Found 27 Enz. Inhib. hit(s) for PDB: 1D3H TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataKi: 30nM IC50: 260nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
3D Structure (crystal)TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataKi: 32nM IC50: 261nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in ratMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of dihydroorotate dehydrogenase in Wistar rat liver mitochondrial/microsomal membranes measured for 5 mins by 2,6-dichlorophenolindophenol...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of rat dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 64nMpH: 8.0Assay Description:Recombinant human DHODH (final enzyme concentration between 20 and 60 nM in the assay well) were incubated at 37 °C in 50 mM Tris-HCl, 0.1% Triton X-...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel
Curated by ChEMBL
Hoechst Marion Roussel
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 130nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli BL21(DE3) using L-dihydroorotate as substrate after 10 mins by DCIP dye reduction assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 137nMAssay Description:Inhibition of N-terminal His10-tagged human DHODH (Met30 to Arg396) expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate measur...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel
Curated by ChEMBL
Hoechst Marion Roussel
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel
Curated by ChEMBL
Hoechst Marion Roussel
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 163nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate by DCIP assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 200nMAssay Description:Immunosuppressive activity of the compound expressed as ability to inhibit human recombinant dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 210nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 230nMAssay Description:Spectrophotometric assay using crude human, recombinant DHODHase.More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 356nMAssay Description:Inhibition of human DHODH assessed as decrease in DCIP using dihydroorotate as substrate measured every 30 seconds for 6 minsMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 388nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 420nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 435nMAssay Description:In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 440nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds
University Of Leeds
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
