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Patent code WO2022076495

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530621
PNG
(1-(5-(difluoromethoxy)-2-fluorophenyl)-3-(3-hydrox...)
Show SMILES CC(n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O
Show InChI InChI=1S/C24H26F3N3O6S/c1-13(23(2,3)33)29-19-9-14(20(31)28-24(4)11-37(34,35)12-24)5-8-17(19)30(22(29)32)18-10-15(36-21(26)27)6-7-16(18)25/h5-10,13,21,33H,11-12H2,1-4H3,(H,28,31)
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WIPO WO2022076495
n/an/a 0.700n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530630
PNG
(WO2022076495, EXAMPLE 70a)
Show SMILES C[C@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)(F)F)ccc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C26H28F5N3O6S/c1-14(24(2,3)37)33-20-12-16(22(35)32-25(4)7-9-41(38,39)10-8-25)18(28)13-21(20)34(23(33)36)19-11-15(5-6-17(19)27)40-26(29,30)31/h5-6,11-14,37H,7-10H2,1-4H3,(H,32,35)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 1n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530622
PNG
(WO2022076495, EXAMPLE 66a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H30F3N3O6S/c1-15(25(2,3)35)31-21-13-16(22(33)30-26(4)9-11-39(36,37)12-10-26)5-8-19(21)32(24(31)34)20-14-17(38-23(28)29)6-7-18(20)27/h5-8,13-15,23,35H,9-12H2,1-4H3,(H,30,33)/t15-/m0/s1
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WIPO WO2022076495
n/an/a 1.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530640
PNG
(WO2022076495, EXAMPLE 75a)
Show SMILES C[C@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ccc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C27H31F4N3O6S/c1-15(26(2,3)37)33-21-12-17(24(35)32-27(4)7-9-41(38,39)10-8-27)19(29)13-22(21)34(25(33)36)20-11-16(5-6-18(20)28)40-14-23(30)31/h5-6,11-13,15,23,37H,7-10,14H2,1-4H3,(H,32,35)/t15-/m0/s1
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WIPO WO2022076495
n/an/a 1.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530624
PNG
(WO2022076495, EXAMPLE 67a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H31F2N3O6S/c1-16(25(2,3)34)30-21-14-17(22(32)29-26(4)10-12-38(35,36)13-11-26)8-9-20(21)31(24(30)33)18-6-5-7-19(15-18)37-23(27)28/h5-9,14-16,23,34H,10-13H2,1-4H3,(H,29,32)/t16-/m0/s1
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WIPO WO2022076495
n/an/a 1.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530627
PNG
(WO2022076495, EXAMPLE 68b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cccc(OCC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C27H33F2N3O6S/c1-17(26(2,3)35)31-22-14-18(24(33)30-27(4)10-12-39(36,37)13-11-27)8-9-21(22)32(25(31)34)19-6-5-7-20(15-19)38-16-23(28)29/h5-9,14-15,17,23,35H,10-13,16H2,1-4H3,(H,30,33)/t17-/m1/s1
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WIPO WO2022076495
n/an/a 1.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530556
PNG
(1-(3-(difluoromethoxy)phenyl)-3-(4-fluorophenyl)-A...)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C25H20F3N3O5S/c1-25(13-37(34,35)14-25)29-22(32)15-5-10-20-21(11-15)30(17-8-6-16(26)7-9-17)24(33)31(20)18-3-2-4-19(12-18)36-23(27)28/h2-12,23H,13-14H2,1H3,(H,29,32)
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WIPO WO2022076495
n/an/a 1.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530648
PNG
(1-(5-(Difluoromethoxy)-2-fluorophenyl)-3-isopropyl...)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F3N3O5S/c1-14(2)29-20-12-15(21(31)28-24(3)8-10-36(33,34)11-9-24)4-7-18(20)30(23(29)32)19-13-16(35-22(26)27)5-6-17(19)25/h4-7,12-14,22H,8-11H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 2.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530557
PNG
(WO2022076495, EXAMPLE 3)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C26H22F3N3O5S/c1-26(11-12-38(35,36)15-26)30-23(33)16-5-10-21-22(13-16)31(18-8-6-17(27)7-9-18)25(34)32(21)19-3-2-4-20(14-19)37-24(28)29/h2-10,13-14,24H,11-12,15H2,1H3,(H,30,33)/t26-/m1/s1
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WIPO WO2022076495
n/an/a 2.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530641
PNG
(WO2022076495, EXAMPLE 75b)
Show SMILES C[C@@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ccc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C27H31F4N3O6S/c1-15(26(2,3)37)33-21-12-17(24(35)32-27(4)7-9-41(38,39)10-8-27)19(29)13-22(21)34(25(33)36)20-11-16(5-6-18(20)28)40-14-23(30)31/h5-6,11-13,15,23,37H,7-10,14H2,1-4H3,(H,32,35)/t15-/m1/s1
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WIPO WO2022076495
n/an/a 2.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530636
PNG
(WO2022076495, EXAMPLE 73a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cc(OCC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C27H32F3N3O6S/c1-16(26(2,3)36)32-22-13-17(24(34)31-27(4)9-11-40(37,38)12-10-27)5-8-20(22)33(25(32)35)21-14-18(6-7-19(21)28)39-15-23(29)30/h5-8,13-14,16,23,36H,9-12,15H2,1-4H3,(H,31,34)/t16-/m0/s1
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WIPO WO2022076495
n/an/a 2.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530689
PNG
(WO2022076495, EXAMPLE 120)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)(F)C(F)F)ccn2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F4N4O5S/c1-14(2)31-18-12-15(20(33)30-23(3)7-10-38(35,36)11-8-23)4-5-17(18)32(22(31)34)19-13-16(6-9-29-19)37-24(27,28)21(25)26/h4-6,9,12-14,21H,7-8,10-11H2,1-3H3,(H,30,33)
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WIPO WO2022076495
n/an/a 3.20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530637
PNG
(WO2022076495, EXAMPLE 73b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cc(OCC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C27H32F3N3O6S/c1-16(26(2,3)36)32-22-13-17(24(34)31-27(4)9-11-40(37,38)12-10-27)5-8-20(22)33(25(32)35)21-14-18(6-7-19(21)28)39-15-23(29)30/h5-8,13-14,16,23,36H,9-12,15H2,1-4H3,(H,31,34)/t16-/m1/s1
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WIPO WO2022076495
n/an/a 3.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530629
PNG
(WO2022076495, EXAMPLE 69b)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n([C@H](C)C(C)(C)O)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H33FN4O6S/c1-6-37-22-14-20(18(27)15-28-22)31-19-8-7-17(13-21(19)30(24(31)33)16(2)25(3,4)34)23(32)29-26(5)9-11-38(35,36)12-10-26/h7-8,13-16,34H,6,9-12H2,1-5H3,(H,29,32)/t16-/m1/s1
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WIPO WO2022076495
n/an/a 3.90n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530684
PNG
(WO2022076495, EXAMPLE 115 | l-(2-(2,2-difluoroetho...)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)F)ncc2F)c1=O
Show InChI InChI=1S/C23H24F4N4O5S/c1-12(2)30-17-8-13(20(32)29-23(3)4-6-37(34,35)7-5-23)14(24)9-18(17)31(22(30)33)16-10-19(36-21(26)27)28-11-15(16)25/h8-12,21H,4-7H2,1-3H3,(H,29,32)
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WIPO WO2022076495
n/an/a 4.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530626
PNG
(WO2022076495, EXAMPLE 68a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cccc(OCC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C27H33F2N3O6S/c1-17(26(2,3)35)31-22-14-18(24(33)30-27(4)10-12-39(36,37)13-11-27)8-9-21(22)32(25(31)34)19-6-5-7-20(15-19)38-16-23(28)29/h5-9,14-15,17,23,35H,10-13,16H2,1-4H3,(H,30,33)/t17-/m0/s1
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WIPO WO2022076495
n/an/a 4.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530563
PNG
(WO2022076495, EXAMPLE 9)
Show SMILES CCOc1cccc(c1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H27N3O5S/c1-5-31-18-8-6-7-17(12-18)26-19-10-9-16(11-20(19)25(15(2)3)22(26)28)21(27)24-23(4)13-32(29,30)14-23/h6-12,15H,5,13-14H2,1-4H3,(H,24,27)
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WIPO WO2022076495
n/an/a 4.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530633
PNG
(WO2022076495, EXAMPLE 71b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cc(OC(F)(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H29F4N3O6S/c1-15(24(2,3)36)32-21-13-16(22(34)31-25(4)9-11-40(37,38)12-10-25)5-8-19(21)33(23(32)35)20-14-17(6-7-18(20)27)39-26(28,29)30/h5-8,13-15,36H,9-12H2,1-4H3,(H,31,34)/t15-/m1/s1
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WIPO WO2022076495
n/an/a 5.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530687
PNG
(WO2022076495, EXAMPLE 118)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)(F)C(F)F)ncc2F)c1=O
Show InChI InChI=1S/C24H24F6N4O5S/c1-12(2)33-17-8-13(20(35)32-23(3)4-6-40(37,38)7-5-23)14(25)9-18(17)34(22(33)36)16-10-19(31-11-15(16)26)39-24(29,30)21(27)28/h8-12,21H,4-7H2,1-3H3,(H,32,35)
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WIPO WO2022076495
n/an/a 5.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530644
PNG
(WO2022076495, EXAMPLE 77a)
Show SMILES C[C@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(C)(C)O
Show InChI InChI=1S/C27H30F5N3O6S/c1-15(25(2,3)38)34-20-13-18(22(36)33-26(4)8-10-42(39,40)11-9-26)19(28)14-21(20)35(24(34)37)16-6-5-7-17(12-16)41-27(31,32)23(29)30/h5-7,12-15,23,38H,8-11H2,1-4H3,(H,33,36)/t15-/m0/s1
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WIPO WO2022076495
n/an/a 5.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530651
PNG
(WO2022076495, EXAMPLE 82)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-19-10-14(20(30)27-23(3)8-9-35(32,33)12-23)4-7-17(19)29(22(28)31)18-11-15(34-21(25)26)5-6-16(18)24/h4-7,10-11,13,21H,8-9,12H2,1-3H3,(H,27,30)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 5.70n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530638
PNG
(WO2022076495, EXAMPLE 74a)
Show SMILES C[C@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C26H30F4N4O6S/c1-14(25(2,3)37)33-19-9-15(23(35)32-26(4)5-7-41(38,39)8-6-26)16(27)10-20(19)34(24(33)36)18-11-22(31-12-17(18)28)40-13-21(29)30/h9-12,14,21,37H,5-8,13H2,1-4H3,(H,32,35)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 6.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530650
PNG
(WO2022076495, EXAMPLE 81)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-19-10-14(20(30)27-23(3)8-9-35(32,33)12-23)4-7-17(19)29(22(28)31)18-11-15(34-21(25)26)5-6-16(18)24/h4-7,10-11,13,21H,8-9,12H2,1-3H3,(H,27,30)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 6.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530634
PNG
(WO2022076495, EXAMPLE 72a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H31F3N4O6S/c1-15(25(2,3)36)32-20-11-16(23(34)31-26(4)7-9-40(37,38)10-8-26)5-6-18(20)33(24(32)35)19-12-22(30-13-17(19)27)39-14-21(28)29/h5-6,11-13,15,21,36H,7-10,14H2,1-4H3,(H,31,34)/t15-/m0/s1
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WIPO WO2022076495
n/an/a 6.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530639
PNG
(WO2022076495, EXAMPLE 74b)
Show SMILES C[C@@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C26H30F4N4O6S/c1-14(25(2,3)37)33-19-9-15(23(35)32-26(4)5-7-41(38,39)8-6-26)16(27)10-20(19)34(24(33)36)18-11-22(31-12-17(18)28)40-13-21(29)30/h9-12,14,21,37H,5-8,13H2,1-4H3,(H,32,35)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 6.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530635
PNG
(WO2022076495, EXAMPLE 72b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H31F3N4O6S/c1-15(25(2,3)36)32-20-11-16(23(34)31-26(4)7-9-40(37,38)10-8-26)5-6-18(20)33(24(32)35)19-12-22(30-13-17(19)27)39-14-21(28)29/h5-6,11-13,15,21,36H,7-10,14H2,1-4H3,(H,31,34)/t15-/m1/s1
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WIPO WO2022076495
n/an/a 6.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530569
PNG
(WO2022076495, EXAMPLE 15)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OCC(F)F)ncc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H27F3N4O5S/c1-14(2)30-19-10-15(22(32)29-24(3)6-8-37(34,35)9-7-24)4-5-17(19)31(23(30)33)18-11-21(28-12-16(18)25)36-13-20(26)27/h4-5,10-12,14,20H,6-9,13H2,1-3H3,(H,29,32)
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WIPO WO2022076495
n/an/a 6.70n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530679
PNG
(WO2022076495, EXAMPLE 110)
Show SMILES CC(C)n1c2cc(cc(F)c2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-18-10-14(20(30)27-23(3)7-8-35(32,33)12-23)9-17(24)19(18)29(22(28)31)15-5-4-6-16(11-15)34-21(25)26/h4-6,9-11,13,21H,7-8,12H2,1-3H3,(H,27,30)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 7n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530649
PNG
(WO2022076495, EXAMPLE 80)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H22F3N3O5S/c1-12(2)27-18-8-13(19(29)26-22(3)10-34(31,32)11-22)4-7-16(18)28(21(27)30)17-9-14(33-20(24)25)5-6-15(17)23/h4-9,12,20H,10-11H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 7.70n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530643
PNG
(WO2022076495, EXAMPLE 76b)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O
Show InChI InChI=1S/C25H27F4N3O6S/c1-14(23(2,3)35)31-19-10-15(20(33)30-24(4)12-39(36,37)13-24)8-9-18(19)32(22(31)34)16-6-5-7-17(11-16)38-25(28,29)21(26)27/h5-11,14,21,35H,12-13H2,1-4H3,(H,30,33)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 7.90n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530558
PNG
(3-(3-(difluoromethoxy)phenyl)-1-(4-fluorophenyl)-N...)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2n(-c3cccc(OC(F)F)c3)c(=O)n(-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C24H19F3N4O5S/c1-24(12-37(34,35)13-24)29-21(32)14-9-19-20(28-11-14)31(17-3-2-4-18(10-17)36-22(26)27)23(33)30(19)16-7-5-15(25)6-8-16/h2-11,22H,12-13H2,1H3,(H,29,32)
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WIPO WO2022076495
n/an/a 8.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530678
PNG
(WO2022076495, EXAMPLE 109)
Show SMILES CC(C)n1c2cc(cc(F)c2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-18-10-14(20(30)27-23(3)7-8-35(32,33)12-23)9-17(24)19(18)29(22(28)31)15-5-4-6-16(11-15)34-21(25)26/h4-6,9-11,13,21H,7-8,12H2,1-3H3,(H,27,30)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 9n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530628
PNG
(WO2022076495, EXAMPLE 69a)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n([C@@H](C)C(C)(C)O)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H33FN4O6S/c1-6-37-22-14-20(18(27)15-28-22)31-19-8-7-17(13-21(19)30(24(31)33)16(2)25(3,4)34)23(32)29-26(5)9-11-38(35,36)12-10-26/h7-8,13-16,34H,6,9-12H2,1-5H3,(H,29,32)/t16-/m0/s1
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WIPO WO2022076495
n/an/a 9.70n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530645
PNG
(WO2022076495, EXAMPLE 77b)
Show SMILES C[C@@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(C)(C)O
Show InChI InChI=1S/C27H30F5N3O6S/c1-15(25(2,3)38)34-20-13-18(22(36)33-26(4)8-10-42(39,40)11-9-26)19(28)14-21(20)35(24(34)37)16-6-5-7-17(12-16)41-27(31,32)23(29)30/h5-7,12-15,23,38H,8-11H2,1-4H3,(H,33,36)/t15-/m1/s1
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WIPO WO2022076495
n/an/a 9.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530677
PNG
(1-[3-(difluoromethoxy)phenyl]-7-fluoro-3-isopropyl...)
Show SMILES CC(C)n1c2cc(cc(F)c2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H22F3N3O5S/c1-12(2)27-17-8-13(19(29)26-22(3)10-34(31,32)11-22)7-16(23)18(17)28(21(27)30)14-5-4-6-15(9-14)33-20(24)25/h4-9,12,20H,10-11H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530599
PNG
(WO2022076495, EXAMPLE 45a)
Show SMILES C[C@H](C(F)F)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H25F4N3O5S/c1-14(20(25)26)30-19-12-15(21(32)29-24(2)8-10-37(34,35)11-9-24)6-7-18(19)31(23(30)33)16-4-3-5-17(13-16)36-22(27)28/h3-7,12-14,20,22H,8-11H2,1-2H3,(H,29,32)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530647
PNG
(WO2022076495, EXAMPLE 78b)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n([C@@H](C)C(C)(C)O)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C24H29FN4O6S/c1-6-35-20-10-18(16(25)11-26-20)29-17-8-7-15(21(30)27-24(5)12-36(33,34)13-24)9-19(17)28(22(29)31)14(2)23(3,4)32/h7-11,14,32H,6,12-13H2,1-5H3,(H,27,30)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 13n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530565
PNG
(WO2022076495, EXAMPLE 11)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OCC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H29F2N3O5S/c1-16(2)29-21-13-17(23(31)28-25(3)9-11-36(33,34)12-10-25)7-8-20(21)30(24(29)32)18-5-4-6-19(14-18)35-15-22(26)27/h4-8,13-14,16,22H,9-12,15H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530568
PNG
(WO2022076495, EXAMPLE 14)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC3CC3)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C24H27N3O5S/c1-15(2)26-21-11-16(22(28)25-24(3)13-33(30,31)14-24)7-10-20(21)27(23(26)29)17-5-4-6-19(12-17)32-18-8-9-18/h4-7,10-12,15,18H,8-9,13-14H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530561
PNG
(WO2022076495, EXAMPLE 7)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)(F)C(F)(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H22F5N3O5S/c1-13(2)30-18-9-14(19(32)29-21(3)11-37(34,35)12-21)7-8-17(18)31(20(30)33)15-5-4-6-16(10-15)36-23(27,28)22(24,25)26/h4-10,13H,11-12H2,1-3H3,(H,29,32)
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WIPO WO2022076495
n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530567
PNG
(WO2022076495, EXAMPLE 13)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)C2CC2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C24H27N3O4S/c1-15(2)26-21-12-18(22(28)25-24(3)13-32(30,31)14-24)9-10-20(21)27(23(26)29)19-6-4-5-17(11-19)16-7-8-16/h4-6,9-12,15-16H,7-8,13-14H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 17n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530623
PNG
(WO2022076495, EXAMPLE 66b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H30F3N3O6S/c1-15(25(2,3)35)31-21-13-16(22(33)30-26(4)9-11-39(36,37)12-10-26)5-8-19(21)32(24(31)34)20-14-17(38-23(28)29)6-7-18(20)27/h5-8,13-15,23,35H,9-12H2,1-4H3,(H,30,33)/t15-/m1/s1
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WIPO WO2022076495
n/an/a 17n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530590
PNG
(WO2022076495, EXAMPLE 36)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2n(C3CCOCC3)c(=O)n(-c3cccc(OC(F)F)c3)c2cc1F
Show InChI InChI=1S/C24H24F3N3O6S/c1-24(12-37(33,34)13-24)28-21(31)17-10-19-20(11-18(17)25)30(15-3-2-4-16(9-15)36-22(26)27)23(32)29(19)14-5-7-35-8-6-14/h2-4,9-11,14,22H,5-8,12-13H2,1H3,(H,28,31)
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WIPO WO2022076495
n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530656
PNG
(WO2022076495, EXAMPLE 87 | l-isopropyl-A-(4-methyl...)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F4N4O5S/c1-14(2)31-18-11-15(20(33)30-23(3)7-9-38(35,36)10-8-23)13-29-19(18)32(22(31)34)16-5-4-6-17(12-16)37-24(27,28)21(25)26/h4-6,11-14,21H,7-10H2,1-3H3,(H,30,33)
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WIPO WO2022076495
n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530664
PNG
(WO2022076495, EXAMPLE 95)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F4N4O5S/c1-13(2)30-17-9-14(19(32)29-22(3)7-8-37(34,35)12-22)11-28-18(17)31(21(30)33)15-5-4-6-16(10-15)36-23(26,27)20(24)25/h4-6,9-11,13,20H,7-8,12H2,1-3H3,(H,29,32)/t22-/m1/s1
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WIPO WO2022076495
n/an/a 23n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530579
PNG
(1-(3-(difluoromethoxy)phenyl)-3-isopropyl-N-(4-met...)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H27F2N3O5S/c1-15(2)28-20-13-16(21(30)27-24(3)9-11-35(32,33)12-10-24)7-8-19(20)29(23(28)31)17-5-4-6-18(14-17)34-22(25)26/h4-8,13-15,22H,9-12H2,1-3H3,(H,27,30)
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WIPO WO2022076495
n/an/a 23n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530662
PNG
(WO2022076495, EXAMPLE 93)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H22F4N4O5S/c1-12(2)29-16-7-13(18(31)28-21(3)10-36(33,34)11-21)9-27-17(16)30(20(29)32)14-5-4-6-15(8-14)35-22(25,26)19(23)24/h4-9,12,19H,10-11H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 24n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530592
PNG
(WO2022076495, EXAMPLE 38)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(C3CCCC3)c2c1
Show InChI InChI=1S/C25H27F2N3O5S/c1-25(11-12-36(33,34)15-25)28-22(31)16-9-10-20-21(13-16)29(17-5-2-3-6-17)24(32)30(20)18-7-4-8-19(14-18)35-23(26)27/h4,7-10,13-14,17,23H,2-3,5-6,11-12,15H2,1H3,(H,28,31)/t25-/m1/s1
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WIPO WO2022076495
n/an/a 24n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530686
PNG
(WO2022076495, EXAMPLE 117)
Show SMILES CCOc1cc(c(F)cn1)-n1c2cc(F)c(cc2n(C(C)C)c1=O)C(=O)NC1(CCS(=O)(=O)CC1)C(F)F
Show InChI InChI=1S/C24H26F4N4O5S/c1-4-37-20-11-17(16(26)12-29-20)32-19-10-15(25)14(9-18(19)31(13(2)3)23(32)34)21(33)30-24(22(27)28)5-7-38(35,36)8-6-24/h9-13,22H,4-8H2,1-3H3,(H,30,33)
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WIPO WO2022076495
n/an/a 27n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530572
PNG
(WO2022076495, EXAMPLE 18)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H27FN4O5S/c1-5-33-20-11-18(16(24)12-25-20)28-17-7-6-15(10-19(17)27(14(2)3)22(28)30)21(29)26-23(4)8-9-34(31,32)13-23/h6-7,10-12,14H,5,8-9,13H2,1-4H3,(H,26,29)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 28n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530631
PNG
(WO2022076495, EXAMPLE 70b)
Show SMILES C[C@@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)(F)F)ccc2F)c1=O)C(C)(C)O
Show InChI InChI=1S/C26H28F5N3O6S/c1-14(24(2,3)37)33-20-12-16(22(35)32-25(4)7-9-41(38,39)10-8-25)18(28)13-21(20)34(23(33)36)19-11-15(5-6-17(19)27)40-26(29,30)31/h5-6,11-14,37H,7-10H2,1-4H3,(H,32,35)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530570
PNG
(WO2022076495, EXAMPLE 16 | WO2022076495, EXAMPLE 2...)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H25FN4O5S/c1-5-32-19-9-17(15(23)10-24-19)27-16-7-6-14(8-18(16)26(13(2)3)21(27)29)20(28)25-22(4)11-33(30,31)12-22/h6-10,13H,5,11-12H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a 31n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530584
PNG
(WO2022076495, EXAMPLE 30)
Show SMILES CC(C)n1c2cc(C(=O)N[C@H]3CCCC(F)(F)[C@H]3O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C24H24F5N3O4/c1-12(2)31-18-10-15(21(34)30-17-7-4-8-24(28,29)20(17)33)16(25)11-19(18)32(23(31)35)13-5-3-6-14(9-13)36-22(26)27/h3,5-6,9-12,17,20,22,33H,4,7-8H2,1-2H3,(H,30,34)/t17-,20-/m0/s1
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WIPO WO2022076495
n/an/a 31n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530570
PNG
(WO2022076495, EXAMPLE 16 | WO2022076495, EXAMPLE 2...)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H25FN4O5S/c1-5-32-19-9-17(15(23)10-24-19)27-16-7-6-14(8-18(16)26(13(2)3)21(27)29)20(28)25-22(4)11-33(30,31)12-22/h6-10,13H,5,11-12H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a 32n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530559
PNG
(WO2022076495, EXAMPLE 5 | l-(2-(Difluoromethoxy)-5...)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ncc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H25F3N4O5S/c1-13(2)29-18-10-14(20(31)28-23(3)6-8-36(33,34)9-7-23)4-5-16(18)30(22(29)32)17-11-19(35-21(25)26)27-12-15(17)24/h4-5,10-13,21H,6-9H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 34n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530620
PNG
(1-(3-(difluoromethoxy)phenyl)-3-(2-hydroxy-2-methy...)
Show SMILES CC(C)(O)Cn1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O6S/c1-22(2,31)11-27-18-9-14(19(29)26-23(3)12-35(32,33)13-23)7-8-17(18)28(21(27)30)15-5-4-6-16(10-15)34-20(24)25/h4-10,20,31H,11-13H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 37n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530615
PNG
(WO2022076495, EXAMPLE 59)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(Cc3ccc(F)cc3)c2c1
Show InChI InChI=1S/C28H26F3N3O5S/c1-28(11-13-40(37,38)14-12-28)32-25(35)19-7-10-23-24(15-19)33(17-18-5-8-20(29)9-6-18)27(36)34(23)21-3-2-4-22(16-21)39-26(30)31/h2-10,15-16,26H,11-14,17H2,1H3,(H,32,35)
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WIPO WO2022076495
n/an/a 38n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530562
PNG
(WO2022076495, EXAMPLE 8)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OCC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-14(2)27-19-9-15(21(29)26-23(3)12-34(31,32)13-23)7-8-18(19)28(22(27)30)16-5-4-6-17(10-16)33-11-20(24)25/h4-10,14,20H,11-13H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 43n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530688
PNG
(WO2022076495, EXAMPLE 119)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OCC(F)F)ccn2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H28F2N4O5S/c1-15(2)29-19-12-16(22(31)28-24(3)7-10-36(33,34)11-8-24)4-5-18(19)30(23(29)32)21-13-17(6-9-27-21)35-14-20(25)26/h4-6,9,12-13,15,20H,7-8,10-11,14H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 51n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530668
PNG
(WO2022076495, EXAMPLE 99)
Show SMILES CCOc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H30N4O5S/c1-5-33-19-8-6-7-18(14-19)28-21-20(27(16(2)3)23(28)30)13-17(15-25-21)22(29)26-24(4)9-11-34(31,32)12-10-24/h6-8,13-16H,5,9-12H2,1-4H3,(H,26,29)
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WIPO WO2022076495
n/an/a 52n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530578
PNG
(WO2022076495, EXAMPLE 24 | WO2022076495, EXAMPLE 2...)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CS(=O)(=O)C3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C22H22F3N3O5S/c1-12(2)27-17-8-15(19(29)26-22(3)10-34(31,32)11-22)16(23)9-18(17)28(21(27)30)13-5-4-6-14(7-13)33-20(24)25/h4-9,12,20H,10-11H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 54n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530691
PNG
(WO2022076495, EXAMPLE 122)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ncc2F)c1=O
Show InChI InChI=1S/C24H26F4N4O5S/c1-13(2)31-18-8-14(22(33)30-24(3)4-6-38(35,36)7-5-24)15(25)9-19(18)32(23(31)34)17-10-21(29-11-16(17)26)37-12-20(27)28/h8-11,13,20H,4-7,12H2,1-3H3,(H,30,33)
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WIPO WO2022076495
n/an/a 56n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530588
PNG
(WO2022076495, EXAMPLE 34)
Show SMILES CC(C)[C@@H](CO)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(C(C)C)c2c1
Show InChI InChI=1S/C23H27F2N3O4/c1-13(2)18(12-29)26-21(30)15-8-9-19-20(10-15)27(14(3)4)23(31)28(19)16-6-5-7-17(11-16)32-22(24)25/h5-11,13-14,18,22,29H,12H2,1-4H3,(H,26,30)/t18-/m1/s1
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WIPO WO2022076495
n/an/a 62n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530657
PNG
(WO2022076495, EXAMPLE 88)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H26F2N4O5S/c1-14(2)28-18-11-15(20(30)27-23(3)7-9-35(32,33)10-8-23)13-26-19(18)29(22(28)31)16-5-4-6-17(12-16)34-21(24)25/h4-6,11-14,21H,7-10H2,1-3H3,(H,27,30)
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WIPO WO2022076495
n/an/a 62n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530577
PNG
(WO2022076495, EXAMPLE 23)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-14(2)27-19-11-15(20(29)26-23(3)9-10-34(31,32)13-23)7-8-18(19)28(22(27)30)16-5-4-6-17(12-16)33-21(24)25/h4-8,11-12,14,21H,9-10,13H2,1-3H3,(H,26,29)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 63n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530591
PNG
(WO2022076495, EXAMPLE 37)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(C3CCC3)c2c1
Show InChI InChI=1S/C24H25F2N3O5S/c1-24(10-11-35(32,33)14-24)27-21(30)15-8-9-19-20(12-15)28(16-4-2-5-16)23(31)29(19)17-6-3-7-18(13-17)34-22(25)26/h3,6-9,12-13,16,22H,2,4-5,10-11,14H2,1H3,(H,27,30)/t24-/m1/s1
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WIPO WO2022076495
n/an/a 64n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530576
PNG
(WO2022076495, EXAMPLE 22)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)C2CC2(F)F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C24H25F2N3O4S/c1-14(2)28-20-10-16(21(30)27-23(3)12-34(32,33)13-23)7-8-19(20)29(22(28)31)17-6-4-5-15(9-17)18-11-24(18,25)26/h4-10,14,18H,11-13H2,1-3H3,(H,27,30)
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WIPO WO2022076495
n/an/a 66n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530578
PNG
(WO2022076495, EXAMPLE 24 | WO2022076495, EXAMPLE 2...)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CS(=O)(=O)C3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C22H22F3N3O5S/c1-12(2)27-17-8-15(19(29)26-22(3)10-34(31,32)11-22)16(23)9-18(17)28(21(27)30)13-5-4-6-14(7-13)33-20(24)25/h4-9,12,20H,10-11H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 66n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530680
PNG
(WO2022076495, EXAMPLE 111)
Show SMILES CC(C)n1c2cc(cc(F)c2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F3N3O5S/c1-14(2)29-19-12-15(21(31)28-24(3)7-9-36(33,34)10-8-24)11-18(25)20(19)30(23(29)32)16-5-4-6-17(13-16)35-22(26)27/h4-6,11-14,22H,7-10H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 68n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530675
PNG
(WO2022076495, EXAMPLE 106)
Show SMILES CC(C)n1c2cc(ncc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H26F2N4O5S/c1-14(2)28-18-12-17(20(30)27-23(3)7-9-35(32,33)10-8-23)26-13-19(18)29(22(28)31)15-5-4-6-16(11-15)34-21(24)25/h4-6,11-14,21H,7-10H2,1-3H3,(H,27,30)
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WIPO WO2022076495
n/an/a 70n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530653
PNG
(WO2022076495, EXAMPLE 84)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cncc(c2)C2CC2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H26N4O4S/c1-14(2)26-20-9-16(21(28)25-23(3)12-32(30,31)13-23)6-7-19(20)27(22(26)29)18-8-17(10-24-11-18)15-4-5-15/h6-11,14-15H,4-5,12-13H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 71n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530589
PNG
(WO2022076495, EXAMPLE 35)
Show SMILES CC(C)n1c2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C24H26F3N3O4/c1-13(2)29-19-11-16(22(32)28-18-8-3-4-9-21(18)31)17(25)12-20(19)30(24(29)33)14-6-5-7-15(10-14)34-23(26)27/h5-7,10-13,18,21,23,31H,3-4,8-9H2,1-2H3,(H,28,32)/t18-,21-/m0/s1
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WIPO WO2022076495
n/an/a 71n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530632
PNG
(WO2022076495, EXAMPLE 71a)
Show SMILES C[C@H](n1c2cc(ccc2n(-c2cc(OC(F)(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H29F4N3O6S/c1-15(24(2,3)36)32-21-13-16(22(34)31-25(4)9-11-40(37,38)12-10-25)5-8-19(21)33(23(32)35)20-14-17(6-7-18(20)27)39-26(28,29)30/h5-8,13-15,36H,9-12H2,1-4H3,(H,31,34)/t15-/m0/s1
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WIPO WO2022076495
n/an/a 71n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530692
PNG
(WO2022076495, EXAMPLE 123)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CS(=O)(=O)C3)c(F)cc2n(-c2cc(OC(F)F)ncc2F)c1=O
Show InChI InChI=1S/C21H20F4N4O5S/c1-10(2)28-15-4-11(18(30)27-21(3)8-35(32,33)9-21)12(22)5-16(15)29(20(28)31)14-6-17(34-19(24)25)26-7-13(14)23/h4-7,10,19H,8-9H2,1-3H3,(H,27,30)
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WIPO WO2022076495
n/an/a 73n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530681
PNG
(1-(3-(Difluoromethoxy)phenyl)-6-fluoro-3-isopropyl...)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C24H26F3N3O5S/c1-14(2)29-19-12-17(21(31)28-24(3)7-9-36(33,34)10-8-24)18(25)13-20(19)30(23(29)32)15-5-4-6-16(11-15)35-22(26)27/h4-6,11-14,22H,7-10H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 74n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530672
PNG
(WO2022076495, EXAMPLE 103)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H25F3N4O5S/c1-13(2)29-18-10-14(20(31)28-23(3)6-8-36(33,34)9-7-23)12-27-19(18)30(22(29)32)17-11-15(35-21(25)26)4-5-16(17)24/h4-5,10-13,21H,6-9H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 74n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530574
PNG
(WO2022076495, EXAMPLE 20)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ncc2F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H21F3N4O5S/c1-11(2)27-16-6-12(18(29)26-21(3)9-34(31,32)10-21)4-5-14(16)28(20(27)30)15-7-17(33-19(23)24)25-8-13(15)22/h4-8,11,19H,9-10H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 76n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530682
PNG
(WO2022076495, EXAMPLE 113)
Show SMILES CC(C)n1c2cc(C(=O)N[C@]3(C)CCS(=O)(=O)C3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-18-10-16(20(30)27-23(3)7-8-35(32,33)12-23)17(24)11-19(18)29(22(28)31)14-5-4-6-15(9-14)34-21(25)26/h4-6,9-11,13,21H,7-8,12H2,1-3H3,(H,27,30)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 78n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530683
PNG
(WO2022076495, EXAMPLE 114)
Show SMILES CC(C)n1c2cc(C(=O)N[C@@]3(C)CCS(=O)(=O)C3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-18-10-16(20(30)27-23(3)7-8-35(32,33)12-23)17(24)11-19(18)29(22(28)31)14-5-4-6-15(9-14)34-21(25)26/h4-6,9-11,13,21H,7-8,12H2,1-3H3,(H,27,30)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530642
PNG
(WO2022076495, EXAMPLE 76a)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O
Show InChI InChI=1S/C25H27F4N3O6S/c1-14(23(2,3)35)31-19-10-15(20(33)30-24(4)12-39(36,37)13-24)8-9-18(19)32(22(31)34)16-6-5-7-17(11-16)38-25(28,29)21(26)27/h5-11,14,21,35H,12-13H2,1-4H3,(H,30,33)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530601
PNG
(WO2022076495, EXAMPLE 46a)
Show SMILES CC[C@@H](C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-4-14(2)27-19-10-15(20(29)26-23(3)12-34(31,32)13-23)8-9-18(19)28(22(27)30)16-6-5-7-17(11-16)33-21(24)25/h5-11,14,21H,4,12-13H2,1-3H3,(H,26,29)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 81n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530598
PNG
(WO2022076495, EXAMPLE 44)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C23H22F5N3O5S/c1-22(7-9-37(34,35)10-8-22)29-19(32)14-5-6-17-18(11-14)30(13-23(26,27)28)21(33)31(17)15-3-2-4-16(12-15)36-20(24)25/h2-6,11-12,20H,7-10,13H2,1H3,(H,29,32)
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WIPO WO2022076495
n/an/a 87n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530560
PNG
(WO2022076495, EXAMPLE 12 | WO2022076495, EXAMPLE 6)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H23F2N3O5S/c1-13(2)26-18-9-14(19(28)25-22(3)11-33(30,31)12-22)7-8-17(18)27(21(26)29)15-5-4-6-16(10-15)32-20(23)24/h4-10,13,20H,11-12H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 88n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530602
PNG
(WO2022076495, EXAMPLE 46b)
Show SMILES CC[C@H](C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-4-14(2)27-19-10-15(20(29)26-23(3)12-34(31,32)13-23)8-9-18(19)28(22(27)30)16-6-5-7-17(11-16)33-21(24)25/h5-11,14,21H,4,12-13H2,1-3H3,(H,26,29)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 92n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530690
PNG
(WO2022076495, EXAMPLE 121)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ccn2)c1=O
Show InChI InChI=1S/C24H27F3N4O5S/c1-14(2)30-18-11-16(22(32)29-24(3)5-8-37(34,35)9-6-24)17(25)12-19(18)31(23(30)33)21-10-15(4-7-28-21)36-13-20(26)27/h4,7,10-12,14,20H,5-6,8-9,13H2,1-3H3,(H,29,32)
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WIPO WO2022076495
n/an/a 92n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530685
PNG
(WO2022076495, EXAMPLE 116)
Show SMILES CCOc1cc(c(F)cn1)-n1c2cc(F)c(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H24F2N4O5S/c1-5-33-19-8-16(15(24)9-25-19)28-18-7-14(23)13(6-17(18)27(12(2)3)21(28)30)20(29)26-22(4)10-34(31,32)11-22/h6-9,12H,5,10-11H2,1-4H3,(H,26,29)
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WIPO WO2022076495
n/an/a 93n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530665
PNG
(WO2022076495, EXAMPLE 96)
Show SMILES CCOc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H26N4O5S/c1-5-31-17-8-6-7-16(10-17)26-19-18(25(14(2)3)21(26)28)9-15(11-23-19)20(27)24-22(4)12-32(29,30)13-22/h6-11,14H,5,12-13H2,1-4H3,(H,24,27)
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WIPO WO2022076495
n/an/a 93n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530673
PNG
(WO2022076495, EXAMPLE 104)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H22F2N4O5S/c1-12(2)26-16-7-13(18(28)25-21(3)10-33(30,31)11-21)9-24-17(16)27(20(26)29)14-5-4-6-15(8-14)32-19(22)23/h4-9,12,19H,10-11H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 94n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530586
PNG
(WO2022076495, EXAMPLE 32)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-14(2)27-19-11-15(20(29)26-23(3)9-10-34(31,32)13-23)7-8-18(19)28(22(27)30)16-5-4-6-17(12-16)33-21(24)25/h4-8,11-12,14,21H,9-10,13H2,1-3H3,(H,26,29)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 96n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530573
PNG
(WO2022076495, EXAMPLE 19)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H22F3N3O5S/c1-13(2)27-18-9-14(19(29)26-21(3)11-34(31,32)12-21)7-8-17(18)28(20(27)30)15-5-4-6-16(10-15)33-22(23,24)25/h4-10,13H,11-12H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 100n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530600
PNG
(WO2022076495, EXAMPLE 45b)
Show SMILES C[C@@H](C(F)F)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H25F4N3O5S/c1-14(20(25)26)30-19-12-15(21(32)29-24(2)8-10-37(34,35)11-9-24)6-7-18(19)31(23(30)33)16-4-3-5-17(13-16)36-22(27)28/h3-7,12-14,20,22H,8-11H2,1-2H3,(H,29,32)/t14-/m0/s1
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WIPO WO2022076495
n/an/a 101n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530667
PNG
(WO2022076495, EXAMPLE 98)
Show SMILES CCOc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H28N4O5S/c1-5-32-18-8-6-7-17(12-18)27-20-19(26(15(2)3)22(27)29)11-16(13-24-20)21(28)25-23(4)9-10-33(30,31)14-23/h6-8,11-13,15H,5,9-10,14H2,1-4H3,(H,25,28)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 102n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530585
PNG
(WO2022076495, EXAMPLE 31)
Show SMILES CC(C)n1c2cc(C(=O)N[C@@H]3CCCC[C@H]3O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C24H26F3N3O4/c1-13(2)29-19-11-16(22(32)28-18-8-3-4-9-21(18)31)17(25)12-20(19)30(24(29)33)14-6-5-7-15(10-14)34-23(26)27/h5-7,10-13,18,21,23,31H,3-4,8-9H2,1-2H3,(H,28,32)/t18-,21-/m1/s1
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n/an/a 106n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530663
PNG
(WO2022076495, EXAMPLE 94)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)C(F)F)c2)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F4N4O5S/c1-13(2)30-17-9-14(19(32)29-22(3)7-8-37(34,35)12-22)11-28-18(17)31(21(30)33)15-5-4-6-16(10-15)36-23(26,27)20(24)25/h4-6,9-11,13,20H,7-8,12H2,1-3H3,(H,29,32)/t22-/m0/s1
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WIPO WO2022076495
n/an/a 108n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530593
PNG
(WO2022076495, EXAMPLE 39)
Show SMILES CCn1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H25F2N3O5S/c1-3-27-19-13-15(20(29)26-23(2)9-11-34(31,32)12-10-23)7-8-18(19)28(22(27)30)16-5-4-6-17(14-16)33-21(24)25/h4-8,13-14,21H,3,9-12H2,1-2H3,(H,26,29)
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WIPO WO2022076495
n/an/a 109n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530696
PNG
((S)-6-Chloro-1-(3-(difluoromethoxy)phenyl)-3-isopr...)
Show SMILES CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(Cl)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C24H26ClF2N3O5S/c1-14(2)29-19-12-17(21(31)28-24(3)7-9-36(33,34)10-8-24)18(25)13-20(19)30(23(29)32)15-5-4-6-16(11-15)35-22(26)27/h4-6,11-14,22H,7-10H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 112n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530560
PNG
(WO2022076495, EXAMPLE 12 | WO2022076495, EXAMPLE 6)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H23F2N3O5S/c1-13(2)26-18-9-14(19(28)25-22(3)11-33(30,31)12-22)7-8-17(18)27(21(26)29)15-5-4-6-16(10-15)32-20(23)24/h4-10,13,20H,11-12H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 122n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530571
PNG
(WO2022076495, EXAMPLE 17)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H27FN4O5S/c1-5-33-20-11-18(16(24)12-25-20)28-17-7-6-15(10-19(17)27(14(2)3)22(28)30)21(29)26-23(4)8-9-34(31,32)13-23/h6-7,10-12,14H,5,8-9,13H2,1-4H3,(H,26,29)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 122n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530646
PNG
(WO2022076495, EXAMPLE 78a)
Show SMILES CCOc1cc(c(F)cn1)-n1c2ccc(cc2n([C@H](C)C(C)(C)O)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C24H29FN4O6S/c1-6-35-20-10-18(16(25)11-26-20)29-17-8-7-15(21(30)27-24(5)12-36(33,34)13-24)9-19(17)28(22(29)31)14(2)23(3,4)32/h7-11,14,32H,6,12-13H2,1-5H3,(H,27,30)/t14-/m1/s1
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WIPO WO2022076495
n/an/a 123n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530671
PNG
(WO2022076495, EXAMPLE 102)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H21F3N4O5S/c1-11(2)27-16-6-12(18(29)26-21(3)9-34(31,32)10-21)8-25-17(16)28(20(27)30)15-7-13(33-19(23)24)4-5-14(15)22/h4-8,11,19H,9-10H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 148n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530652
PNG
(WO2022076495, EXAMPLE 83)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cncc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H22F2N4O5S/c1-12(2)26-17-6-13(18(28)25-21(3)10-33(30,31)11-21)4-5-16(17)27(20(26)29)14-7-15(9-24-8-14)32-19(22)23/h4-9,12,19H,10-11H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 150n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530564
PNG
(WO2022076495, EXAMPLE 10)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F3N3O5S/c1-15(2)29-20-13-16(21(31)28-23(3)9-11-36(33,34)12-10-23)7-8-19(20)30(22(29)32)17-5-4-6-18(14-17)35-24(25,26)27/h4-8,13-15H,9-12H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 153n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530666
PNG
(WO2022076495, EXAMPLE 97)
Show SMILES CCOc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H28N4O5S/c1-5-32-18-8-6-7-17(12-18)27-20-19(26(15(2)3)22(27)29)11-16(13-24-20)21(28)25-23(4)9-10-33(30,31)14-23/h6-8,11-13,15H,5,9-10,14H2,1-4H3,(H,25,28)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 154n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530587
PNG
(WO2022076495, EXAMPLE 33)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CC(F)(F)C1
Show InChI InChI=1S/C23H23F4N3O3/c1-13(2)29-18-9-14(19(31)28-22(3)11-23(26,27)12-22)7-8-17(18)30(21(29)32)15-5-4-6-16(10-15)33-20(24)25/h4-10,13,20H,11-12H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 182n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530693
PNG
((8)-1-(3-(Difluoromethoxy)phenyl)-4-fluoro-3-isopr...)
Show SMILES CC(C)n1c2c(F)c(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-19-17(29(22(28)31)14-5-4-6-15(11-14)34-21(25)26)8-7-16(18(19)24)20(30)27-23(3)9-10-35(32,33)12-23/h4-8,11,13,21H,9-10,12H2,1-3H3,(H,27,30)/t23-/m0/s1
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WIPO WO2022076495
n/an/a 191n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530659
PNG
(WO2022076495, EXAMPLE 90)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C22H24F2N4O5S/c1-13(2)27-17-9-14(19(29)26-22(3)7-8-34(31,32)12-22)11-25-18(17)28(21(27)30)15-5-4-6-16(10-15)33-20(23)24/h4-6,9-11,13,20H,7-8,12H2,1-3H3,(H,26,29)/t22-/m1/s1
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WIPO WO2022076495
n/an/a 193n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530594
PNG
(WO2022076495, EXAMPLE 40)
Show SMILES CCn1c2cc(C(=O)NC3(C)CS(=O)(=O)C3)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C21H20F3N3O5S/c1-3-26-16-8-14(18(28)25-21(2)10-33(30,31)11-21)15(22)9-17(16)27(20(26)29)12-5-4-6-13(7-12)32-19(23)24/h4-9,19H,3,10-11H2,1-2H3,(H,25,28)
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WIPO WO2022076495
n/an/a 194n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530597
PNG
(WO2022076495, EXAMPLE 43)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2n(CC(F)(F)F)c(=O)n(-c3cccc(OC(F)F)c3)c2cc1F
Show InChI InChI=1S/C21H17F6N3O5S/c1-20(9-36(33,34)10-20)28-17(31)13-6-15-16(7-14(13)22)30(19(32)29(15)8-21(25,26)27)11-3-2-4-12(5-11)35-18(23)24/h2-7,18H,8-10H2,1H3,(H,28,31)
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WIPO WO2022076495
n/an/a 202n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530694
PNG
(WO2022076495, EXAMPLE 125)
Show SMILES CC(C)n1c2c(F)c(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C23H24F3N3O5S/c1-13(2)28-19-17(29(22(28)31)14-5-4-6-15(11-14)34-21(25)26)8-7-16(18(19)24)20(30)27-23(3)9-10-35(32,33)12-23/h4-8,11,13,21H,9-10,12H2,1-3H3,(H,27,30)/t23-/m1/s1
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WIPO WO2022076495
n/an/a 203n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530625
PNG
(WO2022076495, EXAMPLE 67b)
Show SMILES C[C@@H](n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O
Show InChI InChI=1S/C26H31F2N3O6S/c1-16(25(2,3)34)30-21-14-17(22(32)29-26(4)10-12-38(35,36)13-11-26)8-9-20(21)31(24(30)33)18-6-5-7-19(15-18)37-23(27)28/h5-9,14-16,23,34H,10-13H2,1-4H3,(H,29,32)/t16-/m1/s1
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WIPO WO2022076495
n/an/a 211n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530595
PNG
(WO2022076495, EXAMPLE 41)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(C3CC3)c2c1
Show InChI InChI=1S/C24H25F2N3O5S/c1-24(9-11-35(32,33)12-10-24)27-21(30)15-5-8-19-20(13-15)28(16-6-7-16)23(31)29(19)17-3-2-4-18(14-17)34-22(25)26/h2-5,8,13-14,16,22H,6-7,9-12H2,1H3,(H,27,30)
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WIPO WO2022076495
n/an/a 211n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530661
PNG
(WO2022076495, EXAMPLE 92)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H25F3N4O5S/c1-14(2)29-18-11-15(20(31)28-22(3)7-9-36(33,34)10-8-22)13-27-19(18)30(21(29)32)16-5-4-6-17(12-16)35-23(24,25)26/h4-6,11-14H,7-10H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 236n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530698
PNG
(WO2022076495, EXAMPLE 129)
Show SMILES CC(C)n1c2c(C#N)c(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H26F2N4O5S/c1-15(2)30-21-19(14-28)18(22(32)29-25(3)9-11-37(34,35)12-10-25)7-8-20(21)31(24(30)33)16-5-4-6-17(13-16)36-23(26)27/h4-8,13,15,23H,9-12H2,1-3H3,(H,29,32)
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WIPO WO2022076495
n/an/a 248n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530607
PNG
(WO2022076495, EXAMPLE 51)
Show SMILES CC(C)Oc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H31FN4O5S/c1-15(2)29-21-12-17(23(31)28-25(5)8-10-36(33,34)11-9-25)6-7-19(21)30(24(29)32)20-13-22(35-16(3)4)27-14-18(20)26/h6-7,12-16H,8-11H2,1-5H3,(H,28,31)
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WIPO WO2022076495
n/an/a 251n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530695
PNG
(WO2022076495, EXAMPLE 126)
Show SMILES CC(C)n1c2c(F)c(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F3N3O5S/c1-14(2)29-20-18(30(23(29)32)15-5-4-6-16(13-15)35-22(26)27)8-7-17(19(20)25)21(31)28-24(3)9-11-36(33,34)12-10-24/h4-8,13-14,22H,9-12H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 257n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530658
PNG
(WO2022076495, EXAMPLE 89)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C22H24F2N4O5S/c1-13(2)27-17-9-14(19(29)26-22(3)7-8-34(31,32)12-22)11-25-18(17)28(21(27)30)15-5-4-6-16(10-15)33-20(23)24/h4-6,9-11,13,20H,7-8,12H2,1-3H3,(H,26,29)/t22-/m0/s1
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WIPO WO2022076495
n/an/a 288n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530660
PNG
(WO2022076495, EXAMPLE 91)
Show SMILES CC(C)n1c2cc(cnc2n(-c2cccc(OC(F)(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H21F3N4O5S/c1-12(2)27-16-7-13(18(29)26-20(3)10-34(31,32)11-20)9-25-17(16)28(19(27)30)14-5-4-6-15(8-14)33-21(22,23)24/h4-9,12H,10-11H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a 355n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530612
PNG
(WO2022076495, EXAMPLE 56)
Show SMILES CSc1cccc(c1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H29N3O4S2/c1-16(2)26-21-14-17(22(28)25-24(3)10-12-33(30,31)13-11-24)8-9-20(21)27(23(26)29)18-6-5-7-19(15-18)32-4/h5-9,14-16H,10-13H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a 367n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530596
PNG
(WO2022076495, EXAMPLE 42)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(CCC(F)(F)F)c2c1
Show InChI InChI=1S/C24H24F5N3O5S/c1-23(8-11-38(35,36)12-9-23)30-20(33)15-5-6-18-19(13-15)31(10-7-24(27,28)29)22(34)32(18)16-3-2-4-17(14-16)37-21(25)26/h2-6,13-14,21H,7-12H2,1H3,(H,30,33)
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WIPO WO2022076495
n/an/a 405n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530670
PNG
(WO2022076495, EXAMPLE 101)
Show SMILES CC(C)Oc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H32N4O5S/c1-16(2)28-21-13-18(23(30)27-25(5)9-11-35(32,33)12-10-25)15-26-22(21)29(24(28)31)19-7-6-8-20(14-19)34-17(3)4/h6-8,13-17H,9-12H2,1-5H3,(H,27,30)
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WIPO WO2022076495
n/an/a 506n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530555
PNG
((R)-1,3-bis(4-fluorophenyl)-N-(3-methyl-l,1-dioxid...)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2n(-c3ccc(F)cc3)c(=O)n(-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C25H21F2N3O4S/c1-25(12-13-35(33,34)15-25)28-23(31)16-2-11-21-22(14-16)30(20-9-5-18(27)6-10-20)24(32)29(21)19-7-3-17(26)4-8-19/h2-11,14H,12-13,15H2,1H3,(H,28,31)/t25-/m1/s1
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WIPO WO2022076495
n/an/a 573n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530669
PNG
(WO2022076495, EXAMPLE 100)
Show SMILES CC(C)Oc1cccc(c1)-n1c2ncc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H28N4O5S/c1-14(2)26-19-9-16(21(28)25-23(5)12-33(30,31)13-23)11-24-20(19)27(22(26)29)17-7-6-8-18(10-17)32-15(3)4/h6-11,14-15H,12-13H2,1-5H3,(H,25,28)
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WIPO WO2022076495
n/an/a 692n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530582
PNG
(WO2022076495, EXAMPLE 28)
Show SMILES CC(C)n1c2cc(C(=O)N[C@H]3CCC[C@@H]3O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C23H24F3N3O4/c1-12(2)28-18-10-15(21(31)27-17-7-4-8-20(17)30)16(24)11-19(18)29(23(28)32)13-5-3-6-14(9-13)33-22(25)26/h3,5-6,9-12,17,20,22,30H,4,7-8H2,1-2H3,(H,27,31)/t17-,20-/m0/s1
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WIPO WO2022076495
n/an/a 779n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530676
PNG
(1-(3-(difluoromethoxy)phenyl)-3-isopropyl-A-(3-met...)
Show SMILES CC(C)n1c2nc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H22F2N4O5S/c1-12(2)26-17-16(27(20(26)29)13-5-4-6-14(9-13)32-19(22)23)8-7-15(24-17)18(28)25-21(3)10-33(30,31)11-21/h4-9,12,19H,10-11H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 1.08E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530616
PNG
(WO2022076495, EXAMPLE 60)
Show SMILES Cn1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C20H19F2N3O5S/c1-20(10-31(28,29)11-20)23-17(26)12-6-7-15-16(8-12)24(2)19(27)25(15)13-4-3-5-14(9-13)30-18(21)22/h3-9,18H,10-11H2,1-2H3,(H,23,26)
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WIPO WO2022076495
n/an/a 1.09E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530583
PNG
(WO2022076495, EXAMPLE 29)
Show SMILES CC(C)n1c2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C23H24F3N3O5/c1-12(2)28-18-9-15(21(31)27-17-6-7-33-11-20(17)30)16(24)10-19(18)29(23(28)32)13-4-3-5-14(8-13)34-22(25)26/h3-5,8-10,12,17,20,22,30H,6-7,11H2,1-2H3,(H,27,31)/t17-,20-/m0/s1
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WIPO WO2022076495
n/an/a 1.26E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530610
PNG
(WO2022076495, EXAMPLE 54)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)N(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H32N4O4S/c1-17(2)28-22-15-18(23(30)26-25(3)11-13-34(32,33)14-12-25)9-10-21(22)29(24(28)31)20-8-6-7-19(16-20)27(4)5/h6-10,15-17H,11-14H2,1-5H3,(H,26,30)
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WIPO WO2022076495
n/an/a 1.32E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530697
PNG
(4-chloro-1-(3-(difluoromethoxy)phenyl)-3-isopropyl...)
Show SMILES CC(C)n1c2c(Cl)c(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26ClF2N3O5S/c1-14(2)29-20-18(30(23(29)32)15-5-4-6-16(13-15)35-22(26)27)8-7-17(19(20)25)21(31)28-24(3)9-11-36(33,34)12-10-24/h4-8,13-14,22H,9-12H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 1.38E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530654
PNG
(3-(1-amino-1-oxopropan-2-yl)-1-(3-(difluoromethoxy...)
Show SMILES CC(C(N)=O)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F2N4O6S/c1-14(20(27)31)29-19-12-15(21(32)28-24(2)8-10-37(34,35)11-9-24)6-7-18(19)30(23(29)33)16-4-3-5-17(13-16)36-22(25)26/h3-7,12-14,22H,8-11H2,1-2H3,(H2,27,31)(H,28,32)
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WIPO WO2022076495
n/an/a 1.75E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530674
PNG
(3-(3-(difluoromethoxy)phenyl)-1-isopropyl-N-(3-met...)
Show SMILES CC(C)n1c2cc(ncc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C21H22F2N4O5S/c1-12(2)26-16-8-15(18(28)25-21(3)10-33(30,31)11-21)24-9-17(16)27(20(26)29)13-5-4-6-14(7-13)32-19(22)23/h4-9,12,19H,10-11H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a 1.80E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530609
PNG
(WO2022076495, EXAMPLE 53)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)C(F)(F)F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26F3N3O4S/c1-15(2)29-20-13-16(21(31)28-23(3)9-11-35(33,34)12-10-23)7-8-19(20)30(22(29)32)18-6-4-5-17(14-18)24(25,26)27/h4-8,13-15H,9-12H2,1-3H3,(H,28,31)
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WIPO WO2022076495
n/an/a 1.83E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530618
PNG
(WO2022076495, EXAMPLE 62)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NCC1(O)CCOC1
Show InChI InChI=1S/C23H25F2N3O5/c1-14(2)27-19-10-15(20(29)26-12-23(31)8-9-32-13-23)6-7-18(19)28(22(27)30)16-4-3-5-17(11-16)33-21(24)25/h3-7,10-11,14,21,31H,8-9,12-13H2,1-2H3,(H,26,29)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530613
PNG
(WO2022076495, EXAMPLE 57)
Show SMILES CNS(=O)(=O)c1cccc(c1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H30N4O6S2/c1-16(2)27-21-14-17(22(29)26-24(3)10-12-35(31,32)13-11-24)8-9-20(21)28(23(27)30)18-6-5-7-19(15-18)36(33,34)25-4/h5-9,14-16,25H,10-13H2,1-4H3,(H,26,29)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530606
PNG
(WO2022076495, EXAMPLE 50)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H26FN3O4S/c1-15(2)26-20-13-16(21(28)25-23(3)9-11-32(30,31)12-10-23)7-8-19(20)27(22(26)29)18-6-4-5-17(24)14-18/h4-8,13-15H,9-12H2,1-3H3,(H,25,28)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530619
PNG
(WO2022076495, EXAMPLE 63)
Show SMILES CCn1cc(CNC(=O)c2ccc3n(-c4cccc(OC(F)F)c4)c(=O)n(C(C)C)c3c2)cn1
Show InChI InChI=1S/C24H25F2N5O3/c1-4-29-14-16(13-28-29)12-27-22(32)17-8-9-20-21(10-17)30(15(2)3)24(33)31(20)18-6-5-7-19(11-18)34-23(25)26/h5-11,13-15,23H,4,12H2,1-3H3,(H,27,32)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530611
PNG
(WO2022076495, EXAMPLE 55)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)C(N)=O)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H28N4O5S/c1-15(2)27-20-14-17(22(30)26-24(3)9-11-34(32,33)12-10-24)7-8-19(20)28(23(27)31)18-6-4-5-16(13-18)21(25)29/h4-8,13-15H,9-12H2,1-3H3,(H2,25,29)(H,26,30)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530617
PNG
(WO2022076495, EXAMPLE 61)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)Nc1nnc(C)s1
Show InChI InChI=1S/C21H19F2N5O3S/c1-11(2)27-17-9-13(18(29)24-20-26-25-12(3)32-20)7-8-16(17)28(21(27)30)14-5-4-6-15(10-14)31-19(22)23/h4-11,19H,1-3H3,(H,24,26,29)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530655
PNG
(WO2022076495, EXAMPLE 86)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2n(-c3cccc(OC(F)F)c3)c(=O)n(c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H25F2N3O7S2/c1-27(12-14-40(35,36)15-13-27)30-24(33)18-10-11-22-23(16-18)32(41(37,38)21-8-3-2-4-9-21)26(34)31(22)19-6-5-7-20(17-19)39-25(28)29/h2-11,16-17,25H,12-15H2,1H3,(H,30,33)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530614
PNG
(WO2022076495, EXAMPLE 58)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)S(C)(=O)=O)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H29N3O6S2/c1-16(2)26-21-14-17(22(28)25-24(3)10-12-35(32,33)13-11-24)8-9-20(21)27(23(26)29)18-6-5-7-19(15-18)34(4,30)31/h5-9,14-16H,10-13H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530608
PNG
(WO2022076495, EXAMPLE 52)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(c2)C#N)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H26N4O4S/c1-16(2)27-21-14-18(22(29)26-24(3)9-11-33(31,32)12-10-24)7-8-20(21)28(23(27)30)19-6-4-5-17(13-19)15-25/h4-8,13-14,16H,9-12H2,1-3H3,(H,26,29)
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WIPO WO2022076495
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530603
PNG
(WO2022076495, EXAMPLE 47)
Show SMILES CC(C)n1c2cc(ccc2n(-c2ccc(NC(C)=O)c(O)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H26N4O6S/c1-13(2)26-19-9-15(21(30)25-23(4)11-34(32,33)12-23)5-8-18(19)27(22(26)31)16-6-7-17(20(29)10-16)24-14(3)28/h5-10,13,29H,11-12H2,1-4H3,(H,24,28)(H,25,30)
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WIPO WO2022076495
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530581
PNG
(WO2022076495, EXAMPLE 27)
Show SMILES CC(C)n1c2cc(C(=O)NC(C)C(C)(C)O)c(F)cc2n(-c2cccc(OC(F)F)c2)c1=O
Show InChI InChI=1S/C23H26F3N3O4/c1-12(2)28-18-10-16(20(30)27-13(3)23(4,5)32)17(24)11-19(18)29(22(28)31)14-7-6-8-15(9-14)33-21(25)26/h6-13,21,32H,1-5H3,(H,27,30)
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WIPO WO2022076495
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530605
PNG
(WO2022076495, EXAMPLE 49)
Show SMILES CC(C)n1c2cc(ccc2n(-c2ccc3nc(C)oc3c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H24N4O5S/c1-13(2)26-19-9-15(21(28)25-23(4)11-33(30,31)12-23)5-8-18(19)27(22(26)29)16-6-7-17-20(10-16)32-14(3)24-17/h5-10,13H,11-12H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530604
PNG
(WO2022076495, EXAMPLE 48)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc3oc(C)nc23)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H24N4O5S/c1-13(2)26-18-10-15(21(28)25-23(4)11-33(30,31)12-23)8-9-16(18)27(22(26)29)17-6-5-7-19-20(17)24-14(3)32-19/h5-10,13H,11-12H2,1-4H3,(H,25,28)
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WIPO WO2022076495
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...


WIPO WO2022076495 (2022)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%