Compile Data Set for Download or QSAR
maximum 50k data
Found 25 Enz. Inhib. hit(s) with all data for entry = 1439
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50:  260nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11452(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  270nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50:  400nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11449(4-{[5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyri...)
Affinity DataIC50:  730nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11452(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  780nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11449(4-{[5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyri...)
Affinity DataIC50:  970nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11444(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1...)
Affinity DataIC50:  1.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50:  3.40E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50:  4.30E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  5.60E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11450(4-({5-[(4-hydroxycyclohexyl)amino]-[1,2,4]triazolo...)
Affinity DataIC50:  7.40E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11457(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)-1H-1,3,4,...)
Affinity DataIC50:  8.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50:  1.10E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11447(4-{[5-(cyclohexylmethoxy)-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  1.10E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50:  1.60E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  2.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11457(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)-1H-1,3,4,...)
Affinity DataIC50:  2.60E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11447(4-{[5-(cyclohexylmethoxy)-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  2.90E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50:  4.30E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50:  5.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed