Compile Data Set for Download or QSAR
maximum 50k data
Found 41 Enz. Inhib. hit(s) with all data for entry = 50017731
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185904((+/-) 3-phenyl-pyrrolidine-3-carboxylic acid {1-[3...)
Affinity DataKi:  27nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185902(1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-pipe...)
Affinity DataKi:  60nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataKi:  62nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185915(1-(4-chloro-phenyl)-cyclohexanecarboxylic acid {1-...)
Affinity DataKi:  250nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185907(CHEMBL210322 | N-{1-[3-(2-methoxy-phenoxy)-benzyl]...)
Affinity DataKi:  250nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185911(CHEMBL205692 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185903(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185916(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataKi:  9.10E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185913(CHEMBL381354 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185902(1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-pipe...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185914(1-(3-phenoxybenzyl)piperidine-4-carboxylic acid | ...)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataIC50:  11nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185904((+/-) 3-phenyl-pyrrolidine-3-carboxylic acid {1-[3...)
Affinity DataIC50:  22nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50:  43nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185907(CHEMBL210322 | N-{1-[3-(2-methoxy-phenoxy)-benzyl]...)
Affinity DataIC50:  55nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50:  56nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185907(CHEMBL210322 | N-{1-[3-(2-methoxy-phenoxy)-benzyl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185904((+/-) 3-phenyl-pyrrolidine-3-carboxylic acid {1-[3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185902(1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-pipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185916(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185903(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185911(CHEMBL205692 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185913(CHEMBL381354 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185915(1-(4-chloro-phenyl)-cyclohexanecarboxylic acid {1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185914(1-(3-phenoxybenzyl)piperidine-4-carboxylic acid | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed