Compile Data Set for Download or QSAR
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Found 8 Enz. Inhib. hit(s) with all data for entry = 50036937
TargetBeta-secretase 1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100439(4-[2-(5-{2-[2-(2-Amino-3-carboxy-propionylamino)-3...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100440(4-(2-{5-[2-(2-Amino-3-methyl-butyrylamino)-3-carba...)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100436(CHEMBL412768 | NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of beta-secretase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100434(CHEMBL302004 | L-68458 | L-685458 | tert-butyl (2S...)
Affinity DataIC50:  300nMAssay Description:Inhibition of beta-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50369830(CHEMBL1790471)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100435(CHEMBL305152 | [1-(1-Formyl-butylcarbamoyl)-3-meth...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100438(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed