Compile Data Set for Download or QSAR
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Found 12 Enz. Inhib. hit(s) with all data for entry = 50009216
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50:  0.240nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081415((S)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methyl-5-...)
Affinity DataIC50:  0.280nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50:  0.340nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081413((R)-7-(3,5-Bis-trifluoromethyl-benzyl)-5-p-tolyl-8...)
Affinity DataIC50:  0.380nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081414(7-(3,5-Bis-trifluoromethyl-benzyl)-5-p-tolyl-7,8,9...)
Affinity DataIC50:  0.850nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081412(7-(3,5-Bis-trifluoromethyl-benzyl)-5-p-tolyl-7,8,9...)
Affinity DataIC50:  1.80nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081417(6-(3,5-Bis-trifluoromethyl-benzyl)-10-p-tolyl-7,8-...)
Affinity DataIC50:  2.30nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50:  4.20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50:  4.20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081419((R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methyl-5-...)
Affinity DataIC50:  9.5nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081420((7R,9R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methy...)
Affinity DataIC50:  20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50081411((7R,9S)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methy...)
Affinity DataIC50:  340nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed