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Found 2 Enz. Inhib. hit(s) for PDB: 3BGZ
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataKi:  550nM ΔG°:  -36.3kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed