Compile Data Set for Download or QSAR
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Found 22 Enz. Inhib. hit(s) with all data for entry = 50014429
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50026926(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142638(8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-pentyl]-8-a...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142640(8-{3-Hydroxy-4-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50:  12nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50026924(8-[4-(4-Phenyl-piperazin-1-yl)-butyl]-8-aza-spiro[...)
Affinity DataIC50:  15nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataIC50:  25nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142643(8-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  46nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50019422(2-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-isoi...)
Affinity DataIC50:  60nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142649(8-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  63nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142647(8-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-8...)
Affinity DataIC50:  64nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142639(8-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-3-hydrox...)
Affinity DataIC50:  69nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142648(1-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  87nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142642(8-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentyl}-...)
Affinity DataIC50:  99nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50005132(4,4-Dimethyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Affinity DataIC50:  114nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142650(1-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  205nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142636(2-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  210nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142644(2-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-...)
Affinity DataIC50:  440nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142641(8-[4-(2,3,5,6-Tetrahydro-[1,2']bipyrazinyl-4-yl)-b...)
Affinity DataIC50:  460nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142634(8-[3,3-Dimethyl-4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Affinity DataIC50:  710nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142637(8-[3-Hydroxy-4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataIC50:  840nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142635(8-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataIC50:  930nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142646(8-[3-Hydroxy-4-(2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50142645(8-[3-Hydroxy-3-methyl-4-(4-pyrimidin-2-yl-piperazi...)
Affinity DataIC50:  1.46E+3nMAssay Description:In vitro binding affinity of the compound against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in human CYP3A4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed