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PubMed code 1671705

Compile data set for download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50228318
PNG
(CHEMBL279807)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18+/m1/s1
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0.355n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229080
PNG
(CHEMBL349665)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C23H28N2O3S/c1-28-19-8-10-20(11-9-19)29(26,27)25-13-4-6-18-16-24-14-12-17-5-2-3-7-21(17)23(24)15-22(18)25/h2-3,5,7-11,18,22-23H,4,6,12-16H2,1H3/t18-,22+,23+/m1/s1
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0.457n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229162
PNG
(CHEMBL349747)
Show SMILES COCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc(OC)ccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O4S/c1-25-10-11-27(23,24)22-8-3-4-16-14-21-9-7-15-12-17(26-2)5-6-18(15)20(21)13-19(16)22/h5-6,12,16,19-20H,3-4,7-11,13-14H2,1-2H3/t16-,19+,20+/m1/s1
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0.603n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229147
PNG
(CHEMBL348793)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15-,16+/m1/s1
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0.646n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229179
PNG
(DELEQUAMINE | Delequamine)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
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0.661n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229143
PNG
(CHEMBL162971)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15+,16+/m1/s1
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0.661n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229152
PNG
(CHEMBL349004)
Show SMILES Cc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O2S/c1-13-5-6-16-14(10-13)7-9-19-12-15-4-3-8-20(23(2,21)22)17(15)11-18(16)19/h5-6,10,15,17-18H,3-4,7-9,11-12H2,1-2H3/t15-,17+,18+/m1/s1
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0.708n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229155
PNG
(CHEMBL164420)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)N(C)C)CN3CCc2c1
Show InChI InChI=1S/C19H29N3O3S/c1-20(2)26(23,24)22-9-4-5-15-13-21-10-8-14-11-16(25-3)6-7-17(14)19(21)12-18(15)22/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3/t15-,18-,19+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229074
PNG
(CHEMBL163570)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)CCl)CN3CCc2c1
Show InChI InChI=1S/C18H25ClN2O3S/c1-24-15-4-5-16-13(9-15)6-8-20-11-14-3-2-7-21(25(22,23)12-19)17(14)10-18(16)20/h4-5,9,14,17-18H,2-3,6-8,10-12H2,1H3/t14-,17-,18+/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229171
PNG
(CHEMBL411954)
Show SMILES CCCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19+,20+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229149
PNG
(CHEMBL159919)
Show SMILES O=S(=O)(N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12)c1ccccc1
Show InChI InChI=1S/C22H26N2O2S/c25-27(26,19-9-2-1-3-10-19)24-13-6-8-18-16-23-14-12-17-7-4-5-11-20(17)22(23)15-21(18)24/h1-5,7,9-11,18,21-22H,6,8,12-16H2/t18-,21+,22+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229146
PNG
(CHEMBL163290)
Show SMILES CCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H26N2O2S/c1-2-23(21,22)20-10-5-7-15-13-19-11-9-14-6-3-4-8-16(14)18(19)12-17(15)20/h3-4,6,8,15,17-18H,2,5,7,9-13H2,1H3/t15-,17+,18+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229170
PNG
(CHEMBL348831)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)Cc4ccccc4)CN3CCc2c1
Show InChI InChI=1S/C24H30N2O3S/c1-29-21-9-10-22-19(14-21)11-13-25-16-20-8-5-12-26(23(20)15-24(22)25)30(27,28)17-18-6-3-2-4-7-18/h2-4,6-7,9-10,14,20,23-24H,5,8,11-13,15-17H2,1H3/t20-,23-,24+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229178
PNG
(CHEMBL161278)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)c4cccs4)CN3CCc2c1
Show InChI InChI=1S/C21H26N2O3S2/c1-26-17-6-7-18-15(12-17)8-10-22-14-16-4-2-9-23(19(16)13-20(18)22)28(24,25)21-5-3-11-27-21/h3,5-7,11-12,16,19-20H,2,4,8-10,13-14H2,1H3/t16-,19-,20+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229141
PNG
(CHEMBL162965)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)C=C)CN3CCc2c1
Show InChI InChI=1S/C19H26N2O3S/c1-3-25(22,23)21-9-4-5-15-13-20-10-8-14-11-16(24-2)6-7-17(14)19(20)12-18(15)21/h3,6-7,11,15,18-19H,1,4-5,8-10,12-13H2,2H3/t15-,18+,19+/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229077
PNG
(CHEMBL348726)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H26N2O4S/c1-26(22,23)21-5-2-3-14-12-20-6-4-13-9-18-19(25-8-7-24-18)10-15(13)17(20)11-16(14)21/h9-10,14,16-17H,2-8,11-12H2,1H3/t14-,16+,17+/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229072
PNG
(CHEMBL162841)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16+,17+/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229148
PNG
(CHEMBL350388)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)CC(C)C)CN3CCc2c1
Show InChI InChI=1S/C21H32N2O3S/c1-15(2)14-27(24,25)23-9-4-5-17-13-22-10-8-16-11-18(26-3)6-7-19(16)21(22)12-20(17)23/h6-7,11,15,17,20-21H,4-5,8-10,12-14H2,1-3H3/t17-,20+,21+/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229079
PNG
(CHEMBL352278)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-15(2)14-25(23,24)22-10-5-7-17-13-21-11-9-16-6-3-4-8-18(16)20(21)12-19(17)22/h3-4,6,8,15,17,19-20H,5,7,9-14H2,1-2H3/t17-,19+,20+/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229134
PNG
(CHEMBL262446)
Show SMILES CN(C)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H27N3O2S/c1-19(2)24(22,23)21-10-5-7-15-13-20-11-9-14-6-3-4-8-16(14)18(20)12-17(15)21/h3-4,6,8,15,17-18H,5,7,9-13H2,1-2H3/t15-,17+,18+/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229160
PNG
(CHEMBL355140)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H28N2O2S/c1-2-12-24(22,23)21-10-5-7-16-14-20-11-9-15-6-3-4-8-17(15)19(20)13-18(16)21/h3-4,6,8,16,18-19H,2,5,7,9-14H2,1H3/t16-,18+,19+/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229137
PNG
(CHEMBL350168)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H25FN2O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15H2/t17-,21+,22+/m1/s1
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2n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229081
PNG
(CHEMBL162109)
Show SMILES COc1cccc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c12)S(C)(=O)=O
Show InChI InChI=1S/C18H26N2O3S/c1-23-17-7-3-5-13-8-10-19-12-14-6-4-9-20(24(2,21)22)15(14)11-16(19)18(13)17/h3,5,7,14-16H,4,6,8-12H2,1-2H3/t14-,15+,16+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229138
PNG
(CHEMBL162024)
Show SMILES Nc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H27N3O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15,23H2/t17-,21+,22+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229150
PNG
(CHEMBL350393)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)N(C)C)CN3CCc2c1
Show InChI InChI=1S/C19H29N3O3S/c1-20(2)26(23,24)22-9-4-5-15-13-21-10-8-14-11-16(25-3)6-7-17(14)19(21)12-18(15)22/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3/t15-,18+,19+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229139
PNG
(CHEMBL349777)
Show SMILES COCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H28N2O3S/c1-24-11-12-25(22,23)21-9-4-6-16-14-20-10-8-15-5-2-3-7-17(15)19(20)13-18(16)21/h2-3,5,7,16,18-19H,4,6,8-14H2,1H3/t16-,18+,19+/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229161
PNG
(CHEMBL443554)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(N)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C17H25N3O3S/c1-23-14-4-5-15-12(9-14)6-8-19-11-13-3-2-7-20(24(18,21)22)16(13)10-17(15)19/h4-5,9,13,16-17H,2-3,6-8,10-11H2,1H3,(H2,18,21,22)/t13-,16+,17+/m1/s1
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3.70n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229157
PNG
(CHEMBL346462)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1Br
Show InChI InChI=1S/C18H25BrN2O3S/c1-24-17-6-5-13-14(18(17)19)7-9-20-11-12-4-3-8-21(25(2,22)23)15(12)10-16(13)20/h5-6,12,15-16H,3-4,7-11H2,1-2H3/t12-,15-,16+/m1/s1
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5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229163
PNG
(CHEMBL350144)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@@H]4C[C@H]3c2cc1Br)S(C)(=O)=O
Show InChI InChI=1S/C18H25BrN2O3S/c1-24-18-8-12-5-7-20-11-13-4-3-6-21(25(2,22)23)16(13)10-17(20)14(12)9-15(18)19/h8-9,13,16-17H,3-7,10-11H2,1-2H3/t13-,16-,17+/m1/s1
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5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229144
PNG
(CHEMBL161070)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H25ClN2O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15H2/t17-,21+,22+/m1/s1
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5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229168
PNG
(CHEMBL350105)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc(O)ccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O3S/c1-23(21,22)19-7-2-3-13-11-18-8-6-12-9-14(20)4-5-15(12)17(18)10-16(13)19/h4-5,9,13,16-17,20H,2-3,6-8,10-11H2,1H3/t13-,16+,17+/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229070
PNG
(CHEMBL159802)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H30N2O4S/c1-14(2)12-28(24,25)23-6-3-4-16-11-22-7-5-15-8-20-21(27-13-26-20)9-17(15)19(22)10-18(16)23/h8-9,14,16,18-19H,3-7,10-13H2,1-2H3/t16-,18+,19+/m1/s1
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6.80n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229166
PNG
(CHEMBL435057)
Show SMILES OCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H26N2O3S/c21-10-11-24(22,23)20-8-3-5-15-13-19-9-7-14-4-1-2-6-16(14)18(19)12-17(15)20/h1-2,4,6,15,17-18,21H,3,5,7-13H2/t15-,17+,18+/m1/s1
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6.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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7.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229164
PNG
(CHEMBL161531)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(=O)(=O)CC(C)C
Show InChI InChI=1S/C22H34N2O4S/c1-15(2)14-29(25,26)24-8-5-6-17-13-23-9-7-16-10-21(27-3)22(28-4)11-18(16)20(23)12-19(17)24/h10-11,15,17,19-20H,5-9,12-14H2,1-4H3/t17-,19+,20+/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229078
PNG
(CHEMBL354693)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccc(F)cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H23FN2O2S/c1-23(21,22)20-7-2-3-13-11-19-8-6-12-4-5-14(18)9-15(12)17(19)10-16(13)20/h4-5,9,13,16-17H,2-3,6-8,10-11H2,1H3/t13-,16+,17+/m1/s1
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9.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229151
PNG
(CHEMBL30477 | WY-26703)
Show SMILES CC(C)CS(=O)(=O)N(C)[C@@H]1CCN2CCc3ccccc3[C@@H]2C1
Show InChI InChI=1S/C18H28N2O2S/c1-14(2)13-23(21,22)19(3)16-9-11-20-10-8-15-6-4-5-7-17(15)18(20)12-16/h4-7,14,16,18H,8-13H2,1-3H3/t16-,18+/m1/s1
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9.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229069
PNG
(CHEMBL350312)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(C)(=O)=O
Show InChI InChI=1S/C19H28N2O4S/c1-24-18-9-13-6-8-20-12-14-5-4-7-21(26(3,22)23)16(14)11-17(20)15(13)10-19(18)25-2/h9-10,14,16-17H,4-8,11-12H2,1-3H3/t14-,16+,17+/m1/s1
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9.80n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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11n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229145
PNG
(CHEMBL162686)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1OC
Show InChI InChI=1S/C19H28N2O4S/c1-24-18-7-6-14-15(19(18)25-2)8-10-20-12-13-5-4-9-21(26(3,22)23)16(13)11-17(14)20/h6-7,13,16-17H,4-5,8-12H2,1-3H3/t13-,16+,17+/m1/s1
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11n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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13n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229075
PNG
(CHEMBL160028)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18-/m0/s1
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14n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229167
PNG
(CHEMBL351929)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)NC(C)(C)C)CN3CCc2c1
Show InChI InChI=1S/C21H33N3O3S/c1-21(2,3)22-28(25,26)24-10-5-6-16-14-23-11-9-15-12-17(27-4)7-8-18(15)20(23)13-19(16)24/h7-8,12,16,19-20,22H,5-6,9-11,13-14H2,1-4H3/t16-,19+,20+/m1/s1
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17n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229169
PNG
(CHEMBL160023)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H25N3O2S/c1-25(23,24)22-9-4-5-13-12-21-10-8-15-14-6-2-3-7-16(14)20-19(15)18(21)11-17(13)22/h2-3,6-7,13,17-18,20H,4-5,8-12H2,1H3/t13-,17+,18+/m1/s1
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17n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229071
PNG
(CHEMBL354698)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15-,16-/m0/s1
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28n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229176
PNG
(CHEMBL161775)
Show SMILES CS(=O)(=O)N1CC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]2C1
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-7-14-11-18-8-6-13-4-2-3-5-16(13)17(18)10-15(14)12-19/h2-5,14-15,17H,6-12H2,1H3/t14-,15-,17+/m1/s1
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29n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229174
PNG
(CHEMBL350863)
Show SMILES CCCCS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19-,20-/m0/s1
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38n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229158
PNG
(CHEMBL350528)
Show SMILES COc1ccc(OC)c2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc12
Show InChI InChI=1S/C19H28N2O4S/c1-24-17-6-7-18(25-2)19-14(17)8-10-20-12-13-5-4-9-21(26(3,22)23)15(13)11-16(19)20/h6-7,13,15-16H,4-5,8-12H2,1-3H3/t13-,15+,16+/m1/s1
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43n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229172
PNG
(CHEMBL163400)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16-,17-/m0/s1
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56n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229121
PNG
(CHEMBL163802)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15+,16-/m0/s1
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58n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Inhibition of P110delta/p85alpha


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229073
PNG
(CHEMBL349030)
Show SMILES COc1cc2CC(C)N3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(C)(=O)=O
Show InChI InChI=1S/C20H30N2O4S/c1-13-8-15-9-19(25-2)20(26-3)10-16(15)18-11-17-14(12-21(13)18)6-5-7-22(17)27(4,23)24/h9-10,13-14,17-18H,5-8,11-12H2,1-4H3/t13?,14-,17+,18+/m1/s1
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83n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229165
PNG
(CHEMBL349847)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18-/m0/s1
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132n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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316n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229140
PNG
(CHEMBL349218)
Show SMILES CS(=O)(=O)N1CC[C@H]2C[C@@H]3N(CCc4ccccc34)C[C@H]2C1
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-7-14-10-17-16-5-3-2-4-13(16)6-8-18(17)11-15(14)12-19/h2-5,14-15,17H,6-12H2,1H3/t14-,15-,17-/m0/s1
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398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229173
PNG
(CHEMBL355597)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2[C@@H]1CCN1CCc3cc4OCOc4cc3[C@H]21
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-6-2-3-13-15(20)5-8-19-7-4-12-9-16-17(24-11-23-16)10-14(12)18(13)19/h9-10,13,15,18H,2-8,11H2,1H3/t13-,15+,18+/m1/s1
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398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229156
PNG
(CHEMBL163489)
Show SMILES COc1ccc2[C@H]3C[C@@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m0/s1
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479n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229076
PNG
(CHEMBL163575)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]12
Show InChI InChI=1S/C19H25N3O2S/c1-25(23,24)22-9-4-5-13-12-21-10-8-15-14-6-2-3-7-16(14)20-19(15)18(21)11-17(13)22/h2-3,6-7,13,17-18,20H,4-5,8-12H2,1H3/t13-,17+,18-/m0/s1
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550n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229175
PNG
(CHEMBL354248)
Show SMILES CN1C[C@@H]2CCCN([C@@H]2C[C@H]1c1ccc2OCOc2c1)S(C)(=O)=O
Show InChI InChI=1S/C17H24N2O4S/c1-18-10-13-4-3-7-19(24(2,20)21)15(13)9-14(18)12-5-6-16-17(8-12)23-11-22-16/h5-6,8,13-15H,3-4,7,9-11H2,1-2H3/t13-,14-,15+/m0/s1
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741n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229154
PNG
(CHEMBL3143537)
Show SMILES OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C(O)C(I)I)c(=O)[nH]c1=O
Show InChI InChI=1S/C11H14I2N2O6/c12-9(13)8(18)4-2-15(11(20)14-10(4)19)7-1-5(17)6(3-16)21-7/h2,5-9,16-18H,1,3H2,(H,14,19,20)/t5-,6+,7+,8?/m0/s1
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741n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229142
PNG
(CHEMBL163697)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN(CCc3ccccc3)CC[C@H]12
Show InChI InChI=1S/C17H26N2O2S/c1-22(20,21)19-11-5-8-16-14-18(13-10-17(16)19)12-9-15-6-3-2-4-7-15/h2-4,6-7,16-17H,5,8-14H2,1H3/t16-,17+/m1/s1
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759n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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794n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229134
PNG
(CHEMBL262446)
Show SMILES CN(C)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H27N3O2S/c1-19(2)24(22,23)21-10-5-7-15-13-20-11-9-14-6-3-4-8-16(14)18(20)12-17(15)21/h3-4,6,8,15,17-18H,5,7,9-13H2,1-2H3/t15-,17+,18+/m1/s1
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933n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229159
PNG
(CHEMBL163571)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16+,17-/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229121
PNG
(CHEMBL163802)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15+,16-/m0/s1
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1.12E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(Homo sapiens (Human))
BDBM50229153
PNG
(CHEMBL163869)
Show SMILES COC(=O)C1[C@@H](O)CC[C@@H]2CN3CC4C(Nc5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H26N2O3/c1-25-20(24)18-13-8-16-19-14(12-4-2-3-5-15(12)21-19)10-22(16)9-11(13)6-7-17(18)23/h2-5,11,13-14,16-19,21,23H,6-10H2,1H3/t11-,13+,14?,16+,17+,18?,19?/m1/s1
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1.38E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement in human platelet membranes


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229177
PNG
(CHEMBL164472)
Show SMILES CCCCS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19+,20-/m0/s1
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1.51E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229154
PNG
(CHEMBL3143537)
Show SMILES OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C(O)C(I)I)c(=O)[nH]c1=O
Show InChI InChI=1S/C11H14I2N2O6/c12-9(13)8(18)4-2-15(11(20)14-10(4)19)7-1-5(17)6(3-16)21-7/h2,5-9,16-18H,1,3H2,(H,14,19,20)/t5-,6+,7+,8?/m0/s1
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1.51E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229153
PNG
(CHEMBL163869)
Show SMILES COC(=O)C1[C@@H](O)CC[C@@H]2CN3CC4C(Nc5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H26N2O3/c1-25-20(24)18-13-8-16-19-14(12-4-2-3-5-15(12)21-19)10-22(16)9-11(13)6-7-17(18)23/h2-5,11,13-14,16-19,21,23H,6-10H2,1H3/t11-,13+,14?,16+,17+,18?,19?/m1/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229176
PNG
(CHEMBL161775)
Show SMILES CS(=O)(=O)N1CC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]2C1
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-7-14-11-18-8-6-13-4-2-3-5-16(13)17(18)10-15(14)12-19/h2-5,14-15,17H,6-12H2,1H3/t14-,15-,17+/m1/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229177
PNG
(CHEMBL164472)
Show SMILES CCCCS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19+,20-/m0/s1
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1.74E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229151
PNG
(CHEMBL30477 | WY-26703)
Show SMILES CC(C)CS(=O)(=O)N(C)[C@@H]1CCN2CCc3ccccc3[C@@H]2C1
Show InChI InChI=1S/C18H28N2O2S/c1-14(2)13-23(21,22)19(3)16-9-11-20-10-8-15-6-4-5-7-17(15)18(20)12-16/h4-7,14,16,18H,8-13H2,1-3H3/t16-,18+/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229071
PNG
(CHEMBL354698)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15-,16-/m0/s1
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2.24E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229172
PNG
(CHEMBL163400)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16-,17-/m0/s1
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2.24E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229171
PNG
(CHEMBL411954)
Show SMILES CCCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19+,20+/m1/s1
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2.29E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229158
PNG
(CHEMBL350528)
Show SMILES COc1ccc(OC)c2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc12
Show InChI InChI=1S/C19H28N2O4S/c1-24-17-6-7-18(25-2)19-14(17)8-10-20-12-13-5-4-9-21(26(3,22)23)15(13)11-16(19)20/h6-7,13,15-16H,4-5,8-12H2,1-3H3/t13-,15+,16+/m1/s1
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2.34E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229159
PNG
(CHEMBL163571)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16+,17-/m0/s1
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2.63E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229155
PNG
(CHEMBL164420)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)N(C)C)CN3CCc2c1
Show InChI InChI=1S/C19H29N3O3S/c1-20(2)26(23,24)22-9-4-5-15-13-21-10-8-14-11-16(25-3)6-7-17(14)19(21)12-18(15)22/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3/t15-,18-,19+/m1/s1
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2.69E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229175
PNG
(CHEMBL354248)
Show SMILES CN1C[C@@H]2CCCN([C@@H]2C[C@H]1c1ccc2OCOc2c1)S(C)(=O)=O
Show InChI InChI=1S/C17H24N2O4S/c1-18-10-13-4-3-7-19(24(2,20)21)15(13)9-14(18)12-5-6-16-17(8-12)23-11-22-16/h5-6,8,13-15H,3-4,7,9-11H2,1-2H3/t13-,14-,15+/m0/s1
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2.82E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229142
PNG
(CHEMBL163697)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN(CCc3ccccc3)CC[C@H]12
Show InChI InChI=1S/C17H26N2O2S/c1-22(20,21)19-11-5-8-16-14-18(13-10-17(16)19)12-9-15-6-3-2-4-7-15/h2-4,6-7,16-17H,5,8-14H2,1H3/t16-,17+/m1/s1
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3.09E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229076
PNG
(CHEMBL163575)
Show SMILES CS(=O)(=O)N1CCC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]12
Show InChI InChI=1S/C19H25N3O2S/c1-25(23,24)22-9-4-5-13-12-21-10-8-15-14-6-2-3-7-16(14)20-19(15)18(21)11-17(13)22/h2-3,6-7,13,17-18,20H,4-5,8-12H2,1H3/t13-,17+,18-/m0/s1
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3.09E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229081
PNG
(CHEMBL162109)
Show SMILES COc1cccc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c12)S(C)(=O)=O
Show InChI InChI=1S/C18H26N2O3S/c1-23-17-7-3-5-13-8-10-19-12-14-6-4-9-20(24(2,21)22)15(14)11-16(19)18(13)17/h3,5,7,14-16H,4,6,8-12H2,1-2H3/t14-,15+,16+/m1/s1
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3.31E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229148
PNG
(CHEMBL350388)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)CC(C)C)CN3CCc2c1
Show InChI InChI=1S/C21H32N2O3S/c1-15(2)14-27(24,25)23-9-4-5-17-13-22-10-8-16-11-18(26-3)6-7-19(16)21(22)12-20(17)23/h6-7,11,15,17,20-21H,4-5,8-10,12-14H2,1-3H3/t17-,20+,21+/m1/s1
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3.89E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50229136
PNG
(CHEMBL351268)
Show SMILES CN1C[C@H]2CCCN([C@H]2C[C@H]1c1ccc2OCOc2c1)S(C)(=O)=O
Show InChI InChI=1S/C17H24N2O4S/c1-18-10-13-4-3-7-19(24(2,20)21)15(13)9-14(18)12-5-6-16-17(8-12)23-11-22-16/h5-6,8,13-15H,3-4,7,9-11H2,1-2H3/t13-,14+,15+/m1/s1
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4.17E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229137
PNG
(CHEMBL350168)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H25FN2O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15H2/t17-,21+,22+/m1/s1
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4.17E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229079
PNG
(CHEMBL352278)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-15(2)14-25(23,24)22-10-5-7-17-13-21-11-9-16-6-3-4-8-18(16)20(21)12-19(17)22/h3-4,6,8,15,17,19-20H,5,7,9-14H2,1-2H3/t17-,19+,20+/m1/s1
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4.27E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229157
PNG
(CHEMBL346462)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1Br
Show InChI InChI=1S/C18H25BrN2O3S/c1-24-17-6-5-13-14(18(17)19)7-9-20-11-12-4-3-8-21(25(2,22)23)15(12)10-16(13)20/h5-6,12,15-16H,3-4,7-11H2,1-2H3/t12-,15-,16+/m1/s1
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4.47E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229138
PNG
(CHEMBL162024)
Show SMILES Nc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H27N3O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15,23H2/t17-,21+,22+/m1/s1
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4.68E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229141
PNG
(CHEMBL162965)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)C=C)CN3CCc2c1
Show InChI InChI=1S/C19H26N2O3S/c1-3-25(22,23)21-9-4-5-15-13-20-10-8-14-11-16(24-2)6-7-17(14)19(20)12-18(15)21/h3,6-7,11,15,18-19H,1,4-5,8-10,12-13H2,2H3/t15-,18+,19+/m1/s1
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4.68E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229147
PNG
(CHEMBL348793)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15-,16+/m1/s1
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4.79E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229080
PNG
(CHEMBL349665)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C23H28N2O3S/c1-28-19-8-10-20(11-9-19)29(26,27)25-13-4-6-18-16-24-14-12-17-5-2-3-7-21(17)23(24)15-22(18)25/h2-3,5,7-11,18,22-23H,4,6,12-16H2,1H3/t18-,22+,23+/m1/s1
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4.90E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229149
PNG
(CHEMBL159919)
Show SMILES O=S(=O)(N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12)c1ccccc1
Show InChI InChI=1S/C22H26N2O2S/c25-27(26,19-9-2-1-3-10-19)24-13-6-8-18-16-23-14-12-17-7-4-5-11-20(17)22(23)15-21(18)24/h1-5,7,9-11,18,21-22H,6,8,12-16H2/t18-,21+,22+/m1/s1
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4.90E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229174
PNG
(CHEMBL350863)
Show SMILES CCCCS(=O)(=O)N1CCC[C@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O2S/c1-2-3-13-25(23,24)22-11-6-8-17-15-21-12-10-16-7-4-5-9-18(16)20(21)14-19(17)22/h4-5,7,9,17,19-20H,2-3,6,8,10-15H2,1H3/t17-,19-,20-/m0/s1
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5.01E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229160
PNG
(CHEMBL355140)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H28N2O2S/c1-2-12-24(22,23)21-10-5-7-16-14-20-11-9-15-6-3-4-8-17(15)19(20)13-18(16)21/h3-4,6,8,16,18-19H,2,5,7,9-14H2,1H3/t16-,18+,19+/m1/s1
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5.13E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50228318
PNG
(CHEMBL279807)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18+/m1/s1
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5.13E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229168
PNG
(CHEMBL350105)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc(O)ccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O3S/c1-23(21,22)19-7-2-3-13-11-18-8-6-12-9-14(20)4-5-15(12)17(18)10-16(13)19/h4-5,9,13,16-17,20H,2-3,6-8,10-11H2,1H3/t13-,16+,17+/m1/s1
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5.37E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229167
PNG
(CHEMBL351929)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)NC(C)(C)C)CN3CCc2c1
Show InChI InChI=1S/C21H33N3O3S/c1-21(2,3)22-28(25,26)24-10-5-6-16-14-23-11-9-15-12-17(27-4)7-8-18(15)20(23)13-19(16)24/h7-8,12,16,19-20,22H,5-6,9-11,13-14H2,1-4H3/t16-,19+,20+/m1/s1
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5.50E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229072
PNG
(CHEMBL162841)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-4-6-14-12-18-10-8-13-5-2-3-7-15(13)17(18)11-16(14)19/h2-3,5,7,14,16-17H,4,6,8-12H2,1H3/t14-,16+,17+/m1/s1
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5.50E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229150
PNG
(CHEMBL350393)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(=O)(=O)N(C)C)CN3CCc2c1
Show InChI InChI=1S/C19H29N3O3S/c1-20(2)26(23,24)22-9-4-5-15-13-21-10-8-14-11-16(25-3)6-7-17(14)19(21)12-18(15)22/h6-7,11,15,18-19H,4-5,8-10,12-13H2,1-3H3/t15-,18+,19+/m1/s1
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5.62E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229163
PNG
(CHEMBL350144)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@@H]4C[C@H]3c2cc1Br)S(C)(=O)=O
Show InChI InChI=1S/C18H25BrN2O3S/c1-24-18-8-12-5-7-20-11-13-4-3-6-21(25(2,22)23)16(13)10-17(20)14(12)9-15(18)19/h8-9,13,16-17H,3-7,10-11H2,1-2H3/t13-,16-,17+/m1/s1
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5.62E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Inhibition of P110alpha/p85alpha


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229078
PNG
(CHEMBL354693)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccc(F)cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C17H23FN2O2S/c1-23(21,22)20-7-2-3-13-11-19-8-6-12-4-5-14(18)9-15(12)17(19)10-16(13)20/h4-5,9,13,16-17H,2-3,6-8,10-11H2,1H3/t13-,16+,17+/m1/s1
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6.17E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229140
PNG
(CHEMBL349218)
Show SMILES CS(=O)(=O)N1CC[C@H]2C[C@@H]3N(CCc4ccccc34)C[C@H]2C1
Show InChI InChI=1S/C17H24N2O2S/c1-22(20,21)19-9-7-14-10-17-16-5-3-2-4-13(16)6-8-18(17)11-15(14)12-19/h2-5,14-15,17H,6-12H2,1H3/t14-,15-,17-/m0/s1
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6.31E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229075
PNG
(CHEMBL160028)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17-,18-/m0/s1
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6.31E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229144
PNG
(CHEMBL161070)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H25ClN2O2S/c23-18-7-9-19(10-8-18)28(26,27)25-12-3-5-17-15-24-13-11-16-4-1-2-6-20(16)22(24)14-21(17)25/h1-2,4,6-10,17,21-22H,3,5,11-15H2/t17-,21+,22+/m1/s1
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6.46E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229143
PNG
(CHEMBL162971)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-5-2-3-13-10-19-6-4-12-7-17-18(24-11-23-17)8-14(12)16(19)9-15(13)20/h7-8,13,15-16H,2-6,9-11H2,1H3/t13-,15+,16+/m1/s1
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7.24E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229139
PNG
(CHEMBL349777)
Show SMILES COCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H28N2O3S/c1-24-11-12-25(22,23)21-9-4-6-16-14-20-10-8-15-5-2-3-7-17(15)19(20)13-18(16)21/h2-3,5,7,16,18-19H,4,6,8-14H2,1H3/t16-,18+,19+/m1/s1
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7.41E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229074
PNG
(CHEMBL163570)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)CCl)CN3CCc2c1
Show InChI InChI=1S/C18H25ClN2O3S/c1-24-15-4-5-16-13(9-15)6-8-20-11-14-3-2-7-21(25(22,23)12-19)17(14)10-18(16)20/h4-5,9,14,17-18H,2-3,6-8,10-12H2,1H3/t14-,17-,18+/m1/s1
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7.41E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229170
PNG
(CHEMBL348831)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)Cc4ccccc4)CN3CCc2c1
Show InChI InChI=1S/C24H30N2O3S/c1-29-21-9-10-22-19(14-21)11-13-25-16-20-8-5-12-26(23(20)15-24(22)25)30(27,28)17-18-6-3-2-4-7-18/h2-4,6-7,9-10,14,20,23-24H,5,8,11-13,15-17H2,1H3/t20-,23-,24+/m1/s1
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7.41E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229173
PNG
(CHEMBL355597)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2[C@@H]1CCN1CCc3cc4OCOc4cc3[C@H]21
Show InChI InChI=1S/C18H24N2O4S/c1-25(21,22)20-6-2-3-13-15(20)5-8-19-7-4-12-9-16-17(24-11-23-16)10-14(12)18(13)19/h9-10,13,15,18H,2-8,11H2,1H3/t13-,15+,18+/m1/s1
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8.71E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229070
PNG
(CHEMBL159802)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H30N2O4S/c1-14(2)12-28(24,25)23-6-3-4-16-11-22-7-5-15-8-20-21(27-13-26-20)9-17(15)19(22)10-18(16)23/h8-9,14,16,18-19H,3-7,10-13H2,1-2H3/t16-,18+,19+/m1/s1
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9.12E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229162
PNG
(CHEMBL349747)
Show SMILES COCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc(OC)ccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C20H30N2O4S/c1-25-10-11-27(23,24)22-8-3-4-16-14-21-9-7-15-12-17(26-2)5-6-18(15)20(21)13-19(16)22/h5-6,12,16,19-20H,3-4,7-11,13-14H2,1-2H3/t16-,19+,20+/m1/s1
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9.33E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229077
PNG
(CHEMBL348726)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4cc5OCCOc5cc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H26N2O4S/c1-26(22,23)21-5-2-3-14-12-20-6-4-13-9-18-19(25-8-7-24-18)10-15(13)17(20)11-16(14)21/h9-10,14,16-17H,2-8,11-12H2,1H3/t14-,16+,17+/m1/s1
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9.55E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229178
PNG
(CHEMBL161278)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@H](CCCN4S(=O)(=O)c4cccs4)CN3CCc2c1
Show InChI InChI=1S/C21H26N2O3S2/c1-26-17-6-7-18-15(12-17)8-10-22-14-16-4-2-9-23(19(16)13-20(18)22)28(24,25)21-5-3-11-27-21/h3,5-7,11-12,16,19-20H,2,4,8-10,13-14H2,1H3/t16-,19-,20+/m1/s1
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9.77E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229156
PNG
(CHEMBL163489)
Show SMILES COc1ccc2[C@H]3C[C@@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m0/s1
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229179
PNG
(DELEQUAMINE | Delequamine)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
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1.02E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229146
PNG
(CHEMBL163290)
Show SMILES CCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H26N2O2S/c1-2-23(21,22)20-10-5-7-15-13-19-11-9-14-6-3-4-8-16(14)18(19)12-17(15)20/h3-4,6,8,15,17-18H,2,5,7,9-13H2,1H3/t15-,17+,18+/m1/s1
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1.07E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229073
PNG
(CHEMBL349030)
Show SMILES COc1cc2CC(C)N3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(C)(=O)=O
Show InChI InChI=1S/C20H30N2O4S/c1-13-8-15-9-19(25-2)20(26-3)10-16(15)18-11-17-14(12-21(13)18)6-5-7-22(17)27(4,23)24/h9-10,13-14,17-18H,5-8,11-12H2,1-4H3/t13?,14-,17+,18+/m1/s1
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1.17E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229161
PNG
(CHEMBL443554)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(N)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C17H25N3O3S/c1-23-14-4-5-15-12(9-14)6-8-19-11-13-3-2-7-20(24(18,21)22)16(13)10-17(15)19/h4-5,9,13,16-17H,2-3,6-8,10-11H2,1H3,(H2,18,21,22)/t13-,16+,17+/m1/s1
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1.20E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229152
PNG
(CHEMBL349004)
Show SMILES Cc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O2S/c1-13-5-6-16-14(10-13)7-9-19-12-15-4-3-8-20(23(2,21)22)17(15)11-18(16)19/h5-6,10,15,17-18H,3-4,7-9,11-12H2,1-2H3/t15-,17+,18+/m1/s1
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1.29E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229166
PNG
(CHEMBL435057)
Show SMILES OCCS(=O)(=O)N1CCC[C@@H]2CN3CCc4ccccc4[C@@H]3C[C@H]12
Show InChI InChI=1S/C18H26N2O3S/c21-10-11-24(22,23)20-8-3-5-15-13-19-9-7-14-4-1-2-6-16(14)18(19)12-17(15)20/h1-2,4,6,15,17-18,21H,3,5,7-13H2/t15-,17+,18+/m1/s1
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1.29E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229165
PNG
(CHEMBL349847)
Show SMILES COc1ccc2[C@@H]3C[C@@H]4[C@@H](CCCN4S(C)(=O)=O)CN3CCc2c1
Show InChI InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18-/m0/s1
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1.41E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229136
PNG
(CHEMBL351268)
Show SMILES CN1C[C@H]2CCCN([C@H]2C[C@H]1c1ccc2OCOc2c1)S(C)(=O)=O
Show InChI InChI=1S/C17H24N2O4S/c1-18-10-13-4-3-7-19(24(2,20)21)15(13)9-14(18)12-5-6-16-17(8-12)23-11-22-16/h5-6,8,13-15H,3-4,7,9-11H2,1-2H3/t13-,14+,15+/m1/s1
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1.51E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229169
PNG
(CHEMBL160023)
Show SMILES CS(=O)(=O)N1CCC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C19H25N3O2S/c1-25(23,24)22-9-4-5-13-12-21-10-8-15-14-6-2-3-7-16(14)20-19(15)18(21)11-17(13)22/h2-3,6-7,13,17-18,20H,4-5,8-12H2,1H3/t13-,17+,18+/m1/s1
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1.58E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229069
PNG
(CHEMBL350312)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(C)(=O)=O
Show InChI InChI=1S/C19H28N2O4S/c1-24-18-9-13-6-8-20-12-14-5-4-7-21(26(3,22)23)16(14)11-17(20)15(13)10-19(18)25-2/h9-10,14,16-17H,4-8,11-12H2,1-3H3/t14-,16+,17+/m1/s1
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3.47E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229164
PNG
(CHEMBL161531)
Show SMILES COc1cc2CCN3C[C@H]4CCCN([C@H]4C[C@H]3c2cc1OC)S(=O)(=O)CC(C)C
Show InChI InChI=1S/C22H34N2O4S/c1-15(2)14-29(25,26)24-8-5-6-17-13-23-9-7-16-10-21(27-3)22(28-4)11-18(16)20(23)12-19(17)24/h10-11,15,17,19-20H,5-9,12-14H2,1-4H3/t17-,19+,20+/m1/s1
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3.47E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50229145
PNG
(CHEMBL162686)
Show SMILES COc1ccc2[C@@H]3C[C@H]4[C@H](CCCN4S(C)(=O)=O)CN3CCc2c1OC
Show InChI InChI=1S/C19H28N2O4S/c1-24-18-7-6-14-15(19(18)25-2)8-10-20-12-13-5-4-9-21(26(3,22)23)16(13)11-17(14)20/h6-7,13,16-17H,4-5,8-12H2,1-3H3/t13-,16+,17+/m1/s1
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3.80E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]prazosin displacement from rat cortical membrane


J Med Chem 34: 705-17 (1991)


Article DOI: 10.1021/jm00106a036
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%