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Patent code WO2022081807

Compile Data Set for Download or QSAR

Found 252 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534094
PNG
(WO2022081807, Example 201)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)N1CCCC1c1ccccc1
Show InChI InChI=1S/C29H28FN3O5S/c1-37-25-11-10-20(33-14-5-9-24(33)19-7-3-2-4-8-19)17-28(25)39(35,36)31-29(34)27-18-22-23(30)15-21(16-26(22)38-27)32-12-6-13-32/h2-4,7-8,10-11,15-18,24H,5-6,9,12-14H2,1H3,(H,31,34)
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WIPO WO2022081807
n/an/a 0.810n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533971
PNG
(WO2022081807, Example 78)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)(C)C
Show InChI InChI=1S/C24H27FN2O5S/c1-5-31-19-8-7-15(24(2,3)4)11-22(19)33(29,30)26-23(28)21-14-17-18(25)12-16(13-20(17)32-21)27-9-6-10-27/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,26,28)
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WIPO WO2022081807
n/an/a 1.41n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533872
PNG
(WO2022081807, Example 5)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1c(OCc2ccccc2)cccc1OC1CCC1)N1CCC1
Show InChI InChI=1S/C29H27FN2O6S/c30-23-15-20(32-13-6-14-32)16-26-22(23)17-27(38-26)29(33)31-39(34,35)28-24(36-18-19-7-2-1-3-8-19)11-5-12-25(28)37-21-9-4-10-21/h1-3,5,7-8,11-12,15-17,21H,4,6,9-10,13-14,18H2,(H,31,33)
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WIPO WO2022081807
n/an/a 1.42n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534119
PNG
(WO2022081807, Example 226)
Show SMILES CC(C)(C)c1ccc(OCC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C26H29FN2O5S/c1-26(2,3)17-7-8-21(33-15-16-5-6-16)24(11-17)35(31,32)28-25(30)23-14-19-20(27)12-18(13-22(19)34-23)29-9-4-10-29/h7-8,11-14,16H,4-6,9-10,15H2,1-3H3,(H,28,30)
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WIPO WO2022081807
n/an/a 1.79n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534100
PNG
(WO2022081807, Example 207)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)CC
Show InChI InChI=1S/C24H27FN2O5S/c1-4-15(3)16-7-8-20(31-5-2)23(11-16)33(29,30)26-24(28)22-14-18-19(25)12-17(13-21(18)32-22)27-9-6-10-27/h7-8,11-15H,4-6,9-10H2,1-3H3,(H,26,28)
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WIPO WO2022081807
n/an/a 1.86n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534121
PNG
(WO2022081807, Example 228)
Show SMILES CC(C)(C)c1ccc(OC2CCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C26H29FN2O5S/c1-26(2,3)16-8-9-21(33-18-6-4-7-18)24(12-16)35(31,32)28-25(30)23-15-19-20(27)13-17(14-22(19)34-23)29-10-5-11-29/h8-9,12-15,18H,4-7,10-11H2,1-3H3,(H,28,30)
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WIPO WO2022081807
n/an/a 2.57n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534117
PNG
(WO2022081807, Example 224)
Show SMILES CC(C)(C)c1ccc(OC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H27FN2O5S/c1-25(2,3)15-5-8-20(32-17-6-7-17)23(11-15)34(30,31)27-24(29)22-14-18-19(26)12-16(13-21(18)33-22)28-9-4-10-28/h5,8,11-14,17H,4,6-7,9-10H2,1-3H3,(H,27,29)
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WIPO WO2022081807
n/an/a 3.72n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534118
PNG
(6-(Azetidin-1-yl)-N-[(2-(benzyloxy)-5-(tert-butyl)...)
Show SMILES CC(C)(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C29H29FN2O5S/c1-29(2,3)20-10-11-24(36-18-19-8-5-4-6-9-19)27(14-20)38(34,35)31-28(33)26-17-22-23(30)15-21(16-25(22)37-26)32-12-7-13-32/h4-6,8-11,14-17H,7,12-13,18H2,1-3H3,(H,31,33)
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WIPO WO2022081807
n/an/a 3.72n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534107
PNG
(6-(azetidin-1-yl)-N-[2-(cyclopropylmethoxy)-5-isop...)
Show SMILES CC(C)c1ccc(OCC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H27FN2O5S/c1-15(2)17-6-7-21(32-14-16-4-5-16)24(10-17)34(30,31)27-25(29)23-13-19-20(26)11-18(12-22(19)33-23)28-8-3-9-28/h6-7,10-13,15-16H,3-5,8-9,14H2,1-2H3,(H,27,29)
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WIPO WO2022081807
n/an/a 3.91n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533874
PNG
(WO2022081807, Example 7)
Show SMILES CCOc1cccc(Oc2ccccc2)c1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C26H23FN2O6S/c1-2-33-21-10-6-11-22(34-18-8-4-3-5-9-18)25(21)36(31,32)28-26(30)24-16-19-20(27)14-17(15-23(19)35-24)29-12-7-13-29/h3-6,8-11,14-16H,2,7,12-13H2,1H3,(H,28,30)
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WIPO WO2022081807
n/an/a 4.15n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534087
PNG
(6-(Azetidin-1-yl)-N-[5-(3,5-dimethyl-1,2-oxazol-4-...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)-c1c(C)noc1C
Show InChI InChI=1S/C24H22FN3O6S/c1-13-23(14(2)34-26-13)15-5-6-19(32-3)22(9-15)35(30,31)27-24(29)21-12-17-18(25)10-16(11-20(17)33-21)28-7-4-8-28/h5-6,9-12H,4,7-8H2,1-3H3,(H,27,29)
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WIPO WO2022081807
n/an/a 4.19n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534124
PNG
(6-(Azetidin-1-yl)-N-((2-((2,2-difluorocyclopropyl)...)
Show SMILES CC(C)c1ccc(OCC2CC2(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H25F3N2O5S/c1-14(2)15-4-5-20(34-13-16-12-25(16,27)28)23(8-15)36(32,33)29-24(31)22-11-18-19(26)9-17(10-21(18)35-22)30-6-3-7-30/h4-5,8-11,14,16H,3,6-7,12-13H2,1-2H3,(H,29,31)
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WIPO WO2022081807
n/an/a 4.22n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534043
PNG
(WO2022081807, Example 150)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1)C(C)(C)C
Show InChI InChI=1S/C23H24F2N2O5S/c1-23(2,3)13-5-6-18(31-4)21(7-13)33(29,30)26-22(28)20-10-16-17(25)8-15(9-19(16)32-20)27-11-14(24)12-27/h5-10,14H,11-12H2,1-4H3,(H,26,28)
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WIPO WO2022081807
n/an/a 4.25n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533884
PNG
(6-(Azetidin-1-yl)-N-(2,6-dipropoxybenzene-1-sulfon...)
Show SMILES CCCOc1cccc(OCCC)c1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C24H27FN2O6S/c1-3-11-31-19-7-5-8-20(32-12-4-2)23(19)34(29,30)26-24(28)22-15-17-18(25)13-16(14-21(17)33-22)27-9-6-10-27/h5,7-8,13-15H,3-4,6,9-12H2,1-2H3,(H,26,28)
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WIPO WO2022081807
n/an/a 4.47n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534006
PNG
(N-(5-tert-butyl-2-ethoxybenzene-1-sulfonyl)-4-fluo...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1)C(C)(C)C
Show InChI InChI=1S/C24H26F2N2O5S/c1-5-32-19-7-6-14(24(2,3)4)8-22(19)34(30,31)27-23(29)21-11-17-18(26)9-16(10-20(17)33-21)28-12-15(25)13-28/h6-11,15H,5,12-13H2,1-4H3,(H,27,29)
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WIPO WO2022081807
n/an/a 4.48n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534020
PNG
(6-(Azetidin-1-yl)-N-(5-tert-butyl-2-methoxybenzene...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)(C)C
Show InChI InChI=1S/C23H25FN2O5S/c1-23(2,3)14-6-7-18(30-4)21(10-14)32(28,29)25-22(27)20-13-16-17(24)11-15(12-19(16)31-20)26-8-5-9-26/h6-7,10-13H,5,8-9H2,1-4H3,(H,25,27)
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WIPO WO2022081807
n/an/a 4.53n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534122
PNG
(6-(Azetidin-1-yl)-N-[(5-(tert-butyl)-2-isopropoxyp...)
Show SMILES CC(C)Oc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)(C)C
Show InChI InChI=1S/C25H29FN2O5S/c1-15(2)32-20-8-7-16(25(3,4)5)11-23(20)34(30,31)27-24(29)22-14-18-19(26)12-17(13-21(18)33-22)28-9-6-10-28/h7-8,11-15H,6,9-10H2,1-5H3,(H,27,29)
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WIPO WO2022081807
n/an/a 4.79n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534088
PNG
(WO2022081807, Example 195)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)-c1cn(C)nc1C
Show InChI InChI=1S/C24H23FN4O5S/c1-14-18(13-28(2)26-14)15-5-6-20(33-3)23(9-15)35(31,32)27-24(30)22-12-17-19(25)10-16(11-21(17)34-22)29-7-4-8-29/h5-6,9-13H,4,7-8H2,1-3H3,(H,27,30)
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WIPO WO2022081807
n/an/a 5.07n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534120
PNG
(6-(Azetidin-1-yl)-N-[(5-(tert-butyl)-2-(2,2,2-trif...)
Show SMILES CC(C)(C)c1ccc(OCC(F)(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C24H24F4N2O5S/c1-23(2,3)14-5-6-18(34-13-24(26,27)28)21(9-14)36(32,33)29-22(31)20-12-16-17(25)10-15(11-19(16)35-20)30-7-4-8-30/h5-6,9-12H,4,7-8,13H2,1-3H3,(H,29,31)
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WIPO WO2022081807
n/an/a 5.40n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534100
PNG
(WO2022081807, Example 207)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)CC
Show InChI InChI=1S/C24H27FN2O5S/c1-4-15(3)16-7-8-20(31-5-2)23(11-16)33(29,30)26-24(28)22-14-18-19(25)12-17(13-21(18)32-22)27-9-6-10-27/h7-8,11-15H,4-6,9-10H2,1-3H3,(H,26,28)
PDB
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WIPO WO2022081807
n/an/a 5.65n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534020
PNG
(6-(Azetidin-1-yl)-N-(5-tert-butyl-2-methoxybenzene...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)(C)C
Show InChI InChI=1S/C23H25FN2O5S/c1-23(2,3)14-6-7-18(30-4)21(10-14)32(28,29)25-22(27)20-13-16-17(24)11-15(12-19(16)31-20)26-8-5-9-26/h6-7,10-13H,5,8-9H2,1-4H3,(H,25,27)
PDB
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WIPO WO2022081807
n/an/a 5.67n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534044
PNG
(N-[2-ethoxy-5-(propan-2-yl)benzene-1 -sulfonyl]-4-...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1)C(C)C
Show InChI InChI=1S/C23H24F2N2O5S/c1-4-31-19-6-5-14(13(2)3)7-22(19)33(29,30)26-23(28)21-10-17-18(25)8-16(9-20(17)32-21)27-11-15(24)12-27/h5-10,13,15H,4,11-12H2,1-3H3,(H,26,28)
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WIPO WO2022081807
n/an/a 5.81n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534090
PNG
(WO2022081807, Example 197)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C1=CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H32FN3O7S/c1-29(2,3)40-28(35)33-12-8-18(9-13-33)19-6-7-23(38-4)26(14-19)41(36,37)31-27(34)25-17-21-22(30)15-20(16-24(21)39-25)32-10-5-11-32/h6-8,14-17H,5,9-13H2,1-4H3,(H,31,34)
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WIPO WO2022081807
n/an/a 6.06n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534106
PNG
(WO2022081807, Example 213)
Show SMILES CC(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C28H27FN2O5S/c1-18(2)20-9-10-24(35-17-19-7-4-3-5-8-19)27(13-20)37(33,34)30-28(32)26-16-22-23(29)14-21(15-25(22)36-26)31-11-6-12-31/h3-5,7-10,13-16,18H,6,11-12,17H2,1-2H3,(H,30,32)
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WIPO WO2022081807
n/an/a 6.18n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533877
PNG
(WO2022081807, Example 10)
Show SMILES CCCOc1cccc(OCC)c1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C23H25FN2O6S/c1-3-11-31-19-8-5-7-18(30-4-2)22(19)33(28,29)25-23(27)21-14-16-17(24)12-15(13-20(16)32-21)26-9-6-10-26/h5,7-8,12-14H,3-4,6,9-11H2,1-2H3,(H,25,27)
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WIPO WO2022081807
n/an/a 7.12n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534108
PNG
(WO2022081807, Example 215)
Show SMILES CC(C)c1ccc(OCC(F)(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C23H22F4N2O5S/c1-13(2)14-4-5-18(33-12-23(25,26)27)21(8-14)35(31,32)28-22(30)20-11-16-17(24)9-15(10-19(16)34-20)29-6-3-7-29/h4-5,8-11,13H,3,6-7,12H2,1-2H3,(H,28,30)
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WIPO WO2022081807
n/an/a 7.18n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533878
PNG
(6-(Azetidin-1-yl)-N-[2-(dimethylamino)benzene-1-su...)
Show SMILES CN(C)c1ccccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C20H20FN3O4S/c1-23(2)16-6-3-4-7-19(16)29(26,27)22-20(25)18-12-14-15(21)10-13(11-17(14)28-18)24-8-5-9-24/h3-4,6-7,10-12H,5,8-9H2,1-2H3,(H,22,25)
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WIPO WO2022081807
n/an/a 7.52n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534104
PNG
(WO2022081807, Example 211)
Show SMILES CCOc1ccc(Oc2ccccc2)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C26H23FN2O6S/c1-2-33-22-10-9-19(34-18-7-4-3-5-8-18)15-25(22)36(31,32)28-26(30)24-16-20-21(27)13-17(14-23(20)35-24)29-11-6-12-29/h3-5,7-10,13-16H,2,6,11-12H2,1H3,(H,28,30)
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WIPO WO2022081807
n/an/a 7.58n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534097
PNG
(6-(Azetidin-1-yl)-4-fluoro-N-(2,2,5,6-tetramethyl-...)
Show SMILES Cc1cc2CC(C)(C)Oc2c(c1C)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C24H25FN2O5S/c1-13-8-15-12-24(3,4)32-21(15)22(14(13)2)33(29,30)26-23(28)20-11-17-18(25)9-16(10-19(17)31-20)27-6-5-7-27/h8-11H,5-7,12H2,1-4H3,(H,26,28)
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WIPO WO2022081807
n/an/a 7.70n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534123
PNG
(WO2022081807, Example 230)
Show SMILES CC(C)c1ccc(OC2CCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H27FN2O5S/c1-15(2)16-7-8-21(32-18-5-3-6-18)24(11-16)34(30,31)27-25(29)23-14-19-20(26)12-17(13-22(19)33-23)28-9-4-10-28/h7-8,11-15,18H,3-6,9-10H2,1-2H3,(H,27,29)
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WIPO WO2022081807
n/an/a 7.71n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534098
PNG
(WO2022081807, Example 205)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)=C
Show InChI InChI=1S/C22H21FN2O5S/c1-13(2)14-5-6-18(29-3)21(9-14)31(27,28)24-22(26)20-12-16-17(23)10-15(11-19(16)30-20)25-7-4-8-25/h5-6,9-12H,1,4,7-8H2,2-3H3,(H,24,26)
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WIPO WO2022081807
n/an/a 7.97n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533868
PNG
(WO2022081807, Example 3)
Show SMILES CCc1ccc(OC2CCCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H27FN2O5S/c1-2-16-8-9-21(32-18-6-3-4-7-18)24(12-16)34(30,31)27-25(29)23-15-19-20(26)13-17(14-22(19)33-23)28-10-5-11-28/h8-9,12-15,18H,2-7,10-11H2,1H3,(H,27,29)
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WIPO WO2022081807
n/an/a 8.10n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534021
PNG
(WO2022081807, Example 128)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)C
Show InChI InChI=1S/C22H23FN2O5S/c1-13(2)14-5-6-18(29-3)21(9-14)31(27,28)24-22(26)20-12-16-17(23)10-15(11-19(16)30-20)25-7-4-8-25/h5-6,9-13H,4,7-8H2,1-3H3,(H,24,26)
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WIPO WO2022081807
n/an/a 8.15n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534089
PNG
(6-(azetidin-1-yl)-N-[5-(3,6-dihydro-2H-pyran-4-yl)...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C1=CCOCC1
Show InChI InChI=1S/C24H23FN2O6S/c1-31-20-4-3-16(15-5-9-32-10-6-15)11-23(20)34(29,30)26-24(28)22-14-18-19(25)12-17(13-21(18)33-22)27-7-2-8-27/h3-5,11-14H,2,6-10H2,1H3,(H,26,28)
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WIPO WO2022081807
n/an/a 8.25n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534082
PNG
(6-(Azetidin-1-yl)-N-(5-tert-butyl-2,3-dimethylbenz...)
Show SMILES Cc1cc(cc(c1C)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)C(C)(C)C
Show InChI InChI=1S/C24H27FN2O4S/c1-14-9-16(24(3,4)5)10-22(15(14)2)32(29,30)26-23(28)21-13-18-19(25)11-17(12-20(18)31-21)27-7-6-8-27/h9-13H,6-8H2,1-5H3,(H,26,28)
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WIPO WO2022081807
n/an/a 8.59n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533866
PNG
(6-(Azetidin-1 -yl)-N-(2-ethoxy-6-methoxybenzene-1 ...)
Show SMILES COc1cccc(OC)c1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C20H19FN2O6S/c1-27-15-5-3-6-16(28-2)19(15)30(25,26)22-20(24)18-11-13-14(21)9-12(10-17(13)29-18)23-7-4-8-23/h3,5-6,9-11H,4,7-8H2,1-2H3,(H,22,24)
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WIPO WO2022081807
n/an/a 8.61n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533869
PNG
(6-(Azetidin-1-yl)-N-(2-{[butan-2-yl]oxy}-5-methylb...)
Show SMILES CCC(C)Oc1ccc(C)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C23H25FN2O5S/c1-4-15(3)30-19-7-6-14(2)10-22(19)32(28,29)25-23(27)21-13-17-18(24)11-16(12-20(17)31-21)26-8-5-9-26/h6-7,10-13,15H,4-5,8-9H2,1-3H3,(H,25,27)
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WIPO WO2022081807
n/an/a 8.72n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533972
PNG
(6-(Azetidin-1-yl)-4-fluoro-N-[3-(propan-2-yl)pyrid...)
Show SMILES CC(C)c1cccnc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C20H20FN3O4S/c1-12(2)14-5-3-6-22-20(14)29(26,27)23-19(25)18-11-15-16(21)9-13(10-17(15)28-18)24-7-4-8-24/h3,5-6,9-12H,4,7-8H2,1-2H3,(H,23,25)
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WIPO WO2022081807
n/an/a 9.58n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534117
PNG
(WO2022081807, Example 224)
Show SMILES CC(C)(C)c1ccc(OC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C25H27FN2O5S/c1-25(2,3)15-5-8-20(32-17-6-7-17)23(11-15)34(30,31)27-24(29)22-14-18-19(26)12-16(13-21(18)33-22)28-9-4-10-28/h5,8,11-14,17H,4,6-7,9-10H2,1-3H3,(H,27,29)
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WIPO WO2022081807
n/an/a 9.82n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534118
PNG
(6-(Azetidin-1-yl)-N-[(2-(benzyloxy)-5-(tert-butyl)...)
Show SMILES CC(C)(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C29H29FN2O5S/c1-29(2,3)20-10-11-24(36-18-19-8-5-4-6-9-19)27(14-20)38(34,35)31-28(33)26-17-22-23(30)15-21(16-25(22)37-26)32-12-7-13-32/h4-6,8-11,14-17H,7,12-13,18H2,1-3H3,(H,31,33)
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WIPO WO2022081807
n/an/a 9.82n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534046
PNG
(N-(2-ethoxy-5-ethylbenzene-1 -sulfonyl)-4-fluoro-6...)
Show SMILES CCOc1ccc(CC)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1
Show InChI InChI=1S/C22H22F2N2O5S/c1-3-13-5-6-18(30-4-2)21(7-13)32(28,29)25-22(27)20-10-16-17(24)8-15(9-19(16)31-20)26-11-14(23)12-26/h5-10,14H,3-4,11-12H2,1-2H3,(H,25,27)
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WIPO WO2022081807
n/an/a 11n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534062
PNG
(WO2022081807, Example 169 | WO2022081807, Example ...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC[C@@H]1C(N)=O
Show InChI InChI=1S/C21H20FN3O6S/c1-2-30-16-5-3-4-6-19(16)32(28,29)24-21(27)18-11-13-14(22)9-12(10-17(13)31-18)25-8-7-15(25)20(23)26/h3-6,9-11,15H,2,7-8H2,1H3,(H2,23,26)(H,24,27)/t15-/m1/s1
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WIPO WO2022081807
n/an/a 11n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM533973
PNG
(WO2022081807, Example 80)
Show SMILES CC1(C)CCc2cccc(c2O1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C23H23FN2O5S/c1-23(2)8-7-14-5-3-6-20(21(14)31-23)32(28,29)25-22(27)19-13-16-17(24)11-15(12-18(16)30-19)26-9-4-10-26/h3,5-6,11-13H,4,7-10H2,1-2H3,(H,25,27)
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WIPO WO2022081807
n/an/a 12n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534006
PNG
(N-(5-tert-butyl-2-ethoxybenzene-1-sulfonyl)-4-fluo...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1)C(C)(C)C
Show InChI InChI=1S/C24H26F2N2O5S/c1-5-32-19-7-6-14(24(2,3)4)8-22(19)34(30,31)27-23(29)21-11-17-18(26)9-16(10-20(17)33-21)28-12-15(25)13-28/h6-11,15H,5,12-13H2,1-4H3,(H,27,29)
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WIPO WO2022081807
n/an/a 12n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534091
PNG
(6-(Azetidin-1-yl)-4-fluoro-N-(3'-fluoro-4-methoxy[...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1)-c1cccc(F)c1
Show InChI InChI=1S/C25H20F2N2O5S/c1-33-21-7-6-16(15-4-2-5-17(26)10-15)11-24(21)35(31,32)28-25(30)23-14-19-20(27)12-18(13-22(19)34-23)29-8-3-9-29/h2,4-7,10-14H,3,8-9H2,1H3,(H,28,30)
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WIPO WO2022081807
n/an/a 12n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534121
PNG
(WO2022081807, Example 228)
Show SMILES CC(C)(C)c1ccc(OC2CCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C26H29FN2O5S/c1-26(2,3)16-8-9-21(33-18-6-4-7-18)24(12-16)35(31,32)28-25(30)23-15-19-20(27)13-17(14-22(19)34-23)29-10-5-11-29/h8-9,12-15,18H,4-7,10-11H2,1-3H3,(H,28,30)
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WIPO WO2022081807
n/an/a 13n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534047
PNG
(WO2022081807, Example 154)
Show SMILES FC1CN(C1)c1cc(F)c2cc(oc2c1)C(=O)NS(=O)(=O)c1cccc2ccc(Cl)nc12
Show InChI InChI=1S/C21H14ClF2N3O4S/c22-19-5-4-11-2-1-3-18(20(11)25-19)32(29,30)26-21(28)17-8-14-15(24)6-13(7-16(14)31-17)27-9-12(23)10-27/h1-8,12H,9-10H2,(H,26,28)
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WIPO WO2022081807
n/an/a 13n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534023
PNG
(WO2022081807, Example 130)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CCC1
Show InChI InChI=1S/C22H18FN3O4S/c1-13-6-7-14-4-2-5-20(21(14)24-13)31(28,29)25-22(27)19-12-16-17(23)10-15(11-18(16)30-19)26-8-3-9-26/h2,4-7,10-12H,3,8-9H2,1H3,(H,25,27)
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WIPO WO2022081807
n/an/a 14n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534025
PNG
(WO2022081807, Example 132)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1cccc2ccc(Cl)nc12)N1CCC1
Show InChI InChI=1S/C21H15ClFN3O4S/c22-19-6-5-12-3-1-4-18(20(12)24-19)31(28,29)25-21(27)17-11-14-15(23)9-13(10-16(14)30-17)26-7-2-8-26/h1,3-6,9-11H,2,7-8H2,(H,25,27)
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WIPO WO2022081807
n/an/a 14n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534045
PNG
(WO2022081807, Example 152)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)N1CC(F)C1
Show InChI InChI=1S/C22H17F2N3O4S/c1-12-5-6-13-3-2-4-20(21(13)25-12)32(29,30)26-22(28)19-9-16-17(24)7-15(8-18(16)31-19)27-10-14(23)11-27/h2-9,14H,10-11H2,1H3,(H,26,28)
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WIPO WO2022081807
n/an/a 14n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...


WIPO WO2022081807 (2022)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%