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Found 6 Enz. Inhib. hit(s) for PDB: 4F2W
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate assessed as inhibition...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0480nM ΔG°:  -58.3kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase co...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0730nM ΔG°:  -57.9kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Klebsiella pneumoniae)
Albert Einstein College Of Medicine

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKd:  0.784nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKd:  0.00200nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair