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Found 24 Enz. Inhib. hit(s) with all data for entry = 50017629
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  3nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184729(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  4nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184738(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184730(4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184730(4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...)
Affinity DataIC50:  33nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184729(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184745(CHEMBL209124 | N-(4-(3-methylpyridin-2-yl)phenyl)-...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184731(6-(2-methoxyphenyl)-2-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  170nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184735(2-p-tolyl-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-b...)
Affinity DataIC50:  170nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184740(6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  180nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184729(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  220nMAssay Description:Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184729(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  220nMAssay Description:Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184742(2-(4-tert-butylphenyl)-6-(3-(trifluoromethyl)pyrid...)
Affinity DataIC50:  224nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184734(6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184739(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  290nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184741(2-(4-fluorophenyl)-6-(3-(trifluoromethyl)pyridin-2...)
Affinity DataIC50:  320nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184747(2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184743(2-(4-(trifluoromethyl)phenyl)-5-(3-(trifluoromethy...)
Affinity DataIC50:  370nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184746(4-tert-butyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl...)
Affinity DataIC50:  470nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184733(CHEMBL210667 | N-(4-(3-methylpyridin-2-yl)phenyl)-...)
Affinity DataIC50:  640nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184732(4-methyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phe...)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184744(CHEMBL209112 | N-(4-(pyridin-2-yl)phenyl)-4-(trifl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184736(CHEMBL208870 | N-(4-(3-(trifluoromethyl)pyridin-2-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed