Compile Data Set for Download or QSAR
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Found 4 Enz. Inhib. hit(s) for PDB: 2AFX
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7887(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Affinity DataKi:  262nM ΔG°:  -37.6kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7887(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Affinity DataKi:  607nM ΔG°:  -35.5kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Mus musculus (mouse))
Probiodrug

LigandPNGBDBM7887(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Affinity DataKi:  6.40E+3nM ΔG°:  -30.1kJ/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7887(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Affinity DataKi:  7.00E+3nM ΔG°:  -29.9kJ/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair