Affinity Data by Patent

Patent code WO2022070071

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530465 (8-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	1.33	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530467 (3-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-8-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530464 (7-Fluoro-8-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	2.11	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530469 (7-Fluoro-8-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530466 (3-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-8-(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	2.69	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530468 (7-Fluoro-8-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	4.07	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530470 (3-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-8-(2-(2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM530471 (3-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-8-(5-(2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	WIPO WO2022070071	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN BIOTECH, INC. WIPO					Assay Description To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...				WIPO WO2022070071 (2022)
JANSSEN BIOTECH, INC. WIPO					More data for this Ligand-Target Pair

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Change energy units to:kcal/mole

* indicates data uncertainty>20%