Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50017366
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181073(2-(3-chloro-benzyloxy)-6-methyl-isonicotinonitrile...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181066(2-(3-(3-chlorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181075(2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile |...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181076(3-((3-(1,3-dioxoisoindolin-2-yl)-5-methylphenoxy)m...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181067(2-chloro-6-((2-methylpyridin-4-yl)methoxy)isonicot...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181079(CHEMBL207097 | N-(2-(3-chlorobenzyloxy)-6-methylpy...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181065(2-chloro-6-((2-chloropyridin-4-yl)methoxy)isonicot...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181077(CHEMBL204062 | N-(2-(3-chlorobenzyloxy)-6-methylpy...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181084(2-(3-chlorobenzyloxy)-N,6-dimethyl-N-(pyridin-3-yl...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181070(1-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2-methyl-...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181083((5-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)oxa...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181078(CHEMBL206998 | pentyl 3-(3-chlorobenzyloxy)-5-meth...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181081(1-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)-2-m...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181069(2-(3-chlorobenzyloxy)-4-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181087(CHEMBL206427 | N-(3-(3-chlorobenzyloxy)-5-methylph...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181080(2-(3-(benzyloxy)-5-methylphenyl)isoindoline-1,3-di...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181068(3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine |...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181062(CHEMBL204354 | N-(3-(3-chlorobenzyloxy)-5-methylph...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181064(1-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2,5-dimet...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181086(2-(3-(4-fluorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181074(2-(3-(4-methoxybenzyloxy)-5-methylphenyl)isoindoli...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181082(2-(3-(benzyloxy)phenyl)isoindoline-1,3-dione | CHE...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181072(2-(3-chlorobenzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181063(4-(3-chlorobenzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181085(2-(3-(4-chlorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  3.90E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181071(2-[3-methyl-5-(4-methyl-benzyloxy)-phenyl]-isoindo...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181073(2-(3-chloro-benzyloxy)-6-methyl-isonicotinonitrile...)
Affinity DataIC50:  9nMAssay Description:Inhibition of mGlu5 receptor by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50181065(2-chloro-6-((2-chloropyridin-4-yl)methoxy)isonicot...)
Affinity DataIC50:  72nMAssay Description:Inhibition of mGlu5 receptor by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed