Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50327809![]() (1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay | J Med Chem 57: 7016-30 (2014) Article DOI: 10.1021/jm500694p BindingDB Entry DOI: 10.7270/Q2FJ2JJQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50327809![]() (1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eicosis, LLC US Patent | Assay Description FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-... | US Patent US10377744 (2019) BindingDB Entry DOI: 10.7270/Q2N3009K | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50327809![]() (1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carb... | Bioorg Med Chem Lett 23: 3732-7 (2013) Article DOI: 10.1016/j.bmcl.2013.05.011 BindingDB Entry DOI: 10.7270/Q2057HBP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50327809![]() (1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | 7.0 | n/a |
The Regents of the University of California US Patent | Assay Description IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-... | US Patent US9296693 (2016) BindingDB Entry DOI: 10.7270/Q2TX3D7M | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50327809![]() (1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Entomology and University of California Davis Cancer Center Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay | J Med Chem 53: 7067-75 (2010) Article DOI: 10.1021/jm100691c BindingDB Entry DOI: 10.7270/Q2GH9J6V | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |