Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 50009405
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]-Tyr14-nociceptinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of [125I]Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50:  5.90nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]-Tyr14-nociceptinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of [125I]-Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of [125I]-Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataIC50:  12nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataIC50:  20nMAssay Description:Antagonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataIC50:  20nMAssay Description:Antagonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50:  32nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50:  43nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataIC50:  110nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataIC50:  200nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]-Tyr14-nociceptinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataIC50:  440nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataIC50:  780nMAssay Description:Inhibition of [3H]-diprenorphine binding to human Opioid receptor mu 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  820nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]-Tyr14-nociceptinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataIC50:  950nMAssay Description:Inhibition of [3H]-diprenorphine binding to human Opioid receptor mu 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  1.40E+3nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataIC50:  1.70E+3nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50:  1.90E+3nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  2.20E+3nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  2.60E+3nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  3.30E+3nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [125I]Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H][D-Ala2,D-Leu5]enkephalin binding to human Opioid receptor delta 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H][D-Ala2,D-Leu5]enkephalin binding to human Opioid receptor delta 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083227(1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataEC50:  25nMAssay Description:Agonistic activity of the compound against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083229(1-((3S,4S)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity of the compound against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083232(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083231(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137562(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimida...)
Affinity DataEC50:  6.90E+3nMAssay Description:Agonistic activity of the compound against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity of the compound against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed