Compile Data Set for Download or QSAR
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Found 35 Enz. Inhib. hit(s) with all data for entry = 50009639
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085962((Z)[2-(3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50:  120nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085944(CHEMBL6518 | [2-(3-{3-[5-Methyl-2-(4-trifluorometh...)
Affinity DataIC50:  160nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085948(2-(3-{3-[5-Phenyl-2-(4-trifluoromethyl-phenyl)-oxa...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085943(2-(3-{3-[5-Phenyl-2-(4-trifluoromethyl-phenyl)-oxa...)
Affinity DataIC50:  370nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085938(2-{3-[3-(3,5-Dichloro-benzyloxy)-phenyl]-hept-2-en...)
Affinity DataIC50:  800nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085954(CHEMBL203751 | [2-(3-{3-[5-Methyl-2-(4-trifluorome...)
Affinity DataIC50:  850nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085965(2-{3-[3-(2-Butyl-benzofuran-3-ylmethyl)-phenyl]-bu...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085947((2-{3-[3-(3,5-Dichloro-phenoxy)-phenyl]-hept-2-eny...)
Affinity DataIC50:  1.30E+3nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085942(2-{(E)-3-[3-(3,5-Dichloro-phenoxy)-phenyl]-hept-2-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085956(2-[3-(4-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085938(2-{3-[3-(3,5-Dichloro-benzyloxy)-phenyl]-hept-2-en...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of PTPase activity using recombinant Protein-tyrosine phosphatase 1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085941(2-[3-(3-Phenoxy-phenyl)-hept-2-enyl]-[1,2,4]oxadia...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085961(2-{3-[3-(2-Butyl-benzofuran-3-ylmethoxy)-phenyl]-b...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085967(2-{3-[3-(5-Phenyl-[1,2,4]oxadiazol-3-ylmethoxy)-ph...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085958(2-(3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085960(2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-benzyloxy)-ph...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085953(2-{(E)-3-[3-(Pyridin-2-ylmethoxy)-phenyl]-but-2-en...)
Affinity DataIC50:  9.00E+3nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzyme at a concentration 2.5 uM .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085952(2-{3-[3-(4-Methoxy-phenoxy)-phenyl]-hept-2-enyl}-[...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085963(2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-phenoxymethyl...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085945(1-(3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085939(2-[3-(3-p-Tolyloxy-phenyl)-hept-2-enyl]-[1,2,4]oxa...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085968(5-(3-{3-[5-Methyl-2-(4-trifluoromethoxy-phenyl)-ox...)
Affinity DataIC50:  1.30E+4nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085955(2-{3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085949(2-(3-{3-[2-(4-Trifluoromethyl-phenyl)-oxazol-4-ylm...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085942(2-{(E)-3-[3-(3,5-Dichloro-phenoxy)-phenyl]-hept-2-...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085959(2-(3-{3-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085950(2-(4,4-Dimethyl-3-{3-[5-methyl-2-(4-trifluoromethy...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085969(2-(3-{3-[3-(3,5-Bis-trifluoromethyl-phenyl)-prop-2...)
Affinity DataIC50:  2.50E+4nMAssay Description:Concentration required to inhibit PTPase activity, recombinant r-PTP1B as the enzyme at a concentration 2.5 uM .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085946(2-(3-(4-Chloro-phenyl)-3-{3-[5-methyl-2-(4-trifluo...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085966(2-(3-(4-Fluoro-phenyl)-3-{3-[5-methyl-2-(4-trifluo...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085961(2-{3-[3-(2-Butyl-benzofuran-3-ylmethoxy)-phenyl]-b...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085957(2-(3-{2-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxa...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085964(5-(3-{3-[5-Methyl-2-(4-trifluoromethoxy-phenyl)-ox...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of PTPase activity using recombinant r-PTP1B as the enzyme and IR-triphosphopeptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085951((2-{3-[3-(3,5-Dichloro-benzyloxy)-phenyl]-hept-2-e...)
Affinity DataIC50:  4.80E+4nMAssay Description:Concentration required to inhibit PTPase activity, recombinant Protein Tyrosine Phosphatase 1b as the enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50085940(2-(2-Methyl-3-{3-[5-methyl-2-(4-trifluoromethyl-ph...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of PTPase activity in rat hepatic membrane at a concentration of 50 uM using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed