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Found 5 Enz. Inhib. hit(s) for PDB: 2VA7
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  640nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair