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Found 39 Enz. Inhib. hit(s) with all data for entry = 50017635
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184818(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184822(CHEMBL383671 | methyl 4-(4-fluoro-2-methyl-1H-indo...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184812(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184817(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184811((R)-1-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184816(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyr...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184808((S)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184821(CHEMBL206545 | N-(3-(4-(4-fluoro-2-methyl-1H-indol...)
Affinity DataIC50:  66nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184820(CHEMBL205283 | methyl 5-methyl-4-(2-methyl-1H-indo...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184814(CHEMBL207842 | ethyl 4-(1H-indol-5-yloxy)-5-methyl...)
Affinity DataIC50:  87nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  89nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  148nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184819(CHEMBL381104 | methyl 4-(1H-indol-5-yloxy)pyrrolo[...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184810(CHEMBL377302 | ethyl 4-(1H-indol-5-yloxy)-5-ethylp...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184815(CHEMBL381973 | ethyl 4-(1H-indol-5-yloxy)-5-isopro...)
Affinity DataIC50:  470nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184812(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184821(CHEMBL206545 | N-(3-(4-(4-fluoro-2-methyl-1H-indol...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184818(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: >1.90E+3nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibitory activity against LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184817(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184808((S)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibitory activity against PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184811((R)-1-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184813((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against PKC alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed