Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50032216
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi:  37nMAssay Description:Inhibition of unphosporylated AblMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of phosporylated AblMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50326001(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Affinity DataIC50:  6nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Affinity DataIC50:  9nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM17789(benzimidazole-urea, 17 | methyl N-{6-[4-({[2-fluor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  18nMAssay Description:Inhibition of VEGFR-3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  22nMAssay Description:Inhibition of B-Raf kinaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50153859(CHEMBL184659 | N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of PDGFRbeta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  58nMAssay Description:Inhibition of Flt3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50326001(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin...)
Affinity DataIC50:  67nMAssay Description:Inhibition of PDGFRalpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  68nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50:  70nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  98nMAssay Description:Inhibition of JNK2alpha2 kinaseMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  130nMAssay Description:Inhibition of VEGFR-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  188nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13353(3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...)
Affinity DataIC50:  340nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  386nMAssay Description:Inhibition of PDGFRbeta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  413nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  580nMAssay Description:Inhibition of FGFR-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM17789(benzimidazole-urea, 17 | methyl N-{6-[4-({[2-fluor...)
Affinity DataIC50:  695nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  800nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50114250(1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-(4-pyr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Syk kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Fyn kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM14831(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chl...)
Affinity DataKd:  1.16E+3nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair