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Found 9 Enz. Inhib. hit(s) for PDB: 1N4K
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataIC50:  300nMAssay Description:Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cellsMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  24.8nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat IP3R1 expressed in chicken DT40 cells assessed as induction of Ca2+ releaseMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  2.32nMAssay Description:Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  0.210nMAssay Description:Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding ...More data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataEC50:  24.8nMAssay Description:Activity at rat IP3 type 1 receptor expressed in DT40 cell assessed as calcium ion mobilizationMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  260nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 1(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  12.5nMAssay Description:Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair