BindingDB logo
myBDB logout

PubMed code 16709453

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187072
PNG
(4-(4,6-dimethoxy-1H-indol-1-ylsulfonyl)benzenamine...)
Show SMILES COc1cc(OC)c2ccn(c2c1)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-21-12-9-15-14(16(10-12)22-2)7-8-18(15)23(19,20)13-5-3-11(17)4-6-13/h3-10H,17H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187076
PNG
(4-(6-methoxy-1H-indol-1-ylsulfonyl)benzenamine | C...)
Show SMILES COc1ccc2ccn(c2c1)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C15H14N2O3S/c1-20-13-5-2-11-8-9-17(15(11)10-13)21(18,19)14-6-3-12(16)4-7-14/h2-10H,16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187071
PNG
(4-(4-methoxy-1H-indol-1-ylsulfonyl)benzenamine | C...)
Show SMILES COc1cccc2n(ccc12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C15H14N2O3S/c1-20-15-4-2-3-14-13(15)9-10-17(14)21(18,19)12-7-5-11(16)6-8-12/h2-10H,16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187074
PNG
(9-(4-aminophenylsulfonyl)-N-methyl-6,7,8,9-tetrahy...)
Show SMILES CNc1cccc2n(c3CCCCc3c12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C19H21N3O2S/c1-21-16-6-4-8-18-19(16)15-5-2-3-7-17(15)22(18)25(23,24)14-11-9-13(20)10-12-14/h4,6,8-12,21H,2-3,5,7,20H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
165n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187075
PNG
(9-(4-aminophenylsulfonyl)-N-methyl-6,7,8,9-tetrahy...)
Show SMILES CNc1ccc2c3CCCCc3n(c2c1)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C19H21N3O2S/c1-21-14-8-11-17-16-4-2-3-5-18(16)22(19(17)12-14)25(23,24)15-9-6-13(20)7-10-15/h6-12,21H,2-5,20H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
205n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50187073
PNG
(4-(2,4-dimethoxy-5,6,7,8-tetrahydrocarbazol-9-ylsu...)
Show SMILES COc1cc(OC)c2c3CCCCc3n(c2c1)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C20H22N2O4S/c1-25-14-11-18-20(19(12-14)26-2)16-5-3-4-6-17(16)22(18)27(23,24)15-9-7-13(21)8-10-15/h7-12H,3-6,21H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
210n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT6 receptor


Bioorg Med Chem Lett 16: 3793-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.094
BindingDB Entry DOI: 10.7270/Q2H70FDF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%