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Found 3 Enz. Inhib. hit(s) for PDB: 3GOK
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  8.5nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 minsMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataEC50:  49nMAssay Description:Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assayMore data for this Ligand-Target Pair