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Found 15 Enz. Inhib. hit(s) with all data for entry = 50016040
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164198(3,9-difluoro-12-(6-fluoromethyl-3,4,5-trihydroxyte...)
Affinity DataEC50:  76.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50142927(12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahy...)
Affinity DataEC50:  38.4nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164202(2,3,9,10-tetrafluoro-13-(6-fluoromethyl-3,4,5-trih...)
Affinity DataEC50:  240nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50002738
Affinity DataEC50:  704nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164197(3,9-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxym...)
Affinity DataEC50:  17.6nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164196(3,9-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxym...)
Affinity DataEC50:  65.6nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164205(2,3,9,10-tetrafluoro-12-(5-fluoro-3,4-dihydroxy-6-...)
Affinity DataEC50:  120nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164203(2,10-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxy...)
Affinity DataEC50:  32nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164206(3,9-difluoro-13-(6-fluoromethyl-3,4,5-trihydroxyte...)
Affinity DataEC50:  67.2nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164201(12-(6-aminomethyl-5,5-difluoro-3,4-dihydroxytetrah...)
Affinity DataEC50:  8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164200(2,3,9,10-tetrafluoro-13-(5-fluoro-3,4-dihydroxy-6-...)
Affinity DataEC50:  6.40nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164204(13-(5,5-difluoro-3,4-dihydroxy-6-hydroxymethyltetr...)
Affinity DataEC50:  80nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164207(2,3,9,10-tetrafluoro-12-(6-fluoromethyl-3,4,5-trih...)
Affinity DataEC50:  480nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164195(12-(6-aminomethyl-5-fluoro-3,4-dihydroxytetrahydro...)
Affinity DataEC50:  11.2nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164199(3,9-difluoro-12-(5-fluoro-3,4,5-trihydroxy-6-hydro...)
Affinity DataEC50:  12.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed