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Found 9 Enz. Inhib. hit(s) with all data for entry = 2175
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17759((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Affinity DataIC50:  0.100nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17758((2R)-2-(phosphonomethyl)pentanedioic acid | (R)-2-...)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17754((2S)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50:  34nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17757((2S)-2-(3-sulfanylpropyl)pentanedioic acid | (S)-2...)
Affinity DataIC50:  67nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataIC50:  82nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17756((2R)-2-(3-sulfanylpropyl)pentanedioic acid | (R)-2...)
Affinity DataIC50:  85nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17753((2R)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed