Found 3 Enz. Inhib. hit(s) with all data for entry = 2025 TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Janssen Research Foundation
Janssen Research Foundation
Affinity DataIC50: 0.860nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
3D Structure (crystal)TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Janssen Research Foundation
Janssen Research Foundation
Affinity DataIC50: 7.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Janssen Research Foundation
Janssen Research Foundation
Affinity DatapH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of GGTase-1 in vitro using purified human enzyme to catalyze the reaction between [3H] GGPP and a biotinylated pe...More data for this Ligand-Target Pair
