Compile Data Set for Download or QSAR
maximum 50k data
Found 56 Enz. Inhib. hit(s) with all data for entry = 50016419
LigandPNGBDBM50168742((2R,3R)-3-Hydroxy-3-methyl-1-[4-(quinolin-8-ylmeth...)
Affinity DataIC50:  0.480nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168743((2R,3R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168758((2R,3S)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168738((2R,3R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168752((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-benzylox...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168756((2R,3R)-3-Hydroxy-1-[4-(isoquinolin-8-ylmethoxy)-b...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168741((2R,3R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168747((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-pyridin-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against MMP-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168749((2R,3R)-1-[4-(2-Chloro-pyridin-4-ylmethoxy)-benzen...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168754((2R,3R)-3-Hydroxy-3-methyl-1-[4-(pyridin-4-ylmetho...)
Affinity DataIC50:  7.10nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168745(CHEMBL183474 | i(2R,3R)-1-[4-(2-Chloro-benzyloxy)-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against TNF-alpha releasein LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168743((2R,3R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168755((2R,3S)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against MMP-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168744((2R,3R)-3-Hydroxy-1-[4-(2-methoxy-benzyloxy)-benze...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168741((2R,3R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168739((2R,3R)-1-[4-(3-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168746((2R,3R)-1-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168751((2R,3R)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168740((2R,3S)-3-Butyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168753((2R,3R)-1-[4-(2-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  33nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168750((2R,3R)-3-Hydroxy-3-methyl-1-[4-(pyrazin-2-ylmetho...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168757((2R,3R)-1-[4-(4-Chloro-2-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  73nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  83nMAssay Description:Inhibitory concentration against MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168759((2R,3R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168742((2R,3R)-3-Hydroxy-3-methyl-1-[4-(quinolin-8-ylmeth...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168757((2R,3R)-1-[4-(4-Chloro-2-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168753((2R,3R)-1-[4-(2-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  180nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168754((2R,3R)-3-Hydroxy-3-methyl-1-[4-(pyridin-4-ylmetho...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168741((2R,3R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  220nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168745(CHEMBL183474 | i(2R,3R)-1-[4-(2-Chloro-benzyloxy)-...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168752((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-benzylox...)
Affinity DataIC50:  310nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  310nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168739((2R,3R)-1-[4-(3-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  340nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  420nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  420nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168751((2R,3R)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168749((2R,3R)-1-[4-(2-Chloro-pyridin-4-ylmethoxy)-benzen...)
Affinity DataIC50:  520nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168738((2R,3R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168746((2R,3R)-1-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  860nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168755((2R,3S)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168758((2R,3S)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168743((2R,3R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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