Found 8 Enz. Inhib. hit(s) for PDB: 4OTJ TargetProstaglandin G/H synthase 2 [18-604,R106Q](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 90nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
3D Structure (crystal)TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 290nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 290nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 295nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [18-604,V509I](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 1.10E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [18-604,S516A](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: 1.50E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [18-504,V335L](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: >4.00E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [18-604,Y541F](Mus musculus (Mouse))
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Vanderbilt Institute Of Chemical Biology, Vanderbilt University School Of Medicine
Affinity DataIC50: >4.00E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
