Compile Data Set for Download or QSAR
maximum 50k data
Found 13 Enz. Inhib. hit(s) with all data for entry = 50000219
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003059(2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...)
Affinity DataIC50:  1.70E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003059(2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...)
Affinity DataIC50: >4.00E+4nMAssay Description:Compound was evaluated for the inhibition of recombinant human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003059(2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...)
Affinity DataIC50: >4.00E+4nMAssay Description:Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003059(2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...)
Affinity DataIC50: >4.00E+4nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003059(2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...)
Affinity DataIC50: >4.00E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...)
Affinity DataIC50: >8.00E+4nMAssay Description:Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50:  9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR); no inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003058(2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed