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Found 4 Enz. Inhib. hit(s) for PDB: 4YK0
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  2.13E+3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human His-FLAG tagged CBP/EP300 (1082 to 1197 residues) using H4-TetraAc-biotin peptide as substrate after 90 mins by AlphaLISA methodMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  2.70E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50178217(CHEMBL2142704)
Affinity DataIC50:  3.20E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair