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PubMed code 16289819

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177292
PNG
(CHEMBL425407 | N-(4-methyl-2-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H29F3N4O3/c1-18-15-24(30-11-14-33-12-3-2-4-13-33)32-23-10-5-19(16-22(18)23)31-25(34)17-35-20-6-8-21(9-7-20)36-26(27,28)29/h5-10,15-16H,2-4,11-14,17H2,1H3,(H,30,32)(H,31,34)
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n/an/a 0.910n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177299
PNG
(CHEMBL204952 | N-(4-methyl-2-(2-morpholinoethylami...)
Show SMILES Cc1cc(NCCN2CCOCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(29-8-9-32-10-12-34-13-11-32)31-22-7-2-18(15-21(17)22)30-24(33)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15H,8-13,16H2,1H3,(H,29,31)(H,30,33)
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n/an/a 1.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177291
PNG
(CHEMBL205111 | N-(2-(4-(2-hydroxyethyl)piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(32-10-8-31(9-11-32)12-13-33)30-22-7-2-18(15-21(17)22)29-24(34)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15,33H,8-13,16H2,1H3,(H,29,34)
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n/an/a 1.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177279
PNG
(CHEMBL436320 | N-(2-(1,4-diazepan-1-yl)-4-methylqu...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCCNCC1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-2-9-28-10-12-31)30-21-8-3-17(14-20(16)21)29-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14,28H,2,9-12,15H2,1H3,(H,29,32)
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n/an/a 2n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 2.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177281
PNG
(CHEMBL379693 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(31(4)12-11-30(2)3)29-21-10-5-17(14-20(16)21)28-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,11-12,15H2,1-4H3,(H,28,32)
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n/an/a 2.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177285
PNG
(CHEMBL204428 | rac-N-(2-(3-(dimethylamino)pyrrolid...)
Show SMILES CN(C)C1CCN(C1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-16-12-23(32-11-10-18(14-32)31(2)3)30-22-9-4-17(13-21(16)22)29-24(33)15-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,12-13,18H,10-11,14-15H2,1-3H3,(H,29,33)
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n/an/a 2.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177287
PNG
(CHEMBL203586 | N-(2-(2-(diethylamino)ethylamino)-4...)
Show SMILES CCN(CC)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O3/c1-4-32(5-2)13-12-29-23-14-17(3)21-15-18(6-11-22(21)31-23)30-24(33)16-34-19-7-9-20(10-8-19)35-25(26,27)28/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,29,31)(H,30,33)
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n/an/a 3.20n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177293
PNG
(CHEMBL202095 | N-(4-methyl-2-(4-methyl-1,4-diazepa...)
Show SMILES CN1CCCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-17-14-23(32-11-3-10-31(2)12-13-32)30-22-9-4-18(15-21(17)22)29-24(33)16-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,29,33)
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177273
PNG
((S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177296
PNG
((R)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177280
PNG
(CHEMBL203699 | N-(2-(3-(dimethylamino)-2,2-dimethy...)
Show SMILES CN(C)CC(C)(C)CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H31F3N4O3/c1-17-12-23(30-15-25(2,3)16-33(4)5)32-22-11-6-18(13-21(17)22)31-24(34)14-35-19-7-9-20(10-8-19)36-26(27,28)29/h6-13H,14-16H2,1-5H3,(H,30,32)(H,31,34)
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n/an/a 4.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177291
PNG
(CHEMBL205111 | N-(2-(4-(2-hydroxyethyl)piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(32-10-8-31(9-11-32)12-13-33)30-22-7-2-18(15-21(17)22)29-24(34)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15,33H,8-13,16H2,1H3,(H,29,34)
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n/an/a 5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177300
PNG
(CHEMBL379886 | N-(2-(2-(dimethylamino)ethylamino)-...)
Show SMILES CN(C)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H25F3N4O3/c1-15-12-21(27-10-11-30(2)3)29-20-9-4-16(13-19(15)20)28-22(31)14-32-17-5-7-18(8-6-17)33-23(24,25)26/h4-9,12-13H,10-11,14H2,1-3H3,(H,27,29)(H,28,31)
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n/an/a 5.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177292
PNG
(CHEMBL425407 | N-(4-methyl-2-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H29F3N4O3/c1-18-15-24(30-11-14-33-12-3-2-4-13-33)32-23-10-5-19(16-22(18)23)31-25(34)17-35-20-6-8-21(9-7-20)36-26(27,28)29/h5-10,15-16H,2-4,11-14,17H2,1H3,(H,30,32)(H,31,34)
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n/an/a 5.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177284
PNG
(CHEMBL442794 | biphenyl-4-carboxylic acid {2-[(2-d...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C28H30N4O/c1-20-18-27(32(4)17-16-31(2)3)30-26-15-14-24(19-25(20)26)29-28(33)23-12-10-22(11-13-23)21-8-6-5-7-9-21/h5-15,18-19H,16-17H2,1-4H3,(H,29,33)
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n/an/a 5.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177285
PNG
(CHEMBL204428 | rac-N-(2-(3-(dimethylamino)pyrrolid...)
Show SMILES CN(C)C1CCN(C1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-16-12-23(32-11-10-18(14-32)31(2)3)30-22-9-4-17(13-21(16)22)29-24(33)15-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,12-13,18H,10-11,14-15H2,1-3H3,(H,29,33)
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n/an/a 6.20n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177295
PNG
(CHEMBL382161 | N-(2-(2-(diisopropylamino)ethylamin...)
Show SMILES CC(C)N(CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1)C(C)C
Show InChI InChI=1S/C27H33F3N4O3/c1-17(2)34(18(3)4)13-12-31-25-14-19(5)23-15-20(6-11-24(23)33-25)32-26(35)16-36-21-7-9-22(10-8-21)37-27(28,29)30/h6-11,14-15,17-18H,12-13,16H2,1-5H3,(H,31,33)(H,32,35)
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n/an/a 7.10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177299
PNG
(CHEMBL204952 | N-(4-methyl-2-(2-morpholinoethylami...)
Show SMILES Cc1cc(NCCN2CCOCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(29-8-9-32-10-12-34-13-11-32)31-22-7-2-18(15-21(17)22)30-24(33)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15H,8-13,16H2,1H3,(H,29,31)(H,30,33)
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n/an/a 9.60n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177274
PNG
(4'-trifluoromethyl-biphenyl-4-carboxylic acid {2-[...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C29H29F3N4O/c1-19-17-27(36(4)16-15-35(2)3)34-26-14-13-24(18-25(19)26)33-28(37)22-7-5-20(6-8-22)21-9-11-23(12-10-21)29(30,31)32/h5-14,17-18H,15-16H2,1-4H3,(H,33,37)
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n/an/a 10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177279
PNG
(CHEMBL436320 | N-(2-(1,4-diazepan-1-yl)-4-methylqu...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCCNCC1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-2-9-28-10-12-31)30-21-8-3-17(14-20(16)21)29-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14,28H,2,9-12,15H2,1H3,(H,29,32)
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n/an/a 12n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177271
PNG
(CHEMBL204082 | N-(2-(1-benzylpiperidin-4-ylamino)-...)
Show SMILES Cc1cc(NC2CCN(Cc3ccccc3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C31H31F3N4O3/c1-21-17-29(35-23-13-15-38(16-14-23)19-22-5-3-2-4-6-22)37-28-12-7-24(18-27(21)28)36-30(39)20-40-25-8-10-26(11-9-25)41-31(32,33)34/h2-12,17-18,23H,13-16,19-20H2,1H3,(H,35,37)(H,36,39)
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n/an/a 13n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177273
PNG
((S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177275
PNG
(CHEMBL204968 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CCc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,29,33)
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n/an/a 14n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177287
PNG
(CHEMBL203586 | N-(2-(2-(diethylamino)ethylamino)-4...)
Show SMILES CCN(CC)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O3/c1-4-32(5-2)13-12-29-23-14-17(3)21-15-18(6-11-22(21)31-23)30-24(33)16-34-19-7-9-20(10-8-19)35-25(26,27)28/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,29,31)(H,30,33)
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n/an/a 15n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177280
PNG
(CHEMBL203699 | N-(2-(3-(dimethylamino)-2,2-dimethy...)
Show SMILES CN(C)CC(C)(C)CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H31F3N4O3/c1-17-12-23(30-15-25(2,3)16-33(4)5)32-22-11-6-18(13-21(17)22)31-24(34)14-35-19-7-9-20(10-8-19)36-26(27,28)29/h6-13H,14-16H2,1-5H3,(H,30,32)(H,31,34)
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n/an/a 16n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177299
PNG
(CHEMBL204952 | N-(4-methyl-2-(2-morpholinoethylami...)
Show SMILES Cc1cc(NCCN2CCOCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(29-8-9-32-10-12-34-13-11-32)31-22-7-2-18(15-21(17)22)30-24(33)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15H,8-13,16H2,1H3,(H,29,31)(H,30,33)
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n/an/a 16n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172421
PNG
((E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-12,15-16H,13-14H2,1-4H3,(H,29,33)/b12-7+
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n/an/a 16n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177277
PNG
(CHEMBL202563 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C25H30N4O/c1-18-6-8-20(9-7-18)10-13-25(30)26-21-11-12-23-22(17-21)19(2)16-24(27-23)29(5)15-14-28(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,26,30)/b13-10+
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n/an/a 17n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177296
PNG
((R)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177300
PNG
(CHEMBL379886 | N-(2-(2-(dimethylamino)ethylamino)-...)
Show SMILES CN(C)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H25F3N4O3/c1-15-12-21(27-10-11-30(2)3)29-20-9-4-16(13-19(15)20)28-22(31)14-32-17-5-7-18(8-6-17)33-23(24,25)26/h4-9,12-13H,10-11,14H2,1-3H3,(H,27,29)(H,28,31)
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n/an/a 18n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177281
PNG
(CHEMBL379693 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(31(4)12-11-30(2)3)29-21-10-5-17(14-20(16)21)28-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,11-12,15H2,1-4H3,(H,28,32)
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n/an/a 18n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172421
PNG
((E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-12,15-16H,13-14H2,1-4H3,(H,29,33)/b12-7+
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n/an/a 19n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177293
PNG
(CHEMBL202095 | N-(4-methyl-2-(4-methyl-1,4-diazepa...)
Show SMILES CN1CCCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-17-14-23(32-11-3-10-31(2)12-13-32)30-22-9-4-18(15-21(17)22)29-24(33)16-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,29,33)
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n/an/a 20n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177295
PNG
(CHEMBL382161 | N-(2-(2-(diisopropylamino)ethylamin...)
Show SMILES CC(C)N(CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1)C(C)C
Show InChI InChI=1S/C27H33F3N4O3/c1-17(2)34(18(3)4)13-12-31-25-14-19(5)23-15-20(6-11-24(23)33-25)32-26(35)16-36-21-7-9-22(10-8-21)37-27(28,29)30/h6-11,14-15,17-18H,12-13,16H2,1-5H3,(H,31,33)(H,32,35)
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n/an/a 22n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177283
PNG
(4-(4-chlorophenyl)-N-(2-((2-(dimethylamino)ethyl)(...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C28H35ClN4O/c1-19-17-27(33(4)16-15-32(2)3)31-26-14-13-24(18-25(19)26)30-28(34)22-7-5-20(6-8-22)21-9-11-23(29)12-10-21/h9-14,17-18,20,22H,5-8,15-16H2,1-4H3,(H,30,34)
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n/an/a 23n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177291
PNG
(CHEMBL205111 | N-(2-(4-(2-hydroxyethyl)piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(32-10-8-31(9-11-32)12-13-33)30-22-7-2-18(15-21(17)22)29-24(34)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15,33H,8-13,16H2,1H3,(H,29,34)
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n/an/a 23n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177284
PNG
(CHEMBL442794 | biphenyl-4-carboxylic acid {2-[(2-d...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C28H30N4O/c1-20-18-27(32(4)17-16-31(2)3)30-26-15-14-24(19-25(20)26)29-28(33)23-12-10-22(11-13-23)21-8-6-5-7-9-21/h5-15,18-19H,16-17H2,1-4H3,(H,29,33)
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n/an/a 25n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 25n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 29n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177281
PNG
(CHEMBL379693 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(31(4)12-11-30(2)3)29-21-10-5-17(14-20(16)21)28-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,11-12,15H2,1-4H3,(H,28,32)
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n/an/a 31n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177292
PNG
(CHEMBL425407 | N-(4-methyl-2-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H29F3N4O3/c1-18-15-24(30-11-14-33-12-3-2-4-13-33)32-23-10-5-19(16-22(18)23)31-25(34)17-35-20-6-8-21(9-7-20)36-26(27,28)29/h5-10,15-16H,2-4,11-14,17H2,1H3,(H,30,32)(H,31,34)
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n/an/a 33n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 33n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177271
PNG
(CHEMBL204082 | N-(2-(1-benzylpiperidin-4-ylamino)-...)
Show SMILES Cc1cc(NC2CCN(Cc3ccccc3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C31H31F3N4O3/c1-21-17-29(35-23-13-15-38(16-14-23)19-22-5-3-2-4-6-22)37-28-12-7-24(18-27(21)28)36-30(39)20-40-25-8-10-26(11-9-25)41-31(32,33)34/h2-12,17-18,23H,13-16,19-20H2,1H3,(H,35,37)(H,36,39)
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n/an/a 40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177275
PNG
(CHEMBL204968 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CCc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,29,33)
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n/an/a 40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177284
PNG
(CHEMBL442794 | biphenyl-4-carboxylic acid {2-[(2-d...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C28H30N4O/c1-20-18-27(32(4)17-16-31(2)3)30-26-15-14-24(19-25(20)26)29-28(33)23-12-10-22(11-13-23)21-8-6-5-7-9-21/h5-15,18-19H,16-17H2,1-4H3,(H,29,33)
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n/an/a 42n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177290
PNG
(CHEMBL203161 | N-(2-((3S,5R)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-15-10-23(32-12-16(2)29-17(3)13-32)31-22-9-4-18(11-21(15)22)30-24(33)14-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-11,16-17,29H,12-14H2,1-3H3,(H,30,33)/t16-,17+
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n/an/a 44n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177277
PNG
(CHEMBL202563 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C25H30N4O/c1-18-6-8-20(9-7-18)10-13-25(30)26-21-11-12-23-22(17-21)19(2)16-24(27-23)29(5)15-14-28(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,26,30)/b13-10+
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n/an/a 48n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177274
PNG
(4'-trifluoromethyl-biphenyl-4-carboxylic acid {2-[...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C29H29F3N4O/c1-19-17-27(36(4)16-15-35(2)3)34-26-14-13-24(18-25(19)26)33-28(37)22-7-5-20(6-8-22)21-9-11-23(12-10-21)29(30,31)32/h5-14,17-18H,15-16H2,1-4H3,(H,33,37)
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n/an/a 63n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177279
PNG
(CHEMBL436320 | N-(2-(1,4-diazepan-1-yl)-4-methylqu...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCCNCC1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-2-9-28-10-12-31)30-21-8-3-17(14-20(16)21)29-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14,28H,2,9-12,15H2,1H3,(H,29,32)
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n/an/a 71n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177285
PNG
(CHEMBL204428 | rac-N-(2-(3-(dimethylamino)pyrrolid...)
Show SMILES CN(C)C1CCN(C1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-16-12-23(32-11-10-18(14-32)31(2)3)30-22-9-4-17(13-21(16)22)29-24(33)15-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,12-13,18H,10-11,14-15H2,1-3H3,(H,29,33)
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n/an/a 82n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 83n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177290
PNG
(CHEMBL203161 | N-(2-((3S,5R)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-15-10-23(32-12-16(2)29-17(3)13-32)31-22-9-4-18(11-21(15)22)30-24(33)14-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-11,16-17,29H,12-14H2,1-3H3,(H,30,33)/t16-,17+
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n/an/a 87n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177271
PNG
(CHEMBL204082 | N-(2-(1-benzylpiperidin-4-ylamino)-...)
Show SMILES Cc1cc(NC2CCN(Cc3ccccc3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C31H31F3N4O3/c1-21-17-29(35-23-13-15-38(16-14-23)19-22-5-3-2-4-6-22)37-28-12-7-24(18-27(21)28)36-30(39)20-40-25-8-10-26(11-9-25)41-31(32,33)34/h2-12,17-18,23H,13-16,19-20H2,1H3,(H,35,37)(H,36,39)
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n/an/a 91n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177296
PNG
((R)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177286
PNG
(CHEMBL204912 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(Oc4ccccc4)nc3)ccc2n1
Show InChI InChI=1S/C27H29N5O2/c1-19-16-25(32(4)15-14-31(2)3)30-24-12-11-21(17-23(19)24)29-27(33)20-10-13-26(28-18-20)34-22-8-6-5-7-9-22/h5-13,16-18H,14-15H2,1-4H3,(H,29,33)
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n/an/a 105n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177305
PNG
(2-(2,4-dichlorophenylamino)-N-(2-((2-(dimethylamin...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CNc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H27Cl2N5O/c1-15-11-22(30(4)10-9-29(2)3)28-20-8-6-17(13-18(15)20)27-23(31)14-26-21-7-5-16(24)12-19(21)25/h5-8,11-13,26H,9-10,14H2,1-4H3,(H,27,31)
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n/an/a 125n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172421
PNG
((E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-12,15-16H,13-14H2,1-4H3,(H,29,33)/b12-7+
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n/an/a 144n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177289
PNG
(CHEMBL382126 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CCc3nc(c(o3)-c3ccccc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C33H35N5O2/c1-23-21-29(38(4)20-19-37(2)3)35-28-16-15-26(22-27(23)28)34-30(39)17-18-31-36-32(24-11-7-5-8-12-24)33(40-31)25-13-9-6-10-14-25/h5-16,21-22H,17-20H2,1-4H3,(H,34,39)
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n/an/a 162n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177280
PNG
(CHEMBL203699 | N-(2-(3-(dimethylamino)-2,2-dimethy...)
Show SMILES CN(C)CC(C)(C)CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H31F3N4O3/c1-17-12-23(30-15-25(2,3)16-33(4)5)32-22-11-6-18(13-21(17)22)31-24(34)14-35-19-7-9-20(10-8-19)36-26(27,28)29/h6-13H,14-16H2,1-5H3,(H,30,32)(H,31,34)
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n/an/a 192n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177302
PNG
(CHEMBL203549 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(Oc4ccccc4)cc3)ccc2n1
Show InChI InChI=1S/C28H30N4O2/c1-20-18-27(32(4)17-16-31(2)3)30-26-15-12-22(19-25(20)26)29-28(33)21-10-13-24(14-11-21)34-23-8-6-5-7-9-23/h5-15,18-19H,16-17H2,1-4H3,(H,29,33)
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n/an/a 210n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177293
PNG
(CHEMBL202095 | N-(4-methyl-2-(4-methyl-1,4-diazepa...)
Show SMILES CN1CCCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-17-14-23(32-11-3-10-31(2)12-13-32)30-22-9-4-18(15-21(17)22)29-24(33)16-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,29,33)
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n/an/a 244n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177297
PNG
(1-(4-bromobenzyl)-3-(2-((2-(dimethylamino)ethyl)(m...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)NCc3ccc(Br)cc3)ccc2n1
Show InChI InChI=1S/C23H28BrN5O/c1-16-13-22(29(4)12-11-28(2)3)27-21-10-9-19(14-20(16)21)26-23(30)25-15-17-5-7-18(24)8-6-17/h5-10,13-14H,11-12,15H2,1-4H3,(H2,25,26,30)
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n/an/a 271n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177283
PNG
(4-(4-chlorophenyl)-N-(2-((2-(dimethylamino)ethyl)(...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C28H35ClN4O/c1-19-17-27(33(4)16-15-32(2)3)31-26-14-13-24(18-25(19)26)30-28(34)22-7-5-20(6-8-22)21-9-11-23(29)12-10-21/h9-14,17-18,20,22H,5-8,15-16H2,1-4H3,(H,30,34)
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n/an/a 393n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177283
PNG
(4-(4-chlorophenyl)-N-(2-((2-(dimethylamino)ethyl)(...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C28H35ClN4O/c1-19-17-27(33(4)16-15-32(2)3)31-26-14-13-24(18-25(19)26)30-28(34)22-7-5-20(6-8-22)21-9-11-23(29)12-10-21/h9-14,17-18,20,22H,5-8,15-16H2,1-4H3,(H,30,34)
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n/an/a 423n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177274
PNG
(4'-trifluoromethyl-biphenyl-4-carboxylic acid {2-[...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C29H29F3N4O/c1-19-17-27(36(4)16-15-35(2)3)34-26-14-13-24(18-25(19)26)33-28(37)22-7-5-20(6-8-22)21-9-11-23(12-10-21)29(30,31)32/h5-14,17-18H,15-16H2,1-4H3,(H,33,37)
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n/an/a 474n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177277
PNG
(CHEMBL202563 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C25H30N4O/c1-18-6-8-20(9-7-18)10-13-25(30)26-21-11-12-23-22(17-21)19(2)16-24(27-23)29(5)15-14-28(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,26,30)/b13-10+
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n/an/a 478n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177306
PNG
(CHEMBL204168 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)Cc3nc(oc3C)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C27H31N5O2/c1-18-15-25(32(5)14-13-31(3)4)29-23-12-11-21(16-22(18)23)28-26(33)17-24-19(2)34-27(30-24)20-9-7-6-8-10-20/h6-12,15-16H,13-14,17H2,1-5H3,(H,28,33)
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n/an/a 568n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177275
PNG
(CHEMBL204968 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CCc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O2/c1-17-15-23(32(4)14-13-31(2)3)30-22-11-8-19(16-21(17)22)29-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,29,33)
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n/an/a 724n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 807n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177272
PNG
(CHEMBL205112 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3cc4ccccc4s3)ccc2n1
Show InChI InChI=1S/C24H26N4OS/c1-16-13-23(28(4)12-11-27(2)3)26-20-10-9-18(15-19(16)20)25-24(29)22-14-17-7-5-6-8-21(17)30-22/h5-10,13-15H,11-12H2,1-4H3,(H,25,29)
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n/an/a 2.10E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177270
PNG
(3-(2-chlorophenyl)-N-(2-((2-(dimethylamino)ethyl)(...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Show InChI InChI=1S/C24H27ClN4O/c1-17-15-23(29(4)14-13-28(2)3)27-22-11-10-19(16-20(17)22)26-24(30)12-9-18-7-5-6-8-21(18)25/h5-12,15-16H,13-14H2,1-4H3,(H,26,30)/b12-9+
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n/an/a 2.54E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177301
PNG
(CHEMBL381143 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H25F3N4O2/c1-15-13-21(30(4)12-11-29(2)3)28-20-10-7-17(14-19(15)20)27-22(31)16-5-8-18(9-6-16)32-23(24,25)26/h5-10,13-14H,11-12H2,1-4H3,(H,27,31)
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n/an/a 2.76E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177304
PNG
(2-biphenyl-4-yl-N-{2-[(2-dimethylamino-ethyl)-meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)Cc3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C29H32N4O/c1-21-18-28(33(4)17-16-32(2)3)31-27-15-14-25(20-26(21)27)30-29(34)19-22-10-12-24(13-11-22)23-8-6-5-7-9-23/h5-15,18,20H,16-17,19H2,1-4H3,(H,30,34)
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n/an/a 3.28E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177282
PNG
(CHEMBL203858 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)\C=C\c3ccccc3)ccc2n1
Show InChI InChI=1S/C24H28N4O/c1-18-16-23(28(4)15-14-27(2)3)26-22-12-11-20(17-21(18)22)25-24(29)13-10-19-8-6-5-7-9-19/h5-13,16-17H,14-15H2,1-4H3,(H,25,29)/b13-10+
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n/an/a 6.97E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177288
PNG
((E)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)C(\C)=C\c3ccccc3)ccc2n1
Show InChI InChI=1S/C25H30N4O/c1-18-16-24(29(5)14-13-28(3)4)27-23-12-11-21(17-22(18)23)26-25(30)19(2)15-20-9-7-6-8-10-20/h6-12,15-17H,13-14H2,1-5H3,(H,26,30)/b19-15+
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n/an/a 9.46E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177298
PNG
(CHEMBL203820 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccccc3)ccc2n1
Show InChI InChI=1S/C23H28N4O2/c1-17-14-22(27(4)13-12-26(2)3)25-21-11-10-18(15-20(17)21)24-23(28)16-29-19-8-6-5-7-9-19/h5-11,14-15H,12-13,16H2,1-4H3,(H,24,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177294
PNG
(CHEMBL426481 | rac-N-(2-((2-(dimethylamino)ethyl)(...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)C3CC3c3ccccc3)ccc2n1
Show InChI InChI=1S/C25H30N4O/c1-17-14-24(29(4)13-12-28(2)3)27-23-11-10-19(15-20(17)23)26-25(30)22-16-21(22)18-8-6-5-7-9-18/h5-11,14-15,21-22H,12-13,16H2,1-4H3,(H,26,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177303
PNG
(CHEMBL203504 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)CCc3ccccc3)ccc2n1
Show InChI InChI=1S/C24H30N4O/c1-18-16-23(28(4)15-14-27(2)3)26-22-12-11-20(17-21(18)22)25-24(29)13-10-19-8-6-5-7-9-19/h5-9,11-12,16-17H,10,13-15H2,1-4H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%