BindingDB logo
myBDB logout

PubMed code 16466576

Compile data set for download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81608
PNG
(Isocoumarin, 9b)
Show SMILES NC(=N)SCCCOc1oc(=O)c2cc(NC(=O)c3ccccc3)ccc2c1Cl
Show InChI InChI=1S/C20H18ClN3O4S/c21-16-14-8-7-13(24-17(25)12-5-2-1-3-6-12)11-15(14)18(26)28-19(16)27-9-4-10-29-20(22)23/h1-3,5-8,11H,4,9-10H2,(H3,22,23)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81603
PNG
(Isocoumarin, 7a)
Show SMILES NC(=N)SCCOc1oc(=O)c2cc(N)ccc2c1Cl
Show InChI InChI=1S/C12H12ClN3O3S/c13-9-7-2-1-6(14)5-8(7)10(17)19-11(9)18-3-4-20-12(15)16/h1-2,5H,3-4,14H2,(H3,15,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81599
PNG
(Isocoumarin, 5c)
Show SMILES NC(=N)SCCOc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C12H11ClN2O3S/c13-9-7-3-1-2-4-8(7)10(16)18-11(9)17-5-6-19-12(14)15/h1-4H,5-6H2,(H3,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
33n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81606
PNG
(Isocoumarin, 8b)
Show SMILES Clc1c(OCCCBr)oc(=O)c2cc(NC(=O)c3ccccc3)ccc12
Show InChI InChI=1S/C19H15BrClNO4/c20-9-4-10-25-19-16(21)14-8-7-13(11-15(14)18(24)26-19)22-17(23)12-5-2-1-3-6-12/h1-3,5-8,11H,4,9-10H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
34n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81604
PNG
(Isocoumarin, 7b)
Show SMILES NC(=N)SCCCOc1oc(=O)c2cc(N)ccc2c1Cl
Show InChI InChI=1S/C13H14ClN3O3S/c14-10-8-3-2-7(15)6-9(8)11(18)20-12(10)19-4-1-5-21-13(16)17/h2-3,6H,1,4-5,15H2,(H3,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81600
PNG
(Isocoumarin, 5d)
Show SMILES NC(=N)SCCCOc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C13H13ClN2O3S/c14-10-8-4-1-2-5-9(8)11(17)19-12(10)18-6-3-7-20-13(15)16/h1-2,4-5H,3,6-7H2,(H3,15,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81607
PNG
(Isocoumarin, 9a)
Show SMILES NC(=N)SCCOc1oc(=O)c2cc(NC(=O)c3ccccc3)ccc2c1Cl
Show InChI InChI=1S/C19H16ClN3O4S/c20-15-13-7-6-12(23-16(24)11-4-2-1-3-5-11)10-14(13)17(25)27-18(15)26-8-9-28-19(21)22/h1-7,10H,8-9H2,(H3,21,22)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
84n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81601
PNG
(Isocoumarin, 5e)
Show SMILES NC(=N)SCCCCOc1oc(=O)c2ccccc2c1Cl
Show InChI InChI=1S/C14H15ClN2O3S/c15-11-9-5-1-2-6-10(9)12(18)20-13(11)19-7-3-4-8-21-14(16)17/h1-2,5-6H,3-4,7-8H2,(H3,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
140n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81605
PNG
(Isocoumarin, 8a)
Show SMILES Clc1c(OCCBr)oc(=O)c2cc(NC(=O)c3ccccc3)ccc12
Show InChI InChI=1S/C18H13BrClNO4/c19-8-9-24-18-15(20)13-7-6-12(10-14(13)17(23)25-18)21-16(22)11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.40E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81594
PNG
(Isocoumarin, 4a)
Show SMILES Clc1c(OCCBr)oc(=O)c2cc(ccc12)N(=O)=O
Show InChI InChI=1S/C11H7BrClNO5/c12-3-4-18-11-9(13)7-2-1-6(14(16)17)5-8(7)10(15)19-11/h1-2,5H,3-4H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.80E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81595
PNG
(Isocoumarin, 4b)
Show SMILES Clc1c(OCCCBr)oc(=O)c2cc(ccc12)N(=O)=O
Show InChI InChI=1S/C12H9BrClNO5/c13-4-1-5-19-12-10(14)8-3-2-7(15(17)18)6-9(8)11(16)20-12/h2-3,6H,1,4-5H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.40E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81609
PNG
(Isocoumarin, 10a)
Show SMILES BrCCOc1cc2ccc(cc2c(=O)o1)N(=O)=O
Show InChI InChI=1S/C11H8BrNO5/c12-3-4-17-10-5-7-1-2-8(13(15)16)6-9(7)11(14)18-10/h1-2,5-6H,3-4H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.20E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81610
PNG
(Isocoumarin, 10b)
Show SMILES BrCCCOc1cc2ccc(cc2c(=O)o1)N(=O)=O
Show InChI InChI=1S/C12H10BrNO5/c13-4-1-5-18-11-6-8-2-3-9(14(16)17)7-10(8)12(15)19-11/h2-3,6-7H,1,4-5H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.30E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81597
PNG
(Isocoumarin, 4d)
Show SMILES Clc1c(OCCCBr)oc(=O)c2ccccc12
Show InChI InChI=1S/C12H10BrClO3/c13-6-3-7-16-12-10(14)8-4-1-2-5-9(8)11(15)17-12/h1-2,4-5H,3,6-7H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81612
PNG
(Isocoumarin, 6b)
Show SMILES Nc1ccc2c(Cl)c(OCCCBr)oc(=O)c2c1
Show InChI InChI=1S/C12H11BrClNO3/c13-4-1-5-17-12-10(14)8-3-2-7(15)6-9(8)11(16)18-12/h2-3,6H,1,4-5,15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9.50E+3n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81602
PNG
(Isocoumarin, 6a)
Show SMILES Nc1ccc2c(Cl)c(OCCBr)oc(=O)c2c1
Show InChI InChI=1S/C11H9BrClNO3/c12-3-4-16-11-9(13)7-2-1-6(14)5-8(7)10(15)17-11/h1-2,5H,3-4,14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.20E+4n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81596
PNG
(Isocoumarin, 4c)
Show SMILES Clc1c(OCCBr)oc(=O)c2ccccc12
Show InChI InChI=1S/C11H8BrClO3/c12-5-6-15-11-9(13)7-3-1-2-4-8(7)10(14)16-11/h1-4H,5-6H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.40E+4n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81611
PNG
(Isocoumarin, 10c)
Show SMILES FC(F)(F)C(=O)c1c(OCCCBr)oc(=O)c2ccccc12
Show InChI InChI=1S/C14H10BrF3O4/c15-6-3-7-21-13-10(11(19)14(16,17)18)8-4-1-2-5-9(8)12(20)22-13/h1-2,4-5H,3,6-7H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.40E+4n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81598
PNG
(Isocoumarin, 4e)
Show SMILES Clc1c(OCCCCBr)oc(=O)c2ccccc12
Show InChI InChI=1S/C13H12BrClO3/c14-7-3-4-8-17-13-11(15)9-5-1-2-6-10(9)12(16)18-13/h1-2,5-6H,3-4,7-8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80E+4n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM81613
PNG
(Isocoumarin, 11)
Show SMILES Nc1ccc2cc(OCCBr)oc(=O)c2c1
Show InChI InChI=1S/C11H10BrNO3/c12-3-4-15-10-5-7-1-2-8(13)6-9(7)11(14)16-10/h1-2,5-6H,3-4,13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.50E+4n/an/an/an/an/an/an/an/a



University of New Mexico



Assay Description
Inhibition of human urokinase-type plasminogen activator (uPA).


BMC Chem Biol 6: 1 (2006)


Article DOI: 10.1186/1472-6769-6-1
BindingDB Entry DOI: 10.7270/Q20C4T8F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%