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PubMed code 16275072

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 15n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 22n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 32n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 54n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9505
PNG
(N-(Aryl)-thiazole-5-carboxamide 17 | N-[4-(chlorod...)
Show SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H14ClF2N3O2S/c19-18(20,21)26-14-4-2-13(3-5-14)24-17(25)16-15(23-11-27-16)6-1-12-7-9-22-10-8-12/h2-5,7-11H,1,6H2,(H,24,25)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9497
PNG
(N-(4-tert-butylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H23N3OS/c1-21(2,3)16-5-7-17(8-6-16)24-20(25)19-18(23-14-26-19)9-4-15-10-12-22-13-11-15/h5-8,10-14H,4,9H2,1-3H3,(H,24,25)
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n/an/a 110n/an/an/an/a7.522



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9492
PNG
(N-(4-chlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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n/an/a 130n/an/an/an/a7.522



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9501
PNG
(N-(Aryl)-thiazole-5-carboxamide 15 | N-[4-(propan-...)
Show SMILES CC(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C20H21N3OS/c1-14(2)16-4-6-17(7-5-16)23-20(24)19-18(22-13-25-19)8-3-15-9-11-21-12-10-15/h4-7,9-14H,3,8H2,1-2H3,(H,23,24)
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n/an/a 140n/an/an/an/a7.522



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9513
PNG
(N-(3,4-dichlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3OS/c18-13-3-2-12(9-14(13)19)22-17(23)16-15(21-10-24-16)4-1-11-5-7-20-8-6-11/h2-3,5-10H,1,4H2,(H,22,23)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9515
PNG
(N-(Aryl)-thiazole-5-carboxamide 27 | N-[4-chloro-3...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2scnc2CCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C18H13ClF3N3OS/c19-14-3-2-12(9-13(14)18(20,21)22)25-17(26)16-15(24-10-27-16)4-1-11-5-7-23-8-6-11/h2-3,5-10H,1,4H2,(H,25,26)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9517
PNG
(N-(2-fluoro-4-methylphenyl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES Cc1ccc(NC(=O)c2scnc2CCc2ccncc2)c(F)c1
Show InChI InChI=1S/C18H16FN3OS/c1-12-2-4-15(14(19)10-12)22-18(23)17-16(21-11-24-17)5-3-13-6-8-20-9-7-13/h2,4,6-11H,3,5H2,1H3,(H,22,23)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9492
PNG
(N-(4-chlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9518
PNG
(N-(2H-1,3-benzodioxol-5-yl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES O=C(Nc1ccc2OCOc2c1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C18H15N3O3S/c22-18(21-13-2-4-15-16(9-13)24-11-23-15)17-14(20-10-25-17)3-1-12-5-7-19-8-6-12/h2,4-10H,1,3,11H2,(H,21,22)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9507
PNG
(N-(3-methylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Cc1cccc(NC(=O)c2scnc2CCc2ccncc2)c1
Show InChI InChI=1S/C18H17N3OS/c1-13-3-2-4-15(11-13)21-18(22)17-16(20-12-23-17)6-5-14-7-9-19-10-8-14/h2-4,7-12H,5-6H2,1H3,(H,21,22)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9513
PNG
(N-(3,4-dichlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3OS/c18-13-3-2-12(9-14(13)19)22-17(23)16-15(21-10-24-16)4-1-11-5-7-20-8-6-11/h2-3,5-10H,1,4H2,(H,22,23)
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n/an/a 590n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9517
PNG
(N-(2-fluoro-4-methylphenyl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES Cc1ccc(NC(=O)c2scnc2CCc2ccncc2)c(F)c1
Show InChI InChI=1S/C18H16FN3OS/c1-12-2-4-15(14(19)10-12)22-18(23)17-16(21-11-24-17)5-3-13-6-8-20-9-7-13/h2,4,6-11H,3,5H2,1H3,(H,22,23)
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n/an/a 630n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9511
PNG
(N-(Aryl)-thiazole-5-carboxamide 23 | N-[4-(morphol...)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C21H22N4O2S/c26-21(20-19(23-15-28-20)6-1-16-7-9-22-10-8-16)24-17-2-4-18(5-3-17)25-11-13-27-14-12-25/h2-5,7-10,15H,1,6,11-14H2,(H,24,26)
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n/an/a 710n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9515
PNG
(N-(Aryl)-thiazole-5-carboxamide 27 | N-[4-chloro-3...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2scnc2CCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C18H13ClF3N3OS/c19-14-3-2-12(9-13(14)18(20,21)22)25-17(26)16-15(24-10-27-16)4-1-11-5-7-23-8-6-11/h2-3,5-10H,1,4H2,(H,25,26)
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n/an/a 720n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9497
PNG
(N-(4-tert-butylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H23N3OS/c1-21(2,3)16-5-7-17(8-6-16)24-20(25)19-18(23-14-26-19)9-4-15-10-12-22-13-11-15/h5-8,10-14H,4,9H2,1-3H3,(H,24,25)
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n/an/a 720n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9518
PNG
(N-(2H-1,3-benzodioxol-5-yl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES O=C(Nc1ccc2OCOc2c1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C18H15N3O3S/c22-18(21-13-2-4-15-16(9-13)24-11-23-15)17-14(20-10-25-17)3-1-12-5-7-19-8-6-12/h2,4-10H,1,3,11H2,(H,21,22)
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n/an/a 750n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9505
PNG
(N-(Aryl)-thiazole-5-carboxamide 17 | N-[4-(chlorod...)
Show SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H14ClF2N3O2S/c19-18(20,21)26-14-4-2-13(3-5-14)24-17(25)16-15(23-11-27-16)6-1-12-7-9-22-10-8-12/h2-5,7-11H,1,6H2,(H,24,25)
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n/an/a 760n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9501
PNG
(N-(Aryl)-thiazole-5-carboxamide 15 | N-[4-(propan-...)
Show SMILES CC(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C20H21N3OS/c1-14(2)16-4-6-17(7-5-16)23-20(24)19-18(22-13-25-19)8-3-15-9-11-21-12-10-15/h4-7,9-14H,3,8H2,1-2H3,(H,23,24)
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n/an/a 840n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9519
PNG
(N-(4-bromophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-th...)
Show SMILES Brc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14BrN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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n/an/a 860n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9520
PNG
(N-(4-phenylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C23H19N3OS/c27-23(22-21(25-16-28-22)11-6-17-12-14-24-15-13-17)26-20-9-7-19(8-10-20)18-4-2-1-3-5-18/h1-5,7-10,12-16H,6,11H2,(H,26,27)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9512
PNG
(N-(3,4-dichlorophenyl)-4-[2-(1,2-oxazol-4-yl)ethyl...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1Cl
Show InChI InChI=1S/C15H11Cl2N3O2S/c16-11-3-2-10(5-12(11)17)20-15(21)14-13(18-8-23-14)4-1-9-6-19-22-7-9/h2-3,5-8H,1,4H2,(H,20,21)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9495
PNG
(N-(4-tert-butylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C19H21N3O2S/c1-19(2,3)14-5-7-15(8-6-14)22-18(23)17-16(20-12-25-17)9-4-13-10-21-24-11-13/h5-8,10-12H,4,9H2,1-3H3,(H,22,23)
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n/an/a 1.45E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9500
PNG
(4-[2-(1,2-oxazol-4-yl)ethyl]-N-[4-(propan-2-yl)phe...)
Show SMILES CC(C)c1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-12(2)14-4-6-15(7-5-14)21-18(22)17-16(19-11-24-17)8-3-13-9-20-23-10-13/h4-7,9-12H,3,8H2,1-2H3,(H,21,22)
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n/an/a 1.61E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9516
PNG
(N-(2-fluoro-4-methylphenyl)-4-[2-(1,2-oxazol-4-yl)...)
Show SMILES Cc1ccc(NC(=O)c2scnc2CCc2cnoc2)c(F)c1
Show InChI InChI=1S/C16H14FN3O2S/c1-10-2-4-13(12(17)6-10)20-16(21)15-14(18-9-23-15)5-3-11-7-19-22-8-11/h2,4,6-9H,3,5H2,1H3,(H,20,21)
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n/an/a 1.66E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9502
PNG
(N-(Aryl)-thiazole-5-carboxamide 16 | N-[4-(chlorod...)
Show SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C16H12ClF2N3O3S/c17-16(18,19)25-12-4-2-11(3-5-12)22-15(23)14-13(20-9-26-14)6-1-10-7-21-24-8-10/h2-5,7-9H,1,6H2,(H,22,23)
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n/an/a 1.77E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9490
PNG
(N-(4-chlorophenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C15H12ClN3O2S/c16-11-2-4-12(5-3-11)19-15(20)14-13(17-9-22-14)6-1-10-7-18-21-8-10/h2-5,7-9H,1,6H2,(H,19,20)
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n/an/a 1.85E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9521
PNG
(N-(4-phenoxyphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C23H19N3O2S/c27-23(22-21(25-16-29-22)11-6-17-12-14-24-15-13-17)26-18-7-9-20(10-8-18)28-19-4-2-1-3-5-19/h1-5,7-10,12-16H,6,11H2,(H,26,27)
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n/an/a 1.92E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9514
PNG
(N-(Aryl)-thiazole-5-carboxamide 26 | N-[4-chloro-3...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2scnc2CCc2cnoc2)ccc1Cl
Show InChI InChI=1S/C16H11ClF3N3O2S/c17-12-3-2-10(5-11(12)16(18,19)20)23-15(24)14-13(21-8-26-14)4-1-9-6-22-25-7-9/h2-3,5-8H,1,4H2,(H,23,24)
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n/an/a 2.12E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9511
PNG
(N-(Aryl)-thiazole-5-carboxamide 23 | N-[4-(morphol...)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C21H22N4O2S/c26-21(20-19(23-15-28-20)6-1-16-7-9-22-10-8-16)24-17-2-4-18(5-3-17)25-11-13-27-14-12-25/h2-5,7-10,15H,1,6,11-14H2,(H,24,26)
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n/an/a 2.33E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9498
PNG
(N-(4-tert-butylphenyl)-4-[2-(quinolin-4-yl)ethyl]-...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccnc3ccccc23)cc1
Show InChI InChI=1S/C25H25N3OS/c1-25(2,3)18-9-11-19(12-10-18)28-24(29)23-22(27-16-30-23)13-8-17-14-15-26-21-7-5-4-6-20(17)21/h4-7,9-12,14-16H,8,13H2,1-3H3,(H,28,29)
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n/an/a 2.51E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9516
PNG
(N-(2-fluoro-4-methylphenyl)-4-[2-(1,2-oxazol-4-yl)...)
Show SMILES Cc1ccc(NC(=O)c2scnc2CCc2cnoc2)c(F)c1
Show InChI InChI=1S/C16H14FN3O2S/c1-10-2-4-13(12(17)6-10)20-16(21)15-14(18-9-23-15)5-3-11-7-19-22-8-11/h2,4,6-9H,3,5H2,1H3,(H,20,21)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9493
PNG
(N-(4-chlorophenyl)-4-[2-(quinolin-4-yl)ethyl]-1,3-...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccnc3ccccc23)cc1
Show InChI InChI=1S/C21H16ClN3OS/c22-15-6-8-16(9-7-15)25-21(26)20-19(24-13-27-20)10-5-14-11-12-23-18-4-2-1-3-17(14)18/h1-4,6-9,11-13H,5,10H2,(H,25,26)
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n/an/a 3.38E+3n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9510
PNG
(N-(Aryl)-thiazole-5-carboxamide 22 | N-[4-(morphol...)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1)c1scnc1CCc1cnoc1
Show InChI InChI=1S/C19H20N4O3S/c24-19(18-17(20-13-27-18)6-1-14-11-21-26-12-14)22-15-2-4-16(5-3-15)23-7-9-25-10-8-23/h2-5,11-13H,1,6-10H2,(H,22,24)
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n/an/a 3.68E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9519
PNG
(N-(4-bromophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-th...)
Show SMILES Brc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14BrN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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n/an/a 3.85E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9490
PNG
(N-(4-chlorophenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C15H12ClN3O2S/c16-11-2-4-12(5-3-11)19-15(20)14-13(17-9-22-14)6-1-10-7-18-21-8-10/h2-5,7-9H,1,6H2,(H,19,20)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9507
PNG
(N-(3-methylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Cc1cccc(NC(=O)c2scnc2CCc2ccncc2)c1
Show InChI InChI=1S/C18H17N3OS/c1-13-3-2-4-15(11-13)21-18(22)17-16(20-12-23-17)6-5-14-7-9-19-10-8-14/h2-4,7-12H,5-6H2,1H3,(H,21,22)
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n/an/a 4.66E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9514
PNG
(N-(Aryl)-thiazole-5-carboxamide 26 | N-[4-chloro-3...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2scnc2CCc2cnoc2)ccc1Cl
Show InChI InChI=1S/C16H11ClF3N3O2S/c17-12-3-2-10(5-11(12)16(18,19)20)23-15(24)14-13(21-8-26-14)4-1-9-6-22-25-7-9/h2-3,5-8H,1,4H2,(H,23,24)
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n/an/a 5.32E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9512
PNG
(N-(3,4-dichlorophenyl)-4-[2-(1,2-oxazol-4-yl)ethyl...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1Cl
Show InChI InChI=1S/C15H11Cl2N3O2S/c16-11-3-2-10(5-12(11)17)20-15(21)14-13(18-8-23-14)4-1-9-6-19-22-7-9/h2-3,5-8H,1,4H2,(H,20,21)
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n/an/a 5.42E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9498
PNG
(N-(4-tert-butylphenyl)-4-[2-(quinolin-4-yl)ethyl]-...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccnc3ccccc23)cc1
Show InChI InChI=1S/C25H25N3OS/c1-25(2,3)18-9-11-19(12-10-18)28-24(29)23-22(27-16-30-23)13-8-17-14-15-26-21-7-5-4-6-20(17)21/h4-7,9-12,14-16H,8,13H2,1-3H3,(H,28,29)
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n/an/a 5.46E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9500
PNG
(4-[2-(1,2-oxazol-4-yl)ethyl]-N-[4-(propan-2-yl)phe...)
Show SMILES CC(C)c1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-12(2)14-4-6-15(7-5-14)21-18(22)17-16(19-11-24-17)8-3-13-9-20-23-10-13/h4-7,9-12H,3,8H2,1-2H3,(H,21,22)
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n/an/a 6.41E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9493
PNG
(N-(4-chlorophenyl)-4-[2-(quinolin-4-yl)ethyl]-1,3-...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccnc3ccccc23)cc1
Show InChI InChI=1S/C21H16ClN3OS/c22-15-6-8-16(9-7-15)25-21(26)20-19(24-13-27-20)10-5-14-11-12-23-18-4-2-1-3-17(14)18/h1-4,6-9,11-13H,5,10H2,(H,25,26)
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n/an/a 6.85E+3n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9508
PNG
(N-(2-methylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Cc1ccccc1NC(=O)c1scnc1CCc1cnoc1
Show InChI InChI=1S/C16H15N3O2S/c1-11-4-2-3-5-13(11)19-16(20)15-14(17-10-22-15)7-6-12-8-18-21-9-12/h2-5,8-10H,6-7H2,1H3,(H,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9494
PNG
(N-(4-chlorophenyl)-4-[2-(quinolin-2-yl)ethyl]-1,3-...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C21H16ClN3OS/c22-15-6-9-17(10-7-15)25-21(26)20-19(23-13-27-20)12-11-16-8-5-14-3-1-2-4-18(14)24-16/h1-10,13H,11-12H2,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9520
PNG
(N-(4-phenylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C23H19N3OS/c27-23(22-21(25-16-28-22)11-6-17-12-14-24-15-13-17)26-20-9-7-19(8-10-20)18-4-2-1-3-5-18/h1-5,7-10,12-16H,6,11H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9495
PNG
(N-(4-tert-butylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C19H21N3O2S/c1-19(2,3)14-5-7-15(8-6-14)22-18(23)17-16(20-12-25-17)9-4-13-10-21-24-11-13/h5-8,10-12H,4,9H2,1-3H3,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9522
PNG
(N-(4-benzylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES O=C(Nc1ccc(Cc2ccccc2)cc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C24H21N3OS/c28-24(23-22(26-17-29-23)11-8-18-12-14-25-15-13-18)27-21-9-6-20(7-10-21)16-19-4-2-1-3-5-19/h1-7,9-10,12-15,17H,8,11,16H2,(H,27,28)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9509
PNG
(N-(2-methylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Cc1ccccc1NC(=O)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-3-5-15(13)21-18(22)17-16(20-12-23-17)7-6-14-8-10-19-11-9-14/h2-5,8-12H,6-7H2,1H3,(H,21,22)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9496
PNG
(4-[2-(1,2-benzoxazol-3-yl)ethyl]-N-(4-tert-butylph...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2noc3ccccc23)cc1
Show InChI InChI=1S/C23H23N3O2S/c1-23(2,3)15-8-10-16(11-9-15)25-22(27)21-19(24-14-29-21)13-12-18-17-6-4-5-7-20(17)28-26-18/h4-11,14H,12-13H2,1-3H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9491
PNG
(4-[2-(1,2-benzoxazol-3-yl)ethyl]-N-(4-chlorophenyl...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2noc3ccccc23)cc1
Show InChI InChI=1S/C19H14ClN3O2S/c20-12-5-7-13(8-6-12)22-19(24)18-16(21-11-26-18)10-9-15-14-3-1-2-4-17(14)25-23-15/h1-8,11H,9-10H2,(H,22,24)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9496
PNG
(4-[2-(1,2-benzoxazol-3-yl)ethyl]-N-(4-tert-butylph...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2noc3ccccc23)cc1
Show InChI InChI=1S/C23H23N3O2S/c1-23(2,3)15-8-10-16(11-9-15)25-22(27)21-19(24-14-29-21)13-12-18-17-6-4-5-7-20(17)28-26-18/h4-11,14H,12-13H2,1-3H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/a7.522



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9494
PNG
(N-(4-chlorophenyl)-4-[2-(quinolin-2-yl)ethyl]-1,3-...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C21H16ClN3OS/c22-15-6-9-17(10-7-15)25-21(26)20-19(23-13-27-20)12-11-16-8-5-14-3-1-2-4-18(14)24-16/h1-10,13H,11-12H2,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9521
PNG
(N-(4-phenoxyphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C23H19N3O2S/c27-23(22-21(25-16-29-22)11-6-17-12-14-24-15-13-17)26-18-7-9-20(10-8-18)28-19-4-2-1-3-5-19/h1-5,7-10,12-16H,6,11H2,(H,26,27)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9506
PNG
(N-(3-methylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Cc1cccc(NC(=O)c2scnc2CCc2cnoc2)c1
Show InChI InChI=1S/C16H15N3O2S/c1-11-3-2-4-13(7-11)19-16(20)15-14(17-10-22-15)6-5-12-8-18-21-9-12/h2-4,7-10H,5-6H2,1H3,(H,19,20)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9502
PNG
(N-(Aryl)-thiazole-5-carboxamide 16 | N-[4-(chlorod...)
Show SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2scnc2CCc2cnoc2)cc1
Show InChI InChI=1S/C16H12ClF2N3O3S/c17-16(18,19)25-12-4-2-11(3-5-12)22-15(23)14-13(20-9-26-14)6-1-10-7-21-24-8-10/h2-5,7-9H,1,6H2,(H,22,23)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9499
PNG
(N-(4-tert-butylphenyl)-4-[2-(quinolin-2-yl)ethyl]-...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C25H25N3OS/c1-25(2,3)18-9-12-20(13-10-18)28-24(29)23-22(26-16-30-23)15-14-19-11-8-17-6-4-5-7-21(17)27-19/h4-13,16H,14-15H2,1-3H3,(H,28,29)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9506
PNG
(N-(3-methylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Cc1cccc(NC(=O)c2scnc2CCc2cnoc2)c1
Show InChI InChI=1S/C16H15N3O2S/c1-11-3-2-4-13(7-11)19-16(20)15-14(17-10-22-15)6-5-12-8-18-21-9-12/h2-4,7-10H,5-6H2,1H3,(H,19,20)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9491
PNG
(4-[2-(1,2-benzoxazol-3-yl)ethyl]-N-(4-chlorophenyl...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2noc3ccccc23)cc1
Show InChI InChI=1S/C19H14ClN3O2S/c20-12-5-7-13(8-6-12)22-19(24)18-16(21-11-26-18)10-9-15-14-3-1-2-4-17(14)25-23-15/h1-8,11H,9-10H2,(H,22,24)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9508
PNG
(N-(2-methylphenyl)-4-[2-(1,2-oxazol-4-yl)ethyl]-1,...)
Show SMILES Cc1ccccc1NC(=O)c1scnc1CCc1cnoc1
Show InChI InChI=1S/C16H15N3O2S/c1-11-4-2-3-5-13(11)19-16(20)15-14(17-10-22-15)7-6-12-8-18-21-9-12/h2-5,8-10H,6-7H2,1H3,(H,19,20)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9509
PNG
(N-(2-methylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Cc1ccccc1NC(=O)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-3-5-15(13)21-18(22)17-16(20-12-23-17)7-6-14-8-10-19-11-9-14/h2-5,8-12H,6-7H2,1H3,(H,21,22)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9510
PNG
(N-(Aryl)-thiazole-5-carboxamide 22 | N-[4-(morphol...)
Show SMILES O=C(Nc1ccc(cc1)N1CCOCC1)c1scnc1CCc1cnoc1
Show InChI InChI=1S/C19H20N4O3S/c24-19(18-17(20-13-27-18)6-1-14-11-21-26-12-14)22-15-2-4-16(5-3-15)23-7-9-25-10-8-23/h2-5,11-13H,1,6-10H2,(H,22,24)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM9522
PNG
(N-(4-benzylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES O=C(Nc1ccc(Cc2ccccc2)cc1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C24H21N3OS/c28-24(23-22(26-17-29-23)11-8-18-12-14-25-15-13-18)27-21-9-6-20(7-10-21)16-19-4-2-1-3-5-19/h1-7,9-10,12-15,17H,8,11,16H2,(H,27,28)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM9499
PNG
(N-(4-tert-butylphenyl)-4-[2-(quinolin-2-yl)ethyl]-...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C25H25N3OS/c1-25(2,3)18-9-12-20(13-10-18)28-24(29)23-22(26-16-30-23)15-14-19-11-8-17-6-4-5-7-21(17)27-19/h4-13,16H,14-15H2,1-3H3,(H,28,29)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%