Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50000353
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004711(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  96nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455626(CHEMBL2112507)
Affinity DataKi:  310nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  350nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  350nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  370nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  370nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004715(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  440nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004713((R)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  620nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455626(CHEMBL2112507)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455624(CHEMBL2112500)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004722((R)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004711(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455624(CHEMBL2112500)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  9.40E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of of Bodipy-labelled cyclopamine binding to Smo expressed in COS-1 cells in presence of 20% NHS after 4 to 6 hrs by FACS flow cytometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004715(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  3.00E+4nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004710((2S,3S)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004710((2S,3S)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  4.50E+4nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004722((R)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004713((R)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004724(5-Methyl-1-phenyl-6-propoxy-1,5-dihydro-pyrazolo[3...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004720(6-Methoxy-5-methyl-1-phenyl-1,5-dihydro-pyrazolo[3...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004718(5,7-Dimethyl-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]p...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004723(5-Methyl-1-phenyl-7-propyl-1,7-dihydro-pyrazolo[3,...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed