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Found 72 Enz. Inhib. hit(s) with all data for entry = 50011117
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102505(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4,5-t...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102506(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4-dim...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102520(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102503(2,4-Diamino-5-{3-[3-[2-benzoyloxy)ethyl]-3-benzyl-...)
Affinity DataIC50:  220nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102520(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058394(CHEMBL49246 | CHEMBL56311 | ethanesulfonic salt of...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102514(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,5-dim...)
Affinity DataIC50:  378nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102506(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4-dim...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102515(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-metho...)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102505(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4,5-t...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102518(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  620nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102519(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-methy...)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102510(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-pyrid...)
Affinity DataIC50:  640nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102507(2,4-Diamino-5-{3-[3-benzyl-3-[2-(isobutyryloxy)eth...)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102503(2,4-Diamino-5-{3-[3-[2-benzoyloxy)ethyl]-3-benzyl-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058401(2,4-Diamino-5-[4-chloro-3-[3-[2-(acetyloxy)ethyl]-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102502(2,4-Diamino-5-{3-[3-benzyl-3-[2-(propionyloxy)ethy...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102504(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-chlor...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102522(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-nitro...)
Affinity DataIC50:  830nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102509(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(2-methy...)
Affinity DataIC50:  830nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102514(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,5-dim...)
Affinity DataIC50:  845nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102499(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-nitro...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102518(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102501(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-chlor...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102523(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-fluor...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102501(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-chlor...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50131819(CHEMBL2115210)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102522(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-nitro...)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102516(2,4-Diamino-5-{3-[3-phenylethyl-3-(2-hydroxyethyl)...)
Affinity DataIC50:  1.79E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102504(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-chlor...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102508(2,4-Diamino-5-{3-[3-benzyl-3-(3-hydroxypropoyl)(tr...)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102510(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-pyrid...)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102515(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-metho...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102511(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-trifl...)
Affinity DataIC50:  2.54E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50131820(CHEMBL2114205)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102502(2,4-Diamino-5-{3-[3-benzyl-3-[2-(propionyloxy)ethy...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102499(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-nitro...)
Affinity DataIC50:  3.33E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102522(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-nitro...)
Affinity DataIC50:  3.69E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102507(2,4-Diamino-5-{3-[3-benzyl-3-[2-(isobutyryloxy)eth...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102500(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-fluor...)
Affinity DataIC50:  3.83E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102519(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-methy...)
Affinity DataIC50:  3.85E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102523(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-fluor...)
Affinity DataIC50:  3.87E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102508(2,4-Diamino-5-{3-[3-benzyl-3-(3-hydroxypropoyl)(tr...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102523(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3-fluor...)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102514(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,5-dim...)
Affinity DataIC50:  4.36E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102500(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-fluor...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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