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Patent code WO2022086828

Compile Data Set for Download or QSAR

Found 792 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534434
PNG
(WO2022086828, Example 170)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2cccc(Cl)c2F)c1F
Show InChI InChI=1S/C22H15Cl2F4N5O2/c23-13-5-4-11(10-6-7-33-15(8-10)31-21(29)32-33)18(26)16(13)20(35)30-9-22(27,28)19(34)12-2-1-3-14(24)17(12)25/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.100n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534450
PNG
(WO2022086828, Example 186)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2ccc(OC(F)F)cc2)c1F
Show InChI InChI=1S/C23H17ClF5N5O3/c24-15-6-5-14(12-7-8-34-16(9-12)32-22(30)33-34)18(25)17(15)20(36)31-10-23(28,29)19(35)11-1-3-13(4-2-11)37-21(26)27/h1-9,19,21,35H,10H2,(H2,30,33)(H,31,36)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.200n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534402
PNG
(WO2022086828, Example 138)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC(F)(F)[C@H](O)c1ccc(F)cc1)-c1ccn2nc(N)nc2c1F
Show InChI InChI=1S/C23H18F5N5O2/c1-11-2-7-14(15-8-9-33-20(18(15)26)31-22(29)32-33)17(25)16(11)21(35)30-10-23(27,28)19(34)12-3-5-13(24)6-4-12/h2-9,19,34H,10H2,1H3,(H2,29,32)(H,30,35)/t19-/m1/s1
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WIPO WO2022086828
n/an/a 0.200n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534472
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC(F)(F)Cc1ccc(F)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H19F4N5O/c1-13-2-7-17(15-8-9-32-18(10-15)30-22(28)31-32)20(25)19(13)21(33)29-12-23(26,27)11-14-3-5-16(24)6-4-14/h2-10H,11-12H2,1H3,(H2,28,31)(H,29,33)
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WIPO WO2022086828
n/an/a 0.200n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534461
PNG
(3 -(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-y...)
Show SMILES C[C@](O)([C@H](F)CNC(=O)c1c(F)c(ccc1C(F)F)-c1ccn2nc(N)nc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C24H20F5N5O2/c1-24(36,13-2-4-14(25)5-3-13)17(26)11-31-22(35)19-16(21(28)29)7-6-15(20(19)27)12-8-9-34-18(10-12)32-23(30)33-34/h2-10,17,21,36H,11H2,1H3,(H2,30,33)(H,31,35)/t17-,24-/m1/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534427
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@H](O)c2ccc(Cl)cc2F)c1F
Show InChI InChI=1S/C22H15Cl2F4N5O2/c23-11-1-2-13(15(25)8-11)19(34)22(27,28)9-30-20(35)17-14(24)4-3-12(18(17)26)10-5-6-33-16(7-10)31-21(29)32-33/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m1/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534325
PNG
(WO2022086828, Example 52)
Show SMILES Cc1ccc(c(F)c1C(=O)NCCCC1CCCCC1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H28FN5O/c1-15-9-10-18(17-11-13-29-19(14-17)27-23(25)28-29)21(24)20(15)22(30)26-12-5-8-16-6-3-2-4-7-16/h9-11,13-14,16H,2-8,12H2,1H3,(H2,25,28)(H,26,30)
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534445
PNG
(WO2022086828, Example 181)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@H](O)c2cc(Cl)ccc2F)c1F
Show InChI InChI=1S/C22H15Cl2F4N5O2/c23-11-1-4-15(25)13(8-11)19(34)22(27,28)9-30-20(35)17-14(24)3-2-12(18(17)26)10-5-6-33-16(7-10)31-21(29)32-33/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m1/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534424
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(c(F)c1C(=O)NCCC(F)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H20ClF2N5O/c1-13-2-7-17(15-9-11-31-19(12-15)29-23(27)30-31)21(26)20(13)22(32)28-10-8-18(25)14-3-5-16(24)6-4-14/h2-7,9,11-12,18H,8,10H2,1H3,(H2,27,30)(H,28,32)
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534443
PNG
(WO2022086828, Example 179)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@H](O)c2ccc(F)cc2F)c1F
Show InChI InChI=1S/C22H15ClF5N5O2/c23-14-4-3-12(10-5-6-33-16(7-10)31-21(29)32-33)18(26)17(14)20(35)30-9-22(27,28)19(34)13-2-1-11(24)8-15(13)25/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m1/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534452
PNG
(WO2022086828, Example 188)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2cc(F)cc(F)c2)c1F
Show InChI InChI=1S/C22H15ClF5N5O2/c23-15-2-1-14(10-3-4-33-16(7-10)31-21(29)32-33)18(26)17(15)20(35)30-9-22(27,28)19(34)11-5-12(24)8-13(25)6-11/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534440
PNG
(WO2022086828, Example 176)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C22H15ClF5N5O2/c23-14-3-2-12(10-5-6-33-16(7-10)31-21(29)32-33)18(26)17(14)20(35)30-9-22(27,28)19(34)13-8-11(24)1-4-15(13)25/h1-8,19,34H,9H2,(H2,29,32)(H,30,35)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534377
PNG
(5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1c(F)c(F)c(cc1C(=O)NCC(F)(F)[C@@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H18ClF4N5O2/c1-11-15(21(35)30-10-23(27,28)20(34)12-2-4-14(24)5-3-12)9-16(19(26)18(11)25)13-6-7-33-17(8-13)31-22(29)32-33/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534432
PNG
(WO2022086828, Example 168)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)[C@@H](O)c2cccc(F)c2)c1F
Show InChI InChI=1S/C22H16ClF4N5O2/c23-15-5-4-14(11-6-7-32-16(9-11)30-21(28)31-32)18(25)17(15)20(34)29-10-22(26,27)19(33)12-2-1-3-13(24)8-12/h1-9,19,33H,10H2,(H2,28,31)(H,29,34)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534328
PNG
(WO2022086828, Example 55)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCCC(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N5O2/c1-13-2-7-17(15-9-11-33-19(12-15)31-23(29)32-33)21(25)20(13)22(35)30-10-8-18(34)14-3-5-16(6-4-14)24(26,27)28/h2-7,9,11-12,18,34H,8,10H2,1H3,(H2,29,32)(H,30,35)
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534323
PNG
(WO2022086828, Example 50)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC[C@@H](O)c1ccc(F)cc1
Show InChI InChI=1S/C23H21F2N5O2/c1-13-2-7-17(15-9-11-30-19(12-15)28-23(26)29-30)21(25)20(13)22(32)27-10-8-18(31)14-3-5-16(24)6-4-14/h2-7,9,11-12,18,31H,8,10H2,1H3,(H2,26,29)(H,27,32)/t18-/m1/s1
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WIPO WO2022086828
n/an/a 0.300n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534380
PNG
(5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1c(F)c(F)c(cc1C(=O)NCC(F)(F)[C@H](O)c1ccc(F)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H18F5N5O2/c1-11-15(21(35)30-10-23(27,28)20(34)12-2-4-14(24)5-3-12)9-16(19(26)18(11)25)13-6-7-33-17(8-13)31-22(29)32-33/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534567
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(c(F)c1C(=O)NC[C@@H](F)[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H20ClF2N5O2/c1-12-2-7-16(14-8-9-31-18(10-14)29-23(27)30-31)20(26)19(12)22(33)28-11-17(25)21(32)13-3-5-15(24)6-4-13/h2-10,17,21,32H,11H2,1H3,(H2,27,30)(H,28,33)/t17-,21-/m1/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534329
PNG
(WO2022086828, Example 56)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC[C@@H](O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N5O2/c1-13-2-7-17(15-9-11-33-19(12-15)31-23(29)32-33)21(25)20(13)22(35)30-10-8-18(34)14-3-5-16(6-4-14)24(26,27)28/h2-7,9,11-12,18,34H,8,10H2,1H3,(H2,29,32)(H,30,35)/t18-/m1/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534448
PNG
(WO2022086828, Example 184)
Show SMILES COc1ccc(cc1)[C@H](O)C(F)(F)CNC(=O)c1c(Cl)ccc(c1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H19ClF3N5O3/c1-35-14-4-2-12(3-5-14)20(33)23(26,27)11-29-21(34)18-16(24)7-6-15(19(18)25)13-8-9-32-17(10-13)30-22(28)31-32/h2-10,20,33H,11H2,1H3,(H2,28,31)(H,29,34)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534447
PNG
(WO2022086828, Example 183)
Show SMILES Cc1ccc([C@@H](O)C(F)(F)CNC(=O)c2c(Cl)ccc(c2F)-c2ccn3nc(N)nc3c2)c(F)c1
Show InChI InChI=1S/C23H18ClF4N5O2/c1-11-2-3-14(16(25)8-11)20(34)23(27,28)10-30-21(35)18-15(24)5-4-13(19(18)26)12-6-7-33-17(9-12)31-22(29)32-33/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534288
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(c(F)c1C(=O)NCCC1(CC1)c1ccc(F)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C25H23F2N5O/c1-15-2-7-19(16-8-13-32-20(14-16)30-24(28)31-32)22(27)21(15)23(33)29-12-11-25(9-10-25)17-3-5-18(26)6-4-17/h2-8,13-14H,9-12H2,1H3,(H2,28,31)(H,29,33)
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534579
PNG
((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(c(C(=O)NCC(F)(F)[C@@H](O)c2ccc(F)cc2)c1F)C(F)(F)F
Show InChI InChI=1S/C23H16F7N5O2/c24-13-3-1-11(2-4-13)19(36)22(26,27)10-32-20(37)17-15(23(28,29)30)6-5-14(18(17)25)12-7-8-35-16(9-12)33-21(31)34-35/h1-9,19,36H,10H2,(H2,31,34)(H,32,37)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534480
PNG
(WO2022086828, Example 216)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC[C@@H](F)[C@@](C)(O)c1ccc(F)cc1
Show InChI InChI=1S/C24H22F3N5O2/c1-13-3-8-17(14-9-10-32-19(11-14)30-23(28)31-32)21(27)20(13)22(33)29-12-18(26)24(2,34)15-4-6-16(25)7-5-15/h3-11,18,34H,12H2,1-2H3,(H2,28,31)(H,29,33)/t18-,24+/m1/s1
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WIPO WO2022086828
n/an/a 0.400n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534399
PNG
(WO2022086828, Example 135)
Show SMILES COc1c(ccn2nc(N)nc12)-c1ccc(C)c(C(=O)NCC(F)(F)[C@@H](O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C24H21F4N5O3/c1-12-3-8-15(16-9-10-33-21(19(16)36-2)31-23(29)32-33)18(26)17(12)22(35)30-11-24(27,28)20(34)13-4-6-14(25)7-5-13/h3-10,20,34H,11H2,1-2H3,(H2,29,32)(H,30,35)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534302
PNG
(WO2022086828, Example 30)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC(F)(F)[C@@H](O)c1ccc(F)cc1
Show InChI InChI=1S/C23H19F4N5O2/c1-12-2-7-16(14-8-9-32-17(10-14)30-22(28)31-32)19(25)18(12)21(34)29-11-23(26,27)20(33)13-3-5-15(24)6-4-13/h2-10,20,33H,11H2,1H3,(H2,28,31)(H,29,34)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534358
PNG
(WO2022086828, Example 85)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC[C@@H](O)c2ccc(cc2)C(F)(F)F)c1F
Show InChI InChI=1S/C23H18ClF4N5O2/c24-16-6-5-15(13-8-10-33-18(11-13)31-22(29)32-33)20(25)19(16)21(35)30-9-7-17(34)12-1-3-14(4-2-12)23(26,27)28/h1-6,8,10-11,17,34H,7,9H2,(H2,29,32)(H,30,35)/t17-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534378
PNG
(5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1c(F)c(F)c(cc1C(=O)NCC(F)(F)[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H18ClF4N5O2/c1-11-15(21(35)30-10-23(27,28)20(34)12-2-4-14(24)5-3-12)9-16(19(26)18(11)25)13-6-7-33-17(8-13)31-22(29)32-33/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534326
PNG
(WO2018148626, Example 152 | WO2022086828, Example ...)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC[C@@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H21ClFN5O2/c1-13-2-7-17(15-9-11-30-19(12-15)28-23(26)29-30)21(25)20(13)22(32)27-10-8-18(31)14-3-5-16(24)6-4-14/h2-7,9,11-12,18,31H,8,10H2,1H3,(H2,26,29)(H,27,32)/t18-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534562
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyri din-7-y...)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NC[C@@H](F)[C@@H](O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C22H17ClF3N5O2/c23-15-6-5-14(12-7-8-31-17(9-12)29-22(27)30-31)19(26)18(15)21(33)28-10-16(25)20(32)11-1-3-13(24)4-2-11/h1-9,16,20,32H,10H2,(H2,27,30)(H,28,33)/t16-,20+/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534379
PNG
(5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1c(F)c(F)c(cc1C(=O)NCC(F)(F)[C@@H](O)c1ccc(F)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H18F5N5O2/c1-11-15(21(35)30-10-23(27,28)20(34)12-2-4-14(24)5-3-12)9-16(19(26)18(11)25)13-6-7-33-17(8-13)31-22(29)32-33/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534547
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC(F)(F)[C@@H](O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C23H17F6N5O2/c1-10-2-3-13(11-4-5-34-16(6-11)32-22(30)33-34)19(27)17(10)21(36)31-9-23(28,29)20(35)18-14(25)7-12(24)8-15(18)26/h2-8,20,35H,9H2,1H3,(H2,30,33)(H,31,36)/t20-/m0/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534326
PNG
(WO2018148626, Example 152 | WO2022086828, Example ...)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC[C@@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H21ClFN5O2/c1-13-2-7-17(15-9-11-30-19(12-15)28-23(26)29-30)21(25)20(13)22(32)27-10-8-18(31)14-3-5-16(24)6-4-14/h2-7,9,11-12,18,31H,8,10H2,1H3,(H2,26,29)(H,27,32)/t18-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534497
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES CO[C@@H](c1ccc(F)cc1)C(F)(F)CNC(=O)c1c(C)ccc(c1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H21F4N5O2/c1-13-3-8-17(15-9-10-33-18(11-15)31-23(29)32-33)20(26)19(13)22(34)30-12-24(27,28)21(35-2)14-4-6-16(25)7-5-14/h3-11,21H,12H2,1-2H3,(H2,29,32)(H,30,34)/t21-/m0/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534554
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC[C@@H](O)C(F)(F)c1ccc(F)cc1
Show InChI InChI=1S/C23H19F4N5O2/c1-12-2-7-16(13-8-9-32-18(10-13)30-22(28)31-32)20(25)19(12)21(34)29-11-17(33)23(26,27)14-3-5-15(24)6-4-14/h2-10,17,33H,11H2,1H3,(H2,28,31)(H,29,34)/t17-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534554
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC[C@@H](O)C(F)(F)c1ccc(F)cc1
Show InChI InChI=1S/C23H19F4N5O2/c1-12-2-7-16(13-8-9-32-18(10-13)30-22(28)31-32)20(25)19(12)21(34)29-11-17(33)23(26,27)14-3-5-15(24)6-4-14/h2-10,17,33H,11H2,1H3,(H2,28,31)(H,29,34)/t17-/m1/s1
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WIPO WO2022086828
n/an/a 0.5n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534285
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC[C@@H](c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N5O/c1-14-7-8-17(16-10-12-33-19(13-16)31-23(29)32-33)21(25)20(14)22(34)30-11-9-18(24(26,27)28)15-5-3-2-4-6-15/h2-8,10,12-13,18H,9,11H2,1H3,(H2,29,32)(H,30,34)/t18-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534471
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCC(F)(F)Cc2ccc(F)cc2)c1F
Show InChI InChI=1S/C22H16ClF4N5O/c23-16-6-5-15(13-7-8-32-17(9-13)30-21(28)31-32)19(25)18(16)20(33)29-11-22(26,27)10-12-1-3-14(24)4-2-12/h1-9H,10-11H2,(H2,28,31)(H,29,33)
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534569
PNG
(WO2022086828, Example 305)
Show SMILES Nc1nc2cc(ccn2n1)-c1ccc(C2CC2)c(C(=O)NCC(F)(F)[C@H](O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C25H21F4N5O2/c26-16-5-3-14(4-6-16)22(35)25(28,29)12-31-23(36)20-17(13-1-2-13)7-8-18(21(20)27)15-9-10-34-19(11-15)32-24(30)33-34/h3-11,13,22,35H,1-2,12H2,(H2,30,33)(H,31,36)/t22-/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534404
PNG
(WO2022086828, Example 140)
Show SMILES Cc1ccc(c(F)c1C(=O)NCCC(O)c1cccc(c1)C#N)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H21FN6O2/c1-14-5-6-18(16-8-10-31-20(12-16)29-24(27)30-31)22(25)21(14)23(33)28-9-7-19(32)17-4-2-3-15(11-17)13-26/h2-6,8,10-12,19,32H,7,9H2,1H3,(H2,27,30)(H,28,33)
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534410
PNG
((S)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Show SMILES Cc1cc(C)c(cc1C(=O)NCC[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H24ClN5O2/c1-14-11-15(2)20(13-19(14)17-8-10-30-22(12-17)28-24(26)29-30)23(32)27-9-7-21(31)16-3-5-18(25)6-4-16/h3-6,8,10-13,21,31H,7,9H2,1-2H3,(H2,26,29)(H,27,32)/t21-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534497
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES CO[C@@H](c1ccc(F)cc1)C(F)(F)CNC(=O)c1c(C)ccc(c1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H21F4N5O2/c1-13-3-8-17(15-9-10-33-18(11-15)31-23(29)32-33)20(26)19(13)22(34)30-12-24(27,28)21(35-2)14-4-6-16(25)7-5-14/h3-11,21H,12H2,1-2H3,(H2,29,32)(H,30,34)/t21-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534564
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(c(F)c1C(=O)NC[C@@H](F)[C@@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H20ClF2N5O2/c1-12-2-7-16(14-8-9-31-18(10-14)29-23(27)30-31)20(26)19(12)22(33)28-11-17(25)21(32)13-3-5-15(24)6-4-13/h2-10,17,21,32H,11H2,1H3,(H2,27,30)(H,28,33)/t17-,21+/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534275
PNG
(WO2022086828, Example 3)
Show SMILES Cc1cc(F)c(cc1C(=O)NCC[C@@H](O)c1ccc(cc1)C(F)(F)F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H21F4N5O2/c1-13-10-19(25)18(15-7-9-33-21(11-15)31-23(29)32-33)12-17(13)22(35)30-8-6-20(34)14-2-4-16(5-3-14)24(26,27)28/h2-5,7,9-12,20,34H,6,8H2,1H3,(H2,29,32)(H,30,35)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534341
PNG
(WO2022086828, Example 68)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC[C@@H](O)c1ccc(Cl)cc1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H20ClF2N5O2/c1-12-2-4-15(13-7-9-31-19(10-13)29-23(27)30-31)21(26)20(12)22(33)28-8-6-18(32)16-5-3-14(24)11-17(16)25/h2-5,7,9-11,18,32H,6,8H2,1H3,(H2,27,30)(H,28,33)/t18-/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534463
PNG
(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Show SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC(F)(F)[C@H](O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H18F5N5O2/c1-11-2-4-14(12-6-7-33-17(9-12)31-22(29)32-33)19(26)18(11)21(35)30-10-23(27,28)20(34)13-3-5-15(24)16(25)8-13/h2-9,20,34H,10H2,1H3,(H2,29,32)(H,30,35)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534410
PNG
((S)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Show SMILES Cc1cc(C)c(cc1C(=O)NCC[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H24ClN5O2/c1-14-11-15(2)20(13-19(14)17-8-10-30-22(12-17)28-24(26)29-30)23(32)27-9-7-21(31)16-3-5-18(25)6-4-16/h3-6,8,10-13,21,31H,7,9H2,1-2H3,(H2,26,29)(H,27,32)/t21-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534342
PNG
(WO2022086828, Example 69)
Show SMILES Cc1ccc(c(F)c1C(=O)NCC[C@H](O)c1ccc(Cl)cc1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H20ClF2N5O2/c1-12-2-4-15(13-7-9-31-19(10-13)29-23(27)30-31)21(26)20(12)22(33)28-8-6-18(32)16-5-3-14(24)11-17(16)25/h2-5,7,9-11,18,32H,6,8H2,1H3,(H2,27,30)(H,28,33)/t18-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM534419
PNG
((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Show SMILES CCc1ccc(c(F)c1C(=O)NCC[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C24H23ClFN5O2/c1-2-14-5-8-18(16-10-12-31-20(13-16)29-24(27)30-31)22(26)21(14)23(33)28-11-9-19(32)15-3-6-17(25)7-4-15/h3-8,10,12-13,19,32H,2,9,11H2,1H3,(H2,27,30)(H,28,33)/t19-/m0/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
Mixed lineage kinase domain-like protein


(Homo sapiens)
BDBM534449
PNG
(WO2022086828, Example 185)
Show SMILES COc1ccc(cc1)[C@@H](O)C(F)(F)CNC(=O)c1c(Cl)ccc(c1F)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C23H19ClF3N5O3/c1-35-14-4-2-12(3-5-14)20(33)23(26,27)11-29-21(34)18-16(24)7-6-15(19(18)25)13-8-9-32-17(10-13)30-22(28)31-32/h2-10,20,33H,11H2,1H3,(H2,28,31)(H,29,34)/t20-/m1/s1
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WIPO WO2022086828
n/an/a 0.600n/an/an/an/an/an/a



BRISTOL-MYERS SQUIBB COMPANY

WIPO


Assay Description
HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...


WIPO WO2022086828 (2022)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%