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Found 4 Enz. Inhib. hit(s) for PDB: 1RKP
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [535-860](Homo sapiens (Human))
University Of North Carolina At Chapel Hill

LigandPNGBDBM15336(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Affinity DataIC50:  2.10E+3nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875](Homo sapiens (Human))
University Of North Carolina At Chapel Hill

LigandPNGBDBM15336(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Affinity DataIC50:  5.30E+3nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Institute Of Pharmaceutical Chemistry

Curated by ChEMBL
LigandPNGBDBM15336(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of PDE5 from plateletsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875](Homo sapiens (Human))
University Of North Carolina At Chapel Hill

LigandPNGBDBM15336(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Affinity DataIC50:  9.50E+4nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair