Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50012481
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataIC50:  0.300nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119371(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataIC50:  0.5nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  0.600nMAssay Description:Evaluated for binding affinity against rat Melanocortin-4 receptor (rMC4R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  1.20nMAssay Description:Evaluated for binding affinity against human Melanocortin-4 receptor (hMC4R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119366((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataIC50:  1.20nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  1.20nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119373((2S)-2-amino-3-(1H-imidazol-4-yl)-N-[(2R)-1-{1-met...)
Affinity DataIC50:  108nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119369(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataIC50:  127nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119372((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...)
Affinity DataIC50:  238nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  326nMAssay Description:Evaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  761nMAssay Description:Evaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  1.58E+3nMAssay Description:Evaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  1.88E+3nMAssay Description:Evaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  2.07E+3nMAssay Description:Evaluated for binding affinity against human melanocortin 1 (hMC1R) receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119370(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataIC50:  3.05E+3nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  736nMAssay Description:Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.10nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  737nMAssay Description:Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119365((2S)-2-amino-3-(1H-imidazol-4-yl)-N-[(2R)-1-{1-met...)
Affinity DataEC50:  500nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119366((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataEC50:  9.60nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataEC50:  59nMAssay Description:Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataEC50:  0.600nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119366((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataEC50:  1.00E+3nMAssay Description:Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119371(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  8.70nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataEC50:  127nMAssay Description:Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.90nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-4 receptor (rMC4R)More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.10nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119371(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  271nMAssay Description:Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  1.33E+3nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50: >3.00E+3nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-5 receptor (rMC5R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.49E+3nMAssay Description:Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.49E+3nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119372((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...)
Affinity DataEC50:  771nMAssay Description:Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.85E+3nMAssay Description:Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC1R) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed