrazin-2-yl)-7-fluoro-4-isopropyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530431 (6-(4-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530452 (6-(5-Acetyl-1-ethyl-1H-1,2,4-triazol-3-yl)-7-fluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530456 (6-(1-Ethyl-5-(1-hydroxyethyl)-1H-1,2,4-triazol-3-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM530448 (6-(1-Ethyl-5-(2-hydroxypropan-2-yl)-1H-1,2,4-triaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | UniChem | WIPO WO2022070068 | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN BIOTECH, INC. WIPO | Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th... | WIPO WO2022070068 (2022) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
