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Patent code WO2022076496

Compile Data Set for Download or QSAR
Found 170 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530846
PNG
(WO2022076496, Example 137)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1
Show InChI InChI=1S/C22H20F4N2O5S/c1-21(2)13-6-11(18(29)27-22(3)9-34(31,32)10-22)7-15(24)17(13)28(19(21)30)16-8-12(33-20(25)26)4-5-14(16)23/h4-8,20H,9-10H2,1-3H3,(H,27,29)
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WIPO WO2022076496
n/an/a 0.510n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530797
PNG
(WO2022076496, Example 94)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncc1F
Show InChI InChI=1S/C24H25F4N3O5S/c1-23(2)14-8-13(21(32)30-24(3)4-6-37(34,35)7-5-24)15(25)9-17(14)31(22(23)33)18-10-20(29-11-16(18)26)36-12-19(27)28/h8-11,19H,4-7,12H2,1-3H3,(H,30,32)
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WIPO WO2022076496
n/an/a 0.600n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530766
PNG
(WO2022076496, Example 63)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)C(F)F)ccn1
Show InChI InChI=1S/C24H25F4N3O5S/c1-22(2)16-12-14(19(32)30-23(3)7-10-37(34,35)11-8-23)4-5-17(16)31(21(22)33)18-13-15(6-9-29-18)36-24(27,28)20(25)26/h4-6,9,12-13,20H,7-8,10-11H2,1-3H3,(H,30,32)
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WIPO WO2022076496
n/an/a 0.800n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530728
PNG
(WO2022076496, Example 26)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C24H25F4N3O5S/c1-22(2)17-10-14(19(32)30-23(3)6-8-37(34,35)9-7-23)4-5-18(17)31(21(22)33)15-11-16(13-29-12-15)36-24(27,28)20(25)26/h4-5,10-13,20H,6-9H2,1-3H3,(H,30,32)
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WIPO WO2022076496
n/an/a 1n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530847
PNG
(WO2022076496, Example 138)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1
Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-8-12(19(30)28-23(3)6-7-35(32,33)11-23)9-16(25)18(14)29(20(22)31)17-10-13(34-21(26)27)4-5-15(17)24/h4-5,8-10,21H,6-7,11H2,1-3H3,(H,28,30)/t23-/m1/s1
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WIPO WO2022076496
n/an/a 1.20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530798
PNG
(WO2022076496, Example 95)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(C(=O)NC4(C)CCS(=O)(=O)CC4)c(F)cc23)c(F)cn1
Show InChI InChI=1S/C24H27F2N3O5S/c1-5-34-20-12-19(17(26)13-27-20)29-18-11-16(25)14(10-15(18)23(2,3)22(29)31)21(30)28-24(4)6-8-35(32,33)9-7-24/h10-13H,5-9H2,1-4H3,(H,28,30)
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WIPO WO2022076496
n/an/a 1.90n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530849
PNG
(WO2022076496, Example 140)
Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C24H24F4N2O5S/c1-23(2)15-10-13(20(31)29-24(3)6-8-36(33,34)9-7-24)11-17(26)19(15)30(21(23)32)18-12-14(35-22(27)28)4-5-16(18)25/h4-5,10-12,22H,6-9H2,1-3H3,(H,29,31)
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WIPO WO2022076496
n/an/a 2.10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530853
PNG
(WO2022076496, Example 144)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1
Show InChI InChI=1S/C24H27F2N3O5S/c1-5-34-19-12-18(17(26)13-27-19)29-20-15(23(2,3)22(29)31)10-14(11-16(20)25)21(30)28-24(4)6-8-35(32,33)9-7-24/h10-13H,5-9H2,1-4H3,(H,28,30)
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WIPO WO2022076496
n/an/a 2.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530784
PNG
(WO2022076496, Example 81)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)C(F)F)c(F)cn1
Show InChI InChI=1S/C24H24F5N3O5S/c1-22(2)14-10-13(19(33)31-23(3)6-8-38(35,36)9-7-23)4-5-16(14)32(21(22)34)18-11-17(15(25)12-30-18)37-24(28,29)20(26)27/h4-5,10-12,20H,6-9H2,1-3H3,(H,31,33)
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WIPO WO2022076496
n/an/a 3.20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530791
PNG
(1-(2-(2,2-d uoroet oxy)-5- uoropyr dn-4-y)-3,3-dme...)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncc1F
Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-10-14(21(31)29-24(3)6-8-36(33,34)9-7-24)4-5-17(15)30(22(23)32)18-11-20(28-12-16(18)25)35-13-19(26)27/h4-5,10-12,19H,6-9,13H2,1-3H3,(H,29,31)
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WIPO WO2022076496
n/an/a 3.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530848
PNG
(WO2022076496, Example 139)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1
Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-8-12(19(30)28-23(3)6-7-35(32,33)11-23)9-16(25)18(14)29(20(22)31)17-10-13(34-21(26)27)4-5-15(17)24/h4-5,8-10,21H,6-7,11H2,1-3H3,(H,28,30)/t23-/m0/s1
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WIPO WO2022076496
n/an/a 4.40n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530851
PNG
(WO2022076496, Example 142)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C23H25F2N3O5S/c1-5-33-18-10-17(16(25)11-26-18)28-19-14(22(2,3)21(28)30)8-13(9-15(19)24)20(29)27-23(4)6-7-34(31,32)12-23/h8-11H,5-7,12H2,1-4H3,(H,27,29)/t23-/m1/s1
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WIPO WO2022076496
n/an/a 4.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530809
PNG
(WO2022076496, Example 106)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)cc(F)c1F
Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-6-12(20(30)28-23(3)10-35(32,33)11-23)4-5-16(14)29(21(22)31)17-8-13(34-9-18(25)26)7-15(24)19(17)27/h4-8,18H,9-11H2,1-3H3,(H,28,30)
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WIPO WO2022076496
n/an/a 4.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530794
PNG
(WO2022076496, Example 91)
Show SMILES CC(F)(F)COc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1
Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)16-11-15(21(32)30-24(3)7-9-37(34,35)10-8-24)5-6-18(16)31(22(23)33)19-12-20(29-13-17(19)26)36-14-25(4,27)28/h5-6,11-13H,7-10,14H2,1-4H3,(H,30,32)
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WIPO WO2022076496
n/an/a 5.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530862
PNG
(WO2022076496, Example 153)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(c1)C#N
Show InChI InChI=1S/C23H21F2N3O5S/c1-22(2)17-8-13(19(29)27-23(3)11-34(31,32)12-23)7-14(10-26)18(17)28(20(22)30)15-5-4-6-16(9-15)33-21(24)25/h4-9,21H,11-12H2,1-3H3,(H,27,29)
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WIPO WO2022076496
n/an/a 6.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530815
PNG
(WO2022076496, Example 112)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C22H21F3N2O5S/c1-21(2)14-8-12(18(28)26-22(3)10-33(30,31)11-22)4-7-16(14)27(19(21)29)17-9-13(32-20(24)25)5-6-15(17)23/h4-9,20H,10-11H2,1-3H3,(H,26,28)
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WIPO WO2022076496
n/an/a 7.80n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530725
PNG
(WO2022076496, Example 23)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(17(30)28-21(3)10-35(32,33)11-21)4-5-16(15)29(19(20)31)13-7-14(9-27-8-13)34-22(25,26)18(23)24/h4-9,18H,10-11H2,1-3H3,(H,28,30)
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WIPO WO2022076496
n/an/a 9.20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530852
PNG
(WO2022076496, Example 143)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C23H25F2N3O5S/c1-5-33-18-10-17(16(25)11-26-18)28-19-14(22(2,3)21(28)30)8-13(9-15(19)24)20(29)27-23(4)6-7-34(31,32)12-23/h8-11H,5-7,12H2,1-4H3,(H,27,29)/t23-/m0/s1
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WIPO WO2022076496
n/an/a 9.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530850
PNG
(WO2022076496, Example 141)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C22H23F2N3O5S/c1-5-32-17-8-16(15(24)9-25-17)27-18-13(21(2,3)20(27)29)6-12(7-14(18)23)19(28)26-22(4)10-33(30,31)11-22/h6-9H,5,10-11H2,1-4H3,(H,26,28)
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n/an/a 10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530745
PNG
(WO2022076496, Example 42)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC2CC2)c1
Show InChI InChI=1S/C26H30N2O5S/c1-25(2)21-15-17(23(29)27-26(3)11-13-34(31,32)14-12-26)7-10-22(21)28(24(25)30)18-5-4-6-20(16-18)33-19-8-9-19/h4-7,10,15-16,19H,8-9,11-14H2,1-3H3,(H,27,29)
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WIPO WO2022076496
n/an/a 11n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530796
PNG
(WO2022076496, Example 93)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CS(C)(=O)=O)CCC1)c1cc(OCC(F)F)ncc1F
Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-9-14(21(31)29-24(7-4-8-24)13-36(3,33)34)5-6-17(15)30(22(23)32)18-10-20(28-11-16(18)25)35-12-19(26)27/h5-6,9-11,19H,4,7-8,12-13H2,1-3H3,(H,29,31)
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WIPO WO2022076496
n/an/a 11n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530810
PNG
(WO2022076496, Example 107)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)ccc1F
Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-8-13(20(29)27-23(3)11-34(31,32)12-23)4-7-17(15)28(21(22)30)18-9-14(5-6-16(18)24)33-10-19(25)26/h4-9,19H,10-12H2,1-3H3,(H,27,29)
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WIPO WO2022076496
n/an/a 11n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530722
PNG
(WO2022076496, Example 20)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-11-15(21(29)27-24(3)9-10-34(31,32)14-24)7-8-19(18)28(22(23)30)16-5-4-6-17(12-16)33-13-20(25)26/h4-8,11-12,20H,9-10,13-14H2,1-3H3,(H,27,29)/t24-/m1/s1
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530817
PNG
(WO2022076496, Example 114)
Show SMILES CC(F)(F)Oc1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H23F2N3O5S/c1-20(2)16-7-13(18(28)26-21(3)11-33(30,31)12-21)5-6-17(16)27(19(20)29)14-8-15(10-25-9-14)32-22(4,23)24/h5-10H,11-12H2,1-4H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530719
PNG
(WO2022076496, Example 17)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-10-13(19(29)27-23(3)8-9-34(31,32)12-23)4-7-17(15)28(20(22)30)18-11-14(33-21(25)26)5-6-16(18)24/h4-7,10-11,21H,8-9,12H2,1-3H3,(H,27,29)/t23-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530721
PNG
(WO2022076496, Example 19)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C24H25F3N2O5S/c1-23(2)16-12-14(20(30)28-24(3)8-10-35(32,33)11-9-24)4-7-18(16)29(21(23)31)19-13-15(34-22(26)27)5-6-17(19)25/h4-7,12-13,22H,8-11H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530726
PNG
(WO2022076496, Example 24)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(18(31)29-22(3)6-7-36(33,34)12-22)4-5-17(16)30(20(21)32)14-9-15(11-28-10-14)35-23(26,27)19(24)25/h4-5,8-11,19H,6-7,12H2,1-3H3,(H,29,31)/t22-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530742
PNG
(WO2022076496, Example 39)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1
Show InChI InChI=1S/C24H26N2O5S/c1-23(2)19-11-15(21(27)25-24(3)13-32(29,30)14-24)7-10-20(19)26(22(23)28)16-5-4-6-18(12-16)31-17-8-9-17/h4-7,10-12,17H,8-9,13-14H2,1-3H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530724
PNG
(WO2022076496, Example 22)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C25H28F2N2O5S/c1-24(2)19-13-16(22(30)28-25(3)9-11-35(32,33)12-10-25)7-8-20(19)29(23(24)31)17-5-4-6-18(14-17)34-15-21(26)27/h4-8,13-14,21H,9-12,15H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530861
PNG
(WO2022076496, Example 152)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H25F3N2O5S/c1-23(2)17-12-16(20(30)28-24(3)7-9-35(32,33)10-8-24)18(25)13-19(17)29(21(23)31)14-5-4-6-15(11-14)34-22(26)27/h4-6,11-13,22H,7-10H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530741
PNG
(WO2022076496, Example 38)
Show SMILES CCC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-4-23(12-33(30,31)13-23)26-19(28)14-8-9-18-17(10-14)22(2,3)20(29)27(18)15-6-5-7-16(11-15)32-21(24)25/h5-11,21H,4,12-13H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530825
PNG
(WO2022076496, Example 122)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(F)c1
Show InChI InChI=1S/C22H21F3N2O5S/c1-21(2)15-7-12(18(28)26-22(3)10-33(30,31)11-22)8-16(23)17(15)27(19(21)29)13-5-4-6-14(9-13)32-20(24)25/h4-9,20H,10-11H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530774
PNG
(WO2022076496, Example 71)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)F)ncn1
Show InChI InChI=1S/C23H25F3N4O5S/c1-21(2)15-10-14(19(31)29-22(3)6-8-36(33,34)9-7-22)4-5-16(15)30(20(21)32)17-11-18(28-13-27-17)35-12-23(24,25)26/h4-5,10-11,13H,6-9,12H2,1-3H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530743
PNG
(WO2022076496, Example 40)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1
Show InChI InChI=1S/C25H28N2O5S/c1-24(2)20-13-16(22(28)26-25(3)11-12-33(30,31)15-25)7-10-21(20)27(23(24)29)17-5-4-6-19(14-17)32-18-8-9-18/h4-7,10,13-14,18H,8-9,11-12,15H2,1-3H3,(H,26,28)/t25-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530808
PNG
(WO2022076496, Example 105)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)ncc1F
Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)13-6-12(19(29)27-22(3)10-34(31,32)11-22)4-5-15(13)28(20(21)30)16-7-18(26-8-14(16)23)33-9-17(24)25/h4-8,17H,9-11H2,1-3H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530785
PNG
(WO2022076496, Example 82)
Show SMILES CC(F)(F)COc1ccnc(c1)N1C(=O)C(C)(C)c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc12
Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)17-12-16(21(32)30-24(3)6-9-37(34,35)10-7-24)18(26)13-19(17)31(22(23)33)20-11-15(5-8-29-20)36-14-25(4,27)28/h5,8,11-13H,6-7,9-10,14H2,1-4H3,(H,30,32)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530749
PNG
(WO2022076496, Example 46)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@]1(C)CCCN(CC(F)F)C1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H29F4N3O3/c1-25(2)19-12-16(22(34)31-26(3)10-5-11-32(15-26)14-21(27)28)8-9-20(19)33(23(25)35)17-6-4-7-18(13-17)36-24(29)30/h4,6-9,12-13,21,24H,5,10-11,14-15H2,1-3H3,(H,31,34)/t26-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530838
PNG
(WO2022076496, Example 130c)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530821
PNG
(WO2022076496, Example 118)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)CO)c1
Show InChI InChI=1S/C24H27F2N3O6S/c1-22(2)18-10-15(20(31)28-23(3)6-8-36(33,34)9-7-23)4-5-19(18)29(21(22)32)16-11-17(13-27-12-16)35-24(25,26)14-30/h4-5,10-13,30H,6-9,14H2,1-3H3,(H,28,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530727
PNG
(WO2022076496, Example 25)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(18(31)29-22(3)6-7-36(33,34)12-22)4-5-17(16)30(20(21)32)14-9-15(11-28-10-14)35-23(26,27)19(24)25/h4-5,8-11,19H,6-7,12H2,1-3H3,(H,29,31)/t22-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530781
PNG
(WO2022076496, Example 78)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC2)ccn1
Show InChI InChI=1S/C26H31N3O5S/c1-25(2)20-14-18(23(30)28-26(3)9-12-35(32,33)13-10-26)6-7-21(20)29(24(25)31)22-15-19(8-11-27-22)34-16-17-4-5-17/h6-8,11,14-15,17H,4-5,9-10,12-13,16H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530701
PNG
(1-(3-(difluoromethoxy)phenyl)-3,3-dimethyl-N-(3-me...)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H22F2N2O5S/c1-21(2)16-9-13(18(27)25-22(3)11-32(29,30)12-22)7-8-17(16)26(19(21)28)14-5-4-6-15(10-14)31-20(23)24/h4-10,20H,11-12H2,1-3H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530844
PNG
(WO2022076496, Example 135)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C24H24F4N2O5S/c1-22(2)16-12-14(20(31)29-23(3)8-10-36(33,34)11-9-23)4-7-18(16)30(21(22)32)19-13-15(5-6-17(19)25)35-24(26,27)28/h4-7,12-13H,8-11H2,1-3H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530827
PNG
(WO2022076496, Example 124)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2N(C(=O)C3(CCCC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H28F2N2O5S/c1-25(11-13-36(33,34)14-12-25)29-22(31)17-7-8-21-20(15-17)26(9-2-3-10-26)23(32)30(21)18-5-4-6-19(16-18)35-24(27)28/h4-8,15-16,24H,2-3,9-14H2,1H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530842
PNG
(WO2022076496, Example 133)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C23H22F4N2O5S/c1-21(2)15-10-13(19(30)28-22(3)8-9-35(32,33)12-22)4-7-17(15)29(20(21)31)18-11-14(5-6-16(18)24)34-23(25,26)27/h4-7,10-11H,8-9,12H2,1-3H3,(H,28,30)/t22-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530819
PNG
(WO2022076496, Example 116)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)F)n1
Show InChI InChI=1S/C22H24F2N4O5S/c1-21(2)14-10-13(18(29)27-22(3)6-8-34(31,32)9-7-22)4-5-15(14)28(19(21)30)16-11-25-12-17(26-16)33-20(23)24/h4-5,10-12,20H,6-9H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530814
PNG
(WO2022076496, Example 111)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(SC(F)F)ccc1F
Show InChI InChI=1S/C22H21F3N2O4S2/c1-21(2)14-8-12(18(28)26-22(3)10-33(30,31)11-22)4-7-16(14)27(19(21)29)17-9-13(32-20(24)25)5-6-15(17)23/h4-9,20H,10-11H2,1-3H3,(H,26,28)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530723
PNG
(WO2022076496, Example 21)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-11-15(21(29)27-24(3)9-10-34(31,32)14-24)7-8-19(18)28(22(23)30)16-5-4-6-17(12-16)33-13-20(25)26/h4-8,11-12,20H,9-10,13-14H2,1-3H3,(H,27,29)/t24-/m0/s1
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530834
PNG
(WO2022076496, Example 129c)
Show SMILES C[C@H]1CS(=O)(=O)C[C@@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18-/m0/s1
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530746
PNG
(WO2022076496, Example 43)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H25F3N2O5S/c1-22(2)18-13-15(20(30)28-23(3)9-11-35(32,33)12-10-23)7-8-19(18)29(21(22)31)16-5-4-6-17(14-16)34-24(25,26)27/h4-8,13-14H,9-12H2,1-3H3,(H,28,30)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530712
PNG
(1-[3-(difluoromethoxy)phenyl]-3,3-dimethyl-N-(4-me...)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-13-15(20(29)27-24(3)9-11-34(31,32)12-10-24)7-8-19(18)28(21(23)30)16-5-4-6-17(14-16)33-22(25)26/h4-8,13-14,22H,9-12H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530845
PNG
(WO2022076496, Example 136)
Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(19(31)29-22(3)4-6-36(33,34)7-5-22)9-17(24)18(16)30(20(21)32)14-10-15(12-28-11-14)35-23(25,26)27/h8-12H,4-7H2,1-3H3,(H,29,31)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530776
PNG
(WO2022076496, Example 73)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)cnn1
Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)16-10-14(20(30)27-23(3)6-8-35(32,33)9-7-23)4-5-17(16)29(21(22)31)19-11-15(12-26-28-19)34-13-18(24)25/h4-5,10-12,18H,6-9,13H2,1-3H3,(H,27,30)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530713
PNG
(WO2022076496, Example 11)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-11-14(19(28)26-23(3)9-10-33(30,31)13-23)7-8-18(17)27(20(22)29)15-5-4-6-16(12-15)32-21(24)25/h4-8,11-12,21H,9-10,13H2,1-3H3,(H,26,28)/t23-/m1/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530782
PNG
(WO2022076496, Example 79)
Show SMILES CCCOc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H31N3O5S/c1-5-12-33-18-8-11-26-21(16-18)28-20-7-6-17(15-19(20)24(2,3)23(28)30)22(29)27-25(4)9-13-34(31,32)14-10-25/h6-8,11,15-16H,5,9-10,12-14H2,1-4H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530806
PNG
(WO2022076496, Example 103)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OCC(F)F)c1
Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-6-13(19(28)26-22(3)11-33(30,31)12-22)4-5-17(16)27(20(21)29)14-7-15(9-25-8-14)32-10-18(23)24/h4-9,18H,10-12H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530720
PNG
(WO2022076496, Example 18)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-10-13(19(29)27-23(3)8-9-34(31,32)12-23)4-7-17(15)28(20(22)30)18-11-14(33-21(25)26)5-6-16(18)24/h4-7,10-11,21H,8-9,12H2,1-3H3,(H,27,29)/t23-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530841
PNG
(WO2022076496, Example 132)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C22H20F4N2O5S/c1-20(2)14-8-12(18(29)27-21(3)10-34(31,32)11-21)4-7-16(14)28(19(20)30)17-9-13(5-6-15(17)23)33-22(24,25)26/h4-9H,10-11H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530731
PNG
(WO2022076496, Example 28 | WO2022076496, Example 8...)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C22H24FN3O5S/c1-5-31-18-9-17(15(23)10-24-18)26-16-7-6-13(8-14(16)21(2,3)20(26)28)19(27)25-22(4)11-32(29,30)12-22/h6-10H,5,11-12H2,1-4H3,(H,25,27)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530732
PNG
(WO2022076496, Example 29 | WO2022076496, Example 3...)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C23H26FN3O5S/c1-5-32-19-11-18(16(24)12-25-19)27-17-7-6-14(10-15(17)22(2,3)21(27)29)20(28)26-23(4)8-9-33(30,31)13-23/h6-7,10-12H,5,8-9,13H2,1-4H3,(H,26,28)/t23-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530823
PNG
(WO2022076496, Example 120)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(F)c1
Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)16-9-13(19(29)27-23(3)7-8-34(31,32)12-23)10-17(24)18(16)28(20(22)30)14-5-4-6-15(11-14)33-21(25)26/h4-6,9-11,21H,7-8,12H2,1-3H3,(H,27,29)/t23-/m1/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530813
PNG
(WO2022076496, Example 110)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-9-14(20(28)26-23(3)12-33(30,31)13-23)7-8-18(17)27(21(22)29)15-5-4-6-16(10-15)32-11-19(24)25/h4-10,19H,11-13H2,1-3H3,(H,26,28)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530732
PNG
(WO2022076496, Example 29 | WO2022076496, Example 3...)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C23H26FN3O5S/c1-5-32-19-11-18(16(24)12-25-19)27-17-7-6-14(10-15(17)22(2,3)21(27)29)20(28)26-23(4)8-9-33(30,31)13-23/h6-7,10-12H,5,8-9,13H2,1-4H3,(H,26,28)/t23-/m1/s1
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n/an/a 56n/an/an/an/an/an/a



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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530765
PNG
(WO2022076496, Example 62)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ccn1
Show InChI InChI=1S/C24H27F2N3O5S/c1-23(2)17-12-15(21(30)28-24(3)7-10-35(32,33)11-8-24)4-5-18(17)29(22(23)31)20-13-16(6-9-27-20)34-14-19(25)26/h4-6,9,12-13,19H,7-8,10-11,14H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530826
PNG
(WO2022076496, Example 123)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CCCC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H26F2N2O5S/c1-24(11-12-35(32,33)15-24)28-21(30)16-7-8-20-19(13-16)25(9-2-3-10-25)22(31)29(20)17-5-4-6-18(14-17)34-23(26)27/h4-8,13-14,23H,2-3,9-12,15H2,1H3,(H,28,30)/t24-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530699
PNG
(1'-(3-(difluoromethoxy)phenyl)-N-(3-methyl-1,1-dio...)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CCC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H22F2N2O5S/c1-22(12-33(30,31)13-22)26-19(28)14-6-7-18-17(10-14)23(8-3-9-23)20(29)27(18)15-4-2-5-16(11-15)32-21(24)25/h2,4-7,10-11,21H,3,8-9,12-13H2,1H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530744
PNG
(WO2022076496, Example 41)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1
Show InChI InChI=1S/C25H28N2O5S/c1-24(2)20-13-16(22(28)26-25(3)11-12-33(30,31)15-25)7-10-21(20)27(23(24)29)17-5-4-6-19(14-17)32-18-8-9-18/h4-7,10,13-14,18H,8-9,11-12,15H2,1-3H3,(H,26,28)/t25-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530828
PNG
(WO2022076496, Example 125)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C22CCCC2)c2cccc(OC(F)F)c2)c(F)c1
Show InChI InChI=1S/C24H23F3N2O5S/c1-23(12-35(32,33)13-23)28-20(30)14-9-17-19(18(25)10-14)29(21(31)24(17)7-2-3-8-24)15-5-4-6-16(11-15)34-22(26)27/h4-6,9-11,22H,2-3,7-8,12-13H2,1H3,(H,28,30)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530767
PNG
(WO2022076496, Example 64)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)F)ccn1
Show InChI InChI=1S/C24H26F3N3O5S/c1-22(2)17-12-15(20(31)29-23(3)7-10-36(33,34)11-8-23)4-5-18(17)30(21(22)32)19-13-16(6-9-28-19)35-14-24(25,26)27/h4-6,9,12-13H,7-8,10-11,14H2,1-3H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530843
PNG
(WO2022076496, Example 134)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C23H22F4N2O5S/c1-21(2)15-10-13(19(30)28-22(3)8-9-35(32,33)12-22)4-7-17(15)29(20(21)31)18-11-14(5-6-16(18)24)34-23(25,26)27/h4-7,10-11H,8-9,12H2,1-3H3,(H,28,30)/t22-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530802
PNG
(WO2022076496, Example 99)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(C(=O)NC4(CCS(=O)(=O)CC4)C(F)F)c(F)cc23)c(F)cn1
Show InChI InChI=1S/C24H25F4N3O5S/c1-4-36-19-11-18(16(26)12-29-19)31-17-10-15(25)13(9-14(17)23(2,3)22(31)33)20(32)30-24(21(27)28)5-7-37(34,35)8-6-24/h9-12,21H,4-8H2,1-3H3,(H,30,32)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530824
PNG
(WO2022076496, Example 121)
Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)F)c1
Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)16-8-13(19(30)28-23(3)4-6-35(32,33)7-5-23)9-17(24)18(16)29(20(22)31)14-10-15(12-27-11-14)34-21(25)26/h8-12,21H,4-7H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530740
PNG
(WO2022076496, Example 37)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CS(C)(=O)=O)CCCCC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H30F2N2O5S/c1-25(2)20-14-17(22(31)29-26(16-36(3,33)34)12-5-4-6-13-26)10-11-21(20)30(23(25)32)18-8-7-9-19(15-18)35-24(27)28/h7-11,14-15,24H,4-6,12-13,16H2,1-3H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530768
PNG
(WO2022076496, Example 65)
Show SMILES CC(F)(F)COc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H29F2N3O5S/c1-23(2)18-13-16(21(31)29-24(3)8-11-36(33,34)12-9-24)5-6-19(18)30(22(23)32)20-14-17(7-10-28-20)35-15-25(4,26)27/h5-7,10,13-14H,8-9,11-12,15H2,1-4H3,(H,29,31)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530787
PNG
(WO2022076496, Example 84)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ccn1
Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)16-11-15(21(31)29-24(3)5-8-36(33,34)9-6-24)17(25)12-18(16)30(22(23)32)20-10-14(4-7-28-20)35-13-19(26)27/h4,7,10-12,19H,5-6,8-9,13H2,1-3H3,(H,29,31)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530801
PNG
(WO2022076496, Example 98)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ncc1F)N1CC(F)(F)C1
Show InChI InChI=1S/C25H26F4N4O4S/c1-23(2)15-8-14(21(34)31-24(3)4-6-38(36,37)7-5-24)16(26)9-18(15)33(22(23)35)19-10-20(30-11-17(19)27)32-12-25(28,29)13-32/h8-11H,4-7,12-13H2,1-3H3,(H,31,34)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530833
PNG
(WO2022076496, Example 129b)
Show SMILES C[C@@H]1CS(=O)(=O)C[C@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18-/m1/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530754
PNG
(WO2022076496, Example 51)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C1CC1
Show InChI InChI=1S/C26H30N2O4S/c1-25(2)21-16-19(23(29)27-26(3)11-13-33(31,32)14-12-26)9-10-22(21)28(24(25)30)20-6-4-5-18(15-20)17-7-8-17/h4-6,9-10,15-17H,7-8,11-14H2,1-3H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530857
PNG
(WO2022076496, Example 148)
Show SMILES CC1(C)C(=O)N(c2ncc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)15-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)12-27-18(15)29(20(22)31)17-11-14(34-21(25)26)4-5-16(17)24/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530854
PNG
(WO2022076496, Example 145)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C21H20F3N3O5S/c1-20(2)13-6-11(17(28)26-21(3)9-33(30,31)10-21)8-25-16(13)27(18(20)29)15-7-12(32-19(23)24)4-5-14(15)22/h4-8,19H,9-10H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530731
PNG
(WO2022076496, Example 28 | WO2022076496, Example 8...)
Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1
Show InChI InChI=1S/C22H24FN3O5S/c1-5-31-18-9-17(15(23)10-24-18)26-16-7-6-13(8-14(16)21(2,3)20(26)28)19(27)25-22(4)11-32(29,30)12-22/h6-10H,5,11-12H2,1-4H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530739
PNG
(WO2022076496, Example 36)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NCCS(=O)(=O)NC1CCCCC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H31F2N3O5S/c1-26(2)21-15-17(23(32)29-13-14-37(34,35)30-18-7-4-3-5-8-18)11-12-22(21)31(24(26)33)19-9-6-10-20(16-19)36-25(27)28/h6,9-12,15-16,18,25,30H,3-5,7-8,13-14H2,1-2H3,(H,29,32)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530716
PNG
(WO2022076496, Example 14)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H23F3N2O5S/c1-21(2)17-11-14(19(29)27-22(3)9-10-34(31,32)13-22)7-8-18(17)28(20(21)30)15-5-4-6-16(12-15)33-23(24,25)26/h4-8,11-12H,9-10,13H2,1-3H3,(H,27,29)/t22-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530730
PNG
(WO2022076496, Example 27b)
Show SMILES C[C@@H](O)CC(C)(C)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H28F2N2O4/c1-14(29)13-23(2,3)27-20(30)15-9-10-19-18(11-15)24(4,5)21(31)28(19)16-7-6-8-17(12-16)32-22(25)26/h6-12,14,22,29H,13H2,1-5H3,(H,27,30)/t14-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530753
PNG
(WO2022076496, Example 50)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ccc1F)N1CCC1
Show InChI InChI=1S/C26H29F2N3O4S/c1-25(2)18-14-17(23(32)29-26(3)7-11-36(34,35)12-8-26)20(28)15-21(18)31(24(25)33)22-13-16(5-6-19(22)27)30-9-4-10-30/h5-6,13-15H,4,7-12H2,1-3H3,(H,29,32)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530702
PNG
(WO2022076496, Example 4)
Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CS(=O)(=O)C1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-4-23(3)17-10-14(19(28)26-22(2)12-33(30,31)13-22)8-9-18(17)27(20(23)29)15-6-5-7-16(11-15)32-21(24)25/h5-11,21H,4,12-13H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530717
PNG
(WO2022076496, Example 15)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N2O5S/c1-20(2)16-9-13(18(28)26-21(3)11-33(30,31)12-21)7-8-17(16)27(19(20)29)14-5-4-6-15(10-14)32-22(23,24)25/h4-10H,11-12H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530790
PNG
(WO2022076496, Example 87)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)c(F)cn1
Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-10-14(21(31)29-24(3)6-8-36(33,34)9-7-24)4-5-17(15)30(22(23)32)20-11-18(16(25)12-28-20)35-13-19(26)27/h4-5,10-12,19H,6-9,13H2,1-3H3,(H,29,31)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530805
PNG
(WO2022076496, Example 102)
Show SMILES CCOc1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H25N3O5S/c1-5-30-16-9-15(10-23-11-16)25-18-7-6-14(8-17(18)21(2,3)20(25)27)19(26)24-22(4)12-31(28,29)13-22/h6-11H,5,12-13H2,1-4H3,(H,24,26)
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WIPO WO2022076496
n/an/a 111n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530858
PNG
(WO2022076496, Example 149)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1
Show InChI InChI=1S/C21H19F4N3O5S/c1-19(2)14-4-11(17(29)27-20(3)9-34(31,32)10-20)5-15(22)16(14)28(18(19)30)12-6-13(8-26-7-12)33-21(23,24)25/h4-8H,9-10H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530778
PNG
(WO2022076496, Example 75)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncn1
Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)15-10-14(20(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(15)29(21(22)31)18-11-19(27-13-26-18)34-12-17(24)25/h4-5,10-11,13,17H,6-9,12H2,1-3H3,(H,28,30)
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530822
PNG
(WO2022076496, Example 119)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H22F2N2O5S/c1-22(9-10-33(30,31)13-22)26-19(28)14-5-6-18-17(11-14)23(7-8-23)20(29)27(18)15-3-2-4-16(12-15)32-21(24)25/h2-6,11-12,21H,7-10,13H2,1H3,(H,26,28)/t22-/m1/s1
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530859
PNG
(WO2022076496, Example 150)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1
Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(18(30)28-21(3)4-5-35(32,33)11-21)7-16(23)17(15)29(19(20)31)13-8-14(10-27-9-13)34-22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,28,30)/t21-/m1/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530755
PNG
(WO2022076496, Example 52)
Show SMILES CC(C)Oc1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H32N2O5S/c1-17(2)33-20-8-6-7-19(16-20)28-22-10-9-18(15-21(22)25(3,4)24(28)30)23(29)27-26(5)11-13-34(31,32)14-12-26/h6-10,15-17H,11-14H2,1-5H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530820
PNG
(WO2022076496, Example 117)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H24F3N3O5S/c1-21(2)17-10-14(19(30)28-22(3)6-8-35(32,33)9-7-22)4-5-18(17)29(20(21)31)15-11-16(13-27-12-15)34-23(24,25)26/h4-5,10-13H,6-9H2,1-3H3,(H,28,30)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530867
PNG
(WO2022076496, Example 158)
Show SMILES CC1(C)C(=O)N(c2cnc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)16-12-17(19(29)27-23(3)7-9-34(31,32)10-8-23)26-13-18(16)28(20(22)30)14-5-4-6-15(11-14)33-21(24)25/h4-6,11-13,21H,7-10H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530799
PNG
(WO2022076496, Example 96)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ncc1F
Show InChI InChI=1S/C23H23F4N3O5S/c1-22(2)13-8-12(19(31)29-23(3)4-6-36(33,34)7-5-23)14(24)9-16(13)30(20(22)32)17-10-18(35-21(26)27)28-11-15(17)25/h8-11,21H,4-7H2,1-3H3,(H,29,31)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530793
PNG
(WO2022076496, Example 90)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ncc1F
Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)14-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(14)29(20(22)31)17-11-18(34-21(25)26)27-12-15(17)24/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530786
PNG
(WO2022076496, Example 83)
Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccn1
Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)15-11-14(19(30)28-23(3)5-8-35(32,33)9-6-23)16(24)12-17(15)29(20(22)31)18-10-13(4-7-27-18)34-21(25)26/h4,7,10-12,21H,5-6,8-9H2,1-3H3,(H,28,30)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530772
PNG
(WO2022076496, Example 69)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC2CC2)ccn1
Show InChI InChI=1S/C25H29N3O5S/c1-24(2)19-14-16(22(29)27-25(3)9-12-34(31,32)13-10-25)4-7-20(19)28(23(24)30)21-15-18(8-11-26-21)33-17-5-6-17/h4,7-8,11,14-15,17H,5-6,9-10,12-13H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530779
PNG
(WO2022076496, Example 76)
Show SMILES CC(C)Oc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H31N3O5S/c1-16(2)33-18-8-11-26-21(15-18)28-20-7-6-17(14-19(20)24(3,4)23(28)30)22(29)27-25(5)9-12-34(31,32)13-10-25/h6-8,11,14-16H,9-10,12-13H2,1-5H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530863
PNG
(WO2022076496, Example 154)
Show SMILES CC1(C)C(=O)N(c2ncc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)17-11-14(19(29)27-23(3)7-9-34(31,32)10-8-23)13-26-18(17)28(20(22)30)15-5-4-6-16(12-15)33-21(24)25/h4-6,11-13,21H,7-10H2,1-3H3,(H,27,29)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530747
PNG
(WO2022076496, Example 44)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-11-14(19(28)26-23(3)9-10-33(30,31)13-23)7-8-18(17)27(20(22)29)15-5-4-6-16(12-15)32-21(24)25/h4-8,11-12,21H,9-10,13H2,1-3H3,(H,26,28)/t23-/m0/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530711
PNG
(WO2022076496, Example 9b)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](C)(F)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H19F3N2O5S/c1-20(10-32(29,30)11-20)25-17(27)12-6-7-16-15(8-12)21(2,24)18(28)26(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19H,10-11H2,1-2H3,(H,25,27)/t21-/m0/s1
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530866
PNG
(WO2022076496, Example 157)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-9-13(18(28)26-22(3)7-8-33(30,31)12-22)11-25-17(16)27(19(21)29)14-5-4-6-15(10-14)32-20(23)24/h4-6,9-11,20H,7-8,12H2,1-3H3,(H,26,28)/t22-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530769
PNG
(WO2022076496, Example 66)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)C(F)F)ccn1
Show InChI InChI=1S/C25H27F4N3O5S/c1-23(2)17-12-15(20(33)31-24(3)7-10-38(35,36)11-8-24)4-5-18(17)32(22(23)34)19-13-16(6-9-30-19)37-14-25(28,29)21(26)27/h4-6,9,12-13,21H,7-8,10-11,14H2,1-3H3,(H,31,33)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530780
PNG
(WO2022076496, Example 77)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2(F)CC2)ccn1
Show InChI InChI=1S/C26H30FN3O5S/c1-24(2)19-14-17(22(31)29-25(3)9-12-36(33,34)13-10-25)4-5-20(19)30(23(24)32)21-15-18(6-11-28-21)35-16-26(27)7-8-26/h4-6,11,14-15H,7-10,12-13,16H2,1-3H3,(H,29,31)
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MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530771
PNG
(WO2022076496, Example 68)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC(F)(F)C2)ccn1
Show InChI InChI=1S/C27H31F2N3O5S/c1-25(2)20-12-18(23(33)31-26(3)7-10-38(35,36)11-8-26)4-5-21(20)32(24(25)34)22-13-19(6-9-30-22)37-16-17-14-27(28,29)15-17/h4-6,9,12-13,17H,7-8,10-11,14-16H2,1-3H3,(H,31,33)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530807
PNG
(WO2022076496, Example 104)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(SC(F)F)c1
Show InChI InChI=1S/C21H21F2N3O4S2/c1-20(2)15-6-12(17(27)25-21(3)10-32(29,30)11-21)4-5-16(15)26(18(20)28)13-7-14(9-24-8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530818
PNG
(WO2022076496, Example 115)
Show SMILES Cc1ncc(OCC(F)F)cc1N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25F2N3O5S/c1-13-18(8-15(9-26-13)33-10-19(24)25)28-17-6-5-14(7-16(17)22(2,3)21(28)30)20(29)27-23(4)11-34(31,32)12-23/h5-9,19H,10-12H2,1-4H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530837
PNG
(WO2022076496, Example 130b)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@H]1CCC[C@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530856
PNG
(WO2022076496, Example 147)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)14-8-12(18(29)27-22(3)6-7-34(31,32)11-22)10-26-17(14)28(19(21)30)16-9-13(33-20(24)25)4-5-15(16)23/h4-5,8-10,20H,6-7,11H2,1-3H3,(H,27,29)/t22-/m0/s1
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MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530800
PNG
(WO2022076496, Example 97)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(cc1F)N(C(=O)C2(C)C)c1cc(OC(F)F)ncc1F
Show InChI InChI=1S/C21H19F4N3O5S/c1-20(2)11-4-10(17(29)27-21(3)8-34(31,32)9-21)12(22)5-14(11)28(18(20)30)15-6-16(33-19(24)25)26-7-13(15)23/h4-7,19H,8-9H2,1-3H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530830
PNG
(WO2022076496, Example 127)
Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H24F2N2O5S/c1-23(9-11-34(31,32)12-10-23)27-20(29)15-5-6-19-18(13-15)24(7-8-24)21(30)28(19)16-3-2-4-17(14-16)33-22(25)26/h2-6,13-14,22H,7-12H2,1H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530840
PNG
(WO2022076496, Example 131)
Show SMILES CC(C)(CS(C)(=O)=O)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H26F2N2O5S/c1-22(2,13-33(5,30)31)26-19(28)14-9-10-18-17(11-14)23(3,4)20(29)27(18)15-7-6-8-16(12-15)32-21(24)25/h6-12,21H,13H2,1-5H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530704
PNG
(WO2022076496, Example 5b)
Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-4-24(3)18-12-15(20(29)27-23(2)10-11-34(31,32)14-23)8-9-19(18)28(21(24)30)16-6-5-7-17(13-16)33-22(25)26/h5-9,12-13,22H,4,10-11,14H2,1-3H3,(H,27,29)/t23-,24?/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530773
PNG
(WO2022076496, Example 70)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccn1
Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)16-12-14(19(29)27-23(3)7-10-34(31,32)11-8-23)4-5-17(16)28(20(22)30)18-13-15(6-9-26-18)33-21(24)25/h4-6,9,12-13,21H,7-8,10-11H2,1-3H3,(H,27,29)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530789
PNG
(WO2022076496, Example 86)
Show SMILES CC(F)(F)COc1cc(ncc1F)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)16-11-15(21(32)30-24(3)7-9-37(34,35)10-8-24)5-6-18(16)31(22(23)33)20-12-19(17(26)13-29-20)36-14-25(4,27)28/h5-6,11-13H,7-10,14H2,1-4H3,(H,30,32)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530788
PNG
(WO2022076496, Example 85)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)c(F)cn1
Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)14-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(14)29(20(22)31)18-11-17(34-21(25)26)15(24)12-27-18/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530706
PNG
(WO2022076496, Example 6b)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](C)(O)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H20F2N2O6S/c1-20(10-32(29,30)11-20)24-17(26)12-6-7-16-15(8-12)21(2,28)18(27)25(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19,28H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530804
PNG
(WO2022076496, Example 101)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)F)c1
Show InChI InChI=1S/C21H21F2N3O5S/c1-20(2)15-6-12(17(27)25-21(3)10-32(29,30)11-21)4-5-16(15)26(18(20)28)13-7-14(9-24-8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530715
PNG
(WO2022076496, Example 13)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H23F3N2O5S/c1-21(2)17-11-14(19(29)27-22(3)9-10-34(31,32)13-22)7-8-18(17)28(20(21)30)15-5-4-6-16(12-15)33-23(24,25)26/h4-8,11-12H,9-10,13H2,1-3H3,(H,27,29)/t22-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530710
PNG
(WO2022076496, Example 9a)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](C)(F)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H19F3N2O5S/c1-20(10-32(29,30)11-20)25-17(27)12-6-7-16-15(8-12)21(2,24)18(28)26(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19H,10-11H2,1-2H3,(H,25,27)/t21-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530855
PNG
(WO2022076496, Example 146)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F
Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)14-8-12(18(29)27-22(3)6-7-34(31,32)11-22)10-26-17(14)28(19(21)30)16-9-13(33-20(24)25)4-5-15(16)23/h4-5,8-10,20H,6-7,11H2,1-3H3,(H,27,29)/t22-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530803
PNG
(WO2022076496, Example 100)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H20F3N3O5S/c1-19(2)15-6-12(17(28)26-20(3)10-33(30,31)11-20)4-5-16(15)27(18(19)29)13-7-14(9-25-8-13)32-21(22,23)24/h4-9H,10-11H2,1-3H3,(H,26,28)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530795
PNG
(WO2022076496, Example 92)
Show SMILES CC(C)Oc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1
Show InChI InChI=1S/C25H30FN3O5S/c1-15(2)34-21-13-20(18(26)14-27-21)29-19-7-6-16(12-17(19)24(3,4)23(29)31)22(30)28-25(5)8-10-35(32,33)11-9-25/h6-7,12-15H,8-11H2,1-5H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530752
PNG
(WO2022076496, Example 49)
Show SMILES CCC1(CCC(CC1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C27H29F5N2O3/c1-4-26(27(30,31)32)12-10-17(11-13-26)33-22(35)16-8-9-21-20(14-16)25(2,3)23(36)34(21)18-6-5-7-19(15-18)37-24(28)29/h5-9,14-15,17,24H,4,10-13H2,1-3H3,(H,33,35)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530777
PNG
(WO2022076496, Example 74)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1nccc(OCC(F)F)n1
Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)15-12-14(19(30)28-23(3)7-10-35(32,33)11-8-23)4-5-16(15)29(20(22)31)21-26-9-6-18(27-21)34-13-17(24)25/h4-6,9,12,17H,7-8,10-11,13H2,1-3H3,(H,28,30)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530860
PNG
(WO2022076496, Example 151)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1
Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(18(30)28-21(3)4-5-35(32,33)11-21)7-16(23)17(15)29(19(20)31)13-8-14(10-27-9-13)34-22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,28,30)/t21-/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530829
PNG
(WO2022076496, Example 126)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H20F2N2O5S/c1-21(11-32(29,30)12-21)25-18(27)13-5-6-17-16(9-13)22(7-8-22)19(28)26(17)14-3-2-4-15(10-14)31-20(23)24/h2-6,9-10,20H,7-8,11-12H2,1H3,(H,25,27)
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530865
PNG
(WO2022076496, Example 156)
Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-9-13(18(28)26-22(3)7-8-33(30,31)12-22)11-25-17(16)27(19(21)29)14-5-4-6-15(10-14)32-20(23)24/h4-6,9-11,20H,7-8,12H2,1-3H3,(H,26,28)/t22-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530707
PNG
(WO2022076496, Example 7a)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](O)(c2c1)C(F)(F)F)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H17F5N2O6S/c1-19(9-35(32,33)10-19)27-16(29)11-5-6-15-14(7-11)20(31,21(24,25)26)17(30)28(15)12-3-2-4-13(8-12)34-18(22)23/h2-8,18,31H,9-10H2,1H3,(H,27,29)/t20-/m1/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530714
PNG
(WO2022076496, Example 12)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@H]1O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O4/c1-23(2)16-11-13(20(29)26-17-7-4-8-19(17)28)9-10-18(16)27(21(23)30)14-5-3-6-15(12-14)31-22(24)25/h3,5-6,9-12,17,19,22,28H,4,7-8H2,1-2H3,(H,26,29)/t17-,19+/m0/s1
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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530839
PNG
(WO2022076496, Example 130d)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20+/m0/s1
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WIPO WO2022076496
n/an/a 537n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530737
PNG
(WO2022076496, Example 34)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1ccnc(N2CC(F)(F)C2)c1F
Show InChI InChI=1S/C23H23F3N4O4S/c1-21(2)14-8-13(19(31)28-22(3)11-35(33,34)12-22)4-5-15(14)30(20(21)32)16-6-7-27-18(17(16)24)29-9-23(25,26)10-29/h4-8H,9-12H2,1-3H3,(H,28,31)
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WIPO WO2022076496
n/an/a 548n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530770
PNG
(WO2022076496, Example 67)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC2(F)F)ccn1
Show InChI InChI=1S/C26H29F2N3O5S/c1-24(2)19-12-16(22(32)30-25(3)7-10-37(34,35)11-8-25)4-5-20(19)31(23(24)33)21-13-18(6-9-29-21)36-15-17-14-26(17,27)28/h4-6,9,12-13,17H,7-8,10-11,14-15H2,1-3H3,(H,30,32)
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WIPO WO2022076496
n/an/a 594n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530811
PNG
(WO2022076496, Example 108)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OCC(F)F)n1
Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)13-6-12(18(28)26-21(3)10-33(30,31)11-21)4-5-14(13)27(19(20)29)16-7-24-8-17(25-16)32-9-15(22)23/h4-8,15H,9-11H2,1-3H3,(H,26,28)
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WIPO WO2022076496
n/an/a 628n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530775
PNG
(WO2022076496, Example 72)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1nccc(OCC(F)F)c1F
Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-12-14(21(31)29-24(3)7-10-36(33,34)11-8-24)4-5-16(15)30(22(23)32)20-19(27)17(6-9-28-20)35-13-18(25)26/h4-6,9,12,18H,7-8,10-11,13H2,1-3H3,(H,29,31)
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WIPO WO2022076496
n/an/a 821n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530816
PNG
(WO2022076496, Example 113)
Show SMILES CC(F)(F)c1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H23F2N3O4S/c1-20(2)16-7-13(18(28)26-21(3)11-32(30,31)12-21)5-6-17(16)27(19(20)29)15-8-14(9-25-10-15)22(4,23)24/h5-10H,11-12H2,1-4H3,(H,26,28)
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WIPO WO2022076496
n/an/a 821n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530864
PNG
(WO2022076496, Example 155)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H21F2N3O5S/c1-20(2)15-7-12(17(27)25-21(3)10-32(29,30)11-21)9-24-16(15)26(18(20)28)13-5-4-6-14(8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27)
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WIPO WO2022076496
n/an/a 888n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530750
PNG
(WO2022076496, Example 47)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCCN(C1)S(C)(=O)=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C25H29F2N3O5S/c1-24(2)19-13-16(21(31)28-25(3)11-6-12-29(15-25)36(4,33)34)9-10-20(19)30(22(24)32)17-7-5-8-18(14-17)35-23(26)27/h5,7-10,13-14,23H,6,11-12,15H2,1-4H3,(H,28,31)
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WIPO WO2022076496
n/an/a>1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530735
PNG
(WO2022076496, Example 32)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cnc2ccccc2c1
Show InChI InChI=1S/C24H23N3O4S/c1-23(2)18-11-16(21(28)26-24(3)13-32(30,31)14-24)8-9-20(18)27(22(23)29)17-10-15-6-4-5-7-19(15)25-12-17/h4-12H,13-14H2,1-3H3,(H,26,28)
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WIPO WO2022076496
n/an/a>1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530738
PNG
(WO2022076496, Example 35)
Show SMILES CC(=O)Nc1ccc(cc1O)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H25N3O6S/c1-13(27)24-17-7-6-15(10-19(17)28)26-18-8-5-14(9-16(18)22(2,3)21(26)30)20(29)25-23(4)11-33(31,32)12-23/h5-10,28H,11-12H2,1-4H3,(H,24,27)(H,25,29)
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WIPO WO2022076496
n/an/a>1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530831
PNG
(WO2022076496, Example 128)
Show SMILES CC1CC(CS1(=O)=O)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-13-9-15(12-33(13,30)31)26-20(28)14-7-8-19-18(10-14)23(2,3)21(29)27(19)16-5-4-6-17(11-16)32-22(24)25/h4-8,10-11,13,15,22H,9,12H2,1-3H3,(H,26,28)
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WIPO WO2022076496
n/an/a>1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530734
PNG
(WO2022076496, Example 31)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1ccnc(OCC(F)F)n1
Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)13-8-12(17(28)26-21(3)10-33(30,31)11-21)4-5-14(13)27(18(20)29)16-6-7-24-19(25-16)32-9-15(22)23/h4-8,15H,9-11H2,1-3H3,(H,26,28)
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WIPO WO2022076496
n/an/a>1.00E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530868
PNG
(WO2022076496, Example 159)
Show SMILES CC1(C)C(=O)N(c2nnc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H24F2N4O5S/c1-21(2)15-12-16(18(29)25-22(3)7-9-34(31,32)10-8-22)26-27-17(15)28(19(21)30)13-5-4-6-14(11-13)33-20(23)24/h4-6,11-12,20H,7-10H2,1-3H3,(H,25,29)
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WIPO WO2022076496
n/an/a 1.04E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530748
PNG
(WO2022076496, Example 45)
Show SMILES CC1(CC(F)(F)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H22F4N2O3/c1-21(2)16-9-13(18(30)28-22(3)11-23(26,27)12-22)7-8-17(16)29(19(21)31)14-5-4-6-15(10-14)32-20(24)25/h4-10,20H,11-12H2,1-3H3,(H,28,30)
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WIPO WO2022076496
n/an/a 1.06E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530560
PNG
(WO2022076495, EXAMPLE 12 | WO2022076495, EXAMPLE 6)
Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C22H23F2N3O5S/c1-13(2)26-18-9-14(19(28)25-22(3)11-33(30,31)12-22)7-8-17(18)27(21(26)29)15-5-4-6-16(10-15)32-20(23)24/h4-10,13,20H,11-12H2,1-3H3,(H,25,28)
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WIPO WO2022076496
n/an/a 1.09E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530729
PNG
(WO2022076496, Example 27a)
Show SMILES C[C@H](O)CC(C)(C)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H28F2N2O4/c1-14(29)13-23(2,3)27-20(30)15-9-10-19-18(11-15)24(4,5)21(31)28(19)16-7-6-8-17(12-16)32-22(25)26/h6-12,14,22,29H,13H2,1-5H3,(H,27,30)/t14-/m0/s1
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WIPO WO2022076496
n/an/a 1.38E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530718
PNG
(WO2022076496, Example 16)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CO)CCOCC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5/c1-23(2)18-12-15(20(30)27-24(14-29)8-10-32-11-9-24)6-7-19(18)28(21(23)31)16-4-3-5-17(13-16)33-22(25)26/h3-7,12-13,22,29H,8-11,14H2,1-2H3,(H,27,30)
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WIPO WO2022076496
n/an/a 1.45E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530761
PNG
(WO2022076496, Example 58)
Show SMILES CN(C)c1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H31N3O4S/c1-24(2)20-15-17(22(29)26-25(3)11-13-33(31,32)14-12-25)9-10-21(20)28(23(24)30)19-8-6-7-18(16-19)27(4)5/h6-10,15-16H,11-14H2,1-5H3,(H,26,29)
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WIPO WO2022076496
n/an/a 1.80E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530783
PNG
(WO2022076496, Example 80)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O4S/c1-21(2)16-12-14(19(30)28-22(3)7-10-34(32,33)11-8-22)4-5-17(16)29(20(21)31)18-13-15(6-9-27-18)23(24,25)26/h4-6,9,12-13H,7-8,10-11H2,1-3H3,(H,28,30)
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WIPO WO2022076496
n/an/a 2.06E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530703
PNG
(WO2022076496, Example 5a)
Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@]1(C)CCS(=O)(=O)C1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-4-24(3)18-12-15(20(29)27-23(2)10-11-34(31,32)14-23)8-9-19(18)28(21(24)30)16-6-5-7-17(13-16)33-22(25)26/h5-9,12-13,22H,4,10-11,14H2,1-3H3,(H,27,29)/t23-,24?/m0/s1
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WIPO WO2022076496
n/an/a 2.22E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530757
PNG
(WO2022076496, Example 54)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C#N
Show InChI InChI=1S/C24H25N3O4S/c1-23(2)19-14-17(21(28)26-24(3)9-11-32(30,31)12-10-24)7-8-20(19)27(22(23)29)18-6-4-5-16(13-18)15-25/h4-8,13-14H,9-12H2,1-3H3,(H,26,28)
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n/an/a 2.55E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530616
PNG
(WO2022076495, EXAMPLE 60)
Show SMILES Cn1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C20H19F2N3O5S/c1-20(10-31(28,29)11-20)23-17(26)12-6-7-15-16(8-12)24(2)19(27)25(15)13-4-3-5-14(9-13)30-18(21)22/h3-9,18H,10-11H2,1-2H3,(H,23,26)
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n/an/a 2.73E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530736
PNG
(WO2022076496, Example 33)
Show SMILES Cc1nc2ccc(cc2o1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1
Show InChI InChI=1S/C23H23N3O5S/c1-13-24-17-7-6-15(10-19(17)31-13)26-18-8-5-14(9-16(18)22(2,3)21(26)28)20(27)25-23(4)11-32(29,30)12-23/h5-10H,11-12H2,1-4H3,(H,25,27)
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n/an/a 2.75E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530708
PNG
(WO2022076496, Example 7b)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](O)(c2c1)C(F)(F)F)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H17F5N2O6S/c1-19(9-35(32,33)10-19)27-16(29)11-5-6-15-14(7-11)20(31,21(24,25)26)17(30)28(15)12-3-2-4-13(8-12)34-18(22)23/h2-8,18,31H,9-10H2,1H3,(H,27,29)/t20-/m0/s1
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WIPO WO2022076496
n/an/a 2.95E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530705
PNG
(WO2022076496, Example 6a)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](C)(O)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H20F2N2O6S/c1-20(10-32(29,30)11-20)24-17(26)12-6-7-16-15(8-12)21(2,28)18(27)25(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19,28H,10-11H2,1-2H3,(H,24,26)/t21-/m1/s1
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WIPO WO2022076496
n/an/a 3.93E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530756
PNG
(WO2022076496, Example 53)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(F)c1
Show InChI InChI=1S/C23H25FN2O4S/c1-22(2)18-13-15(20(27)25-23(3)9-11-31(29,30)12-10-23)7-8-19(18)26(21(22)28)17-6-4-5-16(24)14-17/h4-8,13-14H,9-12H2,1-3H3,(H,25,27)
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WIPO WO2022076496
n/an/a 4.05E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

WIPO




WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530751
PNG
(WO2022076496, Example 48)
Show SMILES CC(=O)N1CCC[C@](C)(C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C26H29F2N3O4/c1-16(32)30-12-6-11-26(4,15-30)29-22(33)17-9-10-21-20(13-17)25(2,3)23(34)31(21)18-7-5-8-19(14-18)35-24(27)28/h5,7-10,13-14,24H,6,11-12,15H2,1-4H3,(H,29,33)/t26-/m1/s1
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WIPO WO2022076496
n/an/a 4.15E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530762
PNG
(WO2022076496, Example 59)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NCC1(O)CCOC1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5/c1-22(2)17-10-14(19(28)26-12-23(30)8-9-31-13-23)6-7-18(17)27(20(22)29)15-4-3-5-16(11-15)32-21(24)25/h3-7,10-11,21,30H,8-9,12-13H2,1-2H3,(H,26,28)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530764
PNG
(WO2022076496, Example 61)
Show SMILES CCn1cc(CNC(=O)c2ccc3N(C(=O)C(C)(C)c3c2)c2cccc(OC(F)F)c2)cn1
Show InChI InChI=1S/C24H24F2N4O3/c1-4-29-14-15(13-28-29)12-27-21(31)16-8-9-20-19(10-16)24(2,3)22(32)30(20)17-6-5-7-18(11-17)33-23(25)26/h5-11,13-14,23H,4,12H2,1-3H3,(H,27,31)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530763
PNG
(WO2022076496, Example 60)
Show SMILES Cc1nnc(NC(=O)c2ccc3N(C(=O)C(C)(C)c3c2)c2cccc(OC(F)F)c2)s1
Show InChI InChI=1S/C21H18F2N4O3S/c1-11-25-26-20(31-11)24-17(28)12-7-8-16-15(9-12)21(2,3)18(29)27(16)13-5-4-6-14(10-13)30-19(22)23/h4-10,19H,1-3H3,(H,24,26,28)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530760
PNG
(WO2022076496, Example 57)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C24H28N2O6S2/c1-23(2)19-14-16(21(27)25-24(3)10-12-34(31,32)13-11-24)8-9-20(19)26(22(23)28)17-6-5-7-18(15-17)33(4,29)30/h5-9,14-15H,10-13H2,1-4H3,(H,25,27)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530758
PNG
(WO2022076496, Example 55)
Show SMILES CNS(=O)(=O)c1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H29N3O6S2/c1-23(2)19-14-16(21(28)26-24(3)10-12-34(30,31)13-11-24)8-9-20(19)27(22(23)29)17-6-5-7-18(15-17)35(32,33)25-4/h5-9,14-15,25H,10-13H2,1-4H3,(H,26,28)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530759
PNG
(WO2022076496, Example 56)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C(N)=O
Show InChI InChI=1S/C24H27N3O5S/c1-23(2)18-14-16(21(29)26-24(3)9-11-33(31,32)12-10-24)7-8-19(18)27(22(23)30)17-6-4-5-15(13-17)20(25)28/h4-8,13-14H,9-12H2,1-3H3,(H2,25,28)(H,26,29)
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WIPO WO2022076496
n/an/a>9.99E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530832
PNG
(WO2022076496, Example 129a)
Show SMILES C[C@H]1CS(=O)(=O)C[C@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18+/m0/s1
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WIPO WO2022076496
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530836
PNG
(WO2022076496, Example 130a)
Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20+/m1/s1
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WIPO WO2022076496
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530812
PNG
(WO2022076496, Example 109)
Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cnnc(OCC(F)F)c1
Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)14-6-12(18(28)25-21(3)10-33(30,31)11-21)4-5-15(14)27(19(20)29)13-7-17(26-24-8-13)32-9-16(22)23/h4-8,16H,9-11H2,1-3H3,(H,25,28)
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WIPO WO2022076496
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM530835
PNG
(WO2022076496, Example 129d)
Show SMILES C[C@@H]1CS(=O)(=O)C[C@@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18+/m1/s1
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WIPO WO2022076496
n/an/a>1.00E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

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WIPO WO2022076496 (2022)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%