Found 170 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530846
(WO2022076496, Example 137)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1 Show InChI InChI=1S/C22H20F4N2O5S/c1-21(2)13-6-11(18(29)27-22(3)9-34(31,32)10-22)7-15(24)17(13)28(19(21)30)16-8-12(33-20(25)26)4-5-14(16)23/h4-8,20H,9-10H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530797
(WO2022076496, Example 94)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncc1F Show InChI InChI=1S/C24H25F4N3O5S/c1-23(2)14-8-13(21(32)30-24(3)4-6-37(34,35)7-5-24)15(25)9-17(14)31(22(23)33)18-10-20(29-11-16(18)26)36-12-19(27)28/h8-11,19H,4-7,12H2,1-3H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530766
(WO2022076496, Example 63)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)C(F)F)ccn1 Show InChI InChI=1S/C24H25F4N3O5S/c1-22(2)16-12-14(19(32)30-23(3)7-10-37(34,35)11-8-23)4-5-17(16)31(21(22)33)18-13-15(6-9-29-18)36-24(27,28)20(25)26/h4-6,9,12-13,20H,7-8,10-11H2,1-3H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530728
(WO2022076496, Example 26)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)C(F)F)c1 Show InChI InChI=1S/C24H25F4N3O5S/c1-22(2)17-10-14(19(32)30-23(3)6-8-37(34,35)9-7-23)4-5-18(17)31(21(22)33)15-11-16(13-29-12-15)36-24(27,28)20(25)26/h4-5,10-13,20H,6-9H2,1-3H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530847
(WO2022076496, Example 138)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1 Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-8-12(19(30)28-23(3)6-7-35(32,33)11-23)9-16(25)18(14)29(20(22)31)17-10-13(34-21(26)27)4-5-15(17)24/h4-5,8-10,21H,6-7,11H2,1-3H3,(H,28,30)/t23-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530798
(WO2022076496, Example 95)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(C(=O)NC4(C)CCS(=O)(=O)CC4)c(F)cc23)c(F)cn1 Show InChI InChI=1S/C24H27F2N3O5S/c1-5-34-20-12-19(17(26)13-27-20)29-18-11-16(25)14(10-15(18)23(2,3)22(29)31)21(30)28-24(4)6-8-35(32,33)9-7-24/h10-13H,5-9H2,1-4H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530849
(WO2022076496, Example 140)Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C24H24F4N2O5S/c1-23(2)15-10-13(20(31)29-24(3)6-8-36(33,34)9-7-24)11-17(26)19(15)30(21(23)32)18-12-14(35-22(27)28)4-5-16(18)25/h4-5,10-12,22H,6-9H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530853
(WO2022076496, Example 144)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1 Show InChI InChI=1S/C24H27F2N3O5S/c1-5-34-19-12-18(17(26)13-27-19)29-20-15(23(2,3)22(29)31)10-14(11-16(20)25)21(30)28-24(4)6-8-35(32,33)9-7-24/h10-13H,5-9H2,1-4H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530784
(WO2022076496, Example 81)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)C(F)F)c(F)cn1 Show InChI InChI=1S/C24H24F5N3O5S/c1-22(2)14-10-13(19(33)31-23(3)6-8-38(35,36)9-7-23)4-5-16(14)32(21(22)34)18-11-17(15(25)12-30-18)37-24(28,29)20(26)27/h4-5,10-12,20H,6-9H2,1-3H3,(H,31,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530791
(1-(2-(2,2-d uoroet oxy)-5- uoropyr dn-4-y)-3,3-dme...)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncc1F Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-10-14(21(31)29-24(3)6-8-36(33,34)9-7-24)4-5-17(15)30(22(23)32)18-11-20(28-12-16(18)25)35-13-19(26)27/h4-5,10-12,19H,6-9,13H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530848
(WO2022076496, Example 139)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cc(OC(F)F)ccc2F)c(F)c1 Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-8-12(19(30)28-23(3)6-7-35(32,33)11-23)9-16(25)18(14)29(20(22)31)17-10-13(34-21(26)27)4-5-15(17)24/h4-5,8-10,21H,6-7,11H2,1-3H3,(H,28,30)/t23-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530851
(WO2022076496, Example 142)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C23H25F2N3O5S/c1-5-33-18-10-17(16(25)11-26-18)28-19-14(22(2,3)21(28)30)8-13(9-15(19)24)20(29)27-23(4)6-7-34(31,32)12-23/h8-11H,5-7,12H2,1-4H3,(H,27,29)/t23-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530809
(WO2022076496, Example 106)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)cc(F)c1F Show InChI InChI=1S/C23H22F4N2O5S/c1-22(2)14-6-12(20(30)28-23(3)10-35(32,33)11-23)4-5-16(14)29(21(22)31)17-8-13(34-9-18(25)26)7-15(24)19(17)27/h4-8,18H,9-11H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530794
(WO2022076496, Example 91)Show SMILES CC(F)(F)COc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1 Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)16-11-15(21(32)30-24(3)7-9-37(34,35)10-8-24)5-6-18(16)31(22(23)33)19-12-20(29-13-17(19)26)36-14-25(4,27)28/h5-6,11-13H,7-10,14H2,1-4H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530862
(WO2022076496, Example 153)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(c1)C#N Show InChI InChI=1S/C23H21F2N3O5S/c1-22(2)17-8-13(19(29)27-23(3)11-34(31,32)12-23)7-14(10-26)18(17)28(20(22)30)15-5-4-6-16(9-15)33-21(24)25/h4-9,21H,11-12H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530815
(WO2022076496, Example 112)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C22H21F3N2O5S/c1-21(2)14-8-12(18(28)26-22(3)10-33(30,31)11-22)4-7-16(14)27(19(21)29)17-9-13(32-20(24)25)5-6-15(17)23/h4-9,20H,10-11H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530725
(WO2022076496, Example 23)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1 Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(17(30)28-21(3)10-35(32,33)11-21)4-5-16(15)29(19(20)31)13-7-14(9-27-8-13)34-22(25,26)18(23)24/h4-9,18H,10-11H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530852
(WO2022076496, Example 143)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C23H25F2N3O5S/c1-5-33-18-10-17(16(25)11-26-18)28-19-14(22(2,3)21(28)30)8-13(9-15(19)24)20(29)27-23(4)6-7-34(31,32)12-23/h8-11H,5-7,12H2,1-4H3,(H,27,29)/t23-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530850
(WO2022076496, Example 141)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(cc(F)c23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C22H23F2N3O5S/c1-5-32-17-8-16(15(24)9-25-17)27-18-13(21(2,3)20(27)29)6-12(7-14(18)23)19(28)26-22(4)10-33(30,31)11-22/h6-9H,5,10-11H2,1-4H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530745
(WO2022076496, Example 42)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC2CC2)c1 Show InChI InChI=1S/C26H30N2O5S/c1-25(2)21-15-17(23(29)27-26(3)11-13-34(31,32)14-12-26)7-10-22(21)28(24(25)30)18-5-4-6-20(16-18)33-19-8-9-19/h4-7,10,15-16,19H,8-9,11-14H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530796
(WO2022076496, Example 93)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CS(C)(=O)=O)CCC1)c1cc(OCC(F)F)ncc1F Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-9-14(21(31)29-24(7-4-8-24)13-36(3,33)34)5-6-17(15)30(22(23)32)18-10-20(28-11-16(18)25)35-12-19(26)27/h5-6,9-11,19H,4,7-8,12-13H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530810
(WO2022076496, Example 107)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)ccc1F Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-8-13(20(29)27-23(3)11-34(31,32)12-23)4-7-17(15)28(21(22)30)18-9-14(5-6-16(18)24)33-10-19(25)26/h4-9,19H,10-12H2,1-3H3,(H,27,29) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530722
(WO2022076496, Example 20)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-11-15(21(29)27-24(3)9-10-34(31,32)14-24)7-8-19(18)28(22(23)30)16-5-4-6-17(12-16)33-13-20(25)26/h4-8,11-12,20H,9-10,13-14H2,1-3H3,(H,27,29)/t24-/m1/s1 | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530817
(WO2022076496, Example 114)Show SMILES CC(F)(F)Oc1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C22H23F2N3O5S/c1-20(2)16-7-13(18(28)26-21(3)11-33(30,31)12-21)5-6-17(16)27(19(20)29)14-8-15(10-25-9-14)32-22(4,23)24/h5-10H,11-12H2,1-4H3,(H,26,28) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530719
(WO2022076496, Example 17)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-10-13(19(29)27-23(3)8-9-34(31,32)12-23)4-7-17(15)28(20(22)30)18-11-14(33-21(25)26)5-6-16(18)24/h4-7,10-11,21H,8-9,12H2,1-3H3,(H,27,29)/t23-/m1/s1 | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530721
(WO2022076496, Example 19)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C24H25F3N2O5S/c1-23(2)16-12-14(20(30)28-24(3)8-10-35(32,33)11-9-24)4-7-18(16)29(21(23)31)19-13-15(34-22(26)27)5-6-17(19)25/h4-7,12-13,22H,8-11H2,1-3H3,(H,28,30) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530726
(WO2022076496, Example 24)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1 Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(18(31)29-22(3)6-7-36(33,34)12-22)4-5-17(16)30(20(21)32)14-9-15(11-28-10-14)35-23(26,27)19(24)25/h4-5,8-11,19H,6-7,12H2,1-3H3,(H,29,31)/t22-/m1/s1 | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530742
(WO2022076496, Example 39)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1 Show InChI InChI=1S/C24H26N2O5S/c1-23(2)19-11-15(21(27)25-24(3)13-32(29,30)14-24)7-10-20(19)26(22(23)28)16-5-4-6-18(12-16)31-17-8-9-17/h4-7,10-12,17H,8-9,13-14H2,1-3H3,(H,25,27) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530724
(WO2022076496, Example 22)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OCC(F)F)c1 Show InChI InChI=1S/C25H28F2N2O5S/c1-24(2)19-13-16(22(30)28-25(3)9-11-35(32,33)12-10-25)7-8-20(19)29(23(24)31)17-5-4-6-18(14-17)34-15-21(26)27/h4-8,13-14,21H,9-12,15H2,1-3H3,(H,28,30) | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530861
(WO2022076496, Example 152)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H25F3N2O5S/c1-23(2)17-12-16(20(30)28-24(3)7-9-35(32,33)10-8-24)18(25)13-19(17)29(21(23)31)14-5-4-6-15(11-14)34-22(26)27/h4-6,11-13,22H,7-10H2,1-3H3,(H,28,30) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530741
(WO2022076496, Example 38)Show SMILES CCC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-4-23(12-33(30,31)13-23)26-19(28)14-8-9-18-17(10-14)22(2,3)20(29)27(18)15-6-5-7-16(11-15)32-21(24)25/h5-11,21H,4,12-13H2,1-3H3,(H,26,28) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530825
(WO2022076496, Example 122)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(F)c1 Show InChI InChI=1S/C22H21F3N2O5S/c1-21(2)15-7-12(18(28)26-22(3)10-33(30,31)11-22)8-16(23)17(15)27(19(21)29)13-5-4-6-14(9-13)32-20(24)25/h4-9,20H,10-11H2,1-3H3,(H,26,28) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530774
(WO2022076496, Example 71)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)F)ncn1 Show InChI InChI=1S/C23H25F3N4O5S/c1-21(2)15-10-14(19(31)29-22(3)6-8-36(33,34)9-7-22)4-5-16(15)30(20(21)32)17-11-18(28-13-27-17)35-12-23(24,25)26/h4-5,10-11,13H,6-9,12H2,1-3H3,(H,29,31) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530743
(WO2022076496, Example 40)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1 Show InChI InChI=1S/C25H28N2O5S/c1-24(2)20-13-16(22(28)26-25(3)11-12-33(30,31)15-25)7-10-21(20)27(23(24)29)17-5-4-6-19(14-17)32-18-8-9-18/h4-7,10,13-14,18H,8-9,11-12,15H2,1-3H3,(H,26,28)/t25-/m1/s1 | Reactome pathway
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GoogleScholar
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| WIPO WO2022076496
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530808
(WO2022076496, Example 105)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OCC(F)F)ncc1F Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)13-6-12(19(29)27-22(3)10-34(31,32)11-22)4-5-15(13)28(20(21)30)16-7-18(26-8-14(16)23)33-9-17(24)25/h4-8,17H,9-11H2,1-3H3,(H,27,29) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530785
(WO2022076496, Example 82)Show SMILES CC(F)(F)COc1ccnc(c1)N1C(=O)C(C)(C)c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc12 Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)17-12-16(21(32)30-24(3)6-9-37(34,35)10-7-24)18(26)13-19(17)31(22(23)33)20-11-15(5-8-29-20)36-14-25(4,27)28/h5,8,11-13H,6-7,9-10,14H2,1-4H3,(H,30,32) | Reactome pathway
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GoogleScholar
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| WIPO WO2022076496
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530749
(WO2022076496, Example 46)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@]1(C)CCCN(CC(F)F)C1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H29F4N3O3/c1-25(2)19-12-16(22(34)31-26(3)10-5-11-32(15-26)14-21(27)28)8-9-20(19)33(23(25)35)17-6-4-7-18(13-17)36-24(29)30/h4,6-9,12-13,21,24H,5,10-11,14-15H2,1-3H3,(H,31,34)/t26-/m1/s1 | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530838
(WO2022076496, Example 130c)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20-/m0/s1 | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530821
(WO2022076496, Example 118)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)CO)c1 Show InChI InChI=1S/C24H27F2N3O6S/c1-22(2)18-10-15(20(31)28-23(3)6-8-36(33,34)9-7-23)4-5-19(18)29(21(22)32)16-11-17(13-27-12-16)35-24(25,26)14-30/h4-5,10-13,30H,6-9,14H2,1-3H3,(H,28,31) | Reactome pathway
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GoogleScholar
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| WIPO WO2022076496
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530727
(WO2022076496, Example 25)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)C(F)F)c1 Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(18(31)29-22(3)6-7-36(33,34)12-22)4-5-17(16)30(20(21)32)14-9-15(11-28-10-14)35-23(26,27)19(24)25/h4-5,8-11,19H,6-7,12H2,1-3H3,(H,29,31)/t22-/m0/s1 | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530781
(WO2022076496, Example 78)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC2)ccn1 Show InChI InChI=1S/C26H31N3O5S/c1-25(2)20-14-18(23(30)28-26(3)9-12-35(32,33)13-10-26)6-7-21(20)29(24(25)31)22-15-19(8-11-27-22)34-16-17-4-5-17/h6-8,11,14-15,17H,4-5,9-10,12-13,16H2,1-3H3,(H,28,30) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530701
(1-(3-(difluoromethoxy)phenyl)-3,3-dimethyl-N-(3-me...)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C22H22F2N2O5S/c1-21(2)16-9-13(18(27)25-22(3)11-32(29,30)12-22)7-8-17(16)26(19(21)28)14-5-4-6-15(10-14)31-20(23)24/h4-10,20H,11-12H2,1-3H3,(H,25,27) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530844
(WO2022076496, Example 135)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C24H24F4N2O5S/c1-22(2)16-12-14(20(31)29-23(3)8-10-36(33,34)11-9-23)4-7-18(16)30(21(22)32)19-13-15(5-6-17(19)25)35-24(26,27)28/h4-7,12-13H,8-11H2,1-3H3,(H,29,31) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530827
(WO2022076496, Example 124)Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2N(C(=O)C3(CCCC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H28F2N2O5S/c1-25(11-13-36(33,34)14-12-25)29-22(31)17-7-8-21-20(15-17)26(9-2-3-10-26)23(32)30(21)18-5-4-6-19(16-18)35-24(27)28/h4-8,15-16,24H,2-3,9-14H2,1H3,(H,29,31) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530842
(WO2022076496, Example 133)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C23H22F4N2O5S/c1-21(2)15-10-13(19(30)28-22(3)8-9-35(32,33)12-22)4-7-17(15)29(20(21)31)18-11-14(5-6-16(18)24)34-23(25,26)27/h4-7,10-11H,8-9,12H2,1-3H3,(H,28,30)/t22-/m1/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530819
(WO2022076496, Example 116)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)F)n1 Show InChI InChI=1S/C22H24F2N4O5S/c1-21(2)14-10-13(18(29)27-22(3)6-8-34(31,32)9-7-22)4-5-15(14)28(19(21)30)16-11-25-12-17(26-16)33-20(23)24/h4-5,10-12,20H,6-9H2,1-3H3,(H,27,29) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530814
(WO2022076496, Example 111)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(SC(F)F)ccc1F Show InChI InChI=1S/C22H21F3N2O4S2/c1-21(2)14-8-12(18(28)26-22(3)10-33(30,31)11-22)4-7-16(14)27(19(21)29)17-9-13(32-20(24)25)5-6-15(17)23/h4-9,20H,10-11H2,1-3H3,(H,26,28) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530723
(WO2022076496, Example 21)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-11-15(21(29)27-24(3)9-10-34(31,32)14-24)7-8-19(18)28(22(23)30)16-5-4-6-17(12-16)33-13-20(25)26/h4-8,11-12,20H,9-10,13-14H2,1-3H3,(H,27,29)/t24-/m0/s1 | Reactome pathway
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WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530834
(WO2022076496, Example 129c)Show SMILES C[C@H]1CS(=O)(=O)C[C@@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18-/m0/s1 | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530746
(WO2022076496, Example 43)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H25F3N2O5S/c1-22(2)18-13-15(20(30)28-23(3)9-11-35(32,33)12-10-23)7-8-19(18)29(21(22)31)16-5-4-6-17(14-16)34-24(25,26)27/h4-8,13-14H,9-12H2,1-3H3,(H,28,30) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530712
(1-[3-(difluoromethoxy)phenyl]-3,3-dimethyl-N-(4-me...)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-23(2)18-13-15(20(29)27-24(3)9-11-34(31,32)12-10-24)7-8-19(18)28(21(23)30)16-5-4-6-17(14-16)33-22(25)26/h4-8,13-14,22H,9-12H2,1-3H3,(H,27,29) | Reactome pathway
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| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530845
(WO2022076496, Example 136)Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H23F4N3O5S/c1-21(2)16-8-13(19(31)29-22(3)4-6-36(33,34)7-5-22)9-17(24)18(16)30(20(21)32)14-10-15(12-28-11-14)35-23(25,26)27/h8-12H,4-7H2,1-3H3,(H,29,31) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530776
(WO2022076496, Example 73)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)cnn1 Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)16-10-14(20(30)27-23(3)6-8-35(32,33)9-7-23)4-5-17(16)29(21(22)31)19-11-15(12-26-28-19)34-13-18(24)25/h4-5,10-12,18H,6-9,13H2,1-3H3,(H,27,30) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530713
(WO2022076496, Example 11)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-11-14(19(28)26-23(3)9-10-33(30,31)13-23)7-8-18(17)27(20(22)29)15-5-4-6-16(12-15)32-21(24)25/h4-8,11-12,21H,9-10,13H2,1-3H3,(H,26,28)/t23-/m1/s1 | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530782
(WO2022076496, Example 79)Show SMILES CCCOc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C25H31N3O5S/c1-5-12-33-18-8-11-26-21(16-18)28-20-7-6-17(15-19(20)24(2,3)23(28)30)22(29)27-25(4)9-13-34(31,32)14-10-25/h6-8,11,15-16H,5,9-10,12-14H2,1-4H3,(H,27,29) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530806
(WO2022076496, Example 103)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OCC(F)F)c1 Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-6-13(19(28)26-22(3)11-33(30,31)12-22)4-5-17(16)27(20(21)29)14-7-15(9-25-8-14)32-10-18(23)24/h4-9,18H,10-12H2,1-3H3,(H,26,28) | Reactome pathway
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| WIPO WO2022076496
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530720
(WO2022076496, Example 18)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)15-10-13(19(29)27-23(3)8-9-34(31,32)12-23)4-7-17(15)28(20(22)30)18-11-14(33-21(25)26)5-6-16(18)24/h4-7,10-11,21H,8-9,12H2,1-3H3,(H,27,29)/t23-/m0/s1 | Reactome pathway
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530841
(WO2022076496, Example 132)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C22H20F4N2O5S/c1-20(2)14-8-12(18(29)27-21(3)10-34(31,32)11-21)4-7-16(14)28(19(20)30)17-9-13(5-6-15(17)23)33-22(24,25)26/h4-9H,10-11H2,1-3H3,(H,27,29) | Reactome pathway
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| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530731
(WO2022076496, Example 28 | WO2022076496, Example 8...)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C22H24FN3O5S/c1-5-31-18-9-17(15(23)10-24-18)26-16-7-6-13(8-14(16)21(2,3)20(26)28)19(27)25-22(4)11-32(29,30)12-22/h6-10H,5,11-12H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530732
(WO2022076496, Example 29 | WO2022076496, Example 3...)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C23H26FN3O5S/c1-5-32-19-11-18(16(24)12-25-19)27-17-7-6-14(10-15(17)22(2,3)21(27)29)20(28)26-23(4)8-9-33(30,31)13-23/h6-7,10-12H,5,8-9,13H2,1-4H3,(H,26,28)/t23-/m1/s1 | Reactome pathway
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530823
(WO2022076496, Example 120)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cccc(OC(F)F)c2)c(F)c1 Show InChI InChI=1S/C23H23F3N2O5S/c1-22(2)16-9-13(19(29)27-23(3)7-8-34(31,32)12-23)10-17(24)18(16)28(20(22)30)14-5-4-6-15(11-14)33-21(25)26/h4-6,9-11,21H,7-8,12H2,1-3H3,(H,27,29)/t23-/m1/s1 | Reactome pathway
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530813
(WO2022076496, Example 110)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OCC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-9-14(20(28)26-23(3)12-33(30,31)13-23)7-8-18(17)27(21(22)29)15-5-4-6-16(10-15)32-11-19(24)25/h4-10,19H,11-13H2,1-3H3,(H,26,28) | Reactome pathway
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| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530732
(WO2022076496, Example 29 | WO2022076496, Example 3...)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)N[C@]2(C)CCS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C23H26FN3O5S/c1-5-32-19-11-18(16(24)12-25-19)27-17-7-6-14(10-15(17)22(2,3)21(27)29)20(28)26-23(4)8-9-33(30,31)13-23/h6-7,10-12H,5,8-9,13H2,1-4H3,(H,26,28)/t23-/m1/s1 | Reactome pathway
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530765
(WO2022076496, Example 62)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ccn1 Show InChI InChI=1S/C24H27F2N3O5S/c1-23(2)17-12-15(21(30)28-24(3)7-10-35(32,33)11-8-24)4-5-18(17)29(22(23)31)20-13-16(6-9-27-20)34-14-19(25)26/h4-6,9,12-13,19H,7-8,10-11,14H2,1-3H3,(H,28,30) | Reactome pathway
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GoogleScholar
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| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530826
(WO2022076496, Example 123)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CCCC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C25H26F2N2O5S/c1-24(11-12-35(32,33)15-24)28-21(30)16-7-8-20-19(13-16)25(9-2-3-10-25)22(31)29(20)17-5-4-6-18(14-17)34-23(26)27/h4-8,13-14,23H,2-3,9-12,15H2,1H3,(H,28,30)/t24-/m1/s1 | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530699
(1'-(3-(difluoromethoxy)phenyl)-N-(3-methyl-1,1-dio...)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CCC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H22F2N2O5S/c1-22(12-33(30,31)13-22)26-19(28)14-6-7-18-17(10-14)23(8-3-9-23)20(29)27(18)15-4-2-5-16(11-15)32-21(24)25/h2,4-7,10-11,21H,3,8-9,12-13H2,1H3,(H,26,28) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530744
(WO2022076496, Example 41)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC2CC2)c1 Show InChI InChI=1S/C25H28N2O5S/c1-24(2)20-13-16(22(28)26-25(3)11-12-33(30,31)15-25)7-10-21(20)27(23(24)29)17-5-4-6-19(14-17)32-18-8-9-18/h4-7,10,13-14,18H,8-9,11-12,15H2,1-3H3,(H,26,28)/t25-/m0/s1 | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530828
(WO2022076496, Example 125)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C22CCCC2)c2cccc(OC(F)F)c2)c(F)c1 Show InChI InChI=1S/C24H23F3N2O5S/c1-23(12-35(32,33)13-23)28-20(30)14-9-17-19(18(25)10-14)29(21(31)24(17)7-2-3-8-24)15-5-4-6-16(11-15)34-22(26)27/h4-6,9-11,22H,2-3,7-8,12-13H2,1H3,(H,28,30) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530767
(WO2022076496, Example 64)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)F)ccn1 Show InChI InChI=1S/C24H26F3N3O5S/c1-22(2)17-12-15(20(31)29-23(3)7-10-36(33,34)11-8-23)4-5-18(17)30(21(22)32)19-13-16(6-9-28-19)35-14-24(25,26)27/h4-6,9,12-13H,7-8,10-11,14H2,1-3H3,(H,29,31) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530843
(WO2022076496, Example 134)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C23H22F4N2O5S/c1-21(2)15-10-13(19(30)28-22(3)8-9-35(32,33)12-22)4-7-17(15)29(20(21)31)18-11-14(5-6-16(18)24)34-23(25,26)27/h4-7,10-11H,8-9,12H2,1-3H3,(H,28,30)/t22-/m0/s1 | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530802
(WO2022076496, Example 99)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(C(=O)NC4(CCS(=O)(=O)CC4)C(F)F)c(F)cc23)c(F)cn1 Show InChI InChI=1S/C24H25F4N3O5S/c1-4-36-19-11-18(16(26)12-29-19)31-17-10-15(25)13(9-14(17)23(2,3)22(31)33)20(32)30-24(21(27)28)5-7-37(34,35)8-6-24/h9-12,21H,4-8H2,1-3H3,(H,30,32) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530824
(WO2022076496, Example 121)Show SMILES CC1(C)C(=O)N(c2c1cc(cc2F)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)F)c1 Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)16-8-13(19(30)28-23(3)4-6-35(32,33)7-5-23)9-17(24)18(16)29(20(22)31)14-10-15(12-27-11-14)34-21(25)26/h8-12,21H,4-7H2,1-3H3,(H,28,30) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530740
(WO2022076496, Example 37)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CS(C)(=O)=O)CCCCC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H30F2N2O5S/c1-25(2)20-14-17(22(31)29-26(16-36(3,33)34)12-5-4-6-13-26)10-11-21(20)30(23(25)32)18-8-7-9-19(15-18)35-24(27)28/h7-11,14-15,24H,4-6,12-13,16H2,1-3H3,(H,29,31) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530768
(WO2022076496, Example 65)Show SMILES CC(F)(F)COc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C25H29F2N3O5S/c1-23(2)18-13-16(21(31)29-24(3)8-11-36(33,34)12-9-24)5-6-19(18)30(22(23)32)20-14-17(7-10-28-20)35-15-25(4,26)27/h5-7,10,13-14H,8-9,11-12,15H2,1-4H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530787
(WO2022076496, Example 84)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ccn1 Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)16-11-15(21(31)29-24(3)5-8-36(33,34)9-6-24)17(25)12-18(16)30(22(23)32)20-10-14(4-7-28-20)35-13-19(26)27/h4,7,10-12,19H,5-6,8-9,13H2,1-3H3,(H,29,31) | Reactome pathway
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530801
(WO2022076496, Example 98)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ncc1F)N1CC(F)(F)C1 Show InChI InChI=1S/C25H26F4N4O4S/c1-23(2)15-8-14(21(34)31-24(3)4-6-38(36,37)7-5-24)16(26)9-18(15)33(22(23)35)19-10-20(30-11-17(19)27)32-12-25(28,29)13-32/h8-11H,4-7,12-13H2,1-3H3,(H,31,34) | Reactome pathway
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530833
(WO2022076496, Example 129b)Show SMILES C[C@@H]1CS(=O)(=O)C[C@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18-/m1/s1 | Reactome pathway
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530754
(WO2022076496, Example 51)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C1CC1 Show InChI InChI=1S/C26H30N2O4S/c1-25(2)21-16-19(23(29)27-26(3)11-13-33(31,32)14-12-26)9-10-22(21)28(24(25)30)20-6-4-5-18(15-20)17-7-8-17/h4-6,9-10,15-17H,7-8,11-14H2,1-3H3,(H,27,29) | Reactome pathway
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530857
(WO2022076496, Example 148)Show SMILES CC1(C)C(=O)N(c2ncc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)15-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)12-27-18(15)29(20(22)31)17-11-14(34-21(25)26)4-5-16(17)24/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530854
(WO2022076496, Example 145)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C21H20F3N3O5S/c1-20(2)13-6-11(17(28)26-21(3)9-33(30,31)10-21)8-25-16(13)27(18(20)29)15-7-12(32-19(23)24)4-5-14(15)22/h4-8,19H,9-10H2,1-3H3,(H,26,28) | Reactome pathway
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UniProtKB/SwissProt
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530731
(WO2022076496, Example 28 | WO2022076496, Example 8...)Show SMILES CCOc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CS(=O)(=O)C2)c(F)cn1 Show InChI InChI=1S/C22H24FN3O5S/c1-5-31-18-9-17(15(23)10-24-18)26-16-7-6-13(8-14(16)21(2,3)20(26)28)19(27)25-22(4)11-32(29,30)12-22/h6-10H,5,11-12H2,1-4H3,(H,25,27) | Reactome pathway
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UniProtKB/SwissProt
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530739
(WO2022076496, Example 36)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NCCS(=O)(=O)NC1CCCCC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H31F2N3O5S/c1-26(2)21-15-17(23(32)29-13-14-37(34,35)30-18-7-4-3-5-8-18)11-12-22(21)31(24(26)33)19-9-6-10-20(16-19)36-25(27)28/h6,9-12,15-16,18,25,30H,3-5,7-8,13-14H2,1-2H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530716
(WO2022076496, Example 14)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H23F3N2O5S/c1-21(2)17-11-14(19(29)27-22(3)9-10-34(31,32)13-22)7-8-18(17)28(20(21)30)15-5-4-6-16(12-15)33-23(24,25)26/h4-8,11-12H,9-10,13H2,1-3H3,(H,27,29)/t22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530730
(WO2022076496, Example 27b)Show SMILES C[C@@H](O)CC(C)(C)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H28F2N2O4/c1-14(29)13-23(2,3)27-20(30)15-9-10-19-18(11-15)24(4,5)21(31)28(19)16-7-6-8-17(12-16)32-22(25)26/h6-12,14,22,29H,13H2,1-5H3,(H,27,30)/t14-/m1/s1 | Reactome pathway
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530753
(WO2022076496, Example 50)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ccc1F)N1CCC1 Show InChI InChI=1S/C26H29F2N3O4S/c1-25(2)18-14-17(23(32)29-26(3)7-11-36(34,35)12-8-26)20(28)15-21(18)31(24(25)33)22-13-16(5-6-19(22)27)30-9-4-10-30/h5-6,13-15H,4,7-12H2,1-3H3,(H,29,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530702
(WO2022076496, Example 4)Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CS(=O)(=O)C1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-4-23(3)17-10-14(19(28)26-22(2)12-33(30,31)13-22)8-9-18(17)27(20(23)29)15-6-5-7-16(11-15)32-21(24)25/h5-11,21H,4,12-13H2,1-3H3,(H,26,28) | Reactome pathway
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UniProtKB/SwissProt
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530717
(WO2022076496, Example 15)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C22H21F3N2O5S/c1-20(2)16-9-13(18(28)26-21(3)11-33(30,31)12-21)7-8-17(16)27(19(20)29)14-5-4-6-15(10-14)32-22(23,24)25/h4-10H,11-12H2,1-3H3,(H,26,28) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530790
(WO2022076496, Example 87)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)c(F)cn1 Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-10-14(21(31)29-24(3)6-8-36(33,34)9-7-24)4-5-17(15)30(22(23)32)20-11-18(16(25)12-28-20)35-13-19(26)27/h4-5,10-12,19H,6-9,13H2,1-3H3,(H,29,31) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530805
(WO2022076496, Example 102)Show SMILES CCOc1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C22H25N3O5S/c1-5-30-16-9-15(10-23-11-16)25-18-7-6-14(8-17(18)21(2,3)20(25)27)19(26)24-22(4)12-31(28,29)13-22/h6-11H,5,12-13H2,1-4H3,(H,24,26) | Reactome pathway
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| UniChem
| WIPO WO2022076496
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530858
(WO2022076496, Example 149)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1 Show InChI InChI=1S/C21H19F4N3O5S/c1-19(2)14-4-11(17(29)27-20(3)9-34(31,32)10-20)5-15(22)16(14)28(18(19)30)12-6-13(8-26-7-12)33-21(23,24)25/h4-8H,9-10H2,1-3H3,(H,27,29) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530778
(WO2022076496, Example 75)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)F)ncn1 Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)15-10-14(20(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(15)29(21(22)31)18-11-19(27-13-26-18)34-12-17(24)25/h4-5,10-11,13,17H,6-9,12H2,1-3H3,(H,28,30) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530822
(WO2022076496, Example 119)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H22F2N2O5S/c1-22(9-10-33(30,31)13-22)26-19(28)14-5-6-18-17(11-14)23(7-8-23)20(29)27(18)15-3-2-4-16(12-15)32-21(24)25/h2-6,11-12,21H,7-10,13H2,1H3,(H,26,28)/t22-/m1/s1 | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530859
(WO2022076496, Example 150)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1 Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(18(30)28-21(3)4-5-35(32,33)11-21)7-16(23)17(15)29(19(20)31)13-8-14(10-27-9-13)34-22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,28,30)/t21-/m1/s1 | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530755
(WO2022076496, Example 52)Show SMILES CC(C)Oc1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C26H32N2O5S/c1-17(2)33-20-8-6-7-19(16-20)28-22-10-9-18(15-21(22)25(3,4)24(28)30)23(29)27-26(5)11-13-34(31,32)14-12-26/h6-10,15-17H,11-14H2,1-5H3,(H,27,29) | Reactome pathway
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UniProtKB/SwissProt
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530820
(WO2022076496, Example 117)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cncc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H24F3N3O5S/c1-21(2)17-10-14(19(30)28-22(3)6-8-35(32,33)9-7-22)4-5-18(17)29(20(21)31)15-11-16(13-27-12-15)34-23(24,25)26/h4-5,10-13H,6-9H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530867
(WO2022076496, Example 158)Show SMILES CC1(C)C(=O)N(c2cnc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)16-12-17(19(29)27-23(3)7-9-34(31,32)10-8-23)26-13-18(16)28(20(22)30)14-5-4-6-15(11-14)33-21(24)25/h4-6,11-13,21H,7-10H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530799
(WO2022076496, Example 96)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ncc1F Show InChI InChI=1S/C23H23F4N3O5S/c1-22(2)13-8-12(19(31)29-23(3)4-6-36(33,34)7-5-23)14(24)9-16(13)30(20(22)32)17-10-18(35-21(26)27)28-11-15(17)25/h8-11,21H,4-7H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530793
(WO2022076496, Example 90)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ncc1F Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)14-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(14)29(20(22)31)17-11-18(34-21(25)26)27-12-15(17)24/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530786
(WO2022076496, Example 83)Show SMILES CC1(C)C(=O)N(c2cc(F)c(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccn1 Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)15-11-14(19(30)28-23(3)5-8-35(32,33)9-6-23)16(24)12-17(15)29(20(22)31)18-10-13(4-7-27-18)34-21(25)26/h4,7,10-12,21H,5-6,8-9H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530772
(WO2022076496, Example 69)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC2CC2)ccn1 Show InChI InChI=1S/C25H29N3O5S/c1-24(2)19-14-16(22(29)27-25(3)9-12-34(31,32)13-10-25)4-7-20(19)28(23(24)30)21-15-18(8-11-26-21)33-17-5-6-17/h4,7-8,11,14-15,17H,5-6,9-10,12-13H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530779
(WO2022076496, Example 76)Show SMILES CC(C)Oc1ccnc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C25H31N3O5S/c1-16(2)33-18-8-11-26-21(15-18)28-20-7-6-17(14-19(20)24(3,4)23(28)30)22(29)27-25(5)9-12-34(31,32)13-10-25/h6-8,11,14-16H,9-10,12-13H2,1-5H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530863
(WO2022076496, Example 154)Show SMILES CC1(C)C(=O)N(c2ncc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)17-11-14(19(29)27-23(3)7-9-34(31,32)10-8-23)13-26-18(17)28(20(22)30)15-5-4-6-16(12-15)33-21(24)25/h4-6,11-13,21H,7-10H2,1-3H3,(H,27,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530747
(WO2022076496, Example 44)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-22(2)17-11-14(19(28)26-23(3)9-10-33(30,31)13-23)7-8-18(17)27(20(22)29)15-5-4-6-16(12-15)32-21(24)25/h4-8,11-12,21H,9-10,13H2,1-3H3,(H,26,28)/t23-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 168 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530711
(WO2022076496, Example 9b)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](C)(F)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H19F3N2O5S/c1-20(10-32(29,30)11-20)25-17(27)12-6-7-16-15(8-12)21(2,24)18(28)26(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19H,10-11H2,1-2H3,(H,25,27)/t21-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530866
(WO2022076496, Example 157)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-9-13(18(28)26-22(3)7-8-33(30,31)12-22)11-25-17(16)27(19(21)29)14-5-4-6-15(10-14)32-20(23)24/h4-6,9-11,20H,7-8,12H2,1-3H3,(H,26,28)/t22-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530769
(WO2022076496, Example 66)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC(F)(F)C(F)F)ccn1 Show InChI InChI=1S/C25H27F4N3O5S/c1-23(2)17-12-15(20(33)31-24(3)7-10-38(35,36)11-8-24)4-5-18(17)32(22(23)34)19-13-16(6-9-30-19)37-14-25(28,29)21(26)27/h4-6,9,12-13,21H,7-8,10-11,14H2,1-3H3,(H,31,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 184 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530780
(WO2022076496, Example 77)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2(F)CC2)ccn1 Show InChI InChI=1S/C26H30FN3O5S/c1-24(2)19-14-17(22(31)29-25(3)9-12-36(33,34)13-10-25)4-5-20(19)30(23(24)32)21-15-18(6-11-28-21)35-16-26(27)7-8-26/h4-6,11,14-15H,7-10,12-13,16H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 192 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530771
(WO2022076496, Example 68)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC(F)(F)C2)ccn1 Show InChI InChI=1S/C27H31F2N3O5S/c1-25(2)20-12-18(23(33)31-26(3)7-10-38(35,36)11-8-26)4-5-21(20)32(24(25)34)22-13-19(6-9-30-22)37-16-17-14-27(28,29)15-17/h4-6,9,12-13,17H,7-8,10-11,14-16H2,1-3H3,(H,31,33) | Reactome pathway
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GoogleScholar
| UniChem
| WIPO WO2022076496
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530807
(WO2022076496, Example 104)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(SC(F)F)c1 Show InChI InChI=1S/C21H21F2N3O4S2/c1-20(2)15-6-12(17(27)25-21(3)10-32(29,30)11-21)4-5-16(15)26(18(20)28)13-7-14(9-24-8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530818
(WO2022076496, Example 115)Show SMILES Cc1ncc(OCC(F)F)cc1N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C23H25F2N3O5S/c1-13-18(8-15(9-26-13)33-10-19(24)25)28-17-6-5-14(7-16(17)22(2,3)21(28)30)20(29)27-23(4)11-34(31,32)12-23/h5-9,19H,10-12H2,1-4H3,(H,27,29) | Reactome pathway
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WIPO
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WIPO WO2022076496 (2022)
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Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530837
(WO2022076496, Example 130b)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@H]1CCC[C@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20-/m1/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530856
(WO2022076496, Example 147)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)14-8-12(18(29)27-22(3)6-7-34(31,32)11-22)10-26-17(14)28(19(21)30)16-9-13(33-20(24)25)4-5-15(16)23/h4-5,8-10,20H,6-7,11H2,1-3H3,(H,27,29)/t22-/m0/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530800
(WO2022076496, Example 97)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cc2c(cc1F)N(C(=O)C2(C)C)c1cc(OC(F)F)ncc1F Show InChI InChI=1S/C21H19F4N3O5S/c1-20(2)11-4-10(17(29)27-21(3)8-34(31,32)9-21)12(22)5-14(11)28(18(20)30)15-6-16(33-19(24)25)26-7-13(15)23/h4-7,19H,8-9H2,1-3H3,(H,27,29) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530830
(WO2022076496, Example 127)Show SMILES CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H24F2N2O5S/c1-23(9-11-34(31,32)12-10-23)27-20(29)15-5-6-19-18(13-15)24(7-8-24)21(30)28(19)16-3-2-4-17(14-16)33-22(25)26/h2-6,13-14,22H,7-12H2,1H3,(H,27,29) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530840
(WO2022076496, Example 131)Show SMILES CC(C)(CS(C)(=O)=O)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H26F2N2O5S/c1-22(2,13-33(5,30)31)26-19(28)14-9-10-18-17(11-14)23(3,4)20(29)27(18)15-7-6-8-16(12-15)32-21(24)25/h6-12,21H,13H2,1-5H3,(H,26,28) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530704
(WO2022076496, Example 5b)Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@]1(C)CCS(=O)(=O)C1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-4-24(3)18-12-15(20(29)27-23(2)10-11-34(31,32)14-23)8-9-19(18)28(21(24)30)16-6-5-7-17(13-16)33-22(25)26/h5-9,12-13,22H,4,10-11,14H2,1-3H3,(H,27,29)/t23-,24?/m1/s1 | Reactome pathway
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| n/a | n/a | 274 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530773
(WO2022076496, Example 70)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)ccn1 Show InChI InChI=1S/C23H25F2N3O5S/c1-22(2)16-12-14(19(29)27-23(3)7-10-34(31,32)11-8-23)4-5-17(16)28(20(22)30)18-13-15(6-9-26-18)33-21(24)25/h4-6,9,12-13,21H,7-8,10-11H2,1-3H3,(H,27,29) | Reactome pathway
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GoogleScholar
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530789
(WO2022076496, Example 86)Show SMILES CC(F)(F)COc1cc(ncc1F)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C25H28F3N3O5S/c1-23(2)16-11-15(21(32)30-24(3)7-9-37(34,35)10-8-24)5-6-18(16)31(22(23)33)20-12-19(17(26)13-29-20)36-14-25(4,27)28/h5-6,11-13H,7-10,14H2,1-4H3,(H,30,32) | Reactome pathway
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GoogleScholar
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530788
(WO2022076496, Example 85)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OC(F)F)c(F)cn1 Show InChI InChI=1S/C23H24F3N3O5S/c1-22(2)14-10-13(19(30)28-23(3)6-8-35(32,33)9-7-23)4-5-16(14)29(20(22)31)18-11-17(34-21(25)26)15(24)12-27-18/h4-5,10-12,21H,6-9H2,1-3H3,(H,28,30) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530706
(WO2022076496, Example 6b)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](C)(O)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H20F2N2O6S/c1-20(10-32(29,30)11-20)24-17(26)12-6-7-16-15(8-12)21(2,28)18(27)25(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19,28H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1 | Reactome pathway
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GoogleScholar
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530804
(WO2022076496, Example 101)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)F)c1 Show InChI InChI=1S/C21H21F2N3O5S/c1-20(2)15-6-12(17(27)25-21(3)10-32(29,30)11-21)4-5-16(15)26(18(20)28)13-7-14(9-24-8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27) | Reactome pathway
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GoogleScholar
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530715
(WO2022076496, Example 13)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H23F3N2O5S/c1-21(2)17-11-14(19(29)27-22(3)9-10-34(31,32)13-22)7-8-18(17)28(20(21)30)15-5-4-6-16(12-15)33-23(24,25)26/h4-8,11-12H,9-10,13H2,1-3H3,(H,27,29)/t22-/m0/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530710
(WO2022076496, Example 9a)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](C)(F)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H19F3N2O5S/c1-20(10-32(29,30)11-20)25-17(27)12-6-7-16-15(8-12)21(2,24)18(28)26(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19H,10-11H2,1-2H3,(H,25,27)/t21-/m1/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530855
(WO2022076496, Example 146)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cc(OC(F)F)ccc1F Show InChI InChI=1S/C22H22F3N3O5S/c1-21(2)14-8-12(18(29)27-22(3)6-7-34(31,32)11-22)10-26-17(14)28(19(21)30)16-9-13(33-20(24)25)4-5-15(16)23/h4-5,8-10,20H,6-7,11H2,1-3H3,(H,27,29)/t22-/m1/s1 | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530803
(WO2022076496, Example 100)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OC(F)(F)F)c1 Show InChI InChI=1S/C21H20F3N3O5S/c1-19(2)15-6-12(17(28)26-20(3)10-33(30,31)11-20)4-5-16(15)27(18(19)29)13-7-14(9-25-8-13)32-21(22,23)24/h4-9H,10-11H2,1-3H3,(H,26,28) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530795
(WO2022076496, Example 92)Show SMILES CC(C)Oc1cc(N2C(=O)C(C)(C)c3cc(ccc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1 Show InChI InChI=1S/C25H30FN3O5S/c1-15(2)34-21-13-20(18(26)14-27-21)29-19-7-6-16(12-17(19)24(3,4)23(29)31)22(30)28-25(5)8-10-35(32,33)11-9-25/h6-7,12-15H,8-11H2,1-5H3,(H,28,30) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530752
(WO2022076496, Example 49)Show SMILES CCC1(CCC(CC1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1)C(F)(F)F Show InChI InChI=1S/C27H29F5N2O3/c1-4-26(27(30,31)32)12-10-17(11-13-26)33-22(35)16-8-9-21-20(14-16)25(2,3)23(36)34(21)18-6-5-7-19(15-18)37-24(28)29/h5-9,14-15,17,24H,4,10-13H2,1-3H3,(H,33,35) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530777
(WO2022076496, Example 74)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1nccc(OCC(F)F)n1 Show InChI InChI=1S/C23H26F2N4O5S/c1-22(2)15-12-14(19(30)28-23(3)7-10-35(32,33)11-8-23)4-5-16(15)29(20(22)31)21-26-9-6-18(27-21)34-13-17(24)25/h4-6,9,12,17H,7-8,10-11,13H2,1-3H3,(H,28,30) | Reactome pathway
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MERCK SHARP & DOHME CORP.
WIPO
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WIPO WO2022076496 (2022)
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More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530860
(WO2022076496, Example 151)Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cc2c(N(C(=O)C2(C)C)c2cncc(OC(F)(F)F)c2)c(F)c1 Show InChI InChI=1S/C22H21F4N3O5S/c1-20(2)15-6-12(18(30)28-21(3)4-5-35(32,33)11-21)7-16(23)17(15)29(19(20)31)13-8-14(10-27-9-13)34-22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,28,30)/t21-/m0/s1 | Reactome pathway
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| n/a | n/a | 454 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530829
(WO2022076496, Example 126)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C3(CC3)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C22H20F2N2O5S/c1-21(11-32(29,30)12-21)25-18(27)13-5-6-17-16(9-13)22(7-8-22)19(28)26(17)14-3-2-4-15(10-14)31-20(23)24/h2-6,9-10,20H,7-8,11-12H2,1H3,(H,25,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 461 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530865
(WO2022076496, Example 156)Show SMILES C[C@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C22H23F2N3O5S/c1-21(2)16-9-13(18(28)26-22(3)7-8-33(30,31)12-22)11-25-17(16)27(19(21)29)14-5-4-6-15(10-14)32-20(23)24/h4-6,9-11,20H,7-8,12H2,1-3H3,(H,26,28)/t22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 465 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530707
(WO2022076496, Example 7a)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](O)(c2c1)C(F)(F)F)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H17F5N2O6S/c1-19(9-35(32,33)10-19)27-16(29)11-5-6-15-14(7-11)20(31,21(24,25)26)17(30)28(15)12-3-2-4-13(8-12)34-18(22)23/h2-8,18,31H,9-10H2,1H3,(H,27,29)/t20-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 484 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530714
(WO2022076496, Example 12)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@H]1O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O4/c1-23(2)16-11-13(20(29)26-17-7-4-8-19(17)28)9-10-18(16)27(21(23)30)14-5-3-6-15(12-14)31-22(24)25/h3,5-6,9-12,17,19,22,28H,4,7-8H2,1-2H3,(H,26,29)/t17-,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 508 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530839
(WO2022076496, Example 130d)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@H]1CCC[C@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 537 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530737
(WO2022076496, Example 34)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1ccnc(N2CC(F)(F)C2)c1F Show InChI InChI=1S/C23H23F3N4O4S/c1-21(2)14-8-13(19(31)28-22(3)11-35(33,34)12-22)4-5-15(14)30(20(21)32)16-6-7-27-18(17(16)24)29-9-23(25,26)10-29/h4-8H,9-12H2,1-3H3,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 548 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530770
(WO2022076496, Example 67)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(OCC2CC2(F)F)ccn1 Show InChI InChI=1S/C26H29F2N3O5S/c1-24(2)19-12-16(22(32)30-25(3)7-10-37(34,35)11-8-25)4-5-20(19)31(23(24)33)21-13-18(6-9-29-21)36-15-17-14-26(17,27)28/h4-6,9,12-13,17H,7-8,10-11,14-15H2,1-3H3,(H,30,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 594 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530811
(WO2022076496, Example 108)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cncc(OCC(F)F)n1 Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)13-6-12(18(28)26-21(3)10-33(30,31)11-21)4-5-14(13)27(19(20)29)16-7-24-8-17(25-16)32-9-15(22)23/h4-8,15H,9-11H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 628 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530775
(WO2022076496, Example 72)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1nccc(OCC(F)F)c1F Show InChI InChI=1S/C24H26F3N3O5S/c1-23(2)15-12-14(21(31)29-24(3)7-10-36(33,34)11-8-24)4-5-16(15)30(22(23)32)20-19(27)17(6-9-28-20)35-13-18(25)26/h4-6,9,12,18H,7-8,10-11,13H2,1-3H3,(H,29,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 821 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530816
(WO2022076496, Example 113)Show SMILES CC(F)(F)c1cncc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C22H23F2N3O4S/c1-20(2)16-7-13(18(28)26-21(3)11-32(30,31)12-21)5-6-17(16)27(19(20)29)15-8-14(9-25-10-15)22(4,23)24/h5-10H,11-12H2,1-4H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 821 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530864
(WO2022076496, Example 155)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H21F2N3O5S/c1-20(2)15-7-12(17(27)25-21(3)10-32(29,30)11-21)9-24-16(15)26(18(20)28)13-5-4-6-14(8-13)31-19(22)23/h4-9,19H,10-11H2,1-3H3,(H,25,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 888 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530750
(WO2022076496, Example 47)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCCN(C1)S(C)(=O)=O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C25H29F2N3O5S/c1-24(2)19-13-16(21(31)28-25(3)11-6-12-29(15-25)36(4,33)34)9-10-20(19)30(22(24)32)17-7-5-8-18(14-17)35-23(26)27/h5,7-10,13-14,23H,6,11-12,15H2,1-4H3,(H,28,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530735
(WO2022076496, Example 32)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cnc2ccccc2c1 Show InChI InChI=1S/C24H23N3O4S/c1-23(2)18-11-16(21(28)26-24(3)13-32(30,31)14-24)8-9-20(18)27(22(23)29)17-10-15-6-4-5-7-19(15)25-12-17/h4-12H,13-14H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530738
(WO2022076496, Example 35)Show SMILES CC(=O)Nc1ccc(cc1O)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C23H25N3O6S/c1-13(27)24-17-7-6-15(10-19(17)28)26-18-8-5-14(9-16(18)22(2,3)21(26)30)20(29)25-23(4)11-33(31,32)12-23/h5-10,28H,11-12H2,1-4H3,(H,24,27)(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530831
(WO2022076496, Example 128)Show SMILES CC1CC(CS1(=O)=O)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-13-9-15(12-33(13,30)31)26-20(28)14-7-8-19-18(10-14)23(2,3)21(29)27(19)16-5-4-6-17(11-16)32-22(24)25/h4-8,10-11,13,15,22H,9,12H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530734
(WO2022076496, Example 31)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1ccnc(OCC(F)F)n1 Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)13-8-12(17(28)26-21(3)10-33(30,31)11-21)4-5-14(13)27(18(20)29)16-6-7-24-19(25-16)32-9-15(22)23/h4-8,15H,9-11H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530868
(WO2022076496, Example 159)Show SMILES CC1(C)C(=O)N(c2nnc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C22H24F2N4O5S/c1-21(2)15-12-16(18(29)25-22(3)7-9-34(31,32)10-8-22)26-27-17(15)28(19(21)30)13-5-4-6-14(11-13)33-20(23)24/h4-6,11-12,20H,7-10H2,1-3H3,(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530748
(WO2022076496, Example 45)Show SMILES CC1(CC(F)(F)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H22F4N2O3/c1-21(2)16-9-13(18(30)28-22(3)11-23(26,27)12-22)7-8-17(16)29(19(21)31)14-5-4-6-15(10-14)32-20(24)25/h4-10,20H,11-12H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530560
(WO2022076495, EXAMPLE 12 | WO2022076495, EXAMPLE 6)Show SMILES CC(C)n1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C22H23F2N3O5S/c1-13(2)26-18-9-14(19(28)25-22(3)11-33(30,31)12-22)7-8-17(18)27(21(26)29)15-5-4-6-16(10-15)32-20(23)24/h4-10,13,20H,11-12H2,1-3H3,(H,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530729
(WO2022076496, Example 27a)Show SMILES C[C@H](O)CC(C)(C)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H28F2N2O4/c1-14(29)13-23(2,3)27-20(30)15-9-10-19-18(11-15)24(4,5)21(31)28(19)16-7-6-8-17(12-16)32-22(25)26/h6-12,14,22,29H,13H2,1-5H3,(H,27,30)/t14-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530718
(WO2022076496, Example 16)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(CO)CCOCC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5/c1-23(2)18-12-15(20(30)27-24(14-29)8-10-32-11-9-24)6-7-19(18)28(21(23)31)16-4-3-5-17(13-16)33-22(25)26/h3-7,12-13,22,29H,8-11,14H2,1-2H3,(H,27,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530761
(WO2022076496, Example 58)Show SMILES CN(C)c1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C25H31N3O4S/c1-24(2)20-15-17(22(29)26-25(3)11-13-33(31,32)14-12-25)9-10-21(20)28(23(24)30)19-8-6-7-18(16-19)27(4)5/h6-10,15-16H,11-14H2,1-5H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530783
(WO2022076496, Example 80)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cc(ccn1)C(F)(F)F Show InChI InChI=1S/C23H24F3N3O4S/c1-21(2)16-12-14(19(30)28-22(3)7-10-34(32,33)11-8-22)4-5-17(16)29(20(21)31)18-13-15(6-9-27-18)23(24,25)26/h4-6,9,12-13H,7-8,10-11H2,1-3H3,(H,28,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530703
(WO2022076496, Example 5a)Show SMILES CCC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@]1(C)CCS(=O)(=O)C1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-4-24(3)18-12-15(20(29)27-23(2)10-11-34(31,32)14-23)8-9-19(18)28(21(24)30)16-6-5-7-17(13-16)33-22(25)26/h5-9,12-13,22H,4,10-11,14H2,1-3H3,(H,27,29)/t23-,24?/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530757
(WO2022076496, Example 54)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C#N Show InChI InChI=1S/C24H25N3O4S/c1-23(2)19-14-17(21(28)26-24(3)9-11-32(30,31)12-10-24)7-8-20(19)27(22(23)29)18-6-4-5-16(13-18)15-25/h4-8,13-14H,9-12H2,1-3H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530616
(WO2022076495, EXAMPLE 60)Show SMILES Cn1c2cc(ccc2n(-c2cccc(OC(F)F)c2)c1=O)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C20H19F2N3O5S/c1-20(10-31(28,29)11-20)23-17(26)12-6-7-15-16(8-12)24(2)19(27)25(15)13-4-3-5-14(9-13)30-18(21)22/h3-9,18H,10-11H2,1-2H3,(H,23,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530736
(WO2022076496, Example 33)Show SMILES Cc1nc2ccc(cc2o1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CS(=O)(=O)C1 Show InChI InChI=1S/C23H23N3O5S/c1-13-24-17-7-6-15(10-19(17)31-13)26-18-8-5-14(9-16(18)22(2,3)21(26)28)20(27)25-23(4)11-32(29,30)12-23/h5-10H,11-12H2,1-4H3,(H,25,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530708
(WO2022076496, Example 7b)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@@](O)(c2c1)C(F)(F)F)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H17F5N2O6S/c1-19(9-35(32,33)10-19)27-16(29)11-5-6-15-14(7-11)20(31,21(24,25)26)17(30)28(15)12-3-2-4-13(8-12)34-18(22)23/h2-8,18,31H,9-10H2,1H3,(H,27,29)/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530705
(WO2022076496, Example 6a)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)[C@](C)(O)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C21H20F2N2O6S/c1-20(10-32(29,30)11-20)24-17(26)12-6-7-16-15(8-12)21(2,28)18(27)25(16)13-4-3-5-14(9-13)31-19(22)23/h3-9,19,28H,10-11H2,1-2H3,(H,24,26)/t21-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 3.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530756
(WO2022076496, Example 53)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(F)c1 Show InChI InChI=1S/C23H25FN2O4S/c1-22(2)18-13-15(20(27)25-23(3)9-11-31(29,30)12-10-23)7-8-19(18)26(21(22)28)17-6-4-5-16(24)14-17/h4-8,13-14H,9-12H2,1-3H3,(H,25,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530751
(WO2022076496, Example 48)Show SMILES CC(=O)N1CCC[C@](C)(C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H29F2N3O4/c1-16(32)30-12-6-11-26(4,15-30)29-22(33)17-9-10-21-20(13-17)25(2,3)23(34)31(21)18-7-5-8-19(14-18)35-24(27)28/h5,7-10,13-14,24H,6,11-12,15H2,1-4H3,(H,29,33)/t26-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | 4.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530762
(WO2022076496, Example 59)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NCC1(O)CCOC1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5/c1-22(2)17-10-14(19(28)26-12-23(30)8-9-31-13-23)6-7-18(17)27(20(22)29)15-4-3-5-16(11-15)32-21(24)25/h3-7,10-11,21,30H,8-9,12-13H2,1-2H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530764
(WO2022076496, Example 61)Show SMILES CCn1cc(CNC(=O)c2ccc3N(C(=O)C(C)(C)c3c2)c2cccc(OC(F)F)c2)cn1 Show InChI InChI=1S/C24H24F2N4O3/c1-4-29-14-15(13-28-29)12-27-21(31)16-8-9-20-19(10-16)24(2,3)22(32)30(20)17-6-5-7-18(11-17)33-23(25)26/h5-11,13-14,23H,4,12H2,1-3H3,(H,27,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530763
(WO2022076496, Example 60)Show SMILES Cc1nnc(NC(=O)c2ccc3N(C(=O)C(C)(C)c3c2)c2cccc(OC(F)F)c2)s1 Show InChI InChI=1S/C21H18F2N4O3S/c1-11-25-26-20(31-11)24-17(28)12-7-8-16-15(9-12)21(2,3)18(29)27(16)13-5-4-6-14(10-13)30-19(22)23/h4-10,19H,1-3H3,(H,24,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530760
(WO2022076496, Example 57)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)S(C)(=O)=O Show InChI InChI=1S/C24H28N2O6S2/c1-23(2)19-14-16(21(27)25-24(3)10-12-34(31,32)13-11-24)8-9-20(19)26(22(23)28)17-6-5-7-18(15-17)33(4,29)30/h5-9,14-15H,10-13H2,1-4H3,(H,25,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530758
(WO2022076496, Example 55)Show SMILES CNS(=O)(=O)c1cccc(c1)N1C(=O)C(C)(C)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)CC1 Show InChI InChI=1S/C24H29N3O6S2/c1-23(2)19-14-16(21(28)26-24(3)10-12-34(30,31)13-11-24)8-9-20(19)27(22(23)29)17-6-5-7-18(15-17)35(32,33)25-4/h5-9,14-15,25H,10-13H2,1-4H3,(H,26,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530759
(WO2022076496, Example 56)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)c1cccc(c1)C(N)=O Show InChI InChI=1S/C24H27N3O5S/c1-23(2)18-14-16(21(29)26-24(3)9-11-33(31,32)12-10-24)7-8-19(18)27(22(23)30)17-6-4-5-15(13-17)20(25)28/h4-8,13-14H,9-12H2,1-3H3,(H2,25,28)(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >9.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530832
(WO2022076496, Example 129a)Show SMILES C[C@H]1CS(=O)(=O)C[C@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530836
(WO2022076496, Example 130a)Show SMILES CC1(C)C(=O)N(c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@H]1S(C)(=O)=O)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C24H26F2N2O5S/c1-24(2)17-12-14(21(29)27-18-8-5-9-20(18)34(3,31)32)10-11-19(17)28(22(24)30)15-6-4-7-16(13-15)33-23(25)26/h4,6-7,10-13,18,20,23H,5,8-9H2,1-3H3,(H,27,29)/t18-,20+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530812
(WO2022076496, Example 109)Show SMILES CC1(CS(=O)(=O)C1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cnnc(OCC(F)F)c1 Show InChI InChI=1S/C21H22F2N4O5S/c1-20(2)14-6-12(18(28)25-21(3)10-33(30,31)11-21)4-5-15(14)27(19(20)29)13-7-17(26-24-8-13)32-9-16(22)23/h4-8,16H,9-11H2,1-3H3,(H,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM530835
(WO2022076496, Example 129d)Show SMILES C[C@@H]1CS(=O)(=O)C[C@@H]1NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1 Show InChI InChI=1S/C23H24F2N2O5S/c1-13-11-33(30,31)12-18(13)26-20(28)14-7-8-19-17(9-14)23(2,3)21(29)27(19)15-5-4-6-16(10-15)32-22(24)25/h4-10,13,18,22H,11-12H2,1-3H3,(H,26,28)/t13-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| UniChem
| WIPO WO2022076496
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MERCK SHARP & DOHME CORP.
WIPO
| |
WIPO WO2022076496 (2022)
|
More data for this
Ligand-Target Pair | |
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