Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 50010346
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093750((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093751((6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093749((6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulf...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093747((6R,7R)-7-(2-sec-Butoxy-benzoylamino)-7-methoxy-3-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093746((6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093734((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093748((6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulf...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093735((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration of the compound was measured against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093720((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  280nMAssay Description:Inhibitory concentration of the compound was measured against cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093730((6R,7R)-7-[2-(4-Dimethylamino-phenyl)-acetylamino]...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093727((6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration of the compound was measured against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory concentration of the compound was measured against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibitory concentration of the compound was measured against elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093745((6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of the compound was measured against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093732((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed