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Patent code WO2022081842

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534154
PNG
(6-Cyclopropyl-N-(2-ethoxy-5-sec-butyl-phenyl)sulfo...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1)C(C)CC
Show InChI InChI=1S/C24H26FNO5S/c1-4-14(3)16-8-9-20(30-5-2)23(12-16)32(28,29)26-24(27)22-13-18-19(25)10-17(15-6-7-15)11-21(18)31-22/h8-15H,4-7H2,1-3H3,(H,26,27)
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WIPO WO2022081842
n/an/a 1.84n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534192
PNG
(N-[(2-Cyclobutoxy-5-isopropylphenyl)sulfonyl]-6-cy...)
Show SMILES CC(C)c1ccc(OC2CCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C25H26FNO5S/c1-14(2)16-8-9-21(31-18-4-3-5-18)24(12-16)33(29,30)27-25(28)23-13-19-20(26)10-17(15-6-7-15)11-22(19)32-23/h8-15,18H,3-7H2,1-2H3,(H,27,28)
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WIPO WO2022081842
n/an/a 2.09n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534190
PNG
(N-((5-(tert-Butyl)-2-cyclobutoxyphenyl)sulfonyl)-6...)
Show SMILES CC(C)(C)c1ccc(OC2CCC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C26H28FNO5S/c1-26(2,3)17-9-10-21(32-18-5-4-6-18)24(13-17)34(30,31)28-25(29)23-14-19-20(27)11-16(15-7-8-15)12-22(19)33-23/h9-15,18H,4-8H2,1-3H3,(H,28,29)
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WIPO WO2022081842
n/an/a 2.46n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534187
PNG
(N-[(2-(Benzyloxy)-5-(tert-butyl)phenyl)sulfonyl]-6...)
Show SMILES CC(C)(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C29H28FNO5S/c1-29(2,3)21-11-12-24(35-17-18-7-5-4-6-8-18)27(15-21)37(33,34)31-28(32)26-16-22-23(30)13-20(19-9-10-19)14-25(22)36-26/h4-8,11-16,19H,9-10,17H2,1-3H3,(H,31,32)
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WIPO WO2022081842
n/an/a 2.67n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534188
PNG
(N-((5-(tert-butyl)-2-(cyclopropylmethoxy)phenyl)su...)
Show SMILES CC(C)(C)c1ccc(OCC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C26H28FNO5S/c1-26(2,3)18-8-9-21(32-14-15-4-5-15)24(12-18)34(30,31)28-25(29)23-13-19-20(27)10-17(16-6-7-16)11-22(19)33-23/h8-13,15-16H,4-7,14H2,1-3H3,(H,28,29)
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WIPO WO2022081842
n/an/a 2.92n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534161
PNG
(6-Cyclopropyl-N-[2-(cyclopropylmethoxy)-5-isopropy...)
Show SMILES CC(C)c1ccc(OCC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C25H26FNO5S/c1-14(2)17-7-8-21(31-13-15-3-4-15)24(11-17)33(29,30)27-25(28)23-12-19-20(26)9-18(16-5-6-16)10-22(19)32-23/h7-12,14-16H,3-6,13H2,1-2H3,(H,27,28)
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WIPO WO2022081842
n/an/a 3.01n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534193
PNG
(N-((5-(tert-butyl)-2-methoxyphenyl)sulfonyl)-6-cyc...)
Show SMILES COc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1)C(C)(C)C
Show InChI InChI=1S/C23H24FNO5S/c1-23(2,3)15-7-8-18(29-4)21(11-15)31(27,28)25-22(26)20-12-16-17(24)9-14(13-5-6-13)10-19(16)30-20/h7-13H,5-6H2,1-4H3,(H,25,26)
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WIPO WO2022081842
n/an/a 3.31n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534186
PNG
(N-((5-(tert-butyl)-2-cyclopropoxyphenyl)sulfonyl)-...)
Show SMILES CC(C)(C)c1ccc(OC2CC2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C25H26FNO5S/c1-25(2,3)16-6-9-20(31-17-7-8-17)23(12-16)33(29,30)27-24(28)22-13-18-19(26)10-15(14-4-5-14)11-21(18)32-22/h6,9-14,17H,4-5,7-8H2,1-3H3,(H,27,28)
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WIPO WO2022081842
n/an/a 3.58n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534189
PNG
(N-((5-(tert-butyl)-2-(2,2,2-trifluoroethoxy)phenyl...)
Show SMILES CC(C)(C)c1ccc(OCC(F)(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C24H23F4NO5S/c1-23(2,3)15-6-7-18(33-12-24(26,27)28)21(10-15)35(31,32)29-22(30)20-11-16-17(25)8-14(13-4-5-13)9-19(16)34-20/h6-11,13H,4-5,12H2,1-3H3,(H,29,30)
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WIPO WO2022081842
n/an/a 4.16n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534191
PNG
(N-((5-(tert-Butyl)-2-isopropoxyphenyl)sulfonyl)-6-...)
Show SMILES CC(C)Oc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1)C(C)(C)C
Show InChI InChI=1S/C25H28FNO5S/c1-14(2)31-20-9-8-17(25(3,4)5)12-23(20)33(29,30)27-24(28)22-13-18-19(26)10-16(15-6-7-15)11-21(18)32-22/h8-15H,6-7H2,1-5H3,(H,27,28)
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WIPO WO2022081842
n/an/a 4.33n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534194
PNG
(6-Cyclopropyl-N-{(2-[(2,2-difluorocyclopropyl)meth...)
Show SMILES CC(C)c1ccc(OCC2CC2(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C25H24F3NO5S/c1-13(2)15-5-6-20(33-12-17-11-25(17,27)28)23(9-15)35(31,32)29-24(30)22-10-18-19(26)7-16(14-3-4-14)8-21(18)34-22/h5-10,13-14,17H,3-4,11-12H2,1-2H3,(H,29,30)
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WIPO WO2022081842
n/an/a 4.5n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534174
PNG
(6-Cyclopropyl-4-(difluoromethoxy)-N-[(2-methyl-8-q...)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(OC(F)F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C23H18F2N2O5S/c1-12-5-6-14-3-2-4-20(21(14)26-12)33(29,30)27-22(28)19-11-16-17(31-19)9-15(13-7-8-13)10-18(16)32-23(24)25/h2-6,9-11,13,23H,7-8H2,1H3,(H,27,28)
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WIPO WO2022081842
n/an/a 4.78n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534195
PNG
(6-Cyclopropyl-N-(2-ethoxy-5-isopropyl-phenyl)sulfo...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1)C(C)C
Show InChI InChI=1S/C23H24FNO5S/c1-4-29-19-8-7-15(13(2)3)11-22(19)31(27,28)25-23(26)21-12-17-18(24)9-16(14-5-6-14)10-20(17)30-21/h7-14H,4-6H2,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 4.79n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534168
PNG
(6-Cyclopropyl-4-fluoro-N-[5-isopropyl-2-(2,2,2-tri...)
Show SMILES CC(C)c1ccc(OCC(F)(F)F)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C23H21F4NO5S/c1-12(2)14-5-6-18(32-11-23(25,26)27)21(9-14)34(30,31)28-22(29)20-10-16-17(24)7-15(13-3-4-13)8-19(16)33-20/h5-10,12-13H,3-4,11H2,1-2H3,(H,28,29)
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WIPO WO2022081842
n/an/a 4.99n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534177
PNG
(6-Cyclopropyl-N-[(2-methyl-8-quinolyl)sulfonyl]-4-...)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(cc(cc2o1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N2O4S/c1-12-5-6-14-3-2-4-20(21(14)27-12)33(30,31)28-22(29)19-11-16-17(23(24,25)26)9-15(13-7-8-13)10-18(16)32-19/h2-6,9-11,13H,7-8H2,1H3,(H,28,29)
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WIPO WO2022081842
n/an/a 5.55n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534160
PNG
(N-(2-Benzyloxy-5-isopropyl-phenyl)sulfonyl-6-cyclo...)
Show SMILES CC(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C28H26FNO5S/c1-17(2)20-10-11-24(34-16-18-6-4-3-5-7-18)27(14-20)36(32,33)30-28(31)26-15-22-23(29)12-21(19-8-9-19)13-25(22)35-26/h3-7,10-15,17,19H,8-9,16H2,1-2H3,(H,30,31)
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WIPO WO2022081842
n/an/a 5.99n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534158
PNG
(6-Cyclopropyl-N-(2-ethoxy-5-phenoxy-phenyl)sulfony...)
Show SMILES CCOc1ccc(Oc2ccccc2)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C26H22FNO6S/c1-2-32-22-11-10-19(33-18-6-4-3-5-7-18)14-25(22)35(30,31)28-26(29)24-15-20-21(27)12-17(16-8-9-16)13-23(20)34-24/h3-7,10-16H,2,8-9H2,1H3,(H,28,29)
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WIPO WO2022081842
n/an/a 6.32n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534156
PNG
(6-Cyclopropyl-N-[2-ethoxy-5-(trifluoromethyl)pheny...)
Show SMILES CCOc1ccc(cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C21H17F4NO5S/c1-2-30-16-6-5-13(21(23,24)25)9-19(16)32(28,29)26-20(27)18-10-14-15(22)7-12(11-3-4-11)8-17(14)31-18/h5-11H,2-4H2,1H3,(H,26,27)
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WIPO WO2022081842
n/an/a 8.99n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534146
PNG
(6-Cyclopropyl-4-fluoro-N-(2-methylquinoline-8-sulf...)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C22H17FN2O4S/c1-12-5-6-14-3-2-4-20(21(14)24-12)30(27,28)25-22(26)19-11-16-17(23)9-15(13-7-8-13)10-18(16)29-19/h2-6,9-11,13H,7-8H2,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 9.48n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534170
PNG
(6-Cyclopropyl-4-(dimethylamino)-N-[(2-methyl-8-qui...)
Show SMILES CN(C)c1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1cccc2ccc(C)nc12)C1CC1
Show InChI InChI=1S/C24H23N3O4S/c1-14-7-8-16-5-4-6-22(23(16)25-14)32(29,30)26-24(28)21-13-18-19(27(2)3)11-17(15-9-10-15)12-20(18)31-21/h4-8,11-13,15H,9-10H2,1-3H3,(H,26,28)
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WIPO WO2022081842
n/an/a 13n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534149
PNG
(WO2022081842, Example 24)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1OC1CC1)C1CC1
Show InChI InChI=1S/C21H18FNO5S/c22-16-9-13(12-5-6-12)10-18-15(16)11-19(28-18)21(24)23-29(25,26)20-4-2-1-3-17(20)27-14-7-8-14/h1-4,9-12,14H,5-8H2,(H,23,24)
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WIPO WO2022081842
n/an/a 14n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534163
PNG
(6-Cyclopropyl-4-fluoro-N-(2-phenylphenyl)sulfonyl-...)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C24H18FNO4S/c25-20-12-17(15-10-11-15)13-21-19(20)14-22(30-21)24(27)26-31(28,29)23-9-5-4-8-18(23)16-6-2-1-3-7-16/h1-9,12-15H,10-11H2,(H,26,27)
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WIPO WO2022081842
n/an/a 17n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534149
PNG
(WO2022081842, Example 24)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1OC1CC1)C1CC1
Show InChI InChI=1S/C21H18FNO5S/c22-16-9-13(12-5-6-12)10-18-15(16)11-19(28-18)21(24)23-29(25,26)20-4-2-1-3-17(20)27-14-7-8-14/h1-4,9-12,14H,5-8H2,(H,23,24)
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WIPO WO2022081842
n/an/a 19n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534159
PNG
(6-Cyclopropyl-N-[2-ethoxy-5-(trifluoromethoxy)phen...)
Show SMILES CCOc1ccc(OC(F)(F)F)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C21H17F4NO6S/c1-2-30-16-6-5-13(32-21(23,24)25)9-19(16)33(28,29)26-20(27)18-10-14-15(22)7-12(11-3-4-11)8-17(14)31-18/h5-11H,2-4H2,1H3,(H,26,27)
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WIPO WO2022081842
n/an/a 21n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534146
PNG
(6-Cyclopropyl-4-fluoro-N-(2-methylquinoline-8-sulf...)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C22H17FN2O4S/c1-12-5-6-14-3-2-4-20(21(14)24-12)30(27,28)25-22(26)19-11-16-17(23)9-15(13-7-8-13)10-18(16)29-19/h2-6,9-11,13H,7-8H2,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 23n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534166
PNG
(6-Cyclopropyl-4-fluoro-N-(2-propoxyphenyl)sulfonyl...)
Show SMILES CCCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C21H20FNO5S/c1-2-9-27-17-5-3-4-6-20(17)29(25,26)23-21(24)19-12-15-16(22)10-14(13-7-8-13)11-18(15)28-19/h3-6,10-13H,2,7-9H2,1H3,(H,23,24)
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WIPO WO2022081842
n/an/a 25n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534178
PNG
(6-Cyclopropyl-N-(2-ethoxyphenyl)sulfonyl-4-(triflu...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(cc(cc2o1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C21H18F3NO5S/c1-2-29-16-5-3-4-6-19(16)31(27,28)25-20(26)18-11-14-15(21(22,23)24)9-13(12-7-8-12)10-17(14)30-18/h3-6,9-12H,2,7-8H2,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 26n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534173
PNG
(N-(benzenesulfonyl)-6-cyclopropyl-4-(difluorometho...)
Show SMILES FC(F)Oc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C25H19F2NO5S/c26-25(27)33-21-13-17(15-10-11-15)12-20-19(21)14-22(32-20)24(29)28-34(30,31)23-9-5-4-8-18(23)16-6-2-1-3-7-16/h1-9,12-15,25H,10-11H2,(H,28,29)
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WIPO WO2022081842
n/an/a 27n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534145
PNG
(4,6-Dimethyl-N-(2-methylquinoline-8-sulfonyl)-1-be...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1cccc2ccc(C)nc12
Show InChI InChI=1S/C21H18N2O4S/c1-12-9-13(2)16-11-18(27-17(16)10-12)21(24)23-28(25,26)19-6-4-5-15-8-7-14(3)22-20(15)19/h4-11H,1-3H3,(H,23,24)
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WIPO WO2022081842
n/an/a 27n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534150
PNG
(6-Cyclopropyl-N-(2-ethoxybenzene-1-sulfonyl)-4-flu...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C20H18FNO5S/c1-2-26-16-5-3-4-6-19(16)28(24,25)22-20(23)18-11-14-15(21)9-13(12-7-8-12)10-17(14)27-18/h3-6,9-12H,2,7-8H2,1H3,(H,22,23)
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WIPO WO2022081842
n/an/a 28n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534176
PNG
(6-Cyclopropyl-4-(difluoromethoxy)-N-(2-ethoxypheny...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(OC(F)F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C21H19F2NO6S/c1-2-28-15-5-3-4-6-19(15)31(26,27)24-20(25)18-11-14-16(29-18)9-13(12-7-8-12)10-17(14)30-21(22)23/h3-6,9-12,21H,2,7-8H2,1H3,(H,24,25)
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WIPO WO2022081842
n/an/a 29n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534150
PNG
(6-Cyclopropyl-N-(2-ethoxybenzene-1-sulfonyl)-4-flu...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C20H18FNO5S/c1-2-26-16-5-3-4-6-19(16)28(24,25)22-20(23)18-11-14-15(21)9-13(12-7-8-12)10-17(14)27-18/h3-6,9-12H,2,7-8H2,1H3,(H,22,23)
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WIPO WO2022081842
n/an/a 35n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534155
PNG
(6-Cyclopropyl-N-(2-ethoxy-4-fluoro-phenyl)sulfonyl...)
Show SMILES COc1ccc(F)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C19H15F2NO5S/c1-26-15-5-4-12(20)8-18(15)28(24,25)22-19(23)17-9-13-14(21)6-11(10-2-3-10)7-16(13)27-17/h4-10H,2-3H2,1H3,(H,22,23)
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WIPO WO2022081842
n/an/a 37n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534185
PNG
(6-Cyclopropyl-N-(2-ethoxyphenyl)sulfonyl-4-imidazo...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(cc(cc2o1)C1CC1)-n1ccnc1
Show InChI InChI=1S/C23H21N3O5S/c1-2-30-19-5-3-4-6-22(19)32(28,29)25-23(27)21-13-17-18(26-10-9-24-14-26)11-16(15-7-8-15)12-20(17)31-21/h3-6,9-15H,2,7-8H2,1H3,(H,25,27)
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WIPO WO2022081842
n/an/a 40n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534180
PNG
(6-Cyclopropyl-N-(2-phenylphenyl)sulfonyl-4-(triflu...)
Show SMILES FC(F)(F)c1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C25H18F3NO4S/c26-25(27,28)20-12-17(15-10-11-15)13-21-19(20)14-22(33-21)24(30)29-34(31,32)23-9-5-4-8-18(23)16-6-2-1-3-7-16/h1-9,12-15H,10-11H2,(H,29,30)
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WIPO WO2022081842
n/an/a 43n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534187
PNG
(N-[(2-(Benzyloxy)-5-(tert-butyl)phenyl)sulfonyl]-6...)
Show SMILES CC(C)(C)c1ccc(OCc2ccccc2)c(c1)S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C29H28FNO5S/c1-29(2,3)21-11-12-24(35-17-18-7-5-4-6-8-18)27(15-21)37(33,34)31-28(32)26-16-22-23(30)13-20(19-9-10-19)14-25(22)36-26/h4-8,11-16,19H,9-10,17H2,1-3H3,(H,31,32)
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WIPO WO2022081842
n/an/a 45n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534171
PNG
(6-Cyclopropyl-4-(dimethylamino)-N-(2-phenylphenyl)...)
Show SMILES CN(C)c1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C26H24N2O4S/c1-28(2)22-14-19(17-12-13-17)15-23-21(22)16-24(32-23)26(29)27-33(30,31)25-11-7-6-10-20(25)18-8-4-3-5-9-18/h3-11,14-17H,12-13H2,1-2H3,(H,27,29)
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WIPO WO2022081842
n/an/a 52n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534145
PNG
(4,6-Dimethyl-N-(2-methylquinoline-8-sulfonyl)-1-be...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1cccc2ccc(C)nc12
Show InChI InChI=1S/C21H18N2O4S/c1-12-9-13(2)16-11-18(27-17(16)10-12)21(24)23-28(25,26)19-6-4-5-15-8-7-14(3)22-20(15)19/h4-11H,1-3H3,(H,23,24)
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WIPO WO2022081842
n/an/a 53n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534157
PNG
(6-Cyclopropyl-N-(2-ethoxy-5-fluoro-phenyl)sulfonyl...)
Show SMILES CCOc1ccc(F)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C20H17F2NO5S/c1-2-27-16-6-5-13(21)9-19(16)29(25,26)23-20(24)18-10-14-15(22)7-12(11-3-4-11)8-17(14)28-18/h5-11H,2-4H2,1H3,(H,23,24)
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WIPO WO2022081842
n/an/a 56n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534140
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-cyclopropyl-1-ben...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)C1CC1
Show InChI InChI=1S/C24H19NO4S/c26-24(22-15-19-13-12-18(16-10-11-16)14-21(19)29-22)25-30(27,28)23-9-5-4-8-20(23)17-6-2-1-3-7-17/h1-9,12-16H,10-11H2,(H,25,26)
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WIPO WO2022081842
n/an/a 62n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534135
PNG
(N-(3'-chloro[1,1'-biphenyl]-2-sulfonyl)-4,6-dimeth...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1cccc(Cl)c1
Show InChI InChI=1S/C23H18ClNO4S/c1-14-10-15(2)19-13-21(29-20(19)11-14)23(26)25-30(27,28)22-9-4-3-8-18(22)16-6-5-7-17(24)12-16/h3-13H,1-2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 64n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534165
PNG
(N-(Benzenesulfonyl)-6-cyclopropyl-4-fluoro-benzofu...)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1)C1CC1
Show InChI InChI=1S/C18H14FNO4S/c19-15-8-12(11-6-7-11)9-16-14(15)10-17(24-16)18(21)20-25(22,23)13-4-2-1-3-5-13/h1-5,8-11H,6-7H2,(H,20,21)
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WIPO WO2022081842
n/an/a 71n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534162
PNG
(6-Cyclopropyl-N-(2,4-dichlorophenyl)sulfonyl-4-flu...)
Show SMILES Fc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C18H12Cl2FNO4S/c19-11-3-4-17(13(20)7-11)27(24,25)22-18(23)16-8-12-14(21)5-10(9-1-2-9)6-15(12)26-16/h3-9H,1-2H2,(H,22,23)
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WIPO WO2022081842
n/an/a 78n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534172
PNG
(6-Cyclopropyl-4-(dimethylamino)-N-(2-ethoxyphenyl)...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(cc(cc2o1)C1CC1)N(C)C
Show InChI InChI=1S/C22H24N2O5S/c1-4-28-18-7-5-6-8-21(18)30(26,27)23-22(25)20-13-16-17(24(2)3)11-15(14-9-10-14)12-19(16)29-20/h5-8,11-14H,4,9-10H2,1-3H3,(H,23,25)
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WIPO WO2022081842
n/an/a 80n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534131
PNG
(WO2022081842, Example 7)
Show SMILES Cc1ccc(c(c1)-c1ccccc1)S(=O)(=O)NC(=O)c1cc2c(C)cc(C)cc2o1
Show InChI InChI=1S/C24H21NO4S/c1-15-9-10-23(20(12-15)18-7-5-4-6-8-18)30(27,28)25-24(26)22-14-19-17(3)11-16(2)13-21(19)29-22/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 87n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534133
PNG
(WO2022081842, Example 9)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19NO4S/c1-15-12-16(2)19-14-21(28-20(19)13-15)23(25)24-29(26,27)22-11-7-6-10-18(22)17-8-4-3-5-9-17/h3-14H,1-2H3,(H,24,25)
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WIPO WO2022081842
n/an/a 91n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534140
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-cyclopropyl-1-ben...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)C1CC1
Show InChI InChI=1S/C24H19NO4S/c26-24(22-15-19-13-12-18(16-10-11-16)14-21(19)29-22)25-30(27,28)23-9-5-4-8-20(23)17-6-2-1-3-7-17/h1-9,12-16H,10-11H2,(H,25,26)
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WIPO WO2022081842
n/an/a 104n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534153
PNG
(6-Cyclopropyl-N-(2-ethoxy-3-fluoro-phenyl)sulfonyl...)
Show SMILES CCOc1c(F)cccc1S(=O)(=O)NC(=O)c1cc2c(F)cc(cc2o1)C1CC1
Show InChI InChI=1S/C20H17F2NO5S/c1-2-27-19-14(21)4-3-5-18(19)29(25,26)23-20(24)17-10-13-15(22)8-12(11-6-7-11)9-16(13)28-17/h3-5,8-11H,2,6-7H2,1H3,(H,23,24)
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WIPO WO2022081842
n/an/a 106n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534131
PNG
(WO2022081842, Example 7)
Show SMILES Cc1ccc(c(c1)-c1ccccc1)S(=O)(=O)NC(=O)c1cc2c(C)cc(C)cc2o1
Show InChI InChI=1S/C24H21NO4S/c1-15-9-10-23(20(12-15)18-7-5-4-6-8-18)30(27,28)25-24(26)22-14-19-17(3)11-16(2)13-21(19)29-22/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 114n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534130
PNG
(4,6-Dimethyl-N-(2'-methyl[1,1'-biphenyl]-2-sulfony...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1C
Show InChI InChI=1S/C24H21NO4S/c1-15-12-17(3)20-14-22(29-21(20)13-15)24(26)25-30(27,28)23-11-7-6-10-19(23)18-9-5-4-8-16(18)2/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 128n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534179
PNG
(N-(Benzenesulfonyl)-6-cyclopropyl-4-(trifluorometh...)
Show SMILES FC(F)(F)c1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1)C1CC1
Show InChI InChI=1S/C19H14F3NO4S/c20-19(21,22)15-8-12(11-6-7-11)9-16-14(15)10-17(27-16)18(24)23-28(25,26)13-4-2-1-3-5-13/h1-5,8-11H,6-7H2,(H,23,24)
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WIPO WO2022081842
n/an/a 138n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534173
PNG
(N-(benzenesulfonyl)-6-cyclopropyl-4-(difluorometho...)
Show SMILES FC(F)Oc1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C25H19F2NO5S/c26-25(27)33-21-13-17(15-10-11-15)12-20-19(21)14-22(32-20)24(29)28-34(30,31)23-9-5-4-8-18(23)16-6-2-1-3-7-16/h1-9,12-15,25H,10-11H2,(H,28,29)
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WIPO WO2022081842
n/an/a 148n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534148
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(prop-1-en-2-yl)-...)
Show SMILES CC(=C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H19NO4S/c1-16(2)18-12-13-19-15-22(29-21(19)14-18)24(26)25-30(27,28)23-11-7-6-10-20(23)17-8-4-3-5-9-17/h3-15H,1H2,2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 155n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534148
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(prop-1-en-2-yl)-...)
Show SMILES CC(=C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H19NO4S/c1-16(2)18-12-13-19-15-22(29-21(19)14-18)24(26)25-30(27,28)23-11-7-6-10-20(23)17-8-4-3-5-9-17/h3-15H,1H2,2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 215n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534133
PNG
(WO2022081842, Example 9)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19NO4S/c1-15-12-16(2)19-14-21(28-20(19)13-15)23(25)24-29(26,27)22-11-7-6-10-18(22)17-8-4-3-5-9-17/h3-14H,1-2H3,(H,24,25)
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WIPO WO2022081842
n/an/a 220n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534130
PNG
(4,6-Dimethyl-N-(2'-methyl[1,1'-biphenyl]-2-sulfony...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1C
Show InChI InChI=1S/C24H21NO4S/c1-15-12-17(3)20-14-22(29-21(20)13-15)24(26)25-30(27,28)23-11-7-6-10-19(23)18-9-5-4-8-16(18)2/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 245n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534135
PNG
(N-(3'-chloro[1,1'-biphenyl]-2-sulfonyl)-4,6-dimeth...)
Show SMILES Cc1cc(C)c2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1cccc(Cl)c1
Show InChI InChI=1S/C23H18ClNO4S/c1-14-10-15(2)19-13-21(29-20(19)11-14)23(26)25-30(27,28)22-9-4-3-8-18(22)16-6-5-7-17(24)12-16/h3-13H,1-2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 299n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534136
PNG
(4-Methoxy-6-methyl-N-(5-methyl[1,1'-biphenyl]-2-su...)
Show SMILES COc1cc(C)cc2oc(cc12)C(=O)NS(=O)(=O)c1cc(C)ccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO5S/c1-15-9-10-18(17-7-5-4-6-8-17)23(13-15)31(27,28)25-24(26)22-14-19-20(29-3)11-16(2)12-21(19)30-22/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 372n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534136
PNG
(4-Methoxy-6-methyl-N-(5-methyl[1,1'-biphenyl]-2-su...)
Show SMILES COc1cc(C)cc2oc(cc12)C(=O)NS(=O)(=O)c1cc(C)ccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO5S/c1-15-9-10-18(17-7-5-4-6-8-17)23(13-15)31(27,28)25-24(26)22-14-19-20(29-3)11-16(2)12-21(19)30-22/h4-14H,1-3H3,(H,25,26)
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WIPO WO2022081842
n/an/a 401n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534169
PNG
(N-(Benzenesulfonyl)-6-cyclopropyl-4-(dimethylamino...)
Show SMILES CN(C)c1cc(cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1)C1CC1
Show InChI InChI=1S/C20H20N2O4S/c1-22(2)17-10-14(13-8-9-13)11-18-16(17)12-19(26-18)20(23)21-27(24,25)15-6-4-3-5-7-15/h3-7,10-13H,8-9H2,1-2H3,(H,21,23)
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WIPO WO2022081842
n/an/a 417n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534138
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-3,6-dimethyl-1-benz...)
Show SMILES Cc1c(oc2cc(C)ccc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19NO4S/c1-15-12-13-18-16(2)22(28-20(18)14-15)23(25)24-29(26,27)21-11-7-6-10-19(21)17-8-4-3-5-9-17/h3-14H,1-2H3,(H,24,25)
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WIPO WO2022081842
n/an/a 459n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534181
PNG
(N-{[1,1'-Biphenyl]-2-sulfonyl}-6-(propan-2-yl)-1-b...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO4S/c1-16(2)18-12-13-19-15-22(29-21(19)14-18)24(26)25-30(27,28)23-11-7-6-10-20(23)17-8-4-3-5-9-17/h3-16H,1-2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 464n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534182
PNG
(N-(2-Ethoxybenzenesulfonyl)-6-(propan-2-yl)-1-benz...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2ccc(cc2o1)C(C)C
Show InChI InChI=1S/C20H21NO5S/c1-4-25-16-7-5-6-8-19(16)27(23,24)21-20(22)18-12-15-10-9-14(13(2)3)11-17(15)26-18/h5-13H,4H2,1-3H3,(H,21,22)
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WIPO WO2022081842
n/an/a 538n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534182
PNG
(N-(2-Ethoxybenzenesulfonyl)-6-(propan-2-yl)-1-benz...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2ccc(cc2o1)C(C)C
Show InChI InChI=1S/C20H21NO5S/c1-4-25-16-7-5-6-8-19(16)27(23,24)21-20(22)18-12-15-10-9-14(13(2)3)11-17(15)26-18/h5-13H,4H2,1-3H3,(H,21,22)
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WIPO WO2022081842
n/an/a 596n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534184
PNG
(N-(2,4-Dichlorobenzenesulfonyl)-6-(propan-2-yl)-1-...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H15Cl2NO4S/c1-10(2)11-3-4-12-8-16(25-15(12)7-11)18(22)21-26(23,24)17-6-5-13(19)9-14(17)20/h3-10H,1-2H3,(H,21,22)
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WIPO WO2022081842
n/an/a 611n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534181
PNG
(N-{[1,1'-Biphenyl]-2-sulfonyl}-6-(propan-2-yl)-1-b...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO4S/c1-16(2)18-12-13-19-15-22(29-21(19)14-18)24(26)25-30(27,28)23-11-7-6-10-20(23)17-8-4-3-5-9-17/h3-16H,1-2H3,(H,25,26)
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WIPO WO2022081842
n/an/a 667n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534143
PNG
(N-(2-Methylquinoline-8-sulfonyl)-6-(trifluoromethy...)
Show SMILES Cc1ccc2cccc(c2n1)S(=O)(=O)NC(=O)c1cc2ccc(cc2o1)C(F)(F)F
Show InChI InChI=1S/C20H13F3N2O4S/c1-11-5-6-12-3-2-4-17(18(12)24-11)30(27,28)25-19(26)16-9-13-7-8-14(20(21,22)23)10-15(13)29-16/h2-10H,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 729n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534142
PNG
(N-(2-Ethoxybenzene-1-sulfonyl)-3,6-dimethyl-1-benz...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1oc2cc(C)ccc2c1C
Show InChI InChI=1S/C19H19NO5S/c1-4-24-15-7-5-6-8-17(15)26(22,23)20-19(21)18-13(3)14-10-9-12(2)11-16(14)25-18/h5-11H,4H2,1-3H3,(H,20,21)
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WIPO WO2022081842
n/an/a 827n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534126
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-methyl-1-benzofur...)
Show SMILES Cc1ccc(cc1)-c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H21NO4S/c1-19-11-13-20(14-12-19)22-15-16-23-18-26(33-25(23)17-22)28(30)29-34(31,32)27-10-6-5-9-24(27)21-7-3-2-4-8-21/h2-18H,1H3,(H,29,30)
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WIPO WO2022081842
n/an/a 882n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534139
PNG
(WO2022081842, Example 15)
Show SMILES Fc1c(ccc2cc(oc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1)C1CC1
Show InChI InChI=1S/C24H18FNO4S/c25-22-19(16-10-11-16)13-12-17-14-20(30-23(17)22)24(27)26-31(28,29)21-9-5-4-8-18(21)15-6-2-1-3-7-15/h1-9,12-14,16H,10-11H2,(H,26,27)
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WIPO WO2022081842
n/an/a 908n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534134
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-4-methoxy-6-methyl-...)
Show SMILES COc1cc(C)cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19NO5S/c1-15-12-19(28-2)18-14-21(29-20(18)13-15)23(25)24-30(26,27)22-11-7-6-10-17(22)16-8-4-3-5-9-16/h3-14H,1-2H3,(H,24,25)
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WIPO WO2022081842
n/an/a 933n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534134
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-4-methoxy-6-methyl-...)
Show SMILES COc1cc(C)cc2oc(cc12)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H19NO5S/c1-15-12-19(28-2)18-14-21(29-20(18)13-15)23(25)24-30(26,27)22-11-7-6-10-17(22)16-8-4-3-5-9-16/h3-14H,1-2H3,(H,24,25)
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WIPO WO2022081842
n/an/a 1.12E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534137
PNG
(N-(2-Ethoxybenzene-1-sulfonyl)-4-methoxy-6-methyl-...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(OC)cc(C)cc2o1
Show InChI InChI=1S/C19H19NO6S/c1-4-25-14-7-5-6-8-18(14)27(22,23)20-19(21)17-11-13-15(24-3)9-12(2)10-16(13)26-17/h5-11H,4H2,1-3H3,(H,20,21)
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WIPO WO2022081842
n/an/a 1.13E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534151
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(2-methoxyethyl)-...)
Show SMILES COCCc1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO5S/c1-29-14-13-17-11-12-19-16-22(30-21(19)15-17)24(26)25-31(27,28)23-10-6-5-9-20(23)18-7-3-2-4-8-18/h2-12,15-16H,13-14H2,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 1.13E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534141
PNG
(N-([1,1'-Biphenyl]-2-sulfonyl)-6-(difluoromethyl)-...)
Show SMILES FC(F)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C22H15F2NO4S/c23-21(24)16-11-10-15-12-19(29-18(15)13-16)22(26)25-30(27,28)20-9-5-4-8-17(20)14-6-2-1-3-7-14/h1-13,21H,(H,25,26)
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WIPO WO2022081842
n/an/a 1.30E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534196
PNG
(N-(2-chlorobenzenesulfonyl)-6-(propan-2-yl)-1-benz...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H16ClNO4S/c1-11(2)12-7-8-13-10-16(24-15(13)9-12)18(21)20-25(22,23)17-6-4-3-5-14(17)19/h3-11H,1-2H3,(H,20,21)
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WIPO WO2022081842
n/an/a 1.35E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534183
PNG
(N-(Benzenesulfonyl)-6-(propan-2-yl)-1-benzofuran-2...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H17NO4S/c1-12(2)13-8-9-14-11-17(23-16(14)10-13)18(20)19-24(21,22)15-6-4-3-5-7-15/h3-12H,1-2H3,(H,19,20)
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WIPO WO2022081842
n/an/a 1.56E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534137
PNG
(N-(2-Ethoxybenzene-1-sulfonyl)-4-methoxy-6-methyl-...)
Show SMILES CCOc1ccccc1S(=O)(=O)NC(=O)c1cc2c(OC)cc(C)cc2o1
Show InChI InChI=1S/C19H19NO6S/c1-4-25-14-7-5-6-8-18(14)27(22,23)20-19(21)17-11-13-15(24-3)9-12(2)10-16(13)26-17/h5-11H,4H2,1-3H3,(H,20,21)
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WIPO WO2022081842
n/an/a 1.73E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534196
PNG
(N-(2-chlorobenzenesulfonyl)-6-(propan-2-yl)-1-benz...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H16ClNO4S/c1-11(2)12-7-8-13-10-16(24-15(13)9-12)18(21)20-25(22,23)17-6-4-3-5-14(17)19/h3-11H,1-2H3,(H,20,21)
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WIPO WO2022081842
n/an/a 1.78E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534152
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(butan-2-yl)-1-be...)
Show SMILES CCC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H23NO4S/c1-3-17(2)19-13-14-20-16-23(30-22(20)15-19)25(27)26-31(28,29)24-12-8-7-11-21(24)18-9-5-4-6-10-18/h4-17H,3H2,1-2H3,(H,26,27)
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WIPO WO2022081842
n/an/a 2.03E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534126
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-methyl-1-benzofur...)
Show SMILES Cc1ccc(cc1)-c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H21NO4S/c1-19-11-13-20(14-12-19)22-15-16-23-18-26(33-25(23)17-22)28(30)29-34(31,32)27-10-6-5-9-24(27)21-7-3-2-4-8-21/h2-18H,1H3,(H,29,30)
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WIPO WO2022081842
n/an/a 2.22E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534141
PNG
(N-([1,1'-Biphenyl]-2-sulfonyl)-6-(difluoromethyl)-...)
Show SMILES FC(F)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C22H15F2NO4S/c23-21(24)16-11-10-15-12-19(29-18(15)13-16)22(26)25-30(27,28)20-9-5-4-8-17(20)14-6-2-1-3-7-14/h1-13,21H,(H,25,26)
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WIPO WO2022081842
n/an/a 2.58E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534151
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(2-methoxyethyl)-...)
Show SMILES COCCc1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H21NO5S/c1-29-14-13-17-11-12-19-16-22(30-21(19)15-17)24(26)25-31(27,28)23-10-6-5-9-20(23)18-7-3-2-4-8-18/h2-12,15-16H,13-14H2,1H3,(H,25,26)
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WIPO WO2022081842
n/an/a 2.85E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534125
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(4-fluorophenyl)-...)
Show SMILES Fc1ccc(cc1)-c1ccc2cc(oc2c1)C(=C)OS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H19FO4S/c1-19(33-34(30,31)28-10-6-5-9-25(28)21-7-3-2-4-8-21)26-18-23-12-11-22(17-27(23)32-26)20-13-15-24(29)16-14-20/h2-18H,1H2
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WIPO WO2022081842
n/an/a 3.38E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534183
PNG
(N-(Benzenesulfonyl)-6-(propan-2-yl)-1-benzofuran-2...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H17NO4S/c1-12(2)13-8-9-14-11-17(23-16(14)10-13)18(20)19-24(21,22)15-6-4-3-5-7-15/h3-12H,1-2H3,(H,19,20)
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WIPO WO2022081842
n/an/a 3.94E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534125
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(4-fluorophenyl)-...)
Show SMILES Fc1ccc(cc1)-c1ccc2cc(oc2c1)C(=C)OS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H19FO4S/c1-19(33-34(30,31)28-10-6-5-9-25(28)21-7-3-2-4-8-21)26-18-23-12-11-22(17-27(23)32-26)20-13-15-24(29)16-14-20/h2-18H,1H2
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WIPO WO2022081842
n/an/a 4.79E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534184
PNG
(N-(2,4-Dichlorobenzenesulfonyl)-6-(propan-2-yl)-1-...)
Show SMILES CC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H15Cl2NO4S/c1-10(2)11-3-4-12-8-16(25-15(12)7-11)18(22)21-26(23,24)17-6-5-13(19)9-14(17)20/h3-10H,1-2H3,(H,21,22)
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WIPO WO2022081842
n/an/a 5.25E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534129
PNG
(WO2022081842, Example 5)
Show SMILES OC(=O)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C22H15NO6S/c24-21(19-12-15-10-11-16(22(25)26)13-18(15)29-19)23-30(27,28)20-9-5-4-8-17(20)14-6-2-1-3-7-14/h1-13H,(H,23,24)(H,25,26)
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WIPO WO2022081842
n/an/a 5.75E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534152
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(butan-2-yl)-1-be...)
Show SMILES CCC(C)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H23NO4S/c1-3-17(2)19-13-14-20-16-23(30-22(20)15-19)25(27)26-31(28,29)24-12-8-7-11-21(24)18-9-5-4-6-10-18/h4-17H,3H2,1-2H3,(H,26,27)
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WIPO WO2022081842
n/an/a 9.21E+3n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534128
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(pyridin-3-yl)-1-...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)-c1cccnc1
Show InChI InChI=1S/C26H18N2O4S/c29-26(24-16-20-13-12-19(15-23(20)32-24)21-9-6-14-27-17-21)28-33(30,31)25-11-5-4-10-22(25)18-7-2-1-3-8-18/h1-17H,(H,28,29)
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WIPO WO2022081842
n/an/a 1.52E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534132
PNG
(N2-([1,1'-biphenyl]-2-sulfonyl)-N6,N6-dimethyl-1-b...)
Show SMILES CN(C)C(=O)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H20N2O5S/c1-26(2)24(28)18-13-12-17-14-21(31-20(17)15-18)23(27)25-32(29,30)22-11-7-6-10-19(22)16-8-4-3-5-9-16/h3-15H,1-2H3,(H,25,27)
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WIPO WO2022081842
n/an/a 1.73E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534128
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-(pyridin-3-yl)-1-...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)-c1cccnc1
Show InChI InChI=1S/C26H18N2O4S/c29-26(24-16-20-13-12-19(15-23(20)32-24)21-9-6-14-27-17-21)28-33(30,31)25-11-5-4-10-22(25)18-7-2-1-3-8-18/h1-17H,(H,28,29)
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WIPO WO2022081842
n/an/a>2.00E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534132
PNG
(N2-([1,1'-biphenyl]-2-sulfonyl)-N6,N6-dimethyl-1-b...)
Show SMILES CN(C)C(=O)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H20N2O5S/c1-26(2)24(28)18-13-12-17-14-21(31-20(17)15-18)23(27)25-32(29,30)22-11-7-6-10-19(22)16-8-4-3-5-9-16/h3-15H,1-2H3,(H,25,27)
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WIPO WO2022081842
n/an/a>2.00E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534127
PNG
(N-([1,1'-biphenyl]-2-sulfonyl)-6-cyano-1-benzofura...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H18N2O4S/c29-18-19-10-12-20(13-11-19)22-14-15-23-17-26(34-25(23)16-22)28(31)30-35(32,33)27-9-5-4-8-24(27)21-6-2-1-3-7-21/h1-17H,(H,30,31)
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WIPO WO2022081842
n/an/a>2.00E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM534144
PNG
(N-([1,1'-Biphenyl]-2-sulfonyl)-6-(pyridin-4-yl)-1-...)
Show SMILES O=C(NS(=O)(=O)c1ccccc1-c1ccccc1)c1cc2ccc(cc2o1)-c1ccncc1
Show InChI InChI=1S/C26H18N2O4S/c29-26(24-17-21-11-10-20(16-23(21)32-24)18-12-14-27-15-13-18)28-33(30,31)25-9-5-4-8-22(25)19-6-2-1-3-7-19/h1-17H,(H,28,29)
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WIPO WO2022081842
n/an/a>2.00E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM534129
PNG
(WO2022081842, Example 5)
Show SMILES OC(=O)c1ccc2cc(oc2c1)C(=O)NS(=O)(=O)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C22H15NO6S/c24-21(19-12-15-10-11-16(22(25)26)13-18(15)29-19)23-30(27,28)20-9-5-4-8-17(20)14-6-2-1-3-7-14/h1-13H,(H,23,24)(H,25,26)
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WIPO WO2022081842
n/an/a>2.00E+4n/an/an/an/an/an/a



THE BROAD INSTITUTE, INC.

WIPO


Assay Description
Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...


WIPO WO2022081842 (2022)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%