Compile Data Set for Download or QSAR
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Found 17 Enz. Inhib. hit(s) for PDB: 2AZ5
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR2 extracellular domain preincubated for 1...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataIC50:  1.30E+3nMAssay Description:Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR1 extracellular domain preincubated for 1...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of TNF-alpha (unknown origin) binding to TNFR1 by ELISAMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  9.77E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  8.30E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  6.18E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  8.44E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to TNFMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  7.51E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  7.34E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.36E+3nMpH: 6.5Assay Description:Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assayMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  3.81nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  1.18E+4nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solventMore data for this Ligand-Target Pair
TargetTumor necrosis factor(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50373071(CHEMBL255489)
Affinity DataKd:  5.75E+3nMAssay Description:Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solventMore data for this Ligand-Target Pair